CA2608965C - Device for quantitative analysis of a metabolite profile - Google Patents

Device for quantitative analysis of a metabolite profile Download PDF

Info

Publication number
CA2608965C
CA2608965C CA2608965A CA2608965A CA2608965C CA 2608965 C CA2608965 C CA 2608965C CA 2608965 A CA2608965 A CA 2608965A CA 2608965 A CA2608965 A CA 2608965A CA 2608965 C CA2608965 C CA 2608965C
Authority
CA
Canada
Prior art keywords
insert
sample
analysis
drug
biological sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2608965A
Other languages
English (en)
French (fr)
Other versions
CA2608965A1 (en
Inventor
Steven Lewis Ramsay
Wolfgang Guggenbichler
Klaus Michael Weinberger
Armin Graber
Wolfgang Markus Stoeggl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biocrates Life Sciences AG
Original Assignee
Biocrates Life Sciences AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocrates Life Sciences AG filed Critical Biocrates Life Sciences AG
Publication of CA2608965A1 publication Critical patent/CA2608965A1/en
Application granted granted Critical
Publication of CA2608965C publication Critical patent/CA2608965C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5038—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving detection of metabolites per se
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00594—Quality control, including calibration or testing of components of the analyser
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
    • G16B50/30—Data warehousing; Computing architectures
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Databases & Information Systems (AREA)
  • Medical Informatics (AREA)
  • Bioethics (AREA)
  • Evolutionary Biology (AREA)
  • Toxicology (AREA)
  • Quality & Reliability (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
CA2608965A 2005-06-30 2006-06-29 Device for quantitative analysis of a metabolite profile Active CA2608965C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US69498405P 2005-06-30 2005-06-30
US69498305P 2005-06-30 2005-06-30
US60/694,983 2005-06-30
US60/694,984 2005-06-30
PCT/EP2006/006328 WO2007003344A2 (en) 2005-06-30 2006-06-29 Device for quantitative analysis of a metabolite profile

Publications (2)

Publication Number Publication Date
CA2608965A1 CA2608965A1 (en) 2007-01-11
CA2608965C true CA2608965C (en) 2014-08-19

Family

ID=36783737

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2608965A Active CA2608965C (en) 2005-06-30 2006-06-29 Device for quantitative analysis of a metabolite profile
CA2608963A Active CA2608963C (en) 2005-06-30 2006-06-29 Apparatus and method for analyzing a metabolite profile

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2608963A Active CA2608963C (en) 2005-06-30 2006-06-29 Apparatus and method for analyzing a metabolite profile

Country Status (16)

Country Link
US (2) US8265877B2 (enExample)
EP (2) EP1897014B1 (enExample)
JP (2) JP5155160B2 (enExample)
KR (1) KR100967573B1 (enExample)
CN (1) CN100594501C (enExample)
AU (1) AU2006265381B2 (enExample)
BR (1) BRPI0613478B8 (enExample)
CA (2) CA2608965C (enExample)
DK (2) DK1897014T3 (enExample)
ES (1) ES2452025T3 (enExample)
IL (1) IL187470A (enExample)
IN (1) IN2014DN02241A (enExample)
NO (1) NO339319B1 (enExample)
NZ (1) NZ563431A (enExample)
RU (1) RU2391672C2 (enExample)
WO (2) WO2007003344A2 (enExample)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69535669T2 (de) 1994-05-09 2008-12-04 Oxford Biomedica (Uk) Ltd. Retrovirale vektoren mit verminderter rekombinationsrate
US8969089B2 (en) 2004-10-12 2015-03-03 Quest Diagnostics Investments, Inc. Analysis of amino acids in body fluid by liquid chromatography-mass spectrometry
ES2452025T3 (es) * 2005-06-30 2014-03-31 Biocrates Life Sciences Ag Aparato de análisis de un perfil de metabolitos
US20070259445A1 (en) * 2006-05-05 2007-11-08 Blas Cerda Quantitative analysis of surface-derived samples using mass spectrometry
EP1923806A1 (en) * 2006-11-14 2008-05-21 Metanomics GmbH Fast metabolomic analysis and system therefor
US7999084B2 (en) * 2007-05-16 2011-08-16 Agilent Technologies, Inc. Devices and methods for reducing matrix effects
WO2008145384A1 (en) * 2007-05-31 2008-12-04 Biocrates Life Sciences Ag Inflammation and oxidative stress level assay
JP2010527624A (ja) * 2007-05-31 2010-08-19 バイオクレイツ ライフ サイエンス エージー 酸化ストレスレベルを測定するためのバイオマーカーおよび方法
US12367163B2 (en) 2007-06-29 2025-07-22 Quest Diagnostics Investments Llc Analysis of amino acids in body fluid by liquid chromatography—mass spectrometry
EP3067692B1 (en) * 2007-06-29 2019-04-17 Quest Diagnostics Investments Incorporated Analysis of amino acids in body fluid by liquid chromatography-mass spectrometry (lc-ms)
JP5306345B2 (ja) * 2007-07-26 2013-10-02 フェノメノーム ディスカバリーズ インク 自閉症スペクトラム障害の診断、リスク評価、及びモニタリングを行うための方法
DE102007043614B3 (de) * 2007-09-13 2008-11-20 Biocrates Life Sciences Gmbh Halterung für ein Trägermittel zum Einsetzen in eine zylinderförmige Öffnung
JP2010540911A (ja) * 2007-10-01 2010-12-24 ディーエイチ テクノロジーズ デベロップメント プライベート リミテッド アルコール消費の複合化した代謝産物の分析
WO2009070233A1 (en) * 2007-11-26 2009-06-04 Waters Technologies Corporation Internal standards and methods for use in quantitatively measuring analytes in a sample
WO2009152198A2 (en) * 2008-06-13 2009-12-17 Smiths Detection-Toronto Ltd. Analytical instrument
WO2010056337A2 (en) 2008-11-12 2010-05-20 Caris Mpi, Inc. Methods and systems of using exosomes for determining phenotypes
EP2192196A1 (en) 2008-11-27 2010-06-02 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Prediction of lipid-metabotype-related physiological susceptibilities
JP5325973B2 (ja) 2009-03-05 2013-10-23 株式会社日立ハイテクノロジーズ 分析装置
US8859956B2 (en) * 2009-04-30 2014-10-14 Purdue Research Foundation Ion generation using wetted porous material
US9500572B2 (en) 2009-04-30 2016-11-22 Purdue Research Foundation Sample dispenser including an internal standard and methods of use thereof
ES2799327T3 (es) 2009-05-05 2020-12-16 Infandx Ag Método para diagnosticar asfixia
EP2438441B1 (en) * 2009-06-02 2014-05-21 BIOCRATES Life Sciences AG New biomarkers for assessing kidney diseases
CA2782284A1 (en) 2009-11-30 2011-06-03 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Methods and systems for isolating, storing, and analyzing vesicles
US20140148348A1 (en) 2010-01-13 2014-05-29 Christine Kuslich Dectection of gastrointestinal disorders
EP2542696B1 (en) 2010-03-01 2016-09-28 Caris Life Sciences Switzerland Holdings GmbH Biomarkers for theranostics
JP2013526852A (ja) 2010-04-06 2013-06-27 カリス ライフ サイエンシズ ルクセンブルク ホールディングス 疾患に対する循環バイオマーカー
CN103370627B (zh) 2010-10-29 2016-05-11 恩姆菲舍尔科技公司 用于样品制备和分析的自动化系统的系统布局
SG190048A1 (en) 2010-10-29 2013-06-28 Atonarp Inc Analysis apparatus
EP2492690A1 (en) * 2011-02-22 2012-08-29 BIOCRATES Life Sciences AG Method and use of metabolites for the diagnosis of inflammatory brain injury in preterm born infants
EP2587264A1 (en) 2011-10-25 2013-05-01 InfanDx AG Method and use of metabolites for the diagnosis and differentiation of neonatal encephalopathy
EP3557605B1 (en) 2011-11-23 2021-07-14 Quest Diagnostics Investments Incorporated Kisspeptin-54 detection by tandem mass spectrometry
JP6198408B2 (ja) * 2012-04-02 2017-09-20 株式会社日立ハイテクノロジーズ サンプル液に含まれる揮発性物質の分析方法
US8870028B2 (en) 2012-05-25 2014-10-28 Restek Corporation Dispensing device
CN104769434B (zh) * 2012-08-13 2018-01-02 亥姆霍兹慕尼黑中心德国研究健康与环境有限责任公司 用于2型糖尿病的生物标志物
EP2917738A1 (de) 2012-11-12 2015-09-16 BIOCRATES Life Sciences AG Verwendung von qualitätsindikatoren zum nachweis von auftauprozessen in gefrorenen gewebeproben
WO2014110196A1 (en) * 2013-01-10 2014-07-17 Restek Corporation Dispensing device and method
US9733228B2 (en) 2013-01-31 2017-08-15 Purdue Research Foundation Methods of analyzing crude oil
WO2014120411A1 (en) 2013-01-31 2014-08-07 Purdue Research Foundation Systems and methods for analyzing an extracted sample
WO2014209474A1 (en) 2013-06-25 2014-12-31 Purdue Research Foundation Mass spectrometry analysis of microorganisms in samples
CN103558354B (zh) 2013-11-15 2015-07-15 南京大学 一种基于生物组学整合技术的水体毒性分析方法
JP2017101924A (ja) * 2014-03-31 2017-06-08 積水メディカル株式会社 内部標準物質試薬
CN104200087B (zh) * 2014-06-05 2018-10-02 清华大学 用于机器学习的参数寻优及特征调优的方法及系统
US9786478B2 (en) 2014-12-05 2017-10-10 Purdue Research Foundation Zero voltage mass spectrometry probes and systems
CN107960130A (zh) 2015-02-06 2018-04-24 普度研究基金会 探针、系统、盒及其使用方法
EP3171173A1 (en) 2015-11-19 2017-05-24 Medizinische Universität Innsbruck Method of diagnosis of a thoracic aortic aneurysm
US10001501B2 (en) 2015-12-31 2018-06-19 Universal Diagnostics, S. L. Systems and methods for automated, customizable sample preparation for detection of metabolites and lipids
DE102017112612A1 (de) * 2016-06-10 2017-12-14 Hitachi High-Tech Science Corporation Flüssigkeitschromatograph und Verfahren zum Korrigieren von Schwankungen eines Detektorausgabewerts des Flüssigkeitschromatographen
US10607723B2 (en) 2016-07-05 2020-03-31 University Of Kentucky Research Foundation Method and system for identification of metabolites using mass spectra
US11719702B2 (en) * 2016-11-07 2023-08-08 Battelle Memorial Institute Methods and systems of proteome analysis and imaging
EP3535418B1 (en) 2016-11-07 2021-12-15 Battelle Memorial Institute Nanoscale biochemical sample preparation and analysis
EP3351938A1 (en) * 2017-01-18 2018-07-25 BIOCRATES Life Sciences AG New biomarkers for assessing ovarian cancer
EP3376230A1 (en) 2017-03-13 2018-09-19 Biocross, S.L. Identification of signatures for neurodegeneration diseases diagnoses
WO2018174876A1 (en) * 2017-03-22 2018-09-27 Mprobe Inc. Methods and compositions for providing a preeclampsia assessment with metabolites
CN107727850B (zh) * 2017-10-10 2021-08-27 常州博闻迪医药股份有限公司 一种侧向流层析检测反应启动控制方法
CN110602983B (zh) * 2017-05-17 2022-07-19 雷迪奥米特医学公司 用于检测流体中分析物的多孔光纤
CN107561150A (zh) * 2017-07-03 2018-01-09 宁波华仪宁创智能科技有限公司 吸毒的检测方法
CN107798981A (zh) * 2017-10-31 2018-03-13 楚雄医药高等专科学校 一种永久性教学用微囊标本片及其制作方法
CN109030673A (zh) * 2018-07-04 2018-12-18 易达精准（杭州）科技有限公司 干血片中免疫抑制剂的检测方法以及检测试剂盒
CN109298115B (zh) * 2018-10-19 2020-07-28 深圳市绘云生物科技有限公司 生物样品中多种代谢物定量检测方法及代谢芯片
WO2020099683A1 (en) 2018-11-16 2020-05-22 Biocrates Life Sciences Ag Metabolites for use in ovarian cancer detection and diagnosis
FR3091351B1 (fr) 2018-12-27 2021-05-21 Univ Rouen Centre Hospitalier Biomarqueur de la maladie de fabry
KR102035162B1 (ko) * 2019-03-12 2019-11-08 한국과학기술원 질병 표적 대사 효소에 특이적인 인체 대사 물질을 이용하여 질병에 대한 약물 후보를 예측하는 방법
EP3972933A4 (en) 2019-05-20 2023-06-28 Battelle Energy Alliance, LLC Spark plasma sintering methods for fabricating dense graphite
GB201916046D0 (en) * 2019-11-04 2019-12-18 Amazentis Sa Diagnostic method
CN111579665B (zh) * 2020-05-20 2021-11-05 苏州帕诺米克生物医药科技有限公司 一种基于uplc/hrms的代谢组学相对定量分析方法
EP4153989A4 (en) * 2020-05-21 2023-11-22 Mayo Foundation for Medical Education and Research CALIBRATION PROCEDURE FOR MASS SPECTROMETERY MEASUREMENTS
CN111704654B (zh) * 2020-06-18 2021-12-03 上海交通大学医学院附属仁济医院 肽类化合物及其制备方法与应用
EP4419255A4 (en) * 2021-10-21 2025-10-15 Pinpoint Testing Llc READY-TO-ASSEMBLE ANALYTICAL PLATFORMS FOR CHEMICAL ANALYSES AND QUANTIFICATION OF ANALYTES IN BIOLOGICAL SAMPLES
US11754536B2 (en) 2021-11-01 2023-09-12 Matterworks Inc Methods and compositions for analyte quantification
US12100484B2 (en) 2021-11-01 2024-09-24 Matterworks Inc Methods and compositions for analyte quantification
JP7206365B1 (ja) 2021-12-22 2023-01-17 浜松ホトニクス株式会社 試料支持体
CN117686624A (zh) * 2022-09-02 2024-03-12 首都医科大学附属北京朝阳医院 一种同时测定血清中28种氨基酸、肉毒碱、溶血卵磷脂和神经酰胺的方法
KR102547430B1 (ko) * 2022-11-16 2023-06-23 (주)애터미오롯 노니 함유 조성물의 정성 분석 방법
WO2024123681A2 (en) * 2022-12-05 2024-06-13 Washington University Improved method for scalable untargeted metabolomic workflow
GB2636339A (en) 2023-08-30 2025-06-18 Cambridge Entpr Ltd Biomarkers for bipolar disorder
CN117538530B (zh) * 2023-11-07 2024-07-19 中国医学科学院肿瘤医院 一种检测转移性乳腺癌的生物标志组合物和试剂盒及其应用
GB202413717D0 (en) 2024-09-17 2024-10-30 Quadram Inst Bioscience Exopolysaccharide compositions and use thereof

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2017155C1 (ru) * 1993-05-05 1994-07-30 Геннадий Степанович Власов Диагностическое устройство для иммунохимического анализа
US5756362A (en) 1993-10-12 1998-05-26 Cornell Research Foundation, Inc. Liposome-enhanced immunoaggregation assay and test device
US6358752B1 (en) * 1996-09-27 2002-03-19 Cornell Research Foundation, Inc. Liposome-enhanced test device and method
GB9718129D0 (en) * 1997-08-27 1997-10-29 Isis Innovation Branched structures
US6455321B1 (en) * 1999-01-30 2002-09-24 Neo Gen Screening, Inc. Method for interpreting tandem mass spectrometry data for clinical diagnosis
US6258605B1 (en) 1999-03-26 2001-07-10 Neo Gen Screening, Inc. Clinical method for the genetic screening of newborns using tandem mass spectrometry
US20020009394A1 (en) 1999-04-02 2002-01-24 Hubert Koster Automated process line
ATE343130T1 (de) 1999-12-29 2006-11-15 Perkinelmer Life Sciences Inc Testtablett, kit und verfahren zum screening von körperflüssigkeiten von neugeborenen durch tandem-massenspektrometrie
US20020009740A1 (en) 2000-04-14 2002-01-24 Rima Kaddurah-Daouk Methods for drug discovery, disease treatment, and diagnosis using metabolomics
US6680203B2 (en) 2000-07-10 2004-01-20 Esperion Therapeutics, Inc. Fourier transform mass spectrometry of complex biological samples
NZ524065A (en) * 2000-07-18 2005-02-25 Invitrogen Corp Device and methods for subdividing and filtering gel material and extracting molecules therefrom
US6627444B1 (en) 2000-08-07 2003-09-30 Smiths Detection - Toronto Ltd. Method and solid phase calibration sample for calibration of analytical instructions
US20020155587A1 (en) 2001-04-20 2002-10-24 Sequenom, Inc. System and method for testing a biological sample
WO2003005628A2 (en) 2001-07-06 2003-01-16 Lipomics Technologies, Inc. Generating, viewing, interpreting, and utilizing a quantitative database of metabolites
WO2003016861A2 (en) * 2001-08-14 2003-02-27 President And Fellows Of Harvard College Absolute quantification of proteins and modified forms thereof by multistage mass spectrometry
US6929944B2 (en) * 2001-08-31 2005-08-16 Beckman Coulter, Inc. Analysis using a distributed sample
US6939716B2 (en) 2001-09-19 2005-09-06 Washington University Method for detecting conditions indicative of sepsis
US20030129760A1 (en) * 2001-11-13 2003-07-10 Aguilera Frank Reinaldo Morales Mass intensity profiling system and uses thereof
EP1481356A1 (en) 2001-11-21 2004-12-01 Paradigm Genetics Inc. Methods and systems for analyzing complex biological systems
GB0128498D0 (en) 2001-11-28 2002-01-23 Inst Of Child Health International standards for sphingolipids
WO2003054549A2 (en) 2001-12-08 2003-07-03 Micromass Uk Limited Method of mass spectrometry
AUPS177202A0 (en) 2002-04-16 2002-05-23 Diakyne Pty Ltd Multi-element screening of trace elements
WO2004038602A1 (en) 2002-10-24 2004-05-06 Warner-Lambert Company, Llc Integrated spectral data processing, data mining, and modeling system for use in diverse screening and biomarker discovery applications
WO2004038381A2 (en) * 2002-10-25 2004-05-06 Metabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
CA2502413A1 (en) * 2002-11-01 2004-05-21 The Regents Of The University Of Colorado, A Body Corporate Quantitative analysis of protein isoforms using matrix-assisted laser desorption/ionization time of flight mass spectrometry
US20040121305A1 (en) * 2002-12-18 2004-06-24 Wiegand Roger Charles Generation of efficacy, toxicity and disease signatures and methods of use thereof
US6909981B2 (en) * 2003-01-27 2005-06-21 Ciphergen Biosystems, Inc. Data management system and method for processing signals from sample spots
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
JP2007524844A (ja) 2003-09-22 2007-08-30 ベクトン・ディキンソン・アンド・カンパニー デンドリマー内部標準を使用する質量分析による生体分子検体の定量化
KR20050050714A (ko) * 2003-11-26 2005-06-01 매그나칩 반도체 유한회사 반도체소자의 트랜지스터 제조방법
US7745226B2 (en) * 2005-04-06 2010-06-29 Quest Diagnostics Investments Incorporated Methods for detecting vitamin D metabolites
ES2452025T3 (es) * 2005-06-30 2014-03-31 Biocrates Life Sciences Ag Aparato de análisis de un perfil de metabolitos

Also Published As

Publication number Publication date
JP4829297B2 (ja) 2011-12-07
EP1875401A2 (en) 2008-01-09
CA2608963C (en) 2014-08-26
US20070003965A1 (en) 2007-01-04
CA2608965A1 (en) 2007-01-11
KR20080025092A (ko) 2008-03-19
NZ563431A (en) 2012-05-25
RU2008102835A (ru) 2009-08-10
RU2391672C2 (ru) 2010-06-10
NO339319B1 (no) 2016-11-28
KR100967573B1 (ko) 2010-07-05
US8116983B2 (en) 2012-02-14
JP2008547030A (ja) 2008-12-25
EP1897014A1 (en) 2008-03-12
NO20080559L (no) 2008-01-30
DK1875401T3 (da) 2014-04-07
IL187470A (en) 2015-02-26
CN101208697A (zh) 2008-06-25
WO2007003344A3 (en) 2007-04-26
EP1897014B1 (en) 2014-01-15
US8265877B2 (en) 2012-09-11
BRPI0613478B1 (pt) 2019-07-09
BRPI0613478B8 (pt) 2021-07-27
DK1897014T3 (en) 2014-03-10
CN100594501C (zh) 2010-03-17
BRPI0613478A2 (pt) 2012-01-17
EP1875401B1 (en) 2014-03-05
JP2008547031A (ja) 2008-12-25
JP5155160B2 (ja) 2013-02-27
IL187470A0 (en) 2008-03-20
US20070004044A1 (en) 2007-01-04
WO2007003343A1 (en) 2007-01-11
IN2014DN02241A (enExample) 2015-07-10
CA2608963A1 (en) 2007-01-11
AU2006265381B2 (en) 2010-06-10
ES2452025T3 (es) 2014-03-31
AU2006265381A1 (en) 2007-01-11
WO2007003344A2 (en) 2007-01-11

Similar Documents

Publication Publication Date Title
CA2608965C (en) Device for quantitative analysis of a metabolite profile
Miura et al. In situ metabolomic mass spectrometry imaging: recent advances and difficulties
Satori et al. Bioanalysis of eukaryotic organelles
Burton et al. Enriching extracellular vesicles for mass spectrometry
Kosicek et al. Nano-HPLC–MS analysis of phospholipids in cerebrospinal fluid of Alzheimer’s disease patients—a pilot study
Al-Dirbashi et al. Rapid UPLC-MS/MS method for routine analysis of plasma pristanic, phytanic, and very long chain fatty acid markers of peroxisomal disorders
Ekroos Lipidomics perspective: from molecular lipidomics to validated clinical diagnostics
Wang et al. Advanced shotgun lipidomics for characterization of altered lipid patterns in neurodegenerative diseases and brain injury
Ferreira et al. Pex30-dependent membrane contact sites maintain ER lipid homeostasis
Zheng et al. Contributions of quantitative proteomics to understanding membrane microdomains: Thematic Review Series: Proteomics
Ayre et al. Dried matrix spoting-an innovative sample preparation tool in bioanalysis
Wang et al. Mass spectrometry for protein quantification in biomarker discovery
Kraus et al. Lysosomal storage disease proteo/lipidomic profiling using nMOST links ferritinophagy with mitochondrial iron deficiencies in cells lacking NPC2.
Takamori et al. Supplemental Data Molecular Anatomy of a Trafficking Organelle
Asiri Instability of Amino Acids and Acylcarnitine in Dried Blood Spots Stored at Different Temperatures: The Effect on Retrospective Analysis of Inborn Errors of Metabolism Biomarkers
Ramezani Liquid Chromatography Coupled To Mass Spectrometry Reveals That Aging Affects Lipid Droplet Composition
Bracht et al. Quantitative Proteomics Techniques in Biomarker Discovery
Lindsey et al. How to design a cardiovascular proteomics experiment
Barasa Red Blood Cell Proteomics: Challenges in biomarker discovery for clinical applications
Kaur et al. Quantitation of heat-shock proteins in clinical samples using mass spectrometry

Legal Events

Date Code Title Description
EEER Examination request
MPN Maintenance fee for patent paid

Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 19TH ANNIV.) - STANDARD

Year of fee payment: 19

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250626

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250626