KR101656592B1 - 디히드로-벤조-옥사진 및 디히드로-피리도-옥사진 유도체 - Google Patents

디히드로-벤조-옥사진 및 디히드로-피리도-옥사진 유도체 Download PDF

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KR101656592B1
KR101656592B1 KR1020147019952A KR20147019952A KR101656592B1 KR 101656592 B1 KR101656592 B1 KR 101656592B1 KR 1020147019952 A KR1020147019952 A KR 1020147019952A KR 20147019952 A KR20147019952 A KR 20147019952A KR 101656592 B1 KR101656592 B1 KR 101656592B1
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dihydro
pyrrolidin
oxazin
benzo
pyridin
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KR20140107500A (ko
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조르지오 카라바티
실비 샤모인
파스칼 푸렛
클레멘스 회게나우어
콘스탄츠 허트
크리스토프 칼리스
카렌 카메르톤스
이안 루이스
헨리크 뫼비츠
알렉산더 백스터 스미스
니콜라스 솔더만
로메인 울프
프레드릭 제크리
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노파르티스 아게
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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KR1020147019952A 2011-12-22 2012-12-20 디히드로-벤조-옥사진 및 디히드로-피리도-옥사진 유도체 Active KR101656592B1 (ko)

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Application Number Priority Date Filing Date Title
US201161579231P 2011-12-22 2011-12-22
US61/579,231 2011-12-22
PCT/IB2012/057554 WO2013093849A1 (en) 2011-12-22 2012-12-20 Dihydro-benzo-oxazine and dihydro-pyrido-oxazine derivatives

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KR20140107500A KR20140107500A (ko) 2014-09-04
KR101656592B1 true KR101656592B1 (ko) 2016-09-23

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US (2) US9539260B2 (https=)
EP (1) EP2794600B1 (https=)
JP (1) JP5903499B2 (https=)
KR (1) KR101656592B1 (https=)
CN (1) CN104011045B (https=)
AP (1) AP4055A (https=)
AR (1) AR089424A1 (https=)
AU (1) AU2012356083B2 (https=)
BR (1) BR112014015103B1 (https=)
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CL (1) CL2014001452A1 (https=)
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JP5903499B2 (ja) 2011-12-22 2016-04-13 ノバルティス アーゲー ジヒドロ−ベンゾ−オキサジンおよびジヒドロ−ピリド−オキサジン誘導体
AR089284A1 (es) 2011-12-22 2014-08-13 Galapagos Nv Dihidropirimidinoisoquinolinonas y composiciones farmaceuticas de las mismas para el tratamiento de trastornos inflamatorios
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
LT2928896T (lt) * 2012-11-26 2017-09-25 Novartis Ag Dihidro-pirido-oksazino darinio kieta forma
TW201422625A (zh) * 2012-11-26 2014-06-16 Novartis Ag 二氫－吡啶并－□衍生物之固體形式
CN105541698B (zh) * 2015-12-23 2018-07-10 滨海康杰化学有限公司 一种5-溴-2-三氟甲基吡啶的制备方法
GB2550437B (en) * 2016-05-20 2021-06-23 Bugworks Res Inc Heterocyclic compounds useful as anti-bacterial agents and method for production
ES2971712T3 (es) 2017-12-22 2024-06-06 Hibercell Inc Derivados de cromenopiridina como inhibidores de la fosfatidilinositol fosfato cinasa
ES2986417T3 (es) 2018-08-13 2024-11-11 Hoffmann La Roche Nuevos compuestos heterocíclicos como inhibidores de la monoacilglicerol lipasa
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AU2019395201A1 (en) 2018-12-06 2021-05-20 Daiichi Sankyo Company, Limited Cycloalkane-1,3-diamine derivative
TW202112784A (zh) 2019-06-17 2021-04-01 美商佩特拉製藥公司 作為磷脂酸肌醇磷酸激酶抑制劑之𠳭唏并嘧啶衍生物
EP4028403B1 (en) 2019-09-12 2023-11-22 F. Hoffmann-La Roche AG 4,4a,5,7,8,8a-hexapyrido[4,3-b][1,4]oxazin-3-one compounds as magl inhibitors
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CN119173446A (zh) 2022-03-08 2024-12-20 赤盾医疗有限公司 机器人药物制备系统中的流体转移站
CN116535436B (zh) * 2023-05-06 2024-04-30 遵义医科大学 一种氟离子荧光探针及其合成方法和应用
WO2025099111A1 (en) * 2023-11-10 2025-05-15 Wella Germany Gmbh New telescoping syntheses of 6-hydroxy-benzomorpholine (3,4-dihydro-2h-1,4-benzoxazin-6-ol)
CN120398870A (zh) * 2024-01-31 2025-08-01 深圳晶蛋生物医药科技有限公司 一种苯并吗啉类化合物及其应用

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