AU2006265381B2 - Device for quantitative analysis of a metabolite profile - Google Patents

Device for quantitative analysis of a metabolite profile Download PDF

Info

Publication number
AU2006265381B2
AU2006265381B2 AU2006265381A AU2006265381A AU2006265381B2 AU 2006265381 B2 AU2006265381 B2 AU 2006265381B2 AU 2006265381 A AU2006265381 A AU 2006265381A AU 2006265381 A AU2006265381 A AU 2006265381A AU 2006265381 B2 AU2006265381 B2 AU 2006265381B2
Authority
AU
Australia
Prior art keywords
drug
insert
biological sample
analysis
internal standard
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2006265381A
Other languages
English (en)
Other versions
AU2006265381A1 (en
Inventor
Armin Graber
Wolfgang Guggenbichler
Steven Lewis Ramsay
Wolfgang Markus Stoggl
Klaus Michael Weinberger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biocrates Life Sciences AG
Original Assignee
Biocrates Life Sciences AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocrates Life Sciences AG filed Critical Biocrates Life Sciences AG
Publication of AU2006265381A1 publication Critical patent/AU2006265381A1/en
Application granted granted Critical
Publication of AU2006265381B2 publication Critical patent/AU2006265381B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5038—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving detection of metabolites per se
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00594—Quality control, including calibration or testing of components of the analyser
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
    • G16B50/30—Data warehousing; Computing architectures
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Databases & Information Systems (AREA)
  • Medical Informatics (AREA)
  • Bioethics (AREA)
  • Evolutionary Biology (AREA)
  • Toxicology (AREA)
  • Quality & Reliability (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
AU2006265381A 2005-06-30 2006-06-29 Device for quantitative analysis of a metabolite profile Active AU2006265381B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US69498305P 2005-06-30 2005-06-30
US69498405P 2005-06-30 2005-06-30
US60/694,983 2005-06-30
US60/694,984 2005-06-30
PCT/EP2006/006328 WO2007003344A2 (en) 2005-06-30 2006-06-29 Device for quantitative analysis of a metabolite profile

Publications (2)

Publication Number Publication Date
AU2006265381A1 AU2006265381A1 (en) 2007-01-11
AU2006265381B2 true AU2006265381B2 (en) 2010-06-10

Family

ID=36783737

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2006265381A Active AU2006265381B2 (en) 2005-06-30 2006-06-29 Device for quantitative analysis of a metabolite profile

Country Status (16)

Country Link
US (2) US8265877B2 (enExample)
EP (2) EP1875401B1 (enExample)
JP (2) JP5155160B2 (enExample)
KR (1) KR100967573B1 (enExample)
CN (1) CN100594501C (enExample)
AU (1) AU2006265381B2 (enExample)
BR (1) BRPI0613478B8 (enExample)
CA (2) CA2608963C (enExample)
DK (2) DK1875401T3 (enExample)
ES (1) ES2452025T3 (enExample)
IL (1) IL187470A (enExample)
IN (1) IN2014DN02241A (enExample)
NO (1) NO339319B1 (enExample)
NZ (1) NZ563431A (enExample)
RU (1) RU2391672C2 (enExample)
WO (2) WO2007003343A1 (enExample)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2297831T3 (es) 1994-05-09 2008-05-01 Oxford Biomedica (Uk) Limited Vectores retroviricos que presentan una tasa de recombinacion reducida.
US8969089B2 (en) 2004-10-12 2015-03-03 Quest Diagnostics Investments, Inc. Analysis of amino acids in body fluid by liquid chromatography-mass spectrometry
DK1875401T3 (da) * 2005-06-30 2014-04-07 Biocrates Life Sciences Ag Indretning til kvantitativ analyse af en metabolitprofil
US20070259445A1 (en) * 2006-05-05 2007-11-08 Blas Cerda Quantitative analysis of surface-derived samples using mass spectrometry
EP1923806A1 (en) * 2006-11-14 2008-05-21 Metanomics GmbH Fast metabolomic analysis and system therefor
US7999084B2 (en) * 2007-05-16 2011-08-16 Agilent Technologies, Inc. Devices and methods for reducing matrix effects
DK2164980T3 (da) * 2007-05-31 2013-10-21 Biocrates Life Sciences Ag Biomarkør og fremgangsmåde til fastlæggelse af et oxidativt stressniveau
CA2688506A1 (en) * 2007-05-31 2008-12-04 Biocrates Life Sciences Ag Inflammation and oxidative stress level assay
CN101796408B (zh) * 2007-06-29 2014-05-07 奎斯特诊断投资公司 用液相层析-质谱法分析体液内的氨基酸
US12367163B2 (en) 2007-06-29 2025-07-22 Quest Diagnostics Investments Llc Analysis of amino acids in body fluid by liquid chromatography—mass spectrometry
EP2183589A4 (en) * 2007-07-26 2011-03-16 Phenomenome Discoveries Inc METHODS FOR THE DIAGNOSIS, RISK ASSESSMENT AND MONITORING OF AUTISM SPECTRUM DISORDERS
DE102007043614B3 (de) * 2007-09-13 2008-11-20 Biocrates Life Sciences Gmbh Halterung für ein Trägermittel zum Einsetzen in eine zylinderförmige Öffnung
US20090087913A1 (en) * 2007-10-01 2009-04-02 Mds Analytical Technologies, A Business Unit Of Mds Inc.,Doing Business Through Its Sciex Division Analysis of conjugated metabolites of alcohol consumption
JP2011504596A (ja) * 2007-11-26 2011-02-10 ウオーターズ・テクノロジーズ・コーポレイシヨン サンプル中の分析物を定量測定する際に使用するための内部標準および方法
EP2297771A2 (en) * 2008-06-13 2011-03-23 Smiths Detection-Montreal Inc. Analytical instrument
CN107254538A (zh) 2008-11-12 2017-10-17 卡里斯生命科学瑞士控股有限责任公司 使用外来体来确定表现型的方法和系统
EP2192196A1 (en) 2008-11-27 2010-06-02 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Prediction of lipid-metabotype-related physiological susceptibilities
DE112010000967T5 (de) 2009-03-05 2012-08-16 Hitachi High-Technologies Corp. Analysator
EP3633710B1 (en) * 2009-04-30 2022-12-07 Purdue Research Foundation Ion generation using wetted porous material
US9500572B2 (en) 2009-04-30 2016-11-22 Purdue Research Foundation Sample dispenser including an internal standard and methods of use thereof
EP2249161B1 (en) 2009-05-05 2020-05-13 InfanDx AG Method of diagnosing asphyxia
AU2009347448B2 (en) * 2009-06-02 2015-07-02 Biocrates Life Sciences Ag New biomarkers for assessing kidney diseases
WO2011066589A1 (en) 2009-11-30 2011-06-03 Caris Life Sciences Luxembourg Holdings Methods and systems for isolating, storing, and analyzing vesicles
AU2011205230A1 (en) 2010-01-13 2012-08-02 Caris Life Sciences Switzerland Holdings Gmbh Detection of gastrointestinal disorders
AU2011223789A1 (en) 2010-03-01 2012-09-20 Caris Life Sciences Switzerland Holdings Gmbh Biomarkers for theranostics
BR112012025593A2 (pt) 2010-04-06 2019-06-25 Caris Life Sciences Luxembourg Holdings biomarcadores em circulação para doença
US9536720B2 (en) * 2010-10-29 2017-01-03 Atonarp Inc. Analyzing apparatus
SG190070A1 (en) 2010-10-29 2013-06-28 Thermo Fisher Scientific Oy System layout for an automated system for sample preparation and analysis
EP2492690A1 (en) * 2011-02-22 2012-08-29 BIOCRATES Life Sciences AG Method and use of metabolites for the diagnosis of inflammatory brain injury in preterm born infants
EP2587264A1 (en) 2011-10-25 2013-05-01 InfanDx AG Method and use of metabolites for the diagnosis and differentiation of neonatal encephalopathy
US8916680B2 (en) 2011-11-23 2014-12-23 Quest Diagnostics Investments, Inc. Kisspeptin-54 detection by tandem mass spectrometry
JP6198408B2 (ja) * 2012-04-02 2017-09-20 株式会社日立ハイテクノロジーズ サンプル液に含まれる揮発性物質の分析方法
US8870028B2 (en) 2012-05-25 2014-10-28 Restek Corporation Dispensing device
DK2883058T3 (en) * 2012-08-13 2018-03-26 Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Gesundheit & Umwelt Gmbh Biomarkers for type 2 diabetes
WO2014072537A1 (de) 2012-11-12 2014-05-15 Biocrates Life Sciences Ag Verwendung von qualitätsindikatoren zum nachweis von auftauprozessen in gefrorenen gewebeproben
WO2014110196A1 (en) * 2013-01-10 2014-07-17 Restek Corporation Dispensing device and method
WO2014120411A1 (en) 2013-01-31 2014-08-07 Purdue Research Foundation Systems and methods for analyzing an extracted sample
CA2888351A1 (en) 2013-01-31 2014-08-07 Purdue Research Foundation Methods of analyzing crude oil
EP3014647B1 (en) 2013-06-25 2018-12-19 Purdue Research Foundation Mass spectrometry analysis of microorganisms in samples
CN103558354B (zh) * 2013-11-15 2015-07-15 南京大学 一种基于生物组学整合技术的水体毒性分析方法
JP2017101924A (ja) * 2014-03-31 2017-06-08 積水メディカル株式会社 内部標準物質試薬
CN104200087B (zh) * 2014-06-05 2018-10-02 清华大学 用于机器学习的参数寻优及特征调优的方法及系统
US9786478B2 (en) 2014-12-05 2017-10-10 Purdue Research Foundation Zero voltage mass spectrometry probes and systems
US10381209B2 (en) 2015-02-06 2019-08-13 Purdue Research Foundation Probes, systems, cartridges, and methods of use thereof
EP3171173A1 (en) 2015-11-19 2017-05-24 Medizinische Universität Innsbruck Method of diagnosis of a thoracic aortic aneurysm
EP3397972A2 (en) 2015-12-31 2018-11-07 Universal Diagnostics, S.L. Systems and methods for automated, customizable sample preparation tool, software script, and calibration routine for detection of metabolites and lipids
US10539540B2 (en) * 2016-06-10 2020-01-21 Hitachi High-Tech Science Corporation Liquid chromatograph and method for correcting detector output value fluctuation of liquid chromatograph
US10607723B2 (en) 2016-07-05 2020-03-31 University Of Kentucky Research Foundation Method and system for identification of metabolites using mass spectra
US11719702B2 (en) * 2016-11-07 2023-08-08 Battelle Memorial Institute Methods and systems of proteome analysis and imaging
WO2018085835A1 (en) * 2016-11-07 2018-05-11 Battelle Memorial Institute Nanoscale biochemical sample preparation and analysis
EP3351938A1 (en) 2017-01-18 2018-07-25 BIOCRATES Life Sciences AG New biomarkers for assessing ovarian cancer
EP3376230A1 (en) 2017-03-13 2018-09-19 Biocross, S.L. Identification of signatures for neurodegeneration diseases diagnoses
WO2018174876A1 (en) * 2017-03-22 2018-09-27 Mprobe Inc. Methods and compositions for providing a preeclampsia assessment with metabolites
CN107727850B (zh) * 2017-10-10 2021-08-27 常州博闻迪医药股份有限公司 一种侧向流层析检测反应启动控制方法
WO2018210784A1 (en) * 2017-05-17 2018-11-22 Radiometer Medical Aps Porous optical fiber for the detection of an analyte in a fluid
CN107561150A (zh) * 2017-07-03 2018-01-09 宁波华仪宁创智能科技有限公司 吸毒的检测方法
CN107798981A (zh) * 2017-10-31 2018-03-13 楚雄医药高等专科学校 一种永久性教学用微囊标本片及其制作方法
CN109030673A (zh) * 2018-07-04 2018-12-18 易达精准（杭州）科技有限公司 干血片中免疫抑制剂的检测方法以及检测试剂盒
CN109298115B (zh) * 2018-10-19 2020-07-28 深圳市绘云生物科技有限公司 生物样品中多种代谢物定量检测方法及代谢芯片
WO2020099683A1 (en) 2018-11-16 2020-05-22 Biocrates Life Sciences Ag Metabolites for use in ovarian cancer detection and diagnosis
FR3091351B1 (fr) 2018-12-27 2021-05-21 Univ Rouen Centre Hospitalier Biomarqueur de la maladie de fabry
KR102035162B1 (ko) * 2019-03-12 2019-11-08 한국과학기술원 질병 표적 대사 효소에 특이적인 인체 대사 물질을 이용하여 질병에 대한 약물 후보를 예측하는 방법
JP7455864B2 (ja) 2019-05-20 2024-03-26 バテル エナジー アライアンス，エルエルシー 緻密なグラファイトを作製するための放電プラズマ焼結方法
GB201916046D0 (en) * 2019-11-04 2019-12-18 Amazentis Sa Diagnostic method
CN111579665B (zh) * 2020-05-20 2021-11-05 苏州帕诺米克生物医药科技有限公司 一种基于uplc/hrms的代谢组学相对定量分析方法
US20230204544A1 (en) * 2020-05-21 2023-06-29 Mayo Foundation For Medical Education And Research Calibration methods for mass spectrometry measurements
CN111704654B (zh) * 2020-06-18 2021-12-03 上海交通大学医学院附属仁济医院 肽类化合物及其制备方法与应用
EP4419255A4 (en) * 2021-10-21 2025-10-15 Pinpoint Testing Llc READY-TO-ASSEMBLE ANALYTICAL PLATFORMS FOR CHEMICAL ANALYSES AND QUANTIFICATION OF ANALYTES IN BIOLOGICAL SAMPLES
US12100484B2 (en) 2021-11-01 2024-09-24 Matterworks Inc Methods and compositions for analyte quantification
US20230137741A1 (en) 2021-11-01 2023-05-04 Matterworks Inc Methods and compositions for analyte quantification
JP7206365B1 (ja) 2021-12-22 2023-01-17 浜松ホトニクス株式会社 試料支持体
KR102547430B1 (ko) * 2022-11-16 2023-06-23 (주)애터미오롯 노니 함유 조성물의 정성 분석 방법
WO2024123681A2 (en) * 2022-12-05 2024-06-13 Washington University Improved method for scalable untargeted metabolomic workflow
GB2636339A (en) 2023-08-30 2025-06-18 Cambridge Entpr Ltd Biomarkers for bipolar disorder
CN117538530B (zh) * 2023-11-07 2024-07-19 中国医学科学院肿瘤医院 一种检测转移性乳腺癌的生物标志组合物和试剂盒及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005031304A2 (en) * 2003-09-22 2005-04-07 Becton, Dickinson And Company Quantification of analytes using internal standards

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2017155C1 (ru) * 1993-05-05 1994-07-30 Геннадий Степанович Власов Диагностическое устройство для иммунохимического анализа
US5756362A (en) 1993-10-12 1998-05-26 Cornell Research Foundation, Inc. Liposome-enhanced immunoaggregation assay and test device
US6358752B1 (en) 1996-09-27 2002-03-19 Cornell Research Foundation, Inc. Liposome-enhanced test device and method
GB9718129D0 (en) * 1997-08-27 1997-10-29 Isis Innovation Branched structures
US6258605B1 (en) 1999-03-26 2001-07-10 Neo Gen Screening, Inc. Clinical method for the genetic screening of newborns using tandem mass spectrometry
US6455321B1 (en) 1999-01-30 2002-09-24 Neo Gen Screening, Inc. Method for interpreting tandem mass spectrometry data for clinical diagnosis
US20020009394A1 (en) 1999-04-02 2002-01-24 Hubert Koster Automated process line
DE60031357T2 (de) 1999-12-29 2007-08-30 PerkinElmer Life Sciences, Inc., Norton Geräte, Kits und Verfahren zum Testen von Körperflüssigkeiten zum Screening vonNeugeborenen durch Tandem-Massenspektrometrie-Kits
AU2001262943A1 (en) 2000-04-14 2001-10-30 Metabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
US6680203B2 (en) 2000-07-10 2004-01-20 Esperion Therapeutics, Inc. Fourier transform mass spectrometry of complex biological samples
US6916423B2 (en) * 2000-07-18 2005-07-12 Invitrogen Corporation Device and methods for subdividing and filtering gel material and extracting molecules therefrom
US6627444B1 (en) 2000-08-07 2003-09-30 Smiths Detection - Toronto Ltd. Method and solid phase calibration sample for calibration of analytical instructions
US20020155587A1 (en) * 2001-04-20 2002-10-24 Sequenom, Inc. System and method for testing a biological sample
DE60225145D1 (de) 2001-07-06 2008-04-03 Lipomics Technologies Inc Erzeugen, betrachten, interpretieren und verwenden einer quantitativen datenbank von metaboliten
DE60239962D1 (de) 2001-08-14 2011-06-16 Harvard College Absolute quantifizierung von proteinen und modifizierten formen davon mittels mehrstufiger massenspektrometrie
US6929944B2 (en) * 2001-08-31 2005-08-16 Beckman Coulter, Inc. Analysis using a distributed sample
US6939716B2 (en) * 2001-09-19 2005-09-06 Washington University Method for detecting conditions indicative of sepsis
EP1446667A2 (en) * 2001-11-13 2004-08-18 Caprion Pharmaceuticals, Inc. Mass intensity profiling system and uses thereof
US20030229451A1 (en) * 2001-11-21 2003-12-11 Carol Hamilton Methods and systems for analyzing complex biological systems
GB0128498D0 (en) * 2001-11-28 2002-01-23 Inst Of Child Health International standards for sphingolipids
CA2465297C (en) 2001-12-08 2011-02-15 Micromass Uk Limited Method of mass spectrometry
AUPS177202A0 (en) 2002-04-16 2002-05-23 Diakyne Pty Ltd Multi-element screening of trace elements
AU2003272234A1 (en) 2002-10-24 2004-05-13 Warner-Lambert Company, Llc Integrated spectral data processing, data mining, and modeling system for use in diverse screening and biomarker discovery applications
AU2003286726A1 (en) 2002-10-25 2004-05-13 Metabolon, Inc. Methods for drug discovery, disease treatment, and diagnosis using metabolomics
JP2006504971A (ja) * 2002-11-01 2006-02-09 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・コロラド，ア・ボディー・コーポレイト マトリックス支援レーザー脱離イオン化−飛行時間型質量分析によるタンパク質アイソフォームの定量的解析
US20040121305A1 (en) * 2002-12-18 2004-06-24 Wiegand Roger Charles Generation of efficacy, toxicity and disease signatures and methods of use thereof
US6909981B2 (en) * 2003-01-27 2005-06-21 Ciphergen Biosystems, Inc. Data management system and method for processing signals from sample spots
US7964343B2 (en) 2003-05-13 2011-06-21 Ibis Biosciences, Inc. Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
KR20050050714A (ko) * 2003-11-26 2005-06-01 매그나칩 반도체 유한회사 반도체소자의 트랜지스터 제조방법
US7745226B2 (en) * 2005-04-06 2010-06-29 Quest Diagnostics Investments Incorporated Methods for detecting vitamin D metabolites
DK1875401T3 (da) * 2005-06-30 2014-04-07 Biocrates Life Sciences Ag Indretning til kvantitativ analyse af en metabolitprofil

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005031304A2 (en) * 2003-09-22 2005-04-07 Becton, Dickinson And Company Quantification of analytes using internal standards
US20050112635A1 (en) * 2003-09-22 2005-05-26 Becton, Dickinson And Company Quantification of analytes using internal standards

Also Published As

Publication number Publication date
CN100594501C (zh) 2010-03-17
NZ563431A (en) 2012-05-25
ES2452025T3 (es) 2014-03-31
KR100967573B1 (ko) 2010-07-05
US8116983B2 (en) 2012-02-14
EP1875401B1 (en) 2014-03-05
WO2007003343A1 (en) 2007-01-11
RU2008102835A (ru) 2009-08-10
CA2608965A1 (en) 2007-01-11
WO2007003344A2 (en) 2007-01-11
JP5155160B2 (ja) 2013-02-27
IL187470A0 (en) 2008-03-20
CA2608963C (en) 2014-08-26
BRPI0613478A2 (pt) 2012-01-17
EP1875401A2 (en) 2008-01-09
CN101208697A (zh) 2008-06-25
EP1897014A1 (en) 2008-03-12
CA2608965C (en) 2014-08-19
BRPI0613478B1 (pt) 2019-07-09
JP4829297B2 (ja) 2011-12-07
JP2008547030A (ja) 2008-12-25
AU2006265381A1 (en) 2007-01-11
IN2014DN02241A (enExample) 2015-07-10
CA2608963A1 (en) 2007-01-11
US20070004044A1 (en) 2007-01-04
JP2008547031A (ja) 2008-12-25
DK1875401T3 (da) 2014-04-07
KR20080025092A (ko) 2008-03-19
US20070003965A1 (en) 2007-01-04
IL187470A (en) 2015-02-26
EP1897014B1 (en) 2014-01-15
BRPI0613478B8 (pt) 2021-07-27
NO339319B1 (no) 2016-11-28
DK1897014T3 (en) 2014-03-10
NO20080559L (no) 2008-01-30
WO2007003344A3 (en) 2007-04-26
RU2391672C2 (ru) 2010-06-10
US8265877B2 (en) 2012-09-11

Similar Documents

Publication Publication Date Title
AU2006265381B2 (en) Device for quantitative analysis of a metabolite profile
Blume et al. Rapid, deep and precise profiling of the plasma proteome with multi-nanoparticle protein corona
Gorshkov et al. Protein corona formed on silver nanoparticles in blood plasma is highly selective and resistant to physicochemical changes of the solution
JP5325973B2 (ja) 分析装置
US20140235503A1 (en) Prediction method of glomerular filtration rate from urine samples after kidney transplantation
Goligorsky et al. Diagnostic potential of urine proteome: a broken mirror of renal diseases
McDonnell et al. Going forward: Increasing the accessibility of imaging mass spectrometry
Taverna et al. Multiplexed molecular descriptors of pressure ulcers defined by imaging mass spectrometry
Lin et al. Joint MS‐based platforms for comprehensive comparison of rat plasma and serum metabolic profiling
Lachén-Montes et al. Deployment of label-free quantitative olfactory proteomics to detect cerebrospinal fluid biomarker candidates in Synucleinopathies
Wesseling et al. Technological advances for deciphering the complexity of psychiatric disorders: merging proteomics with cell biology
Horvatovich et al. Current technological challenges in biomarker discovery and validation
CN104297442A (zh) 内源性小分子物质在快速检测早期心脏毒性方面的应用
Chen et al. Metabonomics study of the acute graft rejection in rat renal transplantation using reversed-phase liquid chromatography and hydrophilic interaction chromatography coupled with mass spectrometry
CN114895018A (zh) 检测血清中的代谢物水平的产品在制备诊断各类型sle患者制剂中的应用及制剂
Takamori et al. Supplemental Data Molecular Anatomy of a Trafficking Organelle
Lindsey et al. How to design a cardiovascular proteomics experiment
Finehout Analysis of the cerebrospinal fluid proteome in Alzheimer's disease: Potential biomarkers for differential diagnosis and the effects of intravenous immunoglobulin therapy

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)