KR101329437B1 - Ｈｄａｃ 억제제의 약학 제형 - Google Patents

Ｈｄａｃ 억제제의 약학 제형 Download PDF

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KR101329437B1
KR101329437B1 KR1020137015868A KR20137015868A KR101329437B1 KR 101329437 B1 KR101329437 B1 KR 101329437B1 KR 1020137015868 A KR1020137015868 A KR 1020137015868A KR 20137015868 A KR20137015868 A KR 20137015868A KR 101329437 B1 KR101329437 B1 KR 101329437B1
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pharmaceutical composition
cyclodextrin
meglumine
hdaci
concentration
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KR20130079665A (ko
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리차드 제이. 바스틴
니콜라스 제이. 휴스
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토포타겟 유케이 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
KR1020137015868A 2005-05-13 2006-05-11 Ｈｄａｃ 억제제의 약학 제형 Expired - Fee Related KR101329437B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US68121505P 2005-05-13 2005-05-13
US68123405P 2005-05-13 2005-05-13
US60/681,234 2005-05-13
US60/681,215 2005-05-13
PCT/GB2006/001737 WO2006120456A1 (en) 2005-05-13 2006-05-11 Pharmaceutical formulations of hdac inhibitors

Related Parent Applications (1)

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KR1020077029199A Division KR101340824B1 (ko) 2005-05-13 2006-05-11 Ｈｄａｃ 억제제의 약학 제형

Publications (2)

Publication Number Publication Date
KR20130079665A KR20130079665A (ko) 2013-07-10
KR101329437B1 true KR101329437B1 (ko) 2013-11-14

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ID=36617353

Family Applications (2)

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KR1020137015868A Expired - Fee Related KR101329437B1 (ko) 2005-05-13 2006-05-11 Ｈｄａｃ 억제제의 약학 제형
KR1020077029199A Active KR101340824B1 (ko) 2005-05-13 2006-05-11 Ｈｄａｃ 억제제의 약학 제형

Family Applications After (1)

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Country Status (26)

Country Link
US (3) US8835501B2 (enExample)
EP (2) EP1901729B1 (enExample)
JP (2) JP5108750B2 (enExample)
KR (2) KR101329437B1 (enExample)
CN (2) CN101189003B (enExample)
AT (1) ATE542527T1 (enExample)
AU (1) AU2006245495B2 (enExample)
BR (1) BRPI0610128B1 (enExample)
CA (1) CA2606598C (enExample)
CY (1) CY1112498T1 (enExample)
DK (2) DK1901729T3 (enExample)
EA (2) EA018982B1 (enExample)
EC (1) ECSP078002A (enExample)
ES (2) ES2380887T3 (enExample)
HR (1) HRP20120341T1 (enExample)
IL (2) IL187231A (enExample)
MX (1) MX2007013938A (enExample)
NO (1) NO339954B1 (enExample)
NZ (1) NZ563236A (enExample)
PL (1) PL1901729T3 (enExample)
PT (1) PT1901729E (enExample)
RS (1) RS52214B (enExample)
SI (1) SI1901729T1 (enExample)
UA (1) UA99810C2 (enExample)
WO (1) WO2006120456A1 (enExample)
ZA (1) ZA200710313B (enExample)

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* Cited by examiner, † Cited by third party
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CA2596210C (en) 2005-02-03 2014-07-08 Topotarget Uk Limited Combination therapies using hdac inhibitors
ES2380887T3 (es) 2005-05-13 2012-05-21 Topotarget Uk Limited Formulaciones farmacéuticas de inhibidores de la HDAC
US8828392B2 (en) * 2005-11-10 2014-09-09 Topotarget Uk Limited Histone deacetylase (HDAC) inhibitors (PXD101) for the treatment of cancer alone or in combination with chemotherapeutic agent
ITRM20070038A1 (it) * 2007-01-26 2008-07-27 Uni Degli Studi Di Roma La Sapienza Forme solubili di complessi di inclusione di inibitori dell istone deacetilasi e ciclodestrine loro processi di preparazione e impieghi in campo farmaceutico
EP2192904B1 (en) * 2007-08-27 2016-08-17 Auxagen, Inc. METHODS FOR INHIBITING TGF-beta
EP2203421B1 (en) * 2007-09-25 2014-05-07 TopoTarget UK Limited Methods of synthesis of certain n-hydroxy-3-(3-phenylsulfamoyl-phenyl)-acrylamide compounds
US20110003777A1 (en) * 2008-03-07 2011-01-06 Topotarget A/S Methods of Treatment Employing Prolonged Continuous Infusion of Belinostat
CN102159219B (zh) * 2008-09-16 2015-06-24 圣路易斯大学 提高转化生长因子-β信号发送的方法
NZ592993A (en) * 2008-10-22 2013-02-22 Acucela Inc Compounds for treating ophthalmic diseases and disorders
GB0900555D0 (en) * 2009-01-14 2009-02-11 Topotarget As New methods
WO2011064663A1 (en) 2009-11-25 2011-06-03 Festuccia, Claudio Combination treatment employing belinostat and bicalutamide
ES2627020T3 (es) 2011-03-21 2017-07-26 Valcuria Ab Composición farmacéutica que comprende un inhibidor de HDAC y un esteroide y el uso de la misma
EA028413B1 (ru) * 2011-09-18 2017-11-30 Эро-Селтик С.А. Фармацевтические композиции
CA2862259A1 (en) * 2011-12-29 2013-07-04 Pharmacyclics, Inc. Cinnamic acid hydroxyamides as inhibitors of histone deacetylase 8
AR092790A1 (es) 2012-02-01 2015-05-06 Euro Celtique Sa Derivados bencimidazolicos del acido hidroxamico
MX370099B (es) 2014-03-26 2019-12-02 Astex Therapeutics Ltd Combinación que comprende un inhibidor de fgfr y un inhibidor de cmet para el tratamiento del cáncer.
GB201409471D0 (en) 2014-05-28 2014-07-09 Euro Celtique Sa Pharmaceutical composition
GB201409488D0 (en) 2014-05-28 2014-07-09 Euro Celtique Sa Pharmaceutical composition
GB201409485D0 (en) 2014-05-28 2014-07-09 Euro Celtique Sa Pharmaceutical composition
CA2951912A1 (en) 2014-06-12 2015-12-17 University Of Notre Dame Du Lac Composition and method for the treatment of neurological diseases and cerebral injury
JOP20200201A1 (ar) 2015-02-10 2017-06-16 Astex Therapeutics Ltd تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين
KR20170124602A (ko) 2015-03-13 2017-11-10 포르마 세라퓨틱스 인크. Hdac8 억제제로서의 알파-신나미드 화합물 및 조성물
JP2018517788A (ja) 2015-06-16 2018-07-05 スペクトラム・ファーマシューティカルズ，インコーポレイテッド リンパ腫を治療するためにベリノスタットおよびプララトレキサートを使用する組合せ療法
CN105481736A (zh) * 2015-12-28 2016-04-13 山东大学 一种含有苯甘氨酸的肉桂酰胺类组蛋白去乙酰化酶抑制剂及其制备方法和应用
WO2017144543A1 (en) 2016-02-22 2017-08-31 Onxeo Combination therapies comprising immuno-oncology agents and belinostat
PL3347055T3 (pl) 2016-03-31 2019-11-29 Midatech Ltd Addukt cyklodekstryny-panobinostatu
CN109715141A (zh) * 2016-07-08 2019-05-03 兰迪斯制药公司 治疗和/或预防溶酶体贮积病和其它单基因代谢性疾病的组合物和方法
CN107625967B (zh) * 2016-07-15 2021-07-06 中国人民解放军军事医学科学院毒物药物研究所 一种特考韦瑞注射用药物组合物及其制备方法
CN107638571B (zh) * 2016-07-15 2021-07-06 中国人民解放军军事医学科学院毒物药物研究所 一种特考韦瑞口服药物组合物及其制备方法
WO2018029699A1 (en) * 2016-08-11 2018-02-15 Msn Research & Development Center Solid state forms of (2e)-n-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide and process for preparation thereof
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