KR101011028B1 - 차가버섯 추출물, 영지버섯 추출물 및 상황버섯 추출물을 함유하는 조혈모세포 증식 촉진용 조성물 - Google Patents
차가버섯 추출물, 영지버섯 추출물 및 상황버섯 추출물을 함유하는 조혈모세포 증식 촉진용 조성물 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K37/00—Special means in or on valves or other cut-off apparatus for indicating or recording operation thereof, or for enabling an alarm to be given
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K3/00—Gate valves or sliding valves, i.e. cut-off apparatus with closing members having a sliding movement along the seat for opening and closing
- F16K3/02—Gate valves or sliding valves, i.e. cut-off apparatus with closing members having a sliding movement along the seat for opening and closing with flat sealing faces; Packings therefor
- F16K3/12—Gate valves or sliding valves, i.e. cut-off apparatus with closing members having a sliding movement along the seat for opening and closing with flat sealing faces; Packings therefor with wedge-shaped arrangements of sealing faces
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K31/00—Actuating devices; Operating means; Releasing devices
- F16K31/44—Mechanical actuating means
- F16K31/50—Mechanical actuating means with screw-spindle or internally threaded actuating means
- F16K31/504—Mechanical actuating means with screw-spindle or internally threaded actuating means the actuating means being rotable, rising, and having internal threads which co-operate with threads on the outside of the valve body
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Abstract
Description
성분 | 차가 버섯 추출액 |
영지 버섯 추출액 |
상황 버섯 추출액 |
홍삼 농축액 |
프로 폴리스 농축액 |
인진쑥 추출액 |
울금 추출액 |
감초 추출액 |
돈태반농축액 | 액상과당 | 정제수 |
함량 | 15g | 1.3g | 0.7g | 0.6g | 0.3g | 0.6g | 1.0g | 1.0g | 0.6g | 7.5g | 71.4g |
성분 | 인진쑥 추출액 | 액상과당 | 정제수 |
함량 | 30g | 12.5g | 57.5g |
조혈모세포 증식 촉진용 조성물 음료 복용군(N=27) | 위약 음료 복용군(N=12) |
총합 (N=39) |
||
성별 | 남성 | 23 | 10 | 33 |
여성 | 4 | 2 | 6 | |
연령 | 40~50 | 8 | 2 | 10 |
50~60 | 15 | 6 | 21 | |
>60 | 4 | 4 | 8 | |
알코올 섭취 정도 |
- | 21 | 10 | 31 |
≤1회/1주 | 6 | 2 | 8 | |
≥1회/1주 | 0 | 0 | 0 |
|
위약음료 복용군(12) |
조혈모세포 증식 촉진용 조성물 음료 복용군(27) | p-value1 ) |
Cell No.(/105Leukocytes, Mean±SD) | |||
복용 전 | 8.67±4.66 | 3.89±2.53 | 0.011* |
복용 2주 후 | 2.75±2.49 | 8.78±9.23 | 0.004** |
복용 4주 후 | 4.38±3.20 | 7.14±3.19 | 0.014* |
p-value2 ) 2주 후 | 0.001** | 0.008** | |
p-value2 ) 4주 후 | 0.021* | 0.000*** |
|
위약음료 복용군(12) |
조혈모세포 증식 촉진용 조성물 음료 복용군(27) | p-value1 ) |
Cell No.(×103/㎕, Mean±SD) | |||
복용 전 | 1.08±0.59 | 1.85±0.40 | 0.795 |
복용 2주 후 | 1.70±0.54 | 1.78±0.46 | 0.639 |
복용 4주 후 | 1.81±0.42 | 1.72±0.64 | 0.646 |
p-value2 ) 2주 후 | 0.454 | 0.278 | |
p-value2 ) 4주 후 | 0.949 | 0.125 |
|
위약음료 복용군(12) |
조혈모세포 증식 촉진용 조성물 음료 복용군(27) | p-value1 ) |
Cell Ratio. (%, Mean±SD) | |||
CD4+(%) | |||
복용 전 | 39.63±12.32 | 42.35±7.38 | 0.434 |
복용 2주 후 | 39.98±7.06 | 41.94±8.70 | 0.498 |
복용 4주 후 | 40.55±8.44 | 42.41±7.63 | 0.486 |
p-value2 ) 2주 후 | 0.885 | 0.619 | |
p-value2 ) 4주 후 | 0.636 | 0.607 | |
CD8+(%) | |||
복용 전 | 19.88±8.27 | 22.25±7.51 | 0.437 |
복용 2주 후 | 22.00±9.05 | 23.08±8.24 | 0.717 |
복용 4주 후 | 23.14±8.88 | 24.08±7.52 | 0.727 |
p-value2 ) 2주 후 | 0.014* | 0.050 | |
p-value2 ) 4주 후 | 0.002** | 0.012* | |
CD4+/CD8+(%) | |||
복용 전 | 2.53±2.13 | 2.21±1.16 | 0.579 |
복용 2주 후 | 2.32±1.65 | 2.16±1.27 | 0.747 |
복용 4주 후 | 2.19±1.54 | 2.06±1.30 | 0.778 |
p-value2 ) 2주 후 | 0.268 | 0.381 | |
p-value2 ) 4주 후 | 0.206 | 0.281 |
|
위약음료 복용군(12) |
조혈모세포 증식 촉진용 조성물 음료 복용군(27) | p-value1 ) |
Cell Ratio. (%, Mean±SD) | |||
복용 전 | 19.99±10.24 | 17.54±8.72 | 0.523 |
복용 2주 후 | 17.77±6.83 | 17.53±9.51 | 0.938 |
복용 4주 후 | 18.65±8.54 | 17.01±7.71 | 0.546 |
p-value2 ) 2주 후 | 0.174 | 0.987 | |
p-value2 ) 4주 후 | 0.554 | 0.443 |
번호 | 버섯추출물 | 용도 | 작용기작 |
대한민국 공개특허 2004-0042119 |
차가버섯 | 면역 활성 | 비장세포 증식, IL-2활성화, NO생산능 향상 |
대한민국 공개특허 2003-0082619 |
영지버섯 | 면역 활성 | T세포 및 B세포 활성화, 대식세포 활성화 |
한국특허등록 623270 |
상황버섯 | 면역 활성 | B세포의 활성 |
실시예 1 | 차가버섯, 영지버섯, 상황버섯 | 면역 활성 | 조혈모세포의 수를 증가 |
Claims (4)
- 차가버섯 추출물; 영지버섯 추출물; 상황버섯 추출물; 홍삼 농축액; 프로폴리스 농축액; 인진쑥 추출액; 울금 추출액; 감초 추출액; 돈태반 농축액 및 액상과당을 함유하는 조혈모세포 증식 촉진용 조성물.
- 제 1항에 있어서, 차가버섯 추출물 100중량부에 대해서, 영지버섯 추출물 5~50중량부; 상황버섯 추출물 0.5~30중량부; 홍삼 농축액 0.5~30중량부; 프로폴리스 농축액 0.5~30중량부; 인진쑥 추출액 0.5~30중량부; 울금 추출액 0.5~50중량부; 감초 추출액 0.5~50중량부; 돈태반 농축액 0.5~30중량부 및 액상과당 20~80중량부를 함유하는 조혈모세포 증식 촉진용 조성물.
- 차가버섯 추출물; 영지버섯 추출물; 상황버섯 추출물; 홍삼 농축액; 프로폴리스 농축액; 인진쑥 추출액; 울금 추출액; 감초 추출액; 돈태반 농축액 및 액상과당을 함유하는 조혈모세포 증식 촉진용 기능성 식품.
- 제 3항에 있어서, 차가버섯 추출물 100중량부에 대해서, 영지버섯 추출물 5~50중량부; 상황버섯 추출물 0.5~30중량부; 홍삼 농축액 0.5~30중량부; 프로폴리스 농축액 0.5~30중량부; 인진쑥 추출액 0.5~30중량부; 울금 추출액 0.5~50중량부; 감초 추출액 0.5~50중량부; 돈태반 농축액 0.5~30중량부 및 액상과당 20~80중량부를 함유하는 조혈모세포 증식 촉진용 기능성 식품.
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020090004151A KR101011028B1 (ko) | 2009-01-19 | 2009-01-19 | 차가버섯 추출물, 영지버섯 추출물 및 상황버섯 추출물을 함유하는 조혈모세포 증식 촉진용 조성물 |
JP2011546218A JP5391282B2 (ja) | 2009-01-19 | 2010-01-18 | 樺孔茸抽出物、霊芝抽出物及び桑黄抽出物を含有する造血幹細胞増殖促進用組成物 |
PCT/KR2010/000310 WO2010082798A2 (ko) | 2009-01-19 | 2010-01-18 | 차가버섯 추출물, 영지버섯 추출물 및 상황버섯 추출물을 함유하는 조혈모세포 증식 촉진용 조성물 |
CN2010800036450A CN102256612A (zh) | 2009-01-19 | 2010-01-18 | 包含桦褐灵芝、灵芝和桑黄提取物的用于促进造血干细胞增殖的组合物 |
EP10731413A EP2380580A4 (en) | 2009-01-19 | 2010-01-18 | COMPOSITION CONTAINING EXTRACTS OF FUSCOPORIA OBLIQUA, GONADERMA LUCIDUM AND PHELLINUS LINTEUS TO PROMOTE THE PROLIFERATION OF HEMATOPOIETIC STEM CELLS |
US13/140,244 US20110250226A1 (en) | 2009-01-19 | 2010-01-18 | Composition containing extracts of fuscoporia obliqua, ganoderma lucidum and phellinus linteus for promoting the proliferation of hematopoietic stem cells |
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KR1020090004151A KR101011028B1 (ko) | 2009-01-19 | 2009-01-19 | 차가버섯 추출물, 영지버섯 추출물 및 상황버섯 추출물을 함유하는 조혈모세포 증식 촉진용 조성물 |
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KR20100084812A KR20100084812A (ko) | 2010-07-28 |
KR101011028B1 true KR101011028B1 (ko) | 2011-01-26 |
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US (1) | US20110250226A1 (ko) |
EP (1) | EP2380580A4 (ko) |
JP (1) | JP5391282B2 (ko) |
KR (1) | KR101011028B1 (ko) |
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JP5729936B2 (ja) * | 2009-07-31 | 2015-06-03 | 株式会社 資生堂 | エンプリンとs100a9の結合の阻害を指標とする慢性炎症抑制剤又は癌転移抑制剤のスクリーニング方法 |
CN102304530B (zh) * | 2011-07-17 | 2013-09-04 | 徐州师范大学 | 斜生纤孔菌3-羟基-3-甲基戊二酰辅酶a还原酶基因及其编码的蛋白质和应用 |
WO2016004243A1 (en) * | 2014-07-02 | 2016-01-07 | Shaklee Corporation | Compositions and methods for enhancing immunity |
JP6763604B2 (ja) * | 2016-10-04 | 2020-09-30 | 日本メナード化粧品株式会社 | 幹細胞の未分化状態維持剤及び増殖促進剤 |
CN109852519A (zh) * | 2019-03-06 | 2019-06-07 | 肖文贤 | 一种保健酒及其制备方法 |
JP7317358B2 (ja) * | 2019-07-16 | 2023-07-31 | 日本メナード化粧品株式会社 | 造血幹細胞の分化促進剤 |
CN111808802B (zh) * | 2019-09-20 | 2022-04-26 | 深圳市未来细胞生命科技有限公司 | 白桦茸水提取物在促进脂肪干细胞生长中的应用 |
CN111700138A (zh) * | 2020-07-09 | 2020-09-25 | 西安小天使生命营养科学健康研究院有限公司 | 桦褐孔菌茶饮及其制备工艺 |
KR102557645B1 (ko) * | 2021-02-15 | 2023-07-21 | 주식회사 기운찬 | 복합버섯균사체를 함유하는 인지기능 또는 기억력 개선용 조성물 |
WO2023091607A1 (en) * | 2021-11-19 | 2023-05-25 | The Better For You Company, Llc | Oxalic acid or oxalate free inonotus obliquus extract and uses thereof |
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US7135183B1 (en) * | 2001-08-06 | 2006-11-14 | Academia Sinica | Immuno-modulating antitumor activities of Ganoderma lucidum (Reishi) polysaccharides |
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JPH08143462A (ja) * | 1994-11-18 | 1996-06-04 | San Crest:Kk | 免疫賦活剤及び抗腫瘍剤 |
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- 2009-01-19 KR KR1020090004151A patent/KR101011028B1/ko active IP Right Grant
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2010
- 2010-01-18 US US13/140,244 patent/US20110250226A1/en not_active Abandoned
- 2010-01-18 CN CN2010800036450A patent/CN102256612A/zh active Pending
- 2010-01-18 EP EP10731413A patent/EP2380580A4/en not_active Withdrawn
- 2010-01-18 WO PCT/KR2010/000310 patent/WO2010082798A2/ko active Application Filing
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논문:학위논문 |
인터넷자료 |
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JP5391282B2 (ja) | 2014-01-15 |
EP2380580A2 (en) | 2011-10-26 |
JP2012515199A (ja) | 2012-07-05 |
EP2380580A4 (en) | 2012-06-27 |
WO2010082798A2 (ko) | 2010-07-22 |
CN102256612A (zh) | 2011-11-23 |
KR20100084812A (ko) | 2010-07-28 |
US20110250226A1 (en) | 2011-10-13 |
WO2010082798A3 (ko) | 2010-11-25 |
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