JP5108750B2 - Ｈｄａｃ阻害剤の医薬製剤 - Google Patents

Ｈｄａｃ阻害剤の医薬製剤 Download PDF

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JP5108750B2
JP5108750B2 JP2008510642A JP2008510642A JP5108750B2 JP 5108750 B2 JP5108750 B2 JP 5108750B2 JP 2008510642 A JP2008510642 A JP 2008510642A JP 2008510642 A JP2008510642 A JP 2008510642A JP 5108750 B2 JP5108750 B2 JP 5108750B2
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pharmaceutical composition
composition according
arginine
histone deacetylase
concentration
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JP2008540499A (ja
JP2008540499A5 (enExample
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バスティン，リチャード，ジェイ．
ヒューズ，ニコラス，ジェイ．
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トポターゲット ユーケー リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
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    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Otolaryngology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
JP2008510642A 2005-05-13 2006-05-11 Ｈｄａｃ阻害剤の医薬製剤 Expired - Lifetime JP5108750B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US68123405P 2005-05-13 2005-05-13
US68121505P 2005-05-13 2005-05-13
US60/681,215 2005-05-13
US60/681,234 2005-05-13
PCT/GB2006/001737 WO2006120456A1 (en) 2005-05-13 2006-05-11 Pharmaceutical formulations of hdac inhibitors

Related Child Applications (1)

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JP2012128900A Division JP5567068B2 (ja) 2005-05-13 2012-06-06 Ｈｄａｃ阻害剤の医薬製剤

Publications (3)

Publication Number Publication Date
JP2008540499A JP2008540499A (ja) 2008-11-20
JP2008540499A5 JP2008540499A5 (enExample) 2009-06-25
JP5108750B2 true JP5108750B2 (ja) 2012-12-26

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JP2008510642A Expired - Lifetime JP5108750B2 (ja) 2005-05-13 2006-05-11 Ｈｄａｃ阻害剤の医薬製剤
JP2012128900A Expired - Fee Related JP5567068B2 (ja) 2005-05-13 2012-06-06 Ｈｄａｃ阻害剤の医薬製剤

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Country Link
US (3) US8835501B2 (enExample)
EP (2) EP2494969B1 (enExample)
JP (2) JP5108750B2 (enExample)
KR (2) KR101329437B1 (enExample)
CN (2) CN102579417B (enExample)
AT (1) ATE542527T1 (enExample)
AU (1) AU2006245495B2 (enExample)
BR (1) BRPI0610128B1 (enExample)
CA (1) CA2606598C (enExample)
CY (1) CY1112498T1 (enExample)
DK (2) DK2494969T3 (enExample)
EA (2) EA018982B1 (enExample)
EC (1) ECSP078002A (enExample)
ES (2) ES2540204T3 (enExample)
HR (1) HRP20120341T1 (enExample)
IL (2) IL187231A (enExample)
MX (1) MX2007013938A (enExample)
NO (1) NO339954B1 (enExample)
NZ (1) NZ563236A (enExample)
PL (1) PL1901729T3 (enExample)
PT (1) PT1901729E (enExample)
RS (1) RS52214B (enExample)
SI (1) SI1901729T1 (enExample)
UA (1) UA99810C2 (enExample)
WO (1) WO2006120456A1 (enExample)
ZA (1) ZA200710313B (enExample)

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NZ589276A (en) 2005-02-03 2012-06-29 Topotarget Uk Ltd Combination therapies using hdac inhibitors and erlotinib (tarceva)
SI1901729T1 (sl) 2005-05-13 2012-05-31 Topotarget Uk Ltd Farmacevtske formulacije HDAC inhibitorjev
CA2627923C (en) 2005-11-10 2016-01-12 Topotarget Uk Limited Histone deacetylase (hdac) inhibitors (pxdlol) for the treatment of cancer
ITRM20070038A1 (it) * 2007-01-26 2008-07-27 Uni Degli Studi Di Roma La Sapienza Forme solubili di complessi di inclusione di inibitori dell istone deacetilasi e ciclodestrine loro processi di preparazione e impieghi in campo farmaceutico
CA2699454C (en) * 2007-08-27 2012-07-24 Auxagen, Inc. Methods for inhibiting tgf-.beta.
CN101868446A (zh) 2007-09-25 2010-10-20 托波塔吉特英国有限公司 某些异羟肟酸化合物的合成方法
SI2262493T1 (sl) * 2008-03-07 2015-07-31 Onxeo Dk Branch Of Onxeo S.A. France Postopki zdravljenja z uporabo podaljšane kontinuirane infuzije belinostata
WO2010033507A1 (en) * 2008-09-16 2010-03-25 St. Louis University Method of enhancing tgf-beta signalling
BRPI0919920A2 (pt) 2008-10-22 2016-02-16 Acucela Inc compostos para tratamento de doenças e desordens oftálmicas
GB0900555D0 (en) * 2009-01-14 2009-02-11 Topotarget As New methods
WO2011064663A1 (en) 2009-11-25 2011-06-03 Festuccia, Claudio Combination treatment employing belinostat and bicalutamide
HUE032100T2 (en) 2011-03-21 2017-08-28 Valcuria Ab A pharmaceutical composition comprising an HDAC inhibitor and a steroid and its use
EP2758052B9 (en) * 2011-09-18 2019-03-27 Euro-Celtique S.A. Pharmaceutical composition comprising an HDAC inhibitor and a cyclopolysaccharide
WO2013101600A1 (en) * 2011-12-29 2013-07-04 Pharmacyclics, Inc. Cinnamic acid hydroxyamides as inhibitors of histone deacetylase 8
TWI573792B (zh) 2012-02-01 2017-03-11 歐陸斯迪公司 新穎治療劑
BR112016022056B1 (pt) 2014-03-26 2023-04-11 Astex Therapeutics Limited Combinação, composição farmacêutica, uso de uma combinação ou uma composição farmacêutica, e, produto farmacêutico
GB201409471D0 (en) 2014-05-28 2014-07-09 Euro Celtique Sa Pharmaceutical composition
GB201409488D0 (en) 2014-05-28 2014-07-09 Euro Celtique Sa Pharmaceutical composition
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KR20170012555A (ko) 2014-06-12 2017-02-02 더 유니버시티 오브 노트르 담 듀락 신경 질환 및 대뇌 상해의 치료를 위한 조성물 및 방법
TWI719960B (zh) 2015-02-10 2021-03-01 英商阿斯迪克治療公司 新穎組成物
US9745253B2 (en) 2015-03-13 2017-08-29 Forma Therapeutics, Inc. Alpha-cinnamide compounds and compositions as HDAC8 inhibitors
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
US11439643B2 (en) 2015-06-16 2022-09-13 Acrotech Biopharma Inc. Combination therapy using belinostat and pralatrexate to treat lymphoma
CN105481736A (zh) * 2015-12-28 2016-04-13 山东大学 一种含有苯甘氨酸的肉桂酰胺类组蛋白去乙酰化酶抑制剂及其制备方法和应用
CA3015241A1 (en) 2016-02-22 2017-08-31 Onxeo Combination therapies comprising immuno-oncology agents and belinostat
CA3018923A1 (en) 2016-03-31 2017-10-05 Midatech Ltd. Cyclodextrin-panobinostat adduct for treating brain tumours
MX2019000342A (es) * 2016-07-08 2019-09-04 Ranedis Pharmaceuticals Llc Composiciones y metodos para tratar y/o prevenir enfermedades de almacenamiento lisosomal y otras enfermedades metabolicas monogeneticas.
CN107625967B (zh) * 2016-07-15 2021-07-06 中国人民解放军军事医学科学院毒物药物研究所 一种特考韦瑞注射用药物组合物及其制备方法
CN107638571B (zh) * 2016-07-15 2021-07-06 中国人民解放军军事医学科学院毒物药物研究所 一种特考韦瑞口服药物组合物及其制备方法
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