KR101019402B1 - 항부정맥제로 사용되는 삼환계 벤조피란 화합물 - Google Patents
항부정맥제로 사용되는 삼환계 벤조피란 화합물 Download PDFInfo
- Publication number
- KR101019402B1 KR101019402B1 KR1020067021988A KR20067021988A KR101019402B1 KR 101019402 B1 KR101019402 B1 KR 101019402B1 KR 1020067021988 A KR1020067021988 A KR 1020067021988A KR 20067021988 A KR20067021988 A KR 20067021988A KR 101019402 B1 KR101019402 B1 KR 101019402B1
- Authority
- KR
- South Korea
- Prior art keywords
- group
- amino
- substituted
- dihydro
- pyrano
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 0 CC(C)(C(*1)OC(CN)c2ccccc2)Oc(cc2*)c1cc2N Chemical compound CC(C)(C(*1)OC(CN)c2ccccc2)Oc(cc2*)c1cc2N 0.000 description 3
- JCEJWRWXIUBDKQ-UHFFFAOYSA-N CC(C)(C(C1NCCc2ccccc2)O)Oc(cc2)c1c(C=C1)c2NC1C#N Chemical compound CC(C)(C(C1NCCc2ccccc2)O)Oc(cc2)c1c(C=C1)c2NC1C#N JCEJWRWXIUBDKQ-UHFFFAOYSA-N 0.000 description 1
- KZDQLNPOGAVNCL-UHFFFAOYSA-N CC(C)(C(C1NCCc2ccccc2)O)Oc(cc2)c1c(cc1)c2nc1Cl Chemical compound CC(C)(C(C1NCCc2ccccc2)O)Oc(cc2)c1c(cc1)c2nc1Cl KZDQLNPOGAVNCL-UHFFFAOYSA-N 0.000 description 1
- HITDHXVTZZESMN-XJDOXCRVSA-N CC(C)(C([C@H]1NCCc(cc2)ccc2F)O)Oc(cc2N=C)c1cc2N=C Chemical compound CC(C)(C([C@H]1NCCc(cc2)ccc2F)O)Oc(cc2N=C)c1cc2N=C HITDHXVTZZESMN-XJDOXCRVSA-N 0.000 description 1
- KZBGGBKXHJVDJK-UHFFFAOYSA-N CC(C)(C=Cc1c2)Oc1cc1c2nccc1COC(C)=O Chemical compound CC(C)(C=Cc1c2)Oc1cc1c2nccc1COC(C)=O KZBGGBKXHJVDJK-UHFFFAOYSA-N 0.000 description 1
- CLPYQWMEBMRCCK-SJYOFHSSSA-N CC(C)([C@@H](C(/C=N/CCc1ccccc1)c1c2)O)Oc1cc(c(C)c1)c2nc1O Chemical compound CC(C)([C@@H](C(/C=N/CCc1ccccc1)c1c2)O)Oc1cc(c(C)c1)c2nc1O CLPYQWMEBMRCCK-SJYOFHSSSA-N 0.000 description 1
- SMJWLQUBCNAKOX-UHFFFAOYSA-N CC1(C)OC2=CC3C(C)=CC(C#N)=NC3C=C2C=C1 Chemical compound CC1(C)OC2=CC3C(C)=CC(C#N)=NC3C=C2C=C1 SMJWLQUBCNAKOX-UHFFFAOYSA-N 0.000 description 1
- FVMVAUDICDZRMN-UHFFFAOYSA-N CCCC(C[NH-])/[O]=C(\Cc1c2)/C(C)(C)Oc1cc(N=[IH])c2N=C Chemical compound CCCC(C[NH-])/[O]=C(\Cc1c2)/C(C)(C)Oc1cc(N=[IH])c2N=C FVMVAUDICDZRMN-UHFFFAOYSA-N 0.000 description 1
- ACZVHCBJCSMHIL-RBUKOAKNSA-N CCCCCN[C@H]([C@H](C(C)(C)Oc1c2)O)c1cc1c2c(C)cc(Cl)n1 Chemical compound CCCCCN[C@H]([C@H](C(C)(C)Oc1c2)O)c1cc1c2c(C)cc(Cl)n1 ACZVHCBJCSMHIL-RBUKOAKNSA-N 0.000 description 1
- DBJBGWXVWVDNRJ-LSDHHAIUSA-N CCCCCN[C@H]1c(cc(c(N)c2)N)c2OC(C)(C)[C@@H]1O Chemical compound CCCCCN[C@H]1c(cc(c(N)c2)N)c2OC(C)(C)[C@@H]1O DBJBGWXVWVDNRJ-LSDHHAIUSA-N 0.000 description 1
- NSGQQPYABWODCH-QONHTCSSSA-N CC[C@@H]1C(CCOCC2)[C@@H]2NC1C Chemical compound CC[C@@H]1C(CCOCC2)[C@@H]2NC1C NSGQQPYABWODCH-QONHTCSSSA-N 0.000 description 1
- YQCUZUCILWKWEP-UHFFFAOYSA-N CCc1cc2nc(C#N)cc(C)c2cc1OC(C)O Chemical compound CCc1cc2nc(C#N)cc(C)c2cc1OC(C)O YQCUZUCILWKWEP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D515/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrane Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Dental Preparations (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JPJP-P-2004-00084605 | 2004-03-23 | ||
| JP2004084605 | 2004-03-23 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020107027058A Division KR101085979B1 (ko) | 2004-03-23 | 2005-03-23 | 항부정맥제로 사용되는 삼환계 벤조피란 화합물 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20070009638A KR20070009638A (ko) | 2007-01-18 |
| KR101019402B1 true KR101019402B1 (ko) | 2011-03-07 |
Family
ID=34962589
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020067021988A Expired - Lifetime KR101019402B1 (ko) | 2004-03-23 | 2005-03-23 | 항부정맥제로 사용되는 삼환계 벤조피란 화합물 |
| KR1020107027058A Expired - Fee Related KR101085979B1 (ko) | 2004-03-23 | 2005-03-23 | 항부정맥제로 사용되는 삼환계 벤조피란 화합물 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020107027058A Expired - Fee Related KR101085979B1 (ko) | 2004-03-23 | 2005-03-23 | 항부정맥제로 사용되는 삼환계 벤조피란 화합물 |
Country Status (30)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4840594B2 (ja) * | 2004-03-23 | 2011-12-21 | 日産化学工業株式会社 | 抗不整脈薬としての３環性ベンゾピラン化合物 |
| US8394974B2 (en) | 2006-03-10 | 2013-03-12 | Nissan Chemical Industries, Ltd. | Process for producing optically active chromene oxide compound |
| WO2010018867A1 (ja) * | 2008-08-14 | 2010-02-18 | 日産化学工業株式会社 | ジ置換ベンゾピラン化合物 |
| AR076524A1 (es) * | 2009-04-30 | 2011-06-15 | Nissan Chemical Ind Ltd | Forma cristalina de un compuesto de benzopirano triciclico y metodo de produccion de la misma |
| PT2445502T (pt) | 2009-06-25 | 2017-09-22 | Alkermes Pharma Ireland Ltd | Compostos heterocíclicos para o tratamento de distúrbios neurológicos e psicológicos |
| US9738654B2 (en) | 2012-09-27 | 2017-08-22 | Nissan Chemical Industries, Ltd. | Method for producing nitrogen-containing heterocyclic N-oxide compound |
| CN104507949B (zh) * | 2012-09-27 | 2017-07-28 | 日产化学工业株式会社 | 高纯度的含氮杂环化合物的制造方法 |
| CN105377826A (zh) * | 2013-07-25 | 2016-03-02 | 日产化学工业株式会社 | 杂环化合物的制造方法 |
| CN110177796B (zh) * | 2017-01-06 | 2022-04-08 | 阿斯克里斯有限公司 | 喹啉酮衍生物及其用于预防或治疗变应性疾病的药物组合物 |
| AU2019230014B2 (en) | 2018-03-05 | 2024-11-28 | Alkermes Pharma Ireland Limited | Aripiprazole dosing strategy |
| CN108727261B (zh) * | 2018-06-21 | 2021-09-24 | 济南大学 | 一种硝基取代喹那啶的制备方法 |
| CN113543849B (zh) * | 2018-12-28 | 2025-03-21 | 国立大学法人大阪大学 | 遗传性缓慢性心律失常治疗药 |
| RU2754610C1 (ru) * | 2020-04-14 | 2021-09-03 | Георгий Викторович ТЕЦ | Препарат для лечения заболеваний, вызванных бактериями |
| JP7733887B2 (ja) * | 2020-06-26 | 2025-09-04 | 国立大学法人大阪大学 | 薬剤誘発性徐脈および徐脈性不整脈治療薬 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0488107A2 (en) * | 1990-11-26 | 1992-06-03 | E.R. SQUIBB & SONS, INC. | Tricyclic benzodiazole analogs and their use in the treatment of cardiovascular disorders |
| WO1995034547A1 (en) * | 1994-06-10 | 1995-12-21 | Smithkline Beecham Plc | C-4 amide substituted compounds and their use as therapeutic agents |
| EP0693283A1 (en) * | 1993-04-02 | 1996-01-24 | Nissan Chemical Industries, Limited | Heart failure remedy |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZM7682A1 (en) | 1981-09-25 | 1983-05-23 | Beecham Group Plc | Active compounds |
| JPS5867683U (ja) | 1981-10-28 | 1983-05-09 | 株式会社ナムコ | 歩行ロボツト |
| JPH0699439B2 (ja) | 1988-02-03 | 1994-12-07 | 日産化学工業株式会社 | ピラノベンゾオキサジアゾール誘導体 |
| JP2658198B2 (ja) * | 1988-06-23 | 1997-09-30 | 日産化学工業株式会社 | ピラノベンゾトリアゾール誘導体 |
| US5097037A (en) | 1989-07-17 | 1992-03-17 | Nissan Chemical Industries, Ltd. | Process for the optical resolution of pyranobenzoxadiazole compounds |
| JP2876712B2 (ja) * | 1989-07-17 | 1999-03-31 | 日産化学工業株式会社 | 光学活性ピラノベンゾオキサジアゾール誘導体 |
| JPH07300414A (ja) * | 1993-04-02 | 1995-11-14 | Nissan Chem Ind Ltd | 心不全治療薬 |
| JP2734457B2 (ja) | 1994-02-23 | 1998-03-30 | 日産化学工業株式会社 | 不斉エポキシ化反応 |
| TW496866B (en) * | 1996-05-15 | 2002-08-01 | Hoechst Ag | Sulfonamide-substituted chromans, processes for their preparation, their use as a medicament or a diagnostic, and medicament comprising them |
| WO1999062867A1 (fr) | 1998-06-03 | 1999-12-09 | Nissan Chemical Industries, Ltd. | Derives d'indane |
| AU5444499A (en) | 1998-09-01 | 2000-03-21 | Nissan Chemical Industries Ltd. | Benzoxazine derivatives |
| AU2830800A (en) | 1999-03-25 | 2000-10-16 | Nissan Chemical Industries Ltd. | Chroman derivatives |
| WO2001021610A1 (en) | 1999-09-17 | 2001-03-29 | Nissan Chemical Industries, Ltd. | Benzopyran derivative |
| US6555574B1 (en) | 1999-09-24 | 2003-04-29 | Nissan Chemical Industries, Ltd. | 4-oxybenzopyran derivative |
| US6677371B1 (en) | 1999-10-05 | 2004-01-13 | Nissan Chemical Industries, Ltd. | 4-oxybenzopyran derivative |
| TW589305B (en) | 2001-02-14 | 2004-06-01 | Nissan Chemical Ind Ltd | 4-aminobenzopyran derivatives |
| IL159218A0 (en) | 2001-06-25 | 2004-06-01 | Nissan Chemical Ind Ltd | Substituted benzopyran derivatives against arrhythmia |
| WO2003014113A1 (en) | 2001-08-06 | 2003-02-20 | Glenmark Pharmaceuticals Limited | Novel benzopyran compounds and process for their preparation and use |
| JP4840594B2 (ja) * | 2004-03-23 | 2011-12-21 | 日産化学工業株式会社 | 抗不整脈薬としての３環性ベンゾピラン化合物 |
-
2005
- 2005-03-23 JP JP2006530022A patent/JP4840594B2/ja not_active Expired - Lifetime
- 2005-03-23 UA UAA200611101A patent/UA91189C2/ru unknown
- 2005-03-23 US US10/590,975 patent/US7652008B2/en not_active Expired - Lifetime
- 2005-03-23 NZ NZ549570A patent/NZ549570A/en not_active IP Right Cessation
- 2005-03-23 KR KR1020067021988A patent/KR101019402B1/ko not_active Expired - Lifetime
- 2005-03-23 CN CN2011100751168A patent/CN102190661B/zh not_active Expired - Fee Related
- 2005-03-23 CN CN2005800090295A patent/CN1934116B/zh not_active Expired - Lifetime
- 2005-03-23 PT PT05727581T patent/PT1732929E/pt unknown
- 2005-03-23 PL PL05727581T patent/PL1732929T3/pl unknown
- 2005-03-23 DE DE602005024245T patent/DE602005024245D1/de not_active Expired - Lifetime
- 2005-03-23 RU RU2006137284/04A patent/RU2380370C2/ru not_active IP Right Cessation
- 2005-03-23 SK SK5079-2006A patent/SK287994B6/sk not_active IP Right Cessation
- 2005-03-23 RS RS20110028A patent/RS51742B/sr unknown
- 2005-03-23 CZ CZ20060598A patent/CZ2006598A3/cs unknown
- 2005-03-23 DK DK05727581.0T patent/DK1732929T3/da active
- 2005-03-23 HR HR20110005T patent/HRP20110005T1/hr unknown
- 2005-03-23 MX MXPA06010880A patent/MXPA06010880A/es active IP Right Grant
- 2005-03-23 NZ NZ585606A patent/NZ585606A/en not_active IP Right Cessation
- 2005-03-23 TW TW094108962A patent/TWI352704B/zh not_active IP Right Cessation
- 2005-03-23 BR BRPI0508768-6A patent/BRPI0508768A/pt not_active Application Discontinuation
- 2005-03-23 CA CA2558139A patent/CA2558139C/en not_active Expired - Fee Related
- 2005-03-23 KR KR1020107027058A patent/KR101085979B1/ko not_active Expired - Fee Related
- 2005-03-23 AU AU2005223612A patent/AU2005223612B2/en not_active Ceased
- 2005-03-23 ZA ZA200607388A patent/ZA200607388B/en unknown
- 2005-03-23 CN CN2008101707921A patent/CN101429200B/zh not_active Expired - Fee Related
- 2005-03-23 ES ES05727581T patent/ES2353021T3/es not_active Expired - Lifetime
- 2005-03-23 WO PCT/JP2005/006004 patent/WO2005090357A1/en not_active Ceased
- 2005-03-23 SI SI200531171T patent/SI1732929T1/sl unknown
- 2005-03-23 AT AT05727581T patent/ATE485299T1/de active
- 2005-03-23 EP EP05727581A patent/EP1732929B1/en not_active Expired - Lifetime
-
2006
- 2006-09-02 EG EGNA2006000900 patent/EG27163A/xx active
- 2006-09-07 IL IL177950A patent/IL177950A/en not_active IP Right Cessation
- 2006-10-23 NO NO20064819A patent/NO339495B1/no not_active IP Right Cessation
-
2009
- 2009-11-17 US US12/591,353 patent/US7964623B2/en not_active Expired - Fee Related
-
2010
- 2010-07-08 AU AU2010202900A patent/AU2010202900B2/en not_active Ceased
-
2011
- 2011-01-19 CY CY20111100060T patent/CY1111250T1/el unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0488107A2 (en) * | 1990-11-26 | 1992-06-03 | E.R. SQUIBB & SONS, INC. | Tricyclic benzodiazole analogs and their use in the treatment of cardiovascular disorders |
| EP0693283A1 (en) * | 1993-04-02 | 1996-01-24 | Nissan Chemical Industries, Limited | Heart failure remedy |
| WO1995034547A1 (en) * | 1994-06-10 | 1995-12-21 | Smithkline Beecham Plc | C-4 amide substituted compounds and their use as therapeutic agents |
Also Published As
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| US7964623B2 (en) | Tricyclic benzopyrane compound | |
| US20040152763A1 (en) | Substituted benzopyran derivatives against arrhythmia | |
| KR101010676B1 (ko) | 부정맥 치료에 유용한 벤조피란 화합물 | |
| JP2010065030A (ja) | ３環性スピロベンゾピラン化合物 | |
| JP2010065029A (ja) | 複素環ピラン化合物 | |
| HK1099299B (en) | Tricyclic benzopyran compound as anti-arrhythmic agents | |
| AU2002309284A1 (en) | Substituted benzopyran derivatives against arrhythmia |
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