ATE403872T1 - Massenspektormetrie-verfahren - Google Patents

Massenspektormetrie-verfahren

Info

Publication number
ATE403872T1
ATE403872T1 AT04014463T AT04014463T ATE403872T1 AT E403872 T1 ATE403872 T1 AT E403872T1 AT 04014463 T AT04014463 T AT 04014463T AT 04014463 T AT04014463 T AT 04014463T AT E403872 T1 ATE403872 T1 AT E403872T1
Authority
AT
Austria
Prior art keywords
molecules
physico
chemical properties
look
mass
Prior art date
Application number
AT04014463T
Other languages
English (en)
Inventor
Ashok Dongre
Scott Geromanos
Gregory Opiteck
Jeffrey Silva
Original Assignee
Micromass Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26992114&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE403872(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Micromass Ltd filed Critical Micromass Ltd
Application granted granted Critical
Publication of ATE403872T1 publication Critical patent/ATE403872T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • C12Q1/6872Methods for sequencing involving mass spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • G01N33/6851Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/0027Methods for using particle spectrometers
    • H01J49/0031Step by step routines describing the use of the apparatus
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/24Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Optics & Photonics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Glass Compositions (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Peptides Or Proteins (AREA)
AT04014463T 2001-12-08 2002-12-09 Massenspektormetrie-verfahren ATE403872T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34046001P 2001-12-08 2001-12-08
US36484702P 2002-03-14 2002-03-14

Publications (1)

Publication Number Publication Date
ATE403872T1 true ATE403872T1 (de) 2008-08-15

Family

ID=26992114

Family Applications (2)

Application Number Title Priority Date Filing Date
AT04014463T ATE403872T1 (de) 2001-12-08 2002-12-09 Massenspektormetrie-verfahren
AT02783317T ATE327512T1 (de) 2001-12-08 2002-12-09 Massenspektrometrie-verfahren

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT02783317T ATE327512T1 (de) 2001-12-08 2002-12-09 Massenspektrometrie-verfahren

Country Status (8)

Country Link
US (4) US20050092910A1 (de)
EP (1) EP1456667B2 (de)
JP (2) JP4767496B2 (de)
AT (2) ATE403872T1 (de)
CA (1) CA2465297C (de)
DE (2) DE60228132D1 (de)
GB (1) GB2385918B (de)
WO (1) WO2003054549A2 (de)

Families Citing this family (104)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020115056A1 (en) * 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
IL161498A0 (en) * 2001-10-24 2004-09-27 Univ California Measurement of protein synthesis rates in humans and experimental system by use of isotopically labeled water
CA2466837A1 (en) * 2001-11-13 2003-05-22 Caprion Pharmaceuticals Inc. Mass intensity profiling system and uses thereof
ATE403872T1 (de) 2001-12-08 2008-08-15 Micromass Ltd Massenspektormetrie-verfahren
WO2003068919A2 (en) 2002-02-12 2003-08-21 The Regents Of The University Of California Non-invasive method for measuring rates of biosynthesis of biological molecules by label incorporation
GB0305796D0 (en) * 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
WO2004011426A2 (en) 2002-07-30 2004-02-05 The Regents Of The University Of California Method for automated, large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry
AU2003268416A1 (en) * 2002-09-04 2004-03-29 The Regents Of The University Of California Methods for measuring rates of replication and death of nfectious microbial agents in an infected host organism
ATE415486T1 (de) * 2002-09-13 2008-12-15 Univ California Verfahren zur messung der geschwindigkeiten des cholesterinrückwärtstransports in vivo als index für anti-artherogenese
US20070248540A1 (en) * 2002-09-16 2007-10-25 The Regents Of The University Of California Biochemical methods for measuring metabolic fitness of tissues or whole organisms
AU2003291731B2 (en) 2002-11-04 2009-09-10 The Regents Of The University Of California Deuterated glucose or fat tolerance tests for high-throughput measurement of the metabolism of sugars or fatty acids in the body
AU2003294165A1 (en) * 2002-11-22 2004-06-18 Caprion Pharmaceuticals, Inc. Constellation mapping and uses thereof
US7262020B2 (en) * 2003-07-03 2007-08-28 The Regents Of The University Of California Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol
GB0322356D0 (en) * 2003-09-24 2003-10-22 Micromass Ltd Mass spectrometer
JP2007507771A (ja) * 2003-10-01 2007-03-29 プロテオム システムズ インテレクチュアル プロパティ プロプライエタリー リミテッド 候補組成物又は候補構造体の生物学的尤度を決定する方法
US7759130B2 (en) * 2003-11-21 2010-07-20 Eisai R & D Management Co., Ltd. Mass spectrometric quantitation method for biomolecules based on metabolically labeled internal standards
US20050202406A1 (en) 2003-11-25 2005-09-15 The Regents Of The University Of California Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems
JP4284167B2 (ja) * 2003-12-24 2009-06-24 株式会社日立ハイテクノロジーズ イオントラップ/飛行時間型質量分析計による精密質量測定方法
WO2005079261A2 (en) * 2004-02-13 2005-09-01 Waters Investments Limited System and method for tracking and quatitating chemical entites
TW200538738A (en) 2004-02-20 2005-12-01 Univ California Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
WO2005087943A1 (en) * 2004-03-11 2005-09-22 The Regents Of The University Of California Temporal or spatial characterization of biosynthetic events in living organisms by isotopic fingerprinting under conditions of imposed isotopic gradients
US20050238577A1 (en) * 2004-03-29 2005-10-27 The Regents Of The University Of California Isolation of epithelial cells or their biochemical contents from excreta after in vivo isotopic labeling
JP5008564B2 (ja) 2004-05-20 2012-08-22 ウオーターズ・テクノロジーズ・コーポレイシヨン 混合物中のタンパク質を同定する方法および装置
GB0415046D0 (en) 2004-07-05 2004-08-04 Micromass Ltd Mass spectrometer
AU2005263334C1 (en) * 2004-07-20 2011-01-20 Symphogen A/S A procedure for structural characterization of a recombinant polyclonal protein or a polyclonal cell line
US7910372B2 (en) 2004-07-29 2011-03-22 Eisai R&D Management Co., Ltd. Absolute quantitation of protein contents based on exponentially modified protein abundance index by mass spectrometry
NZ536082A (en) * 2004-10-22 2007-06-29 Syft Technologies Ltd Detection of bromamines and chloramines in breath samples for detecting asthma
JP4118918B2 (ja) * 2005-02-28 2008-07-16 シャープ株式会社 信号品質評価装置、情報記録再生装置、信号品質評価方法、記録条件決定方法、信号品質評価プログラム、信号品質評価プログラムを記録したコンピュータ読み取り可能な記録媒体
CA2602615A1 (en) * 2005-04-04 2006-10-12 Viventia Biotech Inc. Method and system for identification of antigen
US7447597B2 (en) * 2005-05-06 2008-11-04 Exxonmobil Research And Engineering Company Data processing/visualization method for two (multi) dimensional separation gas chromatography xmass spectrometry (GCxMS) technique with a two (multiply) dimensional separation concept as an example
EP1889079B1 (de) * 2005-06-03 2022-08-31 Waters Technologies Corporation Verfahren zur ausführung der abstimmung der verweilzeit
JP5011283B2 (ja) * 2005-06-03 2012-08-29 ウオーターズ・テクノロジーズ・コーポレイシヨン 化学分析のためのポリペプチド関連情報のカタログの発生および使用
WO2006128297A1 (en) * 2005-06-03 2006-12-07 Mds Inc. Doing Business Through Its Mds Sciex Division System and method for analysis of compounds using a mass spectrometer
EP1894019A4 (de) * 2005-06-03 2011-02-09 Mds Inc Doing Business Through Its Mds Sciex Division System und verfahren zur datensammlung bei der rekursiven massenanalyse
TW200711660A (en) * 2005-06-10 2007-04-01 Univ California Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development
US20060287834A1 (en) * 2005-06-16 2006-12-21 Kearney Paul E Virtual mass spectrometry
IN2014DN02241A (de) 2005-06-30 2015-07-10 Biocrates Life Sciences Ag
JP4659831B2 (ja) 2005-07-29 2011-03-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 化合物に対するタンパク質の結合力を解析する方法
JP2009507212A (ja) * 2005-09-02 2009-02-19 オーストラリアン ヌークリア サイエンス アンド テクノロジー オーガニゼイション 同位体比質量分析計および同位体比の決定方法
JPWO2007029431A1 (ja) * 2005-09-07 2009-03-12 ヒューマン・メタボローム・テクノロジーズ株式会社 質量分析装置の検出質量較正方法
WO2007072648A1 (ja) * 2005-12-21 2007-06-28 Japan Health Sciences Foundation 質量分析システムおよび質量分析方法
US20070218505A1 (en) * 2006-03-14 2007-09-20 Paul Kearney Identification of biomolecules through expression patterns in mass spectrometry
GB0609253D0 (en) * 2006-05-10 2006-06-21 Micromass Ltd Mass spectrometer
US9063162B2 (en) * 2006-05-26 2015-06-23 Waters Technologies Corporation Apparatus and method for performing mass spectroscopy
WO2007140251A2 (en) * 2006-05-26 2007-12-06 Waters Investments Limited Apparatus and method for performing mass spectroscopy
US20080073499A1 (en) * 2006-07-25 2008-03-27 George Yefchak Peak finding in low-resolution mass spectrometry by use of chromatographic integration routines
RU2009113801A (ru) * 2006-09-14 2010-10-20 Конинклейке Филипс Электроникс Н.В. (Nl) Способы анализа образцов белков на основе идентификации с-концевых пептидов
US7499807B1 (en) * 2006-09-19 2009-03-03 Battelle Memorial Institute Methods for recalibration of mass spectrometry data
WO2008060929A1 (en) * 2006-11-09 2008-05-22 Alcon Research, Ltd. Punctal plug comprising a water-insoluble polymeric matrix
EP2118652B1 (de) * 2006-12-26 2012-05-23 Brigham Young University Serumproteomiksystem und damit zusammenhängende verfahren
US7595485B1 (en) * 2007-02-07 2009-09-29 Thermo Finnigan Llc Data analysis to provide a revised data set for use in peptide sequencing determination
US20080226133A1 (en) * 2007-03-14 2008-09-18 Jean-Luc Truche Use of Optical Sensors for Spray Jet Diagnostics
US8399827B1 (en) * 2007-09-10 2013-03-19 Cedars-Sinai Medical Center Mass spectrometry systems
EP2279260B1 (de) * 2008-05-29 2021-07-21 Waters Technologies Corporation Verfahren zur durchführung eines verweilzeitabgleichs von vorläufer- und produkt-ionen sowie zur herstellung von vorläufer- und produkt-ionen-spektren
WO2010002819A1 (en) 2008-07-01 2010-01-07 Waters Technologies Corporation Stacked-electrode peptide-fragmentation device
US20100224770A1 (en) * 2009-03-06 2010-09-09 Ensco, Inc. Method for configuring an ion mobility spectrometer system
US9500572B2 (en) * 2009-04-30 2016-11-22 Purdue Research Foundation Sample dispenser including an internal standard and methods of use thereof
US8987662B2 (en) * 2009-05-14 2015-03-24 Agilent Technologies, Inc. System and method for performing tandem mass spectrometry analysis
US20110042564A1 (en) * 2009-08-20 2011-02-24 Yasuhide Naito Laser ablation mass analyzing apparatus
US9453845B2 (en) * 2010-02-01 2016-09-27 Cell Signaling Technology, Inc. Mass spectroscopy analysis of mutant polypeptides in biological samples
US10553412B2 (en) * 2010-05-24 2020-02-04 Agilent Technologies, Inc. System and method of data-dependent acquisition by mass spectrometry
US9530633B2 (en) * 2010-05-25 2016-12-27 Agilent Technologies, Inc. Method for isomer discrimination by tandem mass spectrometry
US20140051092A1 (en) * 2011-04-15 2014-02-20 Micromass Uk Limited Method And Apparatus For The Analysis Of Biological Samples
JP5736235B2 (ja) * 2011-05-23 2015-06-17 株式会社日立製作所 質量分析システム及びコンピュータプログラム
JP2014526685A (ja) 2011-09-08 2014-10-06 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア 代謝流量測定、画像化、および顕微鏡法
CN104024856B (zh) * 2011-11-04 2018-10-26 生物辐射实验室股份有限公司 基于pI的蛋白质分级
EP2773221B1 (de) 2011-11-04 2019-01-09 Bio-Rad Laboratories, Inc. Gleichzeitige reinigung von zellkomponenten
US9766207B2 (en) 2011-11-04 2017-09-19 Bio-Rad Laboratories, Inc. Affinity methods and compositions employing electronic control of pH
JP6294233B2 (ja) 2011-12-07 2018-03-14 グラクソスミスクライン エルエルシー 全身骨格筋量の定量方法
CN104254390B (zh) 2012-02-15 2017-05-10 生物辐射实验室股份有限公司 pH和离子强度的电子控制
US9321012B2 (en) 2012-04-04 2016-04-26 Bio-Rad Laboratories, Inc. Electronic protein fractionation
CA2871346A1 (en) * 2012-04-25 2013-10-31 Atonarp Inc. System that provides content
US9169331B2 (en) 2012-12-21 2015-10-27 Dionex Corporation Separation of glycans by mixed-mode liquid chromatography
US9310344B2 (en) 2013-06-14 2016-04-12 Dionex Corporation HILIC/anion-exchange/cation-exchange multimodal media
PT3387898T (pt) * 2013-03-15 2020-06-17 Mayo Found Medical Education & Res Identificação e monitorização de imunoglobulinas monoclonais pela massa molecular
US9134319B2 (en) 2013-03-15 2015-09-15 The Regents Of The University Of California Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo
GB201306868D0 (en) 2013-04-15 2013-05-29 Micromass Ltd A method of screening samples
US9620344B2 (en) 2013-06-25 2017-04-11 Purdue Research Foundation Mass spectrometry analysis of microorganisms in samples
WO2015082889A1 (en) * 2013-12-02 2015-06-11 Micromass Uk Limited Method of charge state selection
US10153146B2 (en) 2014-03-28 2018-12-11 Wisconsin Alumni Research Foundation High mass accuracy filtering for improved spectral matching of high-resolution gas chromatography-mass spectrometry data against unit-resolution reference databases
EP3126826B1 (de) 2014-04-04 2020-12-16 Mayo Foundation for Medical Education and Research Isotypisierung von immunglobulinen unter verwendung einer genauen molekülmasse
US9720001B2 (en) * 2014-05-21 2017-08-01 Thermo Finnigan Llc Methods for mass spectrometric biopolymer analysis using optimized weighted oligomer scheduling
US10690676B2 (en) 2014-07-29 2020-06-23 Mayo Roundation for Medical Education and Research Quantifying monoclonal antibody therapeutics by LC-MS/MS
US10041907B2 (en) * 2014-09-26 2018-08-07 Micromass Uk Limited Accurate mobility chromatograms
EP3304382B1 (de) 2015-05-29 2025-10-22 Waters Technologies Corporation Techniken zur verarbeitung von massenspektraldaten
GB201509402D0 (en) * 2015-06-01 2015-07-15 Micromass Ltd Lock mass library for internal correction
US9847216B2 (en) * 2015-08-14 2017-12-19 Thermo Finnigan Llc Systems and methods for targeted top down discovery
WO2017053932A1 (en) 2015-09-24 2017-03-30 Mayo Foundation For Medical Education And Research Identification of immunoglobulin free light chains by mass spectrometry
WO2017060991A1 (ja) * 2015-10-07 2017-04-13 株式会社島津製作所 タンデム型質量分析装置
AU2017325022B2 (en) 2016-09-07 2022-10-13 Mayo Foundation For Medical Education And Research Identification and monitoring of cleaved immunoglobulins by molecular mass
CN110352354B (zh) 2017-02-28 2024-05-10 沃特世科技公司 用于分析完整蛋白质、抗体、抗体亚基和抗体药物缀合物的装置和方法
US9911587B1 (en) * 2017-03-10 2018-03-06 Thermo Finnigan Llc Methods and systems for quantitative mass analysis
US9911588B1 (en) * 2017-03-10 2018-03-06 Thermo Finnigan Llc Methods and systems for quantitative mass analysis
US10347477B2 (en) 2017-03-24 2019-07-09 Thermo Finnigan Llc Methods and systems for quantitative mass analysis
WO2019021133A1 (en) * 2017-07-25 2019-01-31 Biocon Limited PEPTIDE CARTOGRAPHY METHOD FOR IDENTIFYING INSULIN SEQUENCES AND INSULIN ANALOGUES
US12153052B2 (en) 2017-09-13 2024-11-26 Mayo Foundation For Medical Education And Research Identification and monitoring of immunoglobulin J chains
WO2019055634A1 (en) 2017-09-13 2019-03-21 Mayo Foundation For Medical Education And Research IDENTIFICATION AND MONITORING OF A MACROPHAGE APOPTOSIS INHIBITOR
WO2020152871A1 (ja) * 2019-01-25 2020-07-30 株式会社島津製作所 クロマトグラフを用いた物質同定方法
JP7306676B2 (ja) * 2019-02-26 2023-07-11 国立大学法人九州大学 脂質プロファイリングシステム、脂質プロファイリング方法、及び脂質プロファイリングプログラム
BE1027232B1 (fr) * 2019-08-28 2020-11-20 Zentech S A Procédé de détection d'au moins un variant de protéine et/ou d'au moins un peptide propre aux chaînes alpha et/ou bêta et/ou delta d'hémoglobine
EP4139673B1 (de) * 2020-04-24 2026-01-28 Waters Technologies Ireland Limited Verfahren zum vergleich von daten in und zwischen kohorten
WO2022146812A1 (en) * 2020-12-30 2022-07-07 Purdue Research Foundation Mass spectrometry to identify predictive failure with chemical detection in microelectronic systems
US12540922B2 (en) * 2021-05-11 2026-02-03 Wisconsin Alumni Research Foundation Quantitative shotgun proteome, lipidome, and metabolome analysis by direct infusion
US20240371465A1 (en) * 2023-05-02 2024-11-07 National Central University Method, system, and computer readable medium for post-translational modifications detection

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB870203A (en) * 1949-10-26 1961-06-14 Edward Whitworth Improvements in or relating to surface moderated propellent powders
US4735777A (en) * 1985-03-11 1988-04-05 Hitachi, Ltd. Instrument for parallel analysis of metabolites in human urine and expired air
JP3001252B2 (ja) * 1990-11-16 2000-01-24 株式会社日立製作所 半導体メモリ
US5428621A (en) * 1992-09-21 1995-06-27 Sundisk Corporation Latent defect handling in EEPROM devices
US5538897A (en) * 1994-03-14 1996-07-23 University Of Washington Use of mass spectrometry fragmentation patterns of peptides to identify amino acid sequences in databases
US6323482B1 (en) * 1997-06-02 2001-11-27 Advanced Research And Technology Institute, Inc. Ion mobility and mass spectrometer
EP1095267A1 (de) * 1998-07-10 2001-05-02 Cetek Corporation Verfahren zur feststellung und analyse von stark bindenden liganden in komplexen biologischen proben
US6147344A (en) * 1998-10-15 2000-11-14 Neogenesis, Inc Method for identifying compounds in a chemical mixture
US20020009394A1 (en) 1999-04-02 2002-01-24 Hubert Koster Automated process line
US6936424B1 (en) * 1999-11-16 2005-08-30 Matritech, Inc. Materials and methods for detection and treatment of breast cancer
CA2298181C (en) 2000-02-02 2006-09-19 Dayan Burke Goodnough Non-targeted complex sample analysis
DE60127813T2 (de) * 2000-02-07 2007-12-27 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Verfahren zur identifizierung und/oder charakterisierung eines (poly)peptides
CA2400484A1 (en) * 2000-02-08 2001-08-16 The Regents Of The University Of Michigan Protein separation and display
JP2001330599A (ja) 2000-05-24 2001-11-30 Shimazu S D Kk Gc/msによる代謝異常スクリーニング診断装置
US20020115056A1 (en) * 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
EP1710577B1 (de) 2000-12-26 2010-07-21 The Institute for Systems Biology Schnelle und quantitative Proteomanalyse und entsprechende Verfahren
US20020119490A1 (en) * 2000-12-26 2002-08-29 Aebersold Ruedi H. Methods for rapid and quantitative proteome analysis
US6931325B2 (en) * 2001-02-07 2005-08-16 Regents Of The University Of Michigan Three dimensional protein mapping
US20030031350A1 (en) 2001-03-09 2003-02-13 Pe Corporation (Ny) Methods for large scale protein matching
US6835927B2 (en) * 2001-10-15 2004-12-28 Surromed, Inc. Mass spectrometric quantification of chemical mixture components
CA2466837A1 (en) 2001-11-13 2003-05-22 Caprion Pharmaceuticals Inc. Mass intensity profiling system and uses thereof
DE10158860B4 (de) 2001-11-30 2007-04-05 Bruker Daltonik Gmbh Massenspektrometrische Proteingemischanalyse
ATE403872T1 (de) 2001-12-08 2008-08-15 Micromass Ltd Massenspektormetrie-verfahren
US6835027B1 (en) * 2003-11-05 2004-12-28 Billy Glass Staple for securing geo-textile material to the ground

Also Published As

Publication number Publication date
WO2003054549A2 (en) 2003-07-03
DE60211744D1 (de) 2006-06-29
EP1456667B1 (de) 2006-05-24
ATE327512T1 (de) 2006-06-15
JP2005513481A (ja) 2005-05-12
EP1456667A2 (de) 2004-09-15
US20080286764A9 (en) 2008-11-20
US20070009898A1 (en) 2007-01-11
DE60228132D1 (de) 2008-09-18
US20050092910A1 (en) 2005-05-05
JP2008076403A (ja) 2008-04-03
DE60211744T2 (de) 2006-11-02
DE60211744T3 (de) 2010-07-01
CA2465297A1 (en) 2003-07-03
CA2465297C (en) 2011-02-15
US20080135744A1 (en) 2008-06-12
GB2385918A (en) 2003-09-03
JP4654230B2 (ja) 2011-03-16
GB0228653D0 (en) 2003-01-15
GB2385918B (en) 2004-05-26
EP1456667B2 (de) 2010-01-20
WO2003054549A3 (en) 2003-10-16
US20080142696A1 (en) 2008-06-19
US8030089B2 (en) 2011-10-04
JP4767496B2 (ja) 2011-09-07

Similar Documents

Publication Publication Date Title
DE60228132D1 (de) Massenspektormetrie-Verfahren
WO2001011354A3 (en) Methods for characterizing, classifying, and identifying unknowns in samples
DE50210457D1 (de) Vorrichtung zur referenzierung von fluoreszenzsignalen
ATE357663T1 (de) Teilchenförmiges markierungsmittel verwendendes analytassay
PT100724A (pt) Processo de determinacao da quantidade de grupos tiol ligados em proteinas e conjunto para a deteccao de estados isquemicos
WO2003073817A3 (en) Rapid and sensitive detection of cells and viruses
WO2004113896A3 (en) System and method for analysis of a biological fluid by the use electrical means
IL124322A0 (en) Detection of an entity in a sample
AU2001287189A1 (en) Detecting polymers and polymer fragments
WO2004101769A3 (en) Proteins, sensors, and methods of characterizing analytes using the same
DE69401717D1 (de) Verfahren zur Aktivierung von polyanionischen,fluoreszierenden Farbstoffen in schwach dielektrischen Medien mit quaternären Oniumverbindungen
EP1415152A4 (de) Verfahren, vorrichtungen und computerprogramme zum verifizieren der integrität einer sonde
WO2004077057A8 (en) Standard for immunohistochemistry, immunocytochemistry and molecular cytogenetics
ATE318930T1 (de) Nukleinsäuresonden zur detektion von candida- spezies
ATE384139T1 (de) Multi-test-analyse von echzeit- nukleinsäureamplifikationen
EP1647825A3 (de) Massenspektrometrieverfahren
AU2001283901A1 (en) Competitive assay method
WO2001084161A3 (en) Process for the measurement of non-transferrin bound iron
AU4651689A (en) Method and apparatus for identifying causes of repeatability problems in near infrared analytical instruments
WO2002057743A3 (en) Methods of analyzing and sorting one or more analytes
WO2005056814A3 (en) Methods and systems for analyzing and determining ligand-residue interaction
TW200502399A (en) Recombinant virus and use thereof and method of detecting an analyte in a sample and kit thereof
WO2004016802A3 (en) Methods and apparatus for preparing and assaying biological samples to determine protein concentration
DE59910326D1 (de) Verwendung derivatisierter Reagenzien in Chemilumineszenz- und Elektrochemilumineszenz-Nachweisverfahren
ATE305980T1 (de) Verwendung von abfangsonden beim nachweis von nukleinsäuren

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties