SG11201402083XA - Production of acetyl-coenzyme a derived isoprenoids - Google Patents

Production of acetyl-coenzyme a derived isoprenoids

Info

Publication number
SG11201402083XA
SG11201402083XA SG11201402083XA SG11201402083XA SG11201402083XA SG 11201402083X A SG11201402083X A SG 11201402083XA SG 11201402083X A SG11201402083X A SG 11201402083XA SG 11201402083X A SG11201402083X A SG 11201402083XA SG 11201402083X A SG11201402083X A SG 11201402083XA
Authority
SG
Singapore
Prior art keywords
coenzyme
acetyl
production
derived isoprenoids
isoprenoids
Prior art date
Application number
SG11201402083XA
Inventor
Timothy Stevens Gardner
Kristy Michelle Hawkins
Adam Leon Meadows
Annie Ening Tsong
Yoseph Tsegaye
Original Assignee
Amyris Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amyris Inc filed Critical Amyris Inc
Publication of SG11201402083XA publication Critical patent/SG11201402083XA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0006Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0008Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1288Transferases for other substituted phosphate groups (2.7.8)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P23/00Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42Hydroxy-carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y101/00Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01034Hydroxymethylglutaryl-CoA reductase (NADPH) (1.1.1.34)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y102/00Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/0101Acetaldehyde dehydrogenase (acetylating) (1.2.1.10)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y207/00Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/08Transferases for other substituted phosphate groups (2.7.8)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
SG11201402083XA 2011-11-09 2012-11-09 Production of acetyl-coenzyme a derived isoprenoids SG11201402083XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161557893P 2011-11-09 2011-11-09
PCT/US2012/064532 WO2013071172A1 (en) 2011-11-09 2012-11-09 Production of acetyl-coenzyme a derived isoprenoids

Publications (1)

Publication Number Publication Date
SG11201402083XA true SG11201402083XA (en) 2014-06-27

Family

ID=47295179

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201402083XA SG11201402083XA (en) 2011-11-09 2012-11-09 Production of acetyl-coenzyme a derived isoprenoids

Country Status (16)

Country Link
US (4) US8415136B1 (en)
EP (1) EP2776571B1 (en)
JP (2) JP6073350B2 (en)
KR (1) KR102021914B1 (en)
CN (1) CN104039974B (en)
AU (1) AU2012335091B2 (en)
BR (1) BR112014010750B1 (en)
CA (1) CA2853679C (en)
DK (1) DK2776571T3 (en)
ES (1) ES2628847T3 (en)
IN (1) IN2014CN03791A (en)
MX (1) MX346459B (en)
PT (1) PT2776571T (en)
SG (1) SG11201402083XA (en)
WO (1) WO2013071172A1 (en)
ZA (1) ZA201402989B (en)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9328364B2 (en) * 2004-03-31 2016-05-03 Cargill Incorporated Process for fermenting sugars containing oligomeric saccharides
US8951764B2 (en) * 2011-08-05 2015-02-10 Danisco Us Inc. Production of isoprenoids under neutral pH conditions
CA2851265A1 (en) * 2011-10-07 2013-05-10 Danisco Us Inc. Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene
CN104039974B (en) * 2011-11-09 2016-10-12 阿迈瑞斯公司 The production of the isoprenoid that S-acetyl-coenzyme-A is derivative
EP3584323B1 (en) * 2012-12-10 2021-03-17 Cargill, Incorporated Batch feed process for fermenting sugars
KR102159691B1 (en) 2013-03-15 2020-09-24 아미리스 인코퍼레이티드 Use of phosphoketolase and phosphotransacetylase for production of acetyl-coenzyme a derived compounds
CN105555952A (en) * 2013-04-10 2016-05-04 丹尼斯科美国公司 Phosphoketolases for improved production of acetyl coenzyme a-derived metabolites, isoprene, isoprenoid precursors, and isoprenoids
EP2873725B1 (en) 2013-11-15 2016-09-07 Samsung Electronics Co., Ltd Genetically Engineered Yeast Cell Producing Lactate Including Acetaldehyde Dehydrogenase, Method of Producing Yeast Cell, and Method of Producing Lactate Using the Same
WO2015084633A1 (en) 2013-12-03 2015-06-11 Genomatica, Inc. Microorganisms and methods for improving product yields on methanol using acetyl-coa synthesis
CA2933902C (en) 2013-12-19 2022-08-30 Amyris, Inc. Methods for genomic integration
BR112016021857B1 (en) 2014-03-28 2024-03-12 Danisco Us Inc RECOMBINANT YEAST CELL AND METHOD FOR PRODUCING ETHANOL FROM GLUCOSE
JP6034332B2 (en) 2014-05-30 2016-11-30 トヨタ自動車株式会社 Recombinant microorganism and method for producing substance using the recombinant microorganism
WO2016029187A2 (en) 2014-08-21 2016-02-25 Givaudan Sa Methods for production of oxygenated terpenes
US10081821B2 (en) 2014-09-08 2018-09-25 Temasek Life Sciences Laboratory Limited Methods for efficient production of polyunsaturated fatty acids (PUFA) in Rhodosporidium and Rhodotorula species
JP6470532B2 (en) * 2014-09-17 2019-02-13 積水化学工業株式会社 Recombinant cells and methods for producing organic compounds
DK3194604T3 (en) 2014-09-18 2020-05-25 Genomatica Inc NON-NATURAL MICROBIAL ORGANISMS WITH IMPROVED ENERGY EFFICIENCY
EP3227461A1 (en) 2014-12-05 2017-10-11 Amyris, Inc. High-throughput sequencing of polynucleotides
DE102015103608A1 (en) * 2015-03-11 2016-09-15 Basf Se Process for the microbial de novo synthesis of terpenes
KR101782891B1 (en) * 2015-07-08 2017-09-29 한국과학기술연구원 Vectors and strains for producing myrcene and method of producing myrcene using the same
CN108473528A (en) 2015-10-29 2018-08-31 赛诺米克斯公司 High intensity sweetner
WO2017075538A1 (en) 2015-10-29 2017-05-04 Amyris, Inc. Compositions and methods for production of myrcene
WO2017094053A1 (en) * 2015-11-30 2017-06-08 積水化学工業株式会社 Recombinant cell, method for producing recombinant cell, and method for producing organic compound
EP3478844A4 (en) * 2016-07-01 2020-04-08 International Flavors & Fragrances Inc. Compositions and methods for producing citrus terpenoids
BR112019012306A2 (en) * 2016-12-16 2019-11-12 Danisco Us Inc bifunctional phosphocetolase phosphotransacetylase fusion polypeptides
CA3049126A1 (en) 2017-01-25 2018-08-02 Amyris Bio Products Portugal, Unipessoal, Lda Co-production of isoprenoids
CN106893726B (en) * 2017-02-20 2020-06-09 天津大学 Promoter and recombinant yeast strain
CN117402799A (en) * 2017-02-27 2024-01-16 积水化学工业株式会社 Recombinant cell, method for producing recombinant cell, and method for producing isoprene or terpene
BR112019023104A2 (en) 2017-05-03 2020-11-03 Firmenich Incorporated methods for making high intensity sweetener
WO2019030007A1 (en) 2017-08-07 2019-02-14 Total Raffinage Chimie Process for the recovery of fermentation products
US11103808B2 (en) 2017-08-07 2021-08-31 Amyris, Inc. Process for recovering isoprenoids produced by microorganisms
JP2019041712A (en) * 2017-09-05 2019-03-22 株式会社デンソー Recombinants and methods for producing squalene
CN107841523A (en) * 2017-10-19 2018-03-27 浙江大学 Triterpene substance method is extracted from Inonotus obliquus using the induction of quorum sensing molecule
CN107937431A (en) * 2017-10-28 2018-04-20 国际竹藤中心 A kind of method for improving saccharomyces cerevisiae synthesis linalool ability
WO2019113387A1 (en) 2017-12-07 2019-06-13 Zymergen Inc. Engineered biosynthetic pathways for production of (6e)-8-hydroxygeraniol by fermentation
CA3086490A1 (en) 2017-12-21 2019-06-27 Zymergen Inc. Nepetalactol oxidoreductases, nepetalactol synthases, and microbes capable of producing nepetalactone
MX2021004192A (en) 2018-10-15 2021-05-27 Amyris Inc Stevia rebaudiana kaurenoic acid hydroxylase variants for high efficiency production of rebaudiosides.
CN111378588A (en) * 2018-12-29 2020-07-07 中国科学院青岛生物能源与过程研究所 Genetically engineered bacterium for synthesizing farnesene by converting cellulose hydrolysate and application thereof
CN111378587B (en) * 2018-12-29 2022-08-05 中国科学院青岛生物能源与过程研究所 Genetically engineered bacterium for synthesizing beta-farnesene and application thereof
CN113631698A (en) 2019-01-24 2021-11-09 阿迈瑞斯公司 ABC transporter for efficient production of rebaudiosides
CN109777815B (en) * 2019-03-28 2021-10-29 昆明理工大学 HMG-CoA synthetase gene RKHMGCS and application thereof
CN109929937B (en) * 2019-04-01 2023-04-21 广东省科学院动物研究所 Primer, kit and method for identifying specificity of dermatophagoides
GB201907088D0 (en) * 2019-05-20 2019-07-03 C3 Bio Tech Limited Linalool synthases
JP7303908B2 (en) * 2019-06-06 2023-07-05 アミリス, インコーポレイテッド Methods for uncoupling yield and productivity of non-degradable compounds produced by host cells
WO2021173925A1 (en) * 2020-02-28 2021-09-02 Wisconsin Alumni Research Foundation Nonviral generation of genome edited chimeric antigen receptor t cells
AU2021305200A1 (en) * 2020-07-08 2023-02-16 The Regents Of The University Of California Modified yeast host cells useful for producing isoprenol
CN113234610B (en) * 2021-03-05 2023-06-13 江南大学 Saccharomyces cerevisiae strain for synthesizing squalene and application thereof
CN113430215B (en) * 2021-06-03 2023-04-18 昆明理工大学 Acetyl CoA synthetase gene RKACS1 and application thereof
CN116376995B (en) * 2022-04-02 2024-01-26 元素驱动(杭州)生物科技有限公司 Method for preparing glycine, acetyl-CoA and acetyl-CoA derivatives by using threonine
NL2032683B1 (en) * 2022-07-18 2024-01-26 Sestina Bio Llc Bioproduction of isoprenoids

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR745875A (en) 1932-11-16 1933-05-17 Adaptation system for wheelbarrows, pneumatic tires
US5272065A (en) 1983-10-20 1993-12-21 Research Foundation Of State University Of New York Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA
US7192751B2 (en) 2001-12-06 2007-03-20 The Regents Of The University Of California Biosynthesis of amorpha-4,11-diene
US7253001B2 (en) 2002-03-19 2007-08-07 Forskarpatent I Syd Ab Metabolic engineering for improved xylose utilisation of Saccharomyces cerevisiae
ATE537269T1 (en) * 2004-05-21 2011-12-15 Univ California METHOD FOR IMPROVING THE PRODUCTION OF ISOPRENOID COMPOSITIONS
RU2004124226A (en) 2004-08-10 2006-01-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) USE OF PHOSPHOCETHOLASE FOR PRODUCTION OF USEFUL METABOLITES
ES2394508T3 (en) * 2004-08-19 2013-02-01 Dsm Ip Assets B.V. Isoprenoid production
US20090053797A1 (en) * 2005-08-19 2009-02-26 Yoichiro Shiba Genetically modified host cells and use of same for producing isoprenoid compounds
PE20071235A1 (en) 2006-01-27 2007-12-02 Ajinomoto Kk METHOD FOR PRODUCING L-AMINO ACIDS
JP2009538601A (en) 2006-05-26 2009-11-12 アミリス バイオテクノロジーズ, インコーポレイテッド Isoprenoid production
WO2009005704A1 (en) * 2007-07-03 2009-01-08 The Regents Of The University Of California Methods of increasing isoprenoid or isoprenoid precursor production
PL2173881T3 (en) 2007-07-23 2017-05-31 Dsm Ip Assets B.V. Acetyl-coa producing enzymes in yeast
BRPI0922187B1 (en) 2008-11-19 2021-05-04 Amyris, Inc METHODS FOR GENERATING A POLYNUCLEOTIDE AND FOR GENERATING A HOST CELL
JP4760951B2 (en) 2009-05-08 2011-08-31 トヨタ自動車株式会社 Recombinant microorganism having butanol-producing ability and method for producing butanol
US20100311065A1 (en) * 2009-06-01 2010-12-09 Ubersax Jeffrey A Genetically modified microbes producing isoprenoids
EP2277989A1 (en) * 2009-07-24 2011-01-26 Technische Universiteit Delft Fermentative glycerol-free ethanol production
WO2011140171A2 (en) 2010-05-05 2011-11-10 Genomatica, Inc. Microorganisms and methods for the biosynthesis of butadiene
JP5056897B2 (en) 2010-05-14 2012-10-24 トヨタ自動車株式会社 Method for producing 2-butanol and recombinant microorganism having 2-butanol-producing ability
DE102010029973A1 (en) * 2010-06-11 2011-12-15 Evonik Degussa Gmbh Microbiological production of C4 bodies from sucrose and carbon dioxide
US8871488B2 (en) 2010-06-18 2014-10-28 Butamax Advanced Biofuels Llc Recombinant host cells comprising phosphoketolases
AU2012289886A1 (en) 2011-08-04 2014-02-20 Danisco Us Inc. Production of isoprene, isoprenoid precursors, and isoprenoids using acetoacetyl-CoA synthase
CN104039974B (en) * 2011-11-09 2016-10-12 阿迈瑞斯公司 The production of the isoprenoid that S-acetyl-coenzyme-A is derivative

Also Published As

Publication number Publication date
JP2017055777A (en) 2017-03-23
CN104039974A (en) 2014-09-10
ES2628847T3 (en) 2017-08-04
EP2776571B1 (en) 2017-04-12
JP6073350B2 (en) 2017-02-01
KR102021914B1 (en) 2019-09-17
JP6461208B2 (en) 2019-01-30
CA2853679A1 (en) 2013-05-16
AU2012335091A1 (en) 2014-06-19
CN104039974B (en) 2016-10-12
PT2776571T (en) 2017-07-07
IN2014CN03791A (en) 2015-10-16
US20130236942A1 (en) 2013-09-12
JP2014532444A (en) 2014-12-08
KR20140093981A (en) 2014-07-29
CA2853679C (en) 2021-05-04
US9914941B2 (en) 2018-03-13
MX2014005543A (en) 2014-06-04
WO2013071172A1 (en) 2013-05-16
BR112014010750A2 (en) 2017-06-13
US20150093797A1 (en) 2015-04-02
US20140154765A1 (en) 2014-06-05
US8603800B2 (en) 2013-12-10
BR112014010750B1 (en) 2021-09-21
MX346459B (en) 2017-03-22
US8415136B1 (en) 2013-04-09
AU2012335091B2 (en) 2016-06-16
ZA201402989B (en) 2015-11-25
DK2776571T3 (en) 2017-06-26
EP2776571A1 (en) 2014-09-17
US8859261B2 (en) 2014-10-14

Similar Documents

Publication Publication Date Title
ZA201402989B (en) Production of Acetyl-Coenzyme a Derived Isoprenoids
GB201104096D0 (en) Production of graphene
PT2723544T (en) Production of a tower
PL2589796T3 (en) Manufacture of a root section
ZA201308393B (en) Production of acetyl-coenzyme a derived compounds
EP2712362A4 (en) Manufacture of lacto-n-tetraose
HK1192332A1 (en) Timepiece
ZA201400114B (en) Can manufacture
AU337152S (en) Watch
PL2667726T3 (en) Food production line
AU337151S (en) Watch
EP2741998A4 (en) Architectural construct having a plurality of implementations
IL238619B (en) Fermentative production of a hydrocarbon
PT2687791T (en) Method for the production of a reflector element
GB2494153B (en) Selection of codecs
HK1201340A1 (en) Timepiece
PL2723181T5 (en) Manufacture of cheese
EP2694461A4 (en) Manufacture of methanol
PL2681199T3 (en) Process for the preparation of (-)-huperzine a
EP2700402A4 (en) Novel uses of licochalcone a
ZA201307229B (en) Prodrugs of d-isoglutamyl-[d/l]- tryprophan
HK1150490A2 (en) A clamping-switch bracelet
GB2497112B (en) Manufacture of a package
EP2702991A4 (en) A composition of entacopone
PL2770874T3 (en) A piece of furniture