KR101119449B1 - 안지오텐신-전환 효소 저해 펩티드 - Google Patents

안지오텐신-전환 효소 저해 펩티드 Download PDF

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Publication number
KR101119449B1
KR101119449B1 KR1020057017447A KR20057017447A KR101119449B1 KR 101119449 B1 KR101119449 B1 KR 101119449B1 KR 1020057017447 A KR1020057017447 A KR 1020057017447A KR 20057017447 A KR20057017447 A KR 20057017447A KR 101119449 B1 KR101119449 B1 KR 101119449B1
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KR
South Korea
Prior art keywords
tripeptide
tyr
val
leu
inhibitory activity
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Expired - Fee Related
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KR1020057017447A
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English (en)
Korean (ko)
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KR20050111778A (ko
Inventor
교이치 오구라
다에코 이이노
스미오 아사미
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산토리 홀딩스 가부시키가이샤
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Publication of KR20050111778A publication Critical patent/KR20050111778A/ko
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Publication of KR101119449B1 publication Critical patent/KR101119449B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
KR1020057017447A 2003-03-18 2004-03-17 안지오텐신-전환 효소 저해 펩티드 Expired - Fee Related KR101119449B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPJP-P-2003-00074488 2003-03-18
JP2003074488 2003-03-18
PCT/JP2004/003588 WO2004082709A1 (en) 2003-03-18 2004-03-17 Angiotensin-converting enzyme inhibitory peptides

Related Child Applications (2)

Application Number Title Priority Date Filing Date
KR1020117000078A Division KR101077801B1 (ko) 2003-03-18 2004-03-17 안지오텐신-전환 효소 저해 펩티드
KR1020117000079A Division KR101078628B1 (ko) 2003-03-18 2004-03-17 안지오텐신-전환 효소 저해 펩티드

Publications (2)

Publication Number Publication Date
KR20050111778A KR20050111778A (ko) 2005-11-28
KR101119449B1 true KR101119449B1 (ko) 2012-03-16

Family

ID=33027809

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020117000079A Expired - Fee Related KR101078628B1 (ko) 2003-03-18 2004-03-17 안지오텐신-전환 효소 저해 펩티드
KR1020057017447A Expired - Fee Related KR101119449B1 (ko) 2003-03-18 2004-03-17 안지오텐신-전환 효소 저해 펩티드
KR1020117000078A Expired - Fee Related KR101077801B1 (ko) 2003-03-18 2004-03-17 안지오텐신-전환 효소 저해 펩티드

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020117000079A Expired - Fee Related KR101078628B1 (ko) 2003-03-18 2004-03-17 안지오텐신-전환 효소 저해 펩티드

Family Applications After (1)

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KR1020117000078A Expired - Fee Related KR101077801B1 (ko) 2003-03-18 2004-03-17 안지오텐신-전환 효소 저해 펩티드

Country Status (14)

Country Link
US (2) US7833985B2 (enExample)
EP (3) EP1605969B1 (enExample)
JP (3) JP4283848B2 (enExample)
KR (3) KR101078628B1 (enExample)
CN (1) CN100402089C (enExample)
AU (3) AU2004222435B2 (enExample)
CA (3) CA2526891C (enExample)
CY (1) CY1114072T1 (enExample)
DK (1) DK1605969T3 (enExample)
ES (3) ES2398788T3 (enExample)
PL (3) PL1938832T3 (enExample)
PT (1) PT1605969E (enExample)
TW (3) TWI328457B (enExample)
WO (1) WO2004082709A1 (enExample)

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JP4046708B2 (ja) * 2004-06-04 2008-02-13 明治製菓株式会社 ３−アルケニルセフェム化合物の製造方法
JP2006219420A (ja) * 2005-02-10 2006-08-24 Nagase Chemtex Corp 抗高血圧剤
ZA200708795B (en) * 2005-04-28 2009-08-26 Unilever Plc Peptides having a healthy benefit and compositions comprising them
EP1874128A1 (en) * 2005-04-28 2008-01-09 Hindustan Unilever Limited Peptides having an ace inhibiting effect
US20090143311A1 (en) * 2005-04-28 2009-06-04 Luppo Edens Compositions comprising tripeptides inhibiting ace
WO2006114193A1 (en) * 2005-04-28 2006-11-02 Unilever N.V. Peptides having an ace inhibiting effect
EP1726659B1 (en) * 2005-05-24 2009-12-30 Chr. Hansen A/S Isolated dipeptides with ACE inhibitor effect
JP4994093B2 (ja) * 2006-04-13 2012-08-08 ロート製薬株式会社 育毛剤
CN100456948C (zh) * 2006-06-30 2009-02-04 北京三友汇智生物技术有限公司 一种燕麦肽及其提取方法
KR100787949B1 (ko) * 2007-08-29 2007-12-24 한양대학교 산학협력단 대두 발효 조성물의 제조방법 및 이 조성물로부터 유래된펩타이드
JP2009073765A (ja) * 2007-09-20 2009-04-09 Nitsukoku Seifun Kk アンジオテンシン変換酵素（ａｃｅ）阻害剤組成物及びその製造方法
JP2010163400A (ja) 2009-01-19 2010-07-29 Kikkoman Corp 新規アンジオテンシン変換酵素阻害ペプチド
CN101618207B (zh) * 2009-06-17 2011-08-03 中国科学院大连化学物理研究所 多肽在制备ace抑制剂及降血压药物中的应用
WO2011007612A1 (ja) * 2009-07-13 2011-01-20 不二製油株式会社 経口性抗炎症剤及び経口性抗炎症ペプチド
CN101696233B (zh) * 2009-10-29 2012-02-01 吉林大学 蛋清蛋白血管紧张素转化酶抑制肽及其制备
JP5654290B2 (ja) * 2010-08-27 2015-01-14 ユニチカ株式会社 アンジオテンシン変換酵素阻害ペプチド及びその製造方法。
CN102399261B (zh) * 2010-09-07 2014-06-25 任发政 具有血管紧张素转化酶c-端选择性抑制活性的三肽及其应用和组合物
CN102475884B (zh) * 2010-11-29 2013-08-14 中国科学院大连化学物理研究所 四个多肽在制备ace抑制剂及降血压药物中的应用
CN102276690B (zh) * 2011-08-05 2013-03-20 成都中医药大学 降血压功能性多肽及其用途
JP6296722B2 (ja) * 2012-07-31 2018-03-20 サンスター株式会社 米糠酵素処理組成物
KR101481416B1 (ko) * 2012-10-17 2015-01-13 건국대학교 산학협력단 안지오텐신 전환 효소 저해 활성을 갖는 펩타이드
JP2014141462A (ja) * 2012-12-27 2014-08-07 Raffinee International Co Ltd ペプチド、並びに、アンジオテンシン変換酵素阻害剤、抗高血圧剤、及び飲食品
US9820504B2 (en) 2013-03-08 2017-11-21 Axiom Foods, Inc. Rice protein supplement and methods of use thereof
CN108271917A (zh) 2013-03-08 2018-07-13 艾斯姆食品公司 大米蛋白补充剂
CN103172698B (zh) * 2013-04-10 2015-02-18 华东理工大学 降血压多肽
CN103242430B (zh) * 2013-05-31 2014-10-08 南京中医药大学 血管紧张素转化酶抑制肽及其制备方法和应用
CN103290086B (zh) * 2013-06-25 2015-01-14 广州合诚实业有限公司 具有ace抑制活性的绿豆蛋白肽及其制备方法与应用
CN104558109B (zh) * 2013-10-21 2018-06-08 中国科学院大连化学物理研究所 源于油菜花粉的具有ace抑制活性的多肽化合物及应用
CN104558110B (zh) * 2013-10-21 2018-06-08 中国科学院大连化学物理研究所 具有ace抑制活性的多肽及其在降血压药物中的应用
CN104447948B (zh) * 2014-11-25 2017-12-08 肽能九号生物科技有限公司 一种从荠菜中分离获得的降血压多肽
EP3473640B1 (en) 2016-06-16 2020-06-24 Sunstar Inc. Novel tripeptide
CN110028549B (zh) * 2016-07-07 2022-08-05 华东理工大学 降血压肽和降血压蛋白质及其应用
EP3634155A4 (en) 2017-05-12 2021-02-17 Axiom Foods Inc. RICE PRODUCTS AND SYSTEMS AND PROCESSES FOR THEIR PRODUCTION
WO2019006951A1 (zh) * 2017-07-07 2019-01-10 广州世优生物科技有限公司 非极性二肽在制备降血压药物或保健品中的应用
CN110498833B (zh) * 2019-08-30 2021-01-15 华南理工大学 一种具有ace抑制作用的三肽及其应用
US20230000120A1 (en) * 2019-12-09 2023-01-05 Societe Des Produits Nestle S.A. Beverage paste
JP7391738B2 (ja) * 2020-03-19 2023-12-05 Ｋｉｓｃｏ株式会社 ペプチド、及び苦味付与剤
CN111548387B (zh) * 2020-03-31 2020-12-18 华南农业大学 一种具有降血压功效的寡肽及其制备方法与应用
CN111471086B (zh) * 2020-04-16 2023-01-24 河南省农业科学院 芝麻多肽及其制备方法和应用
CN111825754B (zh) * 2020-07-16 2022-02-11 河南省农业科学院 一种从芝麻蛋白中获得的具有降血压与降血糖活性的多肽
JP7787424B2 (ja) * 2021-02-04 2025-12-17 ユーハ味覚糖株式会社 デプレスタチン含有組成物の製造方法
CN120904281B (zh) * 2025-08-05 2025-12-23 北京雯茵生物科技有限公司 生物活性肽及其在治疗心脑血管疾病中的应用

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CA2743539A1 (en) 2004-09-30
KR20050111778A (ko) 2005-11-28
EP1938832B1 (en) 2013-02-13
US20060276627A1 (en) 2006-12-07
TW200507871A (en) 2005-03-01
JP2009084295A (ja) 2009-04-23
AU2009236033B2 (en) 2012-04-26
CN100402089C (zh) 2008-07-16
TW201125574A (en) 2011-08-01
KR101077801B1 (ko) 2011-10-28
TWI344371B (en) 2011-07-01
KR20110015674A (ko) 2011-02-16
AU2009236033A1 (en) 2009-12-03
US20090318368A1 (en) 2009-12-24
JP4283848B2 (ja) 2009-06-24
JP2006520809A (ja) 2006-09-14
HK1084604A1 (en) 2006-08-04
TWI411441B (zh) 2013-10-11
CA2743313C (en) 2013-08-13
US7943578B2 (en) 2011-05-17
AU2009236034A1 (en) 2009-12-03
PL1938832T3 (pl) 2013-06-28
JP2009084294A (ja) 2009-04-23
CN1780639A (zh) 2006-05-31
CA2743313A1 (en) 2004-09-30
JP4369985B2 (ja) 2009-11-25
PL1605969T3 (pl) 2013-06-28
ES2400561T3 (es) 2013-04-10
CA2743539C (en) 2013-08-13
ES2400308T3 (es) 2013-04-09
US7833985B2 (en) 2010-11-16
TWI328457B (en) 2010-08-11
CY1114072T1 (el) 2016-07-27
DK1605969T3 (da) 2013-04-29
KR101078628B1 (ko) 2011-11-01
AU2004222435A1 (en) 2004-09-30
AU2004222435B2 (en) 2009-12-17
PL2145630T3 (pl) 2013-04-30
EP2145630B1 (en) 2013-01-09
PT1605969E (pt) 2013-03-27
JP4369986B2 (ja) 2009-11-25
AU2009236034B2 (en) 2012-04-26
EP1605969A1 (en) 2005-12-21
EP2145630A2 (en) 2010-01-20
EP2145630A3 (en) 2010-02-17
CA2526891A1 (en) 2004-09-30
TW200902053A (en) 2009-01-16
CA2526891C (en) 2013-08-13
EP1605969B1 (en) 2013-02-13
WO2004082709A1 (en) 2004-09-30
ES2398788T3 (es) 2013-03-21
KR20110015675A (ko) 2011-02-16
EP1938832A1 (en) 2008-07-02

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