ATE327512T1 - Massenspektrometrie-verfahren - Google Patents

Massenspektrometrie-verfahren

Info

Publication number
ATE327512T1
ATE327512T1 AT02783317T AT02783317T ATE327512T1 AT E327512 T1 ATE327512 T1 AT E327512T1 AT 02783317 T AT02783317 T AT 02783317T AT 02783317 T AT02783317 T AT 02783317T AT E327512 T1 ATE327512 T1 AT E327512T1
Authority
AT
Austria
Prior art keywords
molecules
physico
chemical properties
look
mass spectrometry
Prior art date
Application number
AT02783317T
Other languages
English (en)
Inventor
Scott Geromanos
Ashok Dongre
Gregory Opiteck
Jeffrey Silva
Original Assignee
Micromass Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26992114&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE327512(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Micromass Ltd filed Critical Micromass Ltd
Application granted granted Critical
Publication of ATE327512T1 publication Critical patent/ATE327512T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • C12Q1/6872Methods for sequencing involving mass spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • G01N33/6851Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • HELECTRICITY
    • H01ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometers or separator tubes
    • H01J49/0027Methods for using particle spectrometers
    • H01J49/0031Step by step routines describing the use of the apparatus
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/24Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Optics & Photonics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Peptides Or Proteins (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Glass Compositions (AREA)
AT02783317T 2001-12-08 2002-12-09 Massenspektrometrie-verfahren ATE327512T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34046001P 2001-12-08 2001-12-08
US36484702P 2002-03-14 2002-03-14

Publications (1)

Publication Number Publication Date
ATE327512T1 true ATE327512T1 (de) 2006-06-15

Family

ID=26992114

Family Applications (2)

Application Number Title Priority Date Filing Date
AT02783317T ATE327512T1 (de) 2001-12-08 2002-12-09 Massenspektrometrie-verfahren
AT04014463T ATE403872T1 (de) 2001-12-08 2002-12-09 Massenspektormetrie-verfahren

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT04014463T ATE403872T1 (de) 2001-12-08 2002-12-09 Massenspektormetrie-verfahren

Country Status (8)

Country Link
US (4) US20050092910A1 (de)
EP (1) EP1456667B2 (de)
JP (2) JP4767496B2 (de)
AT (2) ATE327512T1 (de)
CA (1) CA2465297C (de)
DE (2) DE60228132D1 (de)
GB (1) GB2385918B (de)
WO (1) WO2003054549A2 (de)

Families Citing this family (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020115056A1 (en) * 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
AU2002365268B2 (en) * 2001-10-24 2008-02-28 The Regents Of The University Of California Measurement of protein synthesis rates in humans and experimental systems by use of isotopically labeled water
US20030129760A1 (en) * 2001-11-13 2003-07-10 Aguilera Frank Reinaldo Morales Mass intensity profiling system and uses thereof
ATE327512T1 (de) 2001-12-08 2006-06-15 Micromass Ltd Massenspektrometrie-verfahren
AU2003217385B2 (en) 2002-02-12 2008-09-11 The Regents Of The University Of California Non-invasive method for measuring rates of biosynthesis of biological molecules by label incorporation
GB0305796D0 (en) * 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
EP1546364A4 (de) 2002-07-30 2006-09-06 Univ California Verfahren zur automatischen messung im grossmassstab der molekularen flussgeschwindigkeiten des proteoms oder des organoms mittels massenspektrometrie
US20060105339A1 (en) * 2002-09-04 2006-05-18 Marc Hellerstein Methods for measuring the rates of replication and death of microbial infectious agents in an infected
AU2003267283B2 (en) * 2002-09-13 2009-09-03 The Regents Of The University Of California Methods for measuring rates of reserve cholesterol transport in vivo, as an index of anti-atherogenesis
US20070248540A1 (en) * 2002-09-16 2007-10-25 The Regents Of The University Of California Biochemical methods for measuring metabolic fitness of tissues or whole organisms
SG152922A1 (en) 2002-11-04 2009-06-29 Univ California Deuterated glucose or fat tolerance tests for high-throughput measurement of the metabolism of sugars or fatty acids in the body
CA2503292A1 (en) * 2002-11-22 2004-06-10 Caprion Pharmaceuticals, Inc. Constellation mapping and uses thereof
US7262020B2 (en) * 2003-07-03 2007-08-28 The Regents Of The University Of California Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol
GB0322356D0 (en) * 2003-09-24 2003-10-22 Micromass Ltd Mass spectrometer
WO2005031343A1 (en) * 2003-10-01 2005-04-07 Proteome Systems Intellectual Property Pty Ltd A method for determining the biological likelihood of candidate compositions or structures
EP1686372A4 (de) * 2003-11-21 2009-04-01 Eisai R&D Man Co Ltd Quantifizierungsverfahren mit verwendung eines isotopenmarkierten inneren standards, analysesystem zur durchführung des quantifizierungsverfahrens sowie programm zum abbau davon
US20050202406A1 (en) 2003-11-25 2005-09-15 The Regents Of The University Of California Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems
JP4284167B2 (ja) * 2003-12-24 2009-06-24 株式会社日立ハイテクノロジーズ イオントラップ/飛行時間型質量分析計による精密質量測定方法
US9164067B2 (en) * 2004-02-13 2015-10-20 Waters Technologies Corporation System and method for tracking chemical entities in an LC/MS system
TW200538738A (en) * 2004-02-20 2005-12-01 Univ California Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
CA2559095A1 (en) * 2004-03-11 2005-09-22 The Regents Of The University Of California Temporal or spatial characterization of biosynthetic events in living organisms by isotopic fingerprinting under conditions of imposed isotopic gradients
WO2005094327A2 (en) * 2004-03-29 2005-10-13 The Regents Of The University Of California Isolation of epithelial cells or their biochemical contents from excreta after in vivo isotopic labeling
WO2005114930A2 (en) 2004-05-20 2005-12-01 Waters Investments Limited Method and apparatus for identifying proteins in mixtures
GB0415046D0 (en) 2004-07-05 2004-08-04 Micromass Ltd Mass spectrometer
NZ552264A (en) * 2004-07-20 2010-03-26 Symphogen As A procedure for structural characterization of a recombinant polyclonal protein or a polyclonal cell line
WO2006011351A1 (en) * 2004-07-29 2006-02-02 Eisai R&D Management Co., Ltd. Absolute quantitation of protein contents based on exponentially modified protein abundance index by mass spectrometry
NZ536082A (en) * 2004-10-22 2007-06-29 Syft Technologies Ltd Detection of bromamines and chloramines in breath samples for detecting asthma
JP4118918B2 (ja) * 2005-02-28 2008-07-16 シャープ株式会社 信号品質評価装置、情報記録再生装置、信号品質評価方法、記録条件決定方法、信号品質評価プログラム、信号品質評価プログラムを記録したコンピュータ読み取り可能な記録媒体
JP2008534970A (ja) * 2005-04-04 2008-08-28 ヴィヴェンティア バイオテック インコーポレーティッド 抗原の同定のための方法および系
US7447597B2 (en) * 2005-05-06 2008-11-04 Exxonmobil Research And Engineering Company Data processing/visualization method for two (multi) dimensional separation gas chromatography xmass spectrometry (GCxMS) technique with a two (multiply) dimensional separation concept as an example
WO2006128297A1 (en) * 2005-06-03 2006-12-07 Mds Inc. Doing Business Through Its Mds Sciex Division System and method for analysis of compounds using a mass spectrometer
JP4932834B2 (ja) * 2005-06-03 2012-05-16 ウオーターズ・テクノロジーズ・コーポレイシヨン 保持時間整合を行うための方法および装置
WO2006133192A2 (en) * 2005-06-03 2006-12-14 Waters Investments Limited Generation and use of a catalog of polypeptide-related information for chemical analyses
JP2008542729A (ja) * 2005-06-03 2008-11-27 エムディーエス インコーポレイテッド ドゥーイング ビジネス スルー イッツ エムディーエス サイエックス ディヴィジョン 再帰的な質量分析に関するデータのコレクションのためのシステムおよび方法
TW200711660A (en) * 2005-06-10 2007-04-01 Univ California Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development
WO2006133568A1 (en) * 2005-06-16 2006-12-21 Caprion Pharmaceuticals Inc. Virtual mass spectrometry
EP1875401B1 (de) 2005-06-30 2014-03-05 BIOCRATES Life Sciences AG Verfahren zur quantitativen analyse von metabolitprofilen
JP4659831B2 (ja) 2005-07-29 2011-03-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 化合物に対するタンパク質の結合力を解析する方法
WO2007025348A1 (en) * 2005-09-02 2007-03-08 Australian Nuclear Science & Technology Organisation An isotope ratio mass spectrometer and methods for determining isotope ratios
JPWO2007029431A1 (ja) * 2005-09-07 2009-03-12 ヒューマン・メタボローム・テクノロジーズ株式会社 質量分析装置の検出質量較正方法
WO2007072648A1 (ja) * 2005-12-21 2007-06-28 Japan Health Sciences Foundation 質量分析システムおよび質量分析方法
US20070218505A1 (en) * 2006-03-14 2007-09-20 Paul Kearney Identification of biomolecules through expression patterns in mass spectrometry
GB0609253D0 (en) * 2006-05-10 2006-06-21 Micromass Ltd Mass spectrometer
JP5424872B2 (ja) * 2006-05-26 2014-02-26 ウオーターズ・テクノロジーズ・コーポレイシヨン 質量分析法を実施するための装置および方法
US9063162B2 (en) * 2006-05-26 2015-06-23 Waters Technologies Corporation Apparatus and method for performing mass spectroscopy
US20080073499A1 (en) * 2006-07-25 2008-03-27 George Yefchak Peak finding in low-resolution mass spectrometry by use of chromatographic integration routines
RU2009113801A (ru) * 2006-09-14 2010-10-20 Конинклейке Филипс Электроникс Н.В. (Nl) Способы анализа образцов белков на основе идентификации с-концевых пептидов
US7499807B1 (en) * 2006-09-19 2009-03-03 Battelle Memorial Institute Methods for recalibration of mass spectrometry data
CA2669642A1 (en) * 2006-11-09 2008-05-22 Alcon Research, Ltd. Punctal plug comprising a water-insoluble polymeric matrix
WO2008079407A1 (en) * 2006-12-26 2008-07-03 Brigham Young University Serum proteomics system and associated methods
US7595485B1 (en) * 2007-02-07 2009-09-29 Thermo Finnigan Llc Data analysis to provide a revised data set for use in peptide sequencing determination
US20080226133A1 (en) * 2007-03-14 2008-09-18 Jean-Luc Truche Use of Optical Sensors for Spray Jet Diagnostics
US8399827B1 (en) * 2007-09-10 2013-03-19 Cedars-Sinai Medical Center Mass spectrometry systems
WO2009146345A1 (en) * 2008-05-29 2009-12-03 Waters Technologies Corporation Techniques for performing retention-time matching of precursor and product ions and for constructing precursor and product ion spectra
US8389932B2 (en) 2008-07-01 2013-03-05 Waters Technologies Corporation Stacked-electrode peptide-fragmentation device
US20100224770A1 (en) * 2009-03-06 2010-09-09 Ensco, Inc. Method for configuring an ion mobility spectrometer system
US9500572B2 (en) * 2009-04-30 2016-11-22 Purdue Research Foundation Sample dispenser including an internal standard and methods of use thereof
US8987662B2 (en) * 2009-05-14 2015-03-24 Agilent Technologies, Inc. System and method for performing tandem mass spectrometry analysis
US20110042564A1 (en) * 2009-08-20 2011-02-24 Yasuhide Naito Laser ablation mass analyzing apparatus
US9453845B2 (en) 2010-02-01 2016-09-27 Cell Signaling Technology, Inc. Mass spectroscopy analysis of mutant polypeptides in biological samples
US10553412B2 (en) * 2010-05-24 2020-02-04 Agilent Technologies, Inc. System and method of data-dependent acquisition by mass spectrometry
US9530633B2 (en) * 2010-05-25 2016-12-27 Agilent Technologies, Inc. Method for isomer discrimination by tandem mass spectrometry
EP2697655A2 (de) * 2011-04-15 2014-02-19 Micromass UK Limited Verfahren und vorrichtung zur analyse biologischer proben
JP5736235B2 (ja) * 2011-05-23 2015-06-17 株式会社日立製作所 質量分析システム及びコンピュータプログラム
JP2014526685A (ja) 2011-09-08 2014-10-06 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア 代謝流量測定、画像化、および顕微鏡法
WO2013067529A1 (en) * 2011-11-04 2013-05-10 Bio-Rad Laboratories, Inc. PROTEIN FRACTIONATION BASED ON pI
CN104023551A (zh) 2011-11-04 2014-09-03 生物辐射实验室股份有限公司 细胞组分的同时纯化
US9766207B2 (en) 2011-11-04 2017-09-19 Bio-Rad Laboratories, Inc. Affinity methods and compositions employing electronic control of pH
CA2858368A1 (en) 2011-12-07 2013-06-13 Glaxosmithkline Llc Methods for determining total body skeletal muscle mass
WO2013123425A1 (en) 2012-02-15 2013-08-22 Bio-Rad Laboratories, Inc. Electronic control of ph and ionic strength
US9321012B2 (en) 2012-04-04 2016-04-26 Bio-Rad Laboratories, Inc. Electronic protein fractionation
KR20150012247A (ko) * 2012-04-25 2015-02-03 아토나프 가부시키가이샤 컨텐츠를 제공하는 시스템
US9310344B2 (en) 2013-06-14 2016-04-12 Dionex Corporation HILIC/anion-exchange/cation-exchange multimodal media
US9169331B2 (en) 2012-12-21 2015-10-27 Dionex Corporation Separation of glycans by mixed-mode liquid chromatography
DK3729958T3 (da) * 2013-03-15 2023-08-07 Mayo Found Medical Education & Res Identificering og overvågning af monoklonale immunoglobuliner ved hjælp af molekylmasse
US9134319B2 (en) 2013-03-15 2015-09-15 The Regents Of The University Of California Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo
GB201306868D0 (en) 2013-04-15 2013-05-29 Micromass Ltd A method of screening samples
US9620344B2 (en) 2013-06-25 2017-04-11 Purdue Research Foundation Mass spectrometry analysis of microorganisms in samples
WO2015082889A1 (en) 2013-12-02 2015-06-11 Micromass Uk Limited Method of charge state selection
US10153146B2 (en) 2014-03-28 2018-12-11 Wisconsin Alumni Research Foundation High mass accuracy filtering for improved spectral matching of high-resolution gas chromatography-mass spectrometry data against unit-resolution reference databases
JP6759104B2 (ja) 2014-04-04 2020-09-23 メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ 精密分子質量を用いた免疫グロブリンのアイソタイピング
US9720001B2 (en) * 2014-05-21 2017-08-01 Thermo Finnigan Llc Methods for mass spectrometric biopolymer analysis using optimized weighted oligomer scheduling
EP3175242A4 (de) 2014-07-29 2017-12-27 Mayo Foundation for Medical Education and Research Quantifizierung monoklonaler antikörpertherapeutika durch lc-ms/ms
US10041907B2 (en) * 2014-09-26 2018-08-07 Micromass Uk Limited Accurate mobility chromatograms
US10573501B2 (en) 2015-05-29 2020-02-25 Waters Technologies Corporation Techniques for processing of mass spectral data
GB201509402D0 (en) * 2015-06-01 2015-07-15 Micromass Ltd Lock mass library for internal correction
US9847216B2 (en) * 2015-08-14 2017-12-19 Thermo Finnigan Llc Systems and methods for targeted top down discovery
WO2017053932A1 (en) 2015-09-24 2017-03-30 Mayo Foundation For Medical Education And Research Identification of immunoglobulin free light chains by mass spectrometry
CN108139357B (zh) * 2015-10-07 2020-10-27 株式会社岛津制作所 串联型质谱分析装置
US10955420B2 (en) 2016-09-07 2021-03-23 Mayo Foundation For Medical Education And Research Identification and monitoring of cleaved immunoglobulins by molecular mass
US11092597B2 (en) 2017-02-28 2021-08-17 Waters Technoligies Corporation Devices and methods for analyzing intact proteins, antibodies, antibody subunits, and antibody drug conjugates
US9911587B1 (en) * 2017-03-10 2018-03-06 Thermo Finnigan Llc Methods and systems for quantitative mass analysis
US9911588B1 (en) * 2017-03-10 2018-03-06 Thermo Finnigan Llc Methods and systems for quantitative mass analysis
US10347477B2 (en) 2017-03-24 2019-07-09 Thermo Finnigan Llc Methods and systems for quantitative mass analysis
CN111094989A (zh) * 2017-07-25 2020-05-01 拜康有限公司 用于胰岛素和胰岛素类似物的序列识别的肽图谱法
WO2019055634A1 (en) 2017-09-13 2019-03-21 Mayo Foundation For Medical Education And Research IDENTIFICATION AND MONITORING OF A MACROPHAGE APOPTOSIS INHIBITOR
WO2020152871A1 (ja) * 2019-01-25 2020-07-30 株式会社島津製作所 クロマトグラフを用いた物質同定方法
JP7306676B2 (ja) * 2019-02-26 2023-07-11 国立大学法人九州大学 脂質プロファイリングシステム、脂質プロファイリング方法、及び脂質プロファイリングプログラム
BE1027232B1 (fr) * 2019-08-28 2020-11-20 Zentech S A Procédé de détection d'au moins un variant de protéine et/ou d'au moins un peptide propre aux chaînes alpha et/ou bêta et/ou delta d'hémoglobine
EP4139673A1 (de) * 2020-04-24 2023-03-01 Waters Technologies Ireland Limited Verfahren, medien und systeme zum vergleich von daten in und zwischen kohorten
US20240063007A1 (en) * 2020-12-30 2024-02-22 Purdue Research Foundation Mass spectrometry to identify predictive failure with chemical detection in microelectronic systems

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB870203A (en) * 1949-10-26 1961-06-14 Edward Whitworth Improvements in or relating to surface moderated propellent powders
US4735777A (en) * 1985-03-11 1988-04-05 Hitachi, Ltd. Instrument for parallel analysis of metabolites in human urine and expired air
JP3001252B2 (ja) * 1990-11-16 2000-01-24 株式会社日立製作所 半導体メモリ
US5428621A (en) * 1992-09-21 1995-06-27 Sundisk Corporation Latent defect handling in EEPROM devices
US6017693A (en) * 1994-03-14 2000-01-25 University Of Washington Identification of nucleotides, amino acids, or carbohydrates by mass spectrometry
US6323482B1 (en) * 1997-06-02 2001-11-27 Advanced Research And Technology Institute, Inc. Ion mobility and mass spectrometer
EP1095267A1 (de) * 1998-07-10 2001-05-02 Cetek Corporation Verfahren zur feststellung und analyse von stark bindenden liganden in komplexen biologischen proben
US6147344A (en) * 1998-10-15 2000-11-14 Neogenesis, Inc Method for identifying compounds in a chemical mixture
US20020009394A1 (en) 1999-04-02 2002-01-24 Hubert Koster Automated process line
US6936424B1 (en) * 1999-11-16 2005-08-30 Matritech, Inc. Materials and methods for detection and treatment of breast cancer
CA2298181C (en) 2000-02-02 2006-09-19 Dayan Burke Goodnough Non-targeted complex sample analysis
US20040038417A1 (en) * 2000-02-07 2004-02-26 Cahill Dolores J. Method for identifying and/or characterizing a (poly)peptide
WO2001058925A2 (en) * 2000-02-08 2001-08-16 The Regents Of The University Of Michigan Protein separation and display
JP2001330599A (ja) 2000-05-24 2001-11-30 Shimazu S D Kk Gc/msによる代謝異常スクリーニング診断装置
DE60119580T2 (de) 2000-12-26 2007-04-26 The Institute For Systems Biology, Seattle Schnelle und quantitative proteomanalyse und damit zusammenhängende verfahren
US20020119490A1 (en) * 2000-12-26 2002-08-29 Aebersold Ruedi H. Methods for rapid and quantitative proteome analysis
US20020115056A1 (en) * 2000-12-26 2002-08-22 Goodlett David R. Rapid and quantitative proteome analysis and related methods
US6931325B2 (en) * 2001-02-07 2005-08-16 Regents Of The University Of Michigan Three dimensional protein mapping
US20030031350A1 (en) 2001-03-09 2003-02-13 Pe Corporation (Ny) Methods for large scale protein matching
US6835927B2 (en) * 2001-10-15 2004-12-28 Surromed, Inc. Mass spectrometric quantification of chemical mixture components
US20030129760A1 (en) 2001-11-13 2003-07-10 Aguilera Frank Reinaldo Morales Mass intensity profiling system and uses thereof
DE10158860B4 (de) 2001-11-30 2007-04-05 Bruker Daltonik Gmbh Massenspektrometrische Proteingemischanalyse
ATE327512T1 (de) 2001-12-08 2006-06-15 Micromass Ltd Massenspektrometrie-verfahren
US6835027B1 (en) * 2003-11-05 2004-12-28 Billy Glass Staple for securing geo-textile material to the ground

Also Published As

Publication number Publication date
US20080286764A9 (en) 2008-11-20
EP1456667A2 (de) 2004-09-15
CA2465297C (en) 2011-02-15
CA2465297A1 (en) 2003-07-03
GB0228653D0 (en) 2003-01-15
JP2005513481A (ja) 2005-05-12
US20080135744A1 (en) 2008-06-12
GB2385918B (en) 2004-05-26
US8030089B2 (en) 2011-10-04
US20050092910A1 (en) 2005-05-05
EP1456667B2 (de) 2010-01-20
WO2003054549A2 (en) 2003-07-03
EP1456667B1 (de) 2006-05-24
DE60228132D1 (de) 2008-09-18
GB2385918A (en) 2003-09-03
DE60211744T2 (de) 2006-11-02
US20080142696A1 (en) 2008-06-19
WO2003054549A3 (en) 2003-10-16
ATE403872T1 (de) 2008-08-15
DE60211744T3 (de) 2010-07-01
JP4767496B2 (ja) 2011-09-07
JP4654230B2 (ja) 2011-03-16
DE60211744D1 (de) 2006-06-29
JP2008076403A (ja) 2008-04-03
US20070009898A1 (en) 2007-01-11

Similar Documents

Publication Publication Date Title
ATE327512T1 (de) Massenspektrometrie-verfahren
WO2004022721A3 (en) Quantification of gene expression
DE50210457D1 (de) Vorrichtung zur referenzierung von fluoreszenzsignalen
AU2001285063A1 (en) Mass spectrometric analysis of biopolymers
WO2002077895A3 (en) Method for epigenetic feature selection
PT100724A (pt) Processo de determinacao da quantidade de grupos tiol ligados em proteinas e conjunto para a deteccao de estados isquemicos
WO2003073817A3 (en) Rapid and sensitive detection of cells and viruses
AU3625999A (en) Detection of a target in a sample
WO2005106036A3 (en) Methods and compositions for assaying analytes
WO2004101769A3 (en) Proteins, sensors, and methods of characterizing analytes using the same
EP1415152A4 (de) Verfahren, vorrichtungen und computerprogramme zum verifizieren der integrität einer sonde
WO2004011607A3 (en) Reagent and method for determination of a substance using an immunoaggregator
Vinciguerra et al. Identification of proteinaceous binders in paintings: A targeted proteomic approach for cultural heritage
Morse et al. Exploring dinoflagellate biology with high-throughput proteomics
CA2523107A1 (en) Instrumentation, articles of manufacture, and analysis methods
DE60119580D1 (de) Schnelle und quantitative proteomanalyse und damit zusammenhängende verfahren
Falick et al. ABRF-PRG07: advanced quantitative proteomics study
EP1335028A3 (de) Multi-Test-Analyse von Echzeit-Nukleinsäureamplifikationen
EP1647825A3 (de) Massenspektrometrieverfahren
WO2004077057A8 (en) Standard for immunohistochemistry, immunocytochemistry and molecular cytogenetics
WO2001084161A3 (en) Process for the measurement of non-transferrin bound iron
WO2005056814A3 (en) Methods and systems for analyzing and determining ligand-residue interaction
TW200502399A (en) Recombinant virus and use thereof and method of detecting an analyte in a sample and kit thereof
AU2002358892A1 (en) Method for detection and quantitative analysis of nucleic acid molecules comprising an extraction step with a strong base and applications
Segura et al. Proteomic complex detection using sedimentation (ProCoDeS): screening for proteins in stable complexes and their candidate interaction partners

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties