AR076524A1 - Forma cristalina de un compuesto de benzopirano triciclico y metodo de produccion de la misma - Google Patents
Forma cristalina de un compuesto de benzopirano triciclico y metodo de produccion de la mismaInfo
- Publication number
- AR076524A1 AR076524A1 ARP100101484A ARP100101484A AR076524A1 AR 076524 A1 AR076524 A1 AR 076524A1 AR P100101484 A ARP100101484 A AR P100101484A AR P100101484 A ARP100101484 A AR P100101484A AR 076524 A1 AR076524 A1 AR 076524A1
- Authority
- AR
- Argentina
- Prior art keywords
- crystal
- phenethylamino
- quinolin
- pyran
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Proveer formas cristalinas de (3R,4S)-7-hidroximetil-2,2,9-trimetil-4-(fenetilamino)-3,4-dihidro-2H-pirano[2,3-g]quinolin-3-ol a utilizarse como un fármaco, y métodos de produccion de las mismas. Métodos de produccion que incluyen cristalizar (3R,4S)-7-hidroximetil-2,2,9-trimetil-4-(fenetilamino)-3,4-dihidro-2H-pirano[2,3-g]quinolin-3-ol a partir de un solvente de éster de acetato, un solvente hidrocarbonado alifático, un solvente de nitrilo, un solvente hidrocarbonado aromático, un solvente de cetona o un solvente de éter, y formas cristalinas obtenidas de acuerdo con los métodos. Reivindicacion 1: Un cristal de forma A de (3R,4S)-7-hidroximetil-2,2,9-trimetil-4-(fenetilamino)-3,4-dihidro-2H-pirano[2,3-g]quinolin-3-ol de la formula (1): caracterizado porque tiene valores máximos característicos en ángulos de difraccion (2theta) de 5,6, 8,2, 12,0, 14,7, 16,6, 16,9, 17,9, 18,4, 22,5, 24,5, 27,6 en un difractograma de rayos X en polvo del cristal. Reivindicacion 7: Un cristal de forma B de (3R,4S)-7-hidroximetil-2,2,9-trimetil-4-(fenetilamino)-3,4-dihidro-2H-pirano[2,3-g]quinolin-3-ol de la formula (1): caracterizado porque tiene valores máximos característicos en ángulos de difraccion (2theta) de 6,4, 8,7, 12,8, 17,5, 19,1, 20,7, 22,0, 24,8, 26,6 en un difractograma de rayos X en polvo del cristal. Reivindicacion 8: Un cristal de forma E de (3R,4S)-7-hidroximetil-2,2,9-trimetil-4-(fenetilamino)-3,4-dihidro-2H-pirano[2,3-g]quinolin-3-ol de la formula (1): caracterizado porque tiene valores máximos característicos en ángulos de difraccion (2theta) de 9,1, 12,8, 13,1, 14,6, 15,2, 16,4, 22,1, 23,6, 24,8 en un difractograma de rayos X en polvo del cristal. Reivindicacion 9: Un cristal de forma F de (3R,4S)-7-hidroximetil-2,2,9-trimetil-4-(fenetilamino)-3,4-dihidro-2H-pirano[2,3-g]quinolin-3-ol de la formula (1): caracterizado porque tiene valores máximos característicos en ángulos de difraccion (2theta) de 6,8, 11,7, 13,7, 16,8, 18,0, 19,3, 20,4, 20,8, 24,6, 25,6 en un difractograma de rayos X en polvo del cristal. Reivindicacion 10: Un cristal de forma G de (3R,4S)-7-hidroximetil-2,2,9-trimetil-4-(fenetilamino)-3,4-dihidro-2H-pirano[2,3-g]quinolin-3-ol de la formula (1): caracterizado porque tiene valores máximos característicos en ángulos de difraccion (2theta) de 6,7, 11,6, 11,9, 13,6, 16,6, 17,7, 18,6, 19,1, 19,8, 20,1, 20,8 en un difractograma de rayos X en polvo del cristal. Reivindicacion 11: Un cristal de forma H de (3R,4S)-7-hidroximetil-2,2,9-trimetil-4-(fenetilamino)-3,4-dihidro-2H-pirano[2,3-g]quinolin-3-ol de la formula (1): caracterizado porque tiene valores máximos característicos en ángulos de difraccion (2theta) de 6,0, 16,4, 17,0, 19,2, 19,8, 20,3, 21,0, 22,8 en un difractograma de rayos X en polvo del cristal.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009111281 | 2009-04-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR076524A1 true AR076524A1 (es) | 2011-06-15 |
Family
ID=43032280
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP100101484A AR076524A1 (es) | 2009-04-30 | 2010-04-30 | Forma cristalina de un compuesto de benzopirano triciclico y metodo de produccion de la misma |
Country Status (21)
Country | Link |
---|---|
US (1) | US9242992B2 (es) |
EP (1) | EP2426133B1 (es) |
JP (1) | JP5664870B2 (es) |
KR (1) | KR101703202B1 (es) |
CN (1) | CN102414213B (es) |
AR (1) | AR076524A1 (es) |
AU (1) | AU2010242339B2 (es) |
BR (1) | BRPI1007112A2 (es) |
CA (1) | CA2759073C (es) |
ES (1) | ES2562027T3 (es) |
HK (1) | HK1166501A1 (es) |
IL (1) | IL215930A (es) |
MX (1) | MX340918B (es) |
NZ (1) | NZ596060A (es) |
PL (1) | PL2426133T3 (es) |
RU (1) | RU2523279C2 (es) |
SG (1) | SG175377A1 (es) |
TW (1) | TWI480281B (es) |
UA (1) | UA105385C2 (es) |
WO (1) | WO2010126138A1 (es) |
ZA (1) | ZA201107662B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20220071951A1 (en) | 2018-12-28 | 2022-03-10 | Osaka University | Therapeutic agent for inherited bradyarrhythmia |
EP4173623A4 (en) * | 2020-06-26 | 2024-07-24 | Univ Osaka | THERAPEUTIC AGENT FOR DRUG-INDUCED BRADYCARDIA AND BRADYARRHYTHMIA |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2446497A1 (de) * | 1974-09-28 | 1976-04-08 | Boehringer Sohn Ingelheim | 4-oxo-4h-pyrano- eckige klammer auf 3,2-c eckige klammer zu -chinolin-2-carbonsaeuren und ihre salze |
US5164509A (en) * | 1990-11-26 | 1992-11-17 | E. R. Squibb & Sons, Inc. | Benzodiazolo analogs |
GB9224169D0 (en) * | 1992-11-18 | 1993-01-06 | Lilly Industries Ltd | Pharmaceutical compounds |
AU677643B2 (en) * | 1993-04-02 | 1997-05-01 | Nissan Chemical Industries Ltd. | Heart failure remedy |
TR199700369A2 (xx) * | 1996-05-15 | 1997-12-21 | Hoechst Ag | S�lfonamid ile s�bstit�e edilmi� kroman'lar, bunlar�n �retilmesine mahsus usul, ila� veya diyagnostik olarak kullan�lmalar� ve bunlar� i�eren ila�. |
JP2000513362A (ja) * | 1996-06-27 | 2000-10-10 | リガンド・ファーマスーティカルス・インコーポレーテッド | アンドロゲン受容体モジュレーター化合物及び方法 |
KR101019402B1 (ko) * | 2004-03-23 | 2011-03-07 | 닛산 가가쿠 고교 가부시키 가이샤 | 항부정맥제로 사용되는 삼환계 벤조피란 화합물 |
-
2010
- 2010-04-30 AU AU2010242339A patent/AU2010242339B2/en not_active Ceased
- 2010-04-30 CN CN201080018858.0A patent/CN102414213B/zh active Active
- 2010-04-30 UA UAA201114121A patent/UA105385C2/uk unknown
- 2010-04-30 WO PCT/JP2010/057698 patent/WO2010126138A1/ja active Application Filing
- 2010-04-30 NZ NZ596060A patent/NZ596060A/xx unknown
- 2010-04-30 AR ARP100101484A patent/AR076524A1/es not_active Application Discontinuation
- 2010-04-30 TW TW099113885A patent/TWI480281B/zh active
- 2010-04-30 SG SG2011079126A patent/SG175377A1/en unknown
- 2010-04-30 RU RU2011148595/04A patent/RU2523279C2/ru active
- 2010-04-30 ES ES10769836.7T patent/ES2562027T3/es active Active
- 2010-04-30 JP JP2011511472A patent/JP5664870B2/ja active Active
- 2010-04-30 US US13/318,230 patent/US9242992B2/en active Active
- 2010-04-30 PL PL10769836T patent/PL2426133T3/pl unknown
- 2010-04-30 KR KR1020117028198A patent/KR101703202B1/ko active IP Right Grant
- 2010-04-30 BR BRPI1007112-1A patent/BRPI1007112A2/pt active Search and Examination
- 2010-04-30 MX MX2011011329A patent/MX340918B/es active IP Right Grant
- 2010-04-30 EP EP10769836.7A patent/EP2426133B1/en active Active
- 2010-04-30 CA CA2759073A patent/CA2759073C/en active Active
-
2011
- 2011-10-19 ZA ZA2011/07662A patent/ZA201107662B/en unknown
- 2011-10-25 IL IL215930A patent/IL215930A/en active IP Right Grant
-
2012
- 2012-07-23 HK HK12107164.1A patent/HK1166501A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
ES2562027T3 (es) | 2016-03-02 |
EP2426133A1 (en) | 2012-03-07 |
JP5664870B2 (ja) | 2015-02-04 |
SG175377A1 (en) | 2011-12-29 |
NZ596060A (en) | 2012-12-21 |
UA105385C2 (uk) | 2014-05-12 |
CN102414213A (zh) | 2012-04-11 |
TW201111387A (en) | 2011-04-01 |
MX340918B (es) | 2016-07-20 |
KR101703202B1 (ko) | 2017-02-06 |
US9242992B2 (en) | 2016-01-26 |
IL215930A (en) | 2016-09-29 |
ZA201107662B (en) | 2012-12-27 |
EP2426133A4 (en) | 2013-01-09 |
AU2010242339A1 (en) | 2011-11-17 |
EP2426133B1 (en) | 2015-12-16 |
IL215930A0 (en) | 2011-12-29 |
HK1166501A1 (zh) | 2012-11-02 |
US20120059169A1 (en) | 2012-03-08 |
TWI480281B (zh) | 2015-04-11 |
RU2523279C2 (ru) | 2014-07-20 |
CA2759073C (en) | 2017-03-14 |
PL2426133T3 (pl) | 2016-04-29 |
CN102414213B (zh) | 2014-12-24 |
JPWO2010126138A1 (ja) | 2012-11-01 |
AU2010242339B2 (en) | 2015-10-01 |
WO2010126138A1 (ja) | 2010-11-04 |
MX2011011329A (es) | 2011-11-18 |
RU2011148595A (ru) | 2013-06-10 |
KR20120024655A (ko) | 2012-03-14 |
CA2759073A1 (en) | 2010-11-04 |
BRPI1007112A2 (pt) | 2015-08-18 |
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