KR100828748B1 - 소수성 유효성분의 생체내이용효율을 향상시키기 위한경구 또는 국소 투여용 약학적 제형 - Google Patents

소수성 유효성분의 생체내이용효율을 향상시키기 위한경구 또는 국소 투여용 약학적 제형 Download PDF

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KR100828748B1
KR100828748B1 KR1020057015114A KR20057015114A KR100828748B1 KR 100828748 B1 KR100828748 B1 KR 100828748B1 KR 1020057015114 A KR1020057015114 A KR 1020057015114A KR 20057015114 A KR20057015114 A KR 20057015114A KR 100828748 B1 KR100828748 B1 KR 100828748B1
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South Korea
Prior art keywords
pharmaceutical formulation
esters
fatty acids
formula
component
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Expired - Fee Related
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KR1020057015114A
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English (en)
Korean (ko)
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KR20050095651A (ko
Inventor
토마스 안드리섹
밀란 스터츠릭
알레스 브라나
알렉산드르 제고로브
조세프 스터츠릭
블라디미르 마사
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아이박스 파마슈티컬스 에스.알.오.
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Application filed by 아이박스 파마슈티컬스 에스.알.오. filed Critical 아이박스 파마슈티컬스 에스.알.오.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases or cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
KR1020057015114A 1999-08-17 2000-08-17 소수성 유효성분의 생체내이용효율을 향상시키기 위한경구 또는 국소 투여용 약학적 제형 Expired - Fee Related KR100828748B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB?9919288.2? 1999-08-17
GB9919288A GB2355656B (en) 1999-08-17 1999-08-17 Pharmaceutical compositions for oral and topical administration

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020027002109A Division KR100828747B1 (ko) 1999-08-17 2000-08-17 소수성 유효성분의 생체내이용효율을 향상시키기 위한 경구 또는 국소 투여용 약학적 제형

Publications (2)

Publication Number Publication Date
KR20050095651A KR20050095651A (ko) 2005-09-29
KR100828748B1 true KR100828748B1 (ko) 2008-05-09

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ID=10859192

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Application Number Title Priority Date Filing Date
KR1020057015114A Expired - Fee Related KR100828748B1 (ko) 1999-08-17 2000-08-17 소수성 유효성분의 생체내이용효율을 향상시키기 위한경구 또는 국소 투여용 약학적 제형
KR1020027002109A Expired - Fee Related KR100828747B1 (ko) 1999-08-17 2000-08-17 소수성 유효성분의 생체내이용효율을 향상시키기 위한 경구 또는 국소 투여용 약학적 제형

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020027002109A Expired - Fee Related KR100828747B1 (ko) 1999-08-17 2000-08-17 소수성 유효성분의 생체내이용효율을 향상시키기 위한 경구 또는 국소 투여용 약학적 제형

Country Status (40)

Country Link
US (1) US20070190132A1 (https=)
EP (2) EP1334717B1 (https=)
JP (2) JP2003507343A (https=)
KR (2) KR100828748B1 (https=)
CN (2) CN1382061A (https=)
AR (2) AR025324A1 (https=)
AT (2) ATE402691T1 (https=)
AU (1) AU777740B2 (https=)
BR (1) BR0013385A (https=)
CA (2) CA2452118A1 (https=)
CO (1) CO5380014A1 (https=)
CY (1) CY1105318T1 (https=)
CZ (2) CZ296170B6 (https=)
DE (2) DE60018081T2 (https=)
DK (2) DK1210119T3 (https=)
EE (2) EE04954B1 (https=)
EG (1) EG23994A (https=)
ES (2) ES2311077T3 (https=)
GB (1) GB2355656B (https=)
HK (1) HK1049629A1 (https=)
HR (1) HRP20020154B1 (https=)
HU (1) HUP0203236A3 (https=)
IL (4) IL158108A0 (https=)
JO (1) JO2324B1 (https=)
MX (1) MXPA02001631A (https=)
NO (2) NO20020760L (https=)
NZ (1) NZ517271A (https=)
PE (1) PE20010636A1 (https=)
PL (1) PL192769B1 (https=)
PT (2) PT1210119E (https=)
RU (2) RU2279894C2 (https=)
SA (1) SA00210487B1 (https=)
SG (1) SG143019A1 (https=)
SI (1) SI1210119T1 (https=)
SK (2) SK286083B6 (https=)
TN (1) TNSN00173A1 (https=)
UA (2) UA72539C2 (https=)
UY (1) UY26303A1 (https=)
WO (1) WO2001012229A1 (https=)
ZA (2) ZA200308221B (https=)

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FR2826261B1 (fr) * 2001-06-26 2005-03-25 Lmd Composition a usage topique comprenant un produit cytotoxique et son utilisation dans le traitement de l'alopeche
DE10154464B4 (de) * 2001-11-08 2005-10-20 Max Delbrueck Centrum Oral verabreichbare pharmazeutische Zubereitung umfassend liposomal verkapseltes Taxol
KR20030065831A (ko) * 2002-02-01 2003-08-09 주식회사 태평양 사이클로스포린을 함유한 지속 방출형 약학적 조성물
US9101540B2 (en) 2002-04-12 2015-08-11 Alkermes Pharma Ireland Limited Nanoparticulate megestrol formulations
US7101576B2 (en) * 2002-04-12 2006-09-05 Elan Pharma International Limited Nanoparticulate megestrol formulations
EP1935407A1 (en) * 2002-12-03 2008-06-25 Elan Pharma International Limited Low viscosity liquid dosage forms
JP4518042B2 (ja) * 2002-12-04 2010-08-04 日油株式会社 コエンザイムｑ１０を含有する水溶性組成物の製造方法
KR101061679B1 (ko) * 2002-12-04 2011-09-02 닛신 파마 가부시키가이샤 코엔자임 ｑ10 을 함유하는 수용성 조성물
CA2509365C (en) * 2002-12-09 2012-08-07 American Bioscience, Inc. Compositions and methods of delivery of pharmacological agents
US6979672B2 (en) 2002-12-20 2005-12-27 Polichem, S.A. Cyclosporin-based pharmaceutical compositions
TW200616681A (en) * 2004-10-05 2006-06-01 Recordati Ireland Ltd Lercanidipine capsules
WO2006043621A1 (ja) * 2004-10-20 2006-04-27 Kao Corporation 液体口腔用組成物
JP2008531591A (ja) * 2005-02-24 2008-08-14 エラン・ファルマ・インターナショナル・リミテッド ドセタキセルおよびそれらの類似体のナノ粒子製剤
BRPI0921654A2 (pt) * 2008-11-28 2016-02-10 Advance Holdings Ltd formulação farmacêutica
WO2010102862A1 (en) * 2009-03-12 2010-09-16 Advance Holdings Limited Pharmaceutical formulation comprising ketoprofen and a polyoxyalkylene ester of a hydroxy fatty acid
KR101100933B1 (ko) * 2009-04-23 2012-01-02 한국기술교육대학교 산학협력단 솔더 볼 제거 장치
KR20170131641A (ko) 2015-03-27 2017-11-29 아치 퍼스널 케어 프로덕츠, 엘.피. 퍼스널 케어 제품용 점도 증강 조성물
CN112426403B (zh) * 2020-12-09 2021-09-17 南京天纵易康生物科技股份有限公司 一种口腔溃疡凝胶及其制备方法和应用
TW202406566A (zh) * 2022-05-02 2024-02-16 日商中外製藥股份有限公司 包含用於與界面活性劑結合使用之胜肽化合物的組合物
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JO2324B1 (en) 2005-09-12
RU2279894C2 (ru) 2006-07-20
ZA200308221B (en) 2004-09-29
RU2003133451A (ru) 2005-04-20
SA00210487B1 (ar) 2006-09-10
SK286083B6 (sk) 2008-03-05
EP1334717A3 (en) 2004-01-02
IL158108A0 (en) 2004-03-28
DK1210119T3 (da) 2005-06-20
GB2355656A (en) 2001-05-02
ES2311077T3 (es) 2009-02-01
EE04954B1 (et) 2008-02-15
UA75926C2 (en) 2006-06-15
CY1105318T1 (el) 2010-03-03
ES2237443T3 (es) 2005-08-01
CA2452118A1 (en) 2001-02-22
PE20010636A1 (es) 2001-06-02
GB2355656B (en) 2004-04-07
CA2380951A1 (en) 2001-02-22
CN1382061A (zh) 2002-11-27
NO20034778D0 (no) 2003-10-24
KR100828747B1 (ko) 2008-05-09
NO20034778L (no) 2002-04-16
EP1334717A2 (en) 2003-08-13
KR20020059367A (ko) 2002-07-12
DE60322454D1 (de) 2008-09-11
ATE288766T1 (de) 2005-02-15
ZA200201315B (en) 2004-06-30
CO5380014A1 (es) 2004-03-31
JP2004238399A (ja) 2004-08-26
DE60018081D1 (de) 2005-03-17
IL148200A (en) 2007-12-03
IL148200A0 (en) 2002-09-12
HRP20020154A2 (en) 2003-12-31
BR0013385A (pt) 2002-05-07
PL353445A1 (en) 2003-11-17
NZ517271A (en) 2004-02-27
HRP20020154B1 (en) 2006-07-31
RU2279895C2 (ru) 2006-07-20
EP1210119B1 (en) 2005-02-09
CZ296591B6 (cs) 2006-04-12
EE200200075A (et) 2003-04-15
ATE402691T1 (de) 2008-08-15
PT1334717E (pt) 2008-10-09
CN101406453A (zh) 2009-04-15
NO20020760L (no) 2002-04-16
EP1210119A1 (en) 2002-06-05
TNSN00173A1 (en) 2005-11-10
AU6461300A (en) 2001-03-13
US20070190132A1 (en) 2007-08-16
HUP0203236A3 (en) 2004-06-28
DE60018081T2 (de) 2006-01-05
WO2001012229A1 (en) 2001-02-22
SK2482002A3 (en) 2002-12-03
CZ296170B6 (cs) 2006-01-11
AR025324A1 (es) 2002-11-20
AU777740B2 (en) 2004-10-28
UA72539C2 (en) 2005-03-15
HK1049629A1 (zh) 2003-05-23
GB9919288D0 (en) 1999-10-20
DK1334717T3 (da) 2008-11-24
CZ2002575A3 (cs) 2003-05-14
SI1210119T1 (en) 2005-06-30
EG23994A (en) 2008-03-10
MXPA02001631A (es) 2003-07-14
PT1210119E (pt) 2005-05-31
KR20050095651A (ko) 2005-09-29
EE200300371A (et) 2003-10-15
IL158108A (en) 2010-04-15
HUP0203236A2 (hu) 2003-01-28
PL192769B1 (pl) 2006-12-29
SG143019A1 (en) 2008-06-27
EE04955B1 (et) 2008-02-15
EP1334717B1 (en) 2008-07-30
UY26303A1 (es) 2001-03-16
NO20020760D0 (no) 2002-02-15
AR043106A2 (es) 2005-07-20
CA2380951C (en) 2010-03-23
JP2003507343A (ja) 2003-02-25

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