KR100967573B1 - 대사산물 프로파일의 정량 분석용 기구 - Google Patents

대사산물 프로파일의 정량 분석용 기구 Download PDF

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KR100967573B1
KR100967573B1 KR1020077030772A KR20077030772A KR100967573B1 KR 100967573 B1 KR100967573 B1 KR 100967573B1 KR 1020077030772 A KR1020077030772 A KR 1020077030772A KR 20077030772 A KR20077030772 A KR 20077030772A KR 100967573 B1 KR100967573 B1 KR 100967573B1
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metabolites
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KR20080025092A (ko
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스티븐 루이스 램제이
볼프강 구겐바이슐러
클라우스 미하엘 바인베르거
아르민 그라버
볼프강 마르쿠스 스토클
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바이오크레이츠 라이프 사이언시스 아게
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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    • G01—MEASURING; TESTING
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5038—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving detection of metabolites per se
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00594—Quality control, including calibration or testing of components of the analyser
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
    • G16B50/30—Data warehousing; Computing architectures
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    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics

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  • Bioinformatics & Cheminformatics (AREA)
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  • Spectroscopy & Molecular Physics (AREA)
  • Tropical Medicine & Parasitology (AREA)
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  • Databases & Information Systems (AREA)
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  • Bioethics (AREA)
  • Toxicology (AREA)
  • Quality & Reliability (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
KR1020077030772A 2005-06-30 2006-06-29 대사산물 프로파일의 정량 분석용 기구 Active KR100967573B1 (ko)

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US69498305P 2005-06-30 2005-06-30
US69498405P 2005-06-30 2005-06-30
US60/694,984 2005-06-30
US60/694,983 2005-06-30

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KR20080025092A KR20080025092A (ko) 2008-03-19
KR100967573B1 true KR100967573B1 (ko) 2010-07-05

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US (2) US8265877B2 (enExample)
EP (2) EP1897014B1 (enExample)
JP (2) JP5155160B2 (enExample)
KR (1) KR100967573B1 (enExample)
CN (1) CN100594501C (enExample)
AU (1) AU2006265381B2 (enExample)
BR (1) BRPI0613478B8 (enExample)
CA (2) CA2608965C (enExample)
DK (2) DK1875401T3 (enExample)
ES (1) ES2452025T3 (enExample)
IL (1) IL187470A (enExample)
IN (1) IN2014DN02241A (enExample)
NO (1) NO339319B1 (enExample)
NZ (1) NZ563431A (enExample)
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Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995030763A2 (en) 1994-05-09 1995-11-16 Chiron Viagene, Inc. Retroviral vectors having a reduced recombination rate
US8969089B2 (en) 2004-10-12 2015-03-03 Quest Diagnostics Investments, Inc. Analysis of amino acids in body fluid by liquid chromatography-mass spectrometry
DK1875401T3 (da) * 2005-06-30 2014-04-07 Biocrates Life Sciences Ag Indretning til kvantitativ analyse af en metabolitprofil
CN101484808B (zh) * 2006-05-05 2015-11-25 珀金埃尔默·拉斯公司 用质谱法定量分析源自表面的样品
EP1923806A1 (en) * 2006-11-14 2008-05-21 Metanomics GmbH Fast metabolomic analysis and system therefor
US7999084B2 (en) 2007-05-16 2011-08-16 Agilent Technologies, Inc. Devices and methods for reducing matrix effects
JP2010527624A (ja) * 2007-05-31 2010-08-19 バイオクレイツ ライフ サイエンス エージー 酸化ストレスレベルを測定するためのバイオマーカーおよび方法
EP2165195A1 (en) * 2007-05-31 2010-03-24 BIOCRATES Life Sciences AG Inflammation and oxidative stress level assay
US12367163B2 (en) 2007-06-29 2025-07-22 Quest Diagnostics Investments Llc Analysis of amino acids in body fluid by liquid chromatography—mass spectrometry
CN101796408B (zh) * 2007-06-29 2014-05-07 奎斯特诊断投资公司 用液相层析-质谱法分析体液内的氨基酸
CN101802607A (zh) * 2007-07-26 2010-08-11 菲诺梅诺米发现公司 用于诊断、风险评价、和监测孤独症谱系病症的方法
DE102007043614B3 (de) * 2007-09-13 2008-11-20 Biocrates Life Sciences Gmbh Halterung für ein Trägermittel zum Einsetzen in eine zylinderförmige Öffnung
CA2701325A1 (en) * 2007-10-01 2009-04-09 Dh Technologies Development Pte. Ltd. Analysis of conjugated metabolites of alcohol consumption
EP2215460A4 (en) * 2007-11-26 2010-12-29 Waters Technologies Corp INTERNAL STANDARDS AND METHODS FOR USE IN MEASURING QUANTITATIVELY ANALYTES IN A SAMPLE
WO2009152198A2 (en) * 2008-06-13 2009-12-17 Smiths Detection-Toronto Ltd. Analytical instrument
EP3181705A1 (en) 2008-11-12 2017-06-21 Caris Life Sciences Switzerland Holdings GmbH Methods and systems of using exosomes for determining phenotypes
EP2192196A1 (en) 2008-11-27 2010-06-02 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Prediction of lipid-metabotype-related physiological susceptibilities
JP5325973B2 (ja) 2009-03-05 2013-10-23 株式会社日立ハイテクノロジーズ 分析装置
US9500572B2 (en) 2009-04-30 2016-11-22 Purdue Research Foundation Sample dispenser including an internal standard and methods of use thereof
JP5671523B2 (ja) * 2009-04-30 2015-02-18 パーデュー・リサーチ・ファウンデーションＰｕｒｄｕｅ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ 濡れた多孔質材料を用いるイオン生成
EP2249161B1 (en) 2009-05-05 2020-05-13 InfanDx AG Method of diagnosing asphyxia
US20120129265A1 (en) * 2009-06-02 2012-05-24 Biocrates Life Sciences Ag New biomarkers for assessing kidney diseases
EP2507393A4 (en) 2009-11-30 2013-05-01 Caris Life Sciences Luxembourg Holdings METHODS AND SYSTEMS FOR ISOLATING, STORING AND ANALYZING VESICLES
US20140148348A1 (en) 2010-01-13 2014-05-29 Christine Kuslich Dectection of gastrointestinal disorders
CN103237901B (zh) 2010-03-01 2016-08-03 卡里斯生命科学瑞士控股有限责任公司 用于治疗诊断的生物标志物
CA2795776A1 (en) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Circulating biomarkers for disease
CN105911196B (zh) 2010-10-29 2019-04-23 恩姆菲舍尔科技公司 用于样品制备和分析的自动化系统的系统布局
US9536720B2 (en) * 2010-10-29 2017-01-03 Atonarp Inc. Analyzing apparatus
EP2492690A1 (en) * 2011-02-22 2012-08-29 BIOCRATES Life Sciences AG Method and use of metabolites for the diagnosis of inflammatory brain injury in preterm born infants
EP2587264A1 (en) 2011-10-25 2013-05-01 InfanDx AG Method and use of metabolites for the diagnosis and differentiation of neonatal encephalopathy
EP3557605B1 (en) 2011-11-23 2021-07-14 Quest Diagnostics Investments Incorporated Kisspeptin-54 detection by tandem mass spectrometry
JP6198408B2 (ja) * 2012-04-02 2017-09-20 株式会社日立ハイテクノロジーズ サンプル液に含まれる揮発性物質の分析方法
US8870028B2 (en) 2012-05-25 2014-10-28 Restek Corporation Dispensing device
WO2014026991A1 (en) * 2012-08-13 2014-02-20 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Biomarkers for type 2 diabetes
EP2917738A1 (de) 2012-11-12 2015-09-16 BIOCRATES Life Sciences AG Verwendung von qualitätsindikatoren zum nachweis von auftauprozessen in gefrorenen gewebeproben
WO2014110196A1 (en) * 2013-01-10 2014-07-17 Restek Corporation Dispensing device and method
BR112015018484A2 (pt) 2013-01-31 2017-07-18 Purdue Research Foundation métodos de analisar o petróleo bruto
CA2888539C (en) 2013-01-31 2021-07-27 Purdue Research Foundation Systems and methods for analyzing an extracted sample
US9620344B2 (en) 2013-06-25 2017-04-11 Purdue Research Foundation Mass spectrometry analysis of microorganisms in samples
CN103558354B (zh) * 2013-11-15 2015-07-15 南京大学 一种基于生物组学整合技术的水体毒性分析方法
JP2017101924A (ja) * 2014-03-31 2017-06-08 積水メディカル株式会社 内部標準物質試薬
CN104200087B (zh) * 2014-06-05 2018-10-02 清华大学 用于机器学习的参数寻优及特征调优的方法及系统
US9786478B2 (en) 2014-12-05 2017-10-10 Purdue Research Foundation Zero voltage mass spectrometry probes and systems
CN107960130A (zh) 2015-02-06 2018-04-24 普度研究基金会 探针、系统、盒及其使用方法
EP3171173A1 (en) 2015-11-19 2017-05-24 Medizinische Universität Innsbruck Method of diagnosis of a thoracic aortic aneurysm
EP3397972A2 (en) * 2015-12-31 2018-11-07 Universal Diagnostics, S.L. Systems and methods for automated, customizable sample preparation tool, software script, and calibration routine for detection of metabolites and lipids
US10539540B2 (en) 2016-06-10 2020-01-21 Hitachi High-Tech Science Corporation Liquid chromatograph and method for correcting detector output value fluctuation of liquid chromatograph
US10607723B2 (en) 2016-07-05 2020-03-31 University Of Kentucky Research Foundation Method and system for identification of metabolites using mass spectra
US11719702B2 (en) * 2016-11-07 2023-08-08 Battelle Memorial Institute Methods and systems of proteome analysis and imaging
EP3535418B1 (en) 2016-11-07 2021-12-15 Battelle Memorial Institute Nanoscale biochemical sample preparation and analysis
EP3351938A1 (en) 2017-01-18 2018-07-25 BIOCRATES Life Sciences AG New biomarkers for assessing ovarian cancer
EP3376230A1 (en) 2017-03-13 2018-09-19 Biocross, S.L. Identification of signatures for neurodegeneration diseases diagnoses
WO2018174876A1 (en) * 2017-03-22 2018-09-27 Mprobe Inc. Methods and compositions for providing a preeclampsia assessment with metabolites
CN107727850B (zh) * 2017-10-10 2021-08-27 常州博闻迪医药股份有限公司 一种侧向流层析检测反应启动控制方法
JP6991436B2 (ja) * 2017-05-17 2022-01-12 ラジオメーター・メディカル・アー・ペー・エス 流体中の検体を検出するための多孔質光ファイバ
CN107561150A (zh) * 2017-07-03 2018-01-09 宁波华仪宁创智能科技有限公司 吸毒的检测方法
CN107798981A (zh) * 2017-10-31 2018-03-13 楚雄医药高等专科学校 一种永久性教学用微囊标本片及其制作方法
CN109030673A (zh) * 2018-07-04 2018-12-18 易达精准（杭州）科技有限公司 干血片中免疫抑制剂的检测方法以及检测试剂盒
CN109298115B (zh) * 2018-10-19 2020-07-28 深圳市绘云生物科技有限公司 生物样品中多种代谢物定量检测方法及代谢芯片
WO2020099683A1 (en) 2018-11-16 2020-05-22 Biocrates Life Sciences Ag Metabolites for use in ovarian cancer detection and diagnosis
FR3091351B1 (fr) 2018-12-27 2021-05-21 Univ Rouen Centre Hospitalier Biomarqueur de la maladie de fabry
KR102035162B1 (ko) * 2019-03-12 2019-11-08 한국과학기술원 질병 표적 대사 효소에 특이적인 인체 대사 물질을 이용하여 질병에 대한 약물 후보를 예측하는 방법
AU2020279748A1 (en) 2019-05-20 2021-12-23 Battelle Energy Alliance, Llc Spark plasma sintering methods for fabricating dense graphite
GB201916046D0 (en) * 2019-11-04 2019-12-18 Amazentis Sa Diagnostic method
CN111579665B (zh) * 2020-05-20 2021-11-05 苏州帕诺米克生物医药科技有限公司 一种基于uplc/hrms的代谢组学相对定量分析方法
US20230204544A1 (en) * 2020-05-21 2023-06-29 Mayo Foundation For Medical Education And Research Calibration methods for mass spectrometry measurements
CN111704654B (zh) * 2020-06-18 2021-12-03 上海交通大学医学院附属仁济医院 肽类化合物及其制备方法与应用
EP4419255A4 (en) * 2021-10-21 2025-10-15 Pinpoint Testing Llc READY-TO-ASSEMBLE ANALYTICAL PLATFORMS FOR CHEMICAL ANALYSES AND QUANTIFICATION OF ANALYTES IN BIOLOGICAL SAMPLES
US12100484B2 (en) 2021-11-01 2024-09-24 Matterworks Inc Methods and compositions for analyte quantification
US11754536B2 (en) 2021-11-01 2023-09-12 Matterworks Inc Methods and compositions for analyte quantification
JP7206365B1 (ja) 2021-12-22 2023-01-17 浜松ホトニクス株式会社 試料支持体
KR102547430B1 (ko) * 2022-11-16 2023-06-23 (주)애터미오롯 노니 함유 조성물의 정성 분석 방법
AU2023391474A1 (en) * 2022-12-05 2025-06-19 Washington University Improved method for scalable untargeted metabolomic workflow
GB2636339A (en) 2023-08-30 2025-06-18 Cambridge Entpr Ltd Biomarkers for bipolar disorder
CN117538530B (zh) * 2023-11-07 2024-07-19 中国医学科学院肿瘤医院 一种检测转移性乳腺癌的生物标志组合物和试剂盒及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050112635A1 (en) * 2003-09-22 2005-05-26 Becton, Dickinson And Company Quantification of analytes using internal standards

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2017155C1 (ru) * 1993-05-05 1994-07-30 Геннадий Степанович Власов Диагностическое устройство для иммунохимического анализа
US5756362A (en) * 1993-10-12 1998-05-26 Cornell Research Foundation, Inc. Liposome-enhanced immunoaggregation assay and test device
US6358752B1 (en) 1996-09-27 2002-03-19 Cornell Research Foundation, Inc. Liposome-enhanced test device and method
GB9718129D0 (en) * 1997-08-27 1997-10-29 Isis Innovation Branched structures
US6258605B1 (en) 1999-03-26 2001-07-10 Neo Gen Screening, Inc. Clinical method for the genetic screening of newborns using tandem mass spectrometry
US6455321B1 (en) 1999-01-30 2002-09-24 Neo Gen Screening, Inc. Method for interpreting tandem mass spectrometry data for clinical diagnosis
US20020009394A1 (en) * 1999-04-02 2002-01-24 Hubert Koster Automated process line
ATE343130T1 (de) * 1999-12-29 2006-11-15 Perkinelmer Life Sciences Inc Testtablett, kit und verfahren zum screening von körperflüssigkeiten von neugeborenen durch tandem-massenspektrometrie
WO2001078652A2 (en) * 2000-04-14 2001-10-25 Metabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
US6680203B2 (en) 2000-07-10 2004-01-20 Esperion Therapeutics, Inc. Fourier transform mass spectrometry of complex biological samples
NZ524065A (en) * 2000-07-18 2005-02-25 Invitrogen Corp Device and methods for subdividing and filtering gel material and extracting molecules therefrom
US6627444B1 (en) 2000-08-07 2003-09-30 Smiths Detection - Toronto Ltd. Method and solid phase calibration sample for calibration of analytical instructions
US20020155587A1 (en) 2001-04-20 2002-10-24 Sequenom, Inc. System and method for testing a biological sample
EP1417629B1 (en) 2001-07-06 2008-02-20 Lipomics Technologies, Inc. Generating, viewing, interpreting, and utilizing a quantitative database of metabolites
DE60239962D1 (de) 2001-08-14 2011-06-16 Harvard College Absolute quantifizierung von proteinen und modifizierten formen davon mittels mehrstufiger massenspektrometrie
US6929944B2 (en) * 2001-08-31 2005-08-16 Beckman Coulter, Inc. Analysis using a distributed sample
US6939716B2 (en) 2001-09-19 2005-09-06 Washington University Method for detecting conditions indicative of sepsis
JP2005536714A (ja) * 2001-11-13 2005-12-02 カプリオン ファーマシューティカルズ インコーポレーティッド 質量強度プロファイリングシステムおよびその使用法
US6873914B2 (en) * 2001-11-21 2005-03-29 Icoria, Inc. Methods and systems for analyzing complex biological systems
GB0128498D0 (en) 2001-11-28 2002-01-23 Inst Of Child Health International standards for sphingolipids
ATE327512T1 (de) 2001-12-08 2006-06-15 Micromass Ltd Massenspektrometrie-verfahren
AUPS177202A0 (en) * 2002-04-16 2002-05-23 Diakyne Pty Ltd Multi-element screening of trace elements
AU2003272234A1 (en) 2002-10-24 2004-05-13 Warner-Lambert Company, Llc Integrated spectral data processing, data mining, and modeling system for use in diverse screening and biomarker discovery applications
WO2004038381A2 (en) 2002-10-25 2004-05-06 Metabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
JP2006504971A (ja) * 2002-11-01 2006-02-09 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・コロラド，ア・ボディー・コーポレイト マトリックス支援レーザー脱離イオン化−飛行時間型質量分析によるタンパク質アイソフォームの定量的解析
US20040121305A1 (en) 2002-12-18 2004-06-24 Wiegand Roger Charles Generation of efficacy, toxicity and disease signatures and methods of use thereof
US6909981B2 (en) * 2003-01-27 2005-06-21 Ciphergen Biosystems, Inc. Data management system and method for processing signals from sample spots
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
KR20050050714A (ko) * 2003-11-26 2005-06-01 매그나칩 반도체 유한회사 반도체소자의 트랜지스터 제조방법
US7745226B2 (en) * 2005-04-06 2010-06-29 Quest Diagnostics Investments Incorporated Methods for detecting vitamin D metabolites
DK1875401T3 (da) * 2005-06-30 2014-04-07 Biocrates Life Sciences Ag Indretning til kvantitativ analyse af en metabolitprofil

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050112635A1 (en) * 2003-09-22 2005-05-26 Becton, Dickinson And Company Quantification of analytes using internal standards

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