KR101217497B1 - 지방의 감소를 위한 방법 및 관련 조성물 - Google Patents
지방의 감소를 위한 방법 및 관련 조성물 Download PDFInfo
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- KR101217497B1 KR101217497B1 KR1020067023922A KR20067023922A KR101217497B1 KR 101217497 B1 KR101217497 B1 KR 101217497B1 KR 1020067023922 A KR1020067023922 A KR 1020067023922A KR 20067023922 A KR20067023922 A KR 20067023922A KR 101217497 B1 KR101217497 B1 KR 101217497B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
Description
청정제 명 | 분자량(AMU) | 미셀 분자량(AMU) | 물에서의 CMC(M) |
음이온성 | |||
콜레이트 | 430 | 4300 | 1.4x10-2 |
데옥시콜레이트 | 415-432 | 4200 | 5x10-3 |
소듐 도데실 설페이트 | 288 | 18000 | 8.3x10-3 |
양이온성 | |||
C16-TAB | 365 | 62000 | 1x10-3 |
암포테릭(즈위터이온성) | |||
콜린산-설포베타인 | 615 | 6150 | 4x10-3 |
콜린산-설포베타인 | 631 | 6940 | 8x10-3 |
라이소포스파티딜콜린 | 495 | 92000 | 7x10-6 |
즈위터겐트 3-14 | 364 | 30000 | 3x10-4 |
비-이온성 | |||
Brij 35 | 1225 | 49000 | 9x10-5 |
폴리옥실에틸렌(20)세틸 에테르 | 1120 | 82000 | 7.7x10-5 |
루브롤 PX | 582 | 64000 | 1x10-4 |
노니데 P-40 | 603 | 90000 | 3x10-4 |
옥틸페놀폴리(에틸렌글리콜에테르)n10 | 647 | 90000 | 0.2x10-3 |
옥틸페놀폴리(에틸렌글리콜에테르)n7 | 515 | 0.2x10-3 | |
n-옥틸글루코사이드 | 292 | 8000 | 14.5x10-3 |
옥틸-티오글루코피라노사이드 | 308 | 9x10-3 | |
Tween-80 | 1310 | 76000 | 1.2x10-5 |
Tween-20 | 1228 | 6.0x10-5 |
포스파티딜콜린 | 5.00 % (w/v) |
소듐 데옥시콜레이트 | 4.75 % |
벤질 알콜 | 0.90 % |
물 | 10O mL |
지방종 | 크기(cm) 전-처리 | 크기(cm) 후-처리 | 총 처리(% DC 주입됨) |
1 | 2.00x1.00 | 1.25x0.50 | 2(2.5%) |
2 | 2.00 | 1.50x0.50 | 3(5% 및 2.5%) |
3 | 2.00x2.50 | 2.00x1.00 | 3(5% 및 2.5%) |
4 | 4.00x1.75 | 2.50x2.00 | 2(1%) |
5 | 2.00x1.75 | 1.25 | 2(1%) |
6 | 2.80 | 0.50 | 1(5%) |
7 | 1.00 | 감지불가 | 1(1%) |
Claims (53)
- 수술없이 국소적인 지방 축적을 제거하기 위한 의약 조성물을 제조하는 방법에 있어서, 상기 조성물은 데옥시콜릭 염을 포함하되 포스파티딜콜린을 포함하지는 않는, 수술없이 국소적인 지방 축적을 제거하기 위한 의약 조성물을 제조하는 방법.
- 제 1항에 있어서, 상기 데옥시콜릭 염이 데옥시콜린산의 소듐 염인, 수술없이 국소적인 지방 축적을 제거하기 위한 의약 조성물을 제조하는 방법.
- 제 1항에 있어서, 상기 조성물이 벤질 알콜을 더 포함하는, 수술없이 국소적인 지방 축적을 제거하기 위한 의약 조성물을 제조하는 방법.
- 제 1항 내지 제 3항 중 어느 한 항에 있어서, 상기 데옥시콜릭 염이 상기 조성물에서 0.05% w/v 또는 0.5% w/v 의 농도로 존재하는, 수술없이 국소적인 지방 축적을 제거하기 위한 의약 조성물을 제조하는 방법.
- 수술없이 국소적인 지방 축적을 제거하기 위한 의약 조성물을 제조하는 방법에 있어서, 상기 조성물은 데옥시콜릭 염과 포스파티딜콜린을 포함하되, 상기 포스파티딜콜린의 질량이 상기 데옥시콜릭 염의 질량 보다 적은, 수술없이 국소적인 지방 축적을 제거하기 위한 의약 조성물을 제조하는 방법.
- 제 5항에 있어서, 상기 데옥시콜릭 염이 데옥시콜린산의 소듐 염인, 수술없이 국소적인 지방 축적을 제거하기 위한 의약 조성물을 제조하는 방법.
- 제 5항에 있어서, 상기 조성물이 벤질 알콜을 더 포함하는, 수술없이 국소적인 지방 축적을 제거하기 위한 의약 조성물을 제조하는 방법.
- 제 5항 내지 제 7항 중 어느 한 항에 있어서, 상기 데옥시콜릭 염이 상기 조성물에서 0.05% w/v 또는 0.5% w/v 의 농도로 존재하는, 수술없이 국소적인 지방 축적을 제거하기 위한 의약 조성물을 제조하는 방법.
- (a) 데옥시콜릭 염을 포함하되 포스파티딜콜린을 포함하지 않는 조성물을 포함하는 제1 콘테이너; 및(b) 상기 조성물을 피하 지방 축적 부위에 전달할 수 있는 전달 장치를 포함하는, 키트.
- 제 9항에 있어서, 상기 데옥시콜릭 염은 주사 가능한 제형으로 제공되는, 키트.
- 제 10항에 있어서, 상기 전달 장치에는 상기 주사 가능한 제형이 미리 적재되어 있는, 키트.
- 제 9항에 있어서, 상기 데옥시콜릭 염이 데옥시콜린산의 소듐 염인, 키트.
- 제 9항에 있어서, 상기 조성물이 벤질 알콜을 더 포함하는, 키트.
- 제 9항 내지 제 13항 중 어느 한 항에 있어서, 상기 데옥시콜릭 염이 상기 조성물에서 0.05% w/v 또는 0.5% w/v 의 농도로 존재하는, 키트.
- (a) 데옥시콜릭 염과 포스파티딜콜린을 포함하는 조성물을 포함하는 제1 콘테이너; 및(b) 상기 조성물을 피하 지방 축적 부위에 전달할 수 있는 전달 장치를 포함하며,상기 조성물에서 상기 포스파티딜콜린의 질량이 상기 데옥시콜릭 염의 질량 보다 적은, 키트.
- 제 15항에 있어서, 상기 데옥시콜릭 염은 주사 가능한 제형으로 제공되는, 키트.
- 제 16항에 있어서, 상기 전달 장치에는 상기 주사 가능한 제형이 미리 적재되어 있는, 키트.
- 제 15항에 있어서, 상기 데옥시콜릭 염이 데옥시콜린산의 소듐 염인, 키트.
- 제 15항에 있어서, 상기 조성물이 벤질 알콜을 더 포함하는, 키트.
- 제 15항 내지 제 19항 중 어느 한 항에 있어서, 상기 데옥시콜릭 염이 상기 조성물에서 0.05% w/v 또는 0.5% w/v 의 농도로 존재하는, 키트.
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US57287904P | 2004-05-19 | 2004-05-19 | |
US60/572,879 | 2004-05-19 | ||
PCT/US2005/017957 WO2005112942A1 (en) | 2004-05-19 | 2005-05-19 | Methods and related compositions for reduction of fat |
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KR101841193B1 (ko) * | 2016-09-22 | 2018-03-22 | 이경락 | 저장성 지방 분해 조성물 및 그의 제조 방법 |
KR101873539B1 (ko) * | 2016-09-22 | 2018-07-02 | 이경락 | 저장성 지방 분해 조성물 및 그의 제조 방법 |
KR20190004087A (ko) * | 2017-07-03 | 2019-01-11 | 진호성 | 지방제거용 주사제 조성물 및 이의 제조방법 |
KR102093872B1 (ko) * | 2017-07-03 | 2020-03-27 | 진호성 | 지방제거용 주사제 조성물 및 이의 제조방법 |
WO2020162685A1 (ko) | 2019-02-08 | 2020-08-13 | (주)제테마 | 국소 주사용 조성물 |
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