KR100828747B1 - 소수성 유효성분의 생체내이용효율을 향상시키기 위한 경구 또는 국소 투여용 약학적 제형 - Google Patents

소수성 유효성분의 생체내이용효율을 향상시키기 위한 경구 또는 국소 투여용 약학적 제형 Download PDF

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Publication number
KR100828747B1
KR100828747B1 KR1020027002109A KR20027002109A KR100828747B1 KR 100828747 B1 KR100828747 B1 KR 100828747B1 KR 1020027002109 A KR1020027002109 A KR 1020027002109A KR 20027002109 A KR20027002109 A KR 20027002109A KR 100828747 B1 KR100828747 B1 KR 100828747B1
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South Korea
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pharmaceutical formulation
cyclosporin
esters
component
fatty acids
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Expired - Fee Related
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KR1020027002109A
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English (en)
Korean (ko)
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KR20020059367A (ko
Inventor
안드리섹토마스
스터츠릭밀란
브라나알레스
제고로브알렉산드르
스터츠릭조세프
마사블라디미르
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아이박스 파마슈티컬스 에스.알.오.
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Application filed by 아이박스 파마슈티컬스 에스.알.오. filed Critical 아이박스 파마슈티컬스 에스.알.오.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases or cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dispersion Chemistry (AREA)
  • Virology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
KR1020027002109A 1999-08-17 2000-08-17 소수성 유효성분의 생체내이용효율을 향상시키기 위한 경구 또는 국소 투여용 약학적 제형 Expired - Fee Related KR100828747B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9919288A GB2355656B (en) 1999-08-17 1999-08-17 Pharmaceutical compositions for oral and topical administration
GB?9919288.2? 1999-08-17

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020057015114A Division KR100828748B1 (ko) 1999-08-17 2000-08-17 소수성 유효성분의 생체내이용효율을 향상시키기 위한경구 또는 국소 투여용 약학적 제형

Publications (2)

Publication Number Publication Date
KR20020059367A KR20020059367A (ko) 2002-07-12
KR100828747B1 true KR100828747B1 (ko) 2008-05-09

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ID=10859192

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020027002109A Expired - Fee Related KR100828747B1 (ko) 1999-08-17 2000-08-17 소수성 유효성분의 생체내이용효율을 향상시키기 위한 경구 또는 국소 투여용 약학적 제형
KR1020057015114A Expired - Fee Related KR100828748B1 (ko) 1999-08-17 2000-08-17 소수성 유효성분의 생체내이용효율을 향상시키기 위한경구 또는 국소 투여용 약학적 제형

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020057015114A Expired - Fee Related KR100828748B1 (ko) 1999-08-17 2000-08-17 소수성 유효성분의 생체내이용효율을 향상시키기 위한경구 또는 국소 투여용 약학적 제형

Country Status (40)

Country Link
US (1) US20070190132A1 (enExample)
EP (2) EP1334717B1 (enExample)
JP (2) JP2003507343A (enExample)
KR (2) KR100828747B1 (enExample)
CN (2) CN101406453A (enExample)
AR (2) AR025324A1 (enExample)
AT (2) ATE402691T1 (enExample)
AU (1) AU777740B2 (enExample)
BR (1) BR0013385A (enExample)
CA (2) CA2380951C (enExample)
CO (1) CO5380014A1 (enExample)
CY (1) CY1105318T1 (enExample)
CZ (2) CZ296170B6 (enExample)
DE (2) DE60018081T2 (enExample)
DK (2) DK1334717T3 (enExample)
EE (2) EE04954B1 (enExample)
EG (1) EG23994A (enExample)
ES (2) ES2311077T3 (enExample)
GB (1) GB2355656B (enExample)
HK (1) HK1049629A1 (enExample)
HR (1) HRP20020154B1 (enExample)
HU (1) HUP0203236A3 (enExample)
IL (4) IL158108A0 (enExample)
JO (1) JO2324B1 (enExample)
MX (1) MXPA02001631A (enExample)
NO (2) NO20020760L (enExample)
NZ (1) NZ517271A (enExample)
PE (1) PE20010636A1 (enExample)
PL (1) PL192769B1 (enExample)
PT (2) PT1210119E (enExample)
RU (2) RU2279894C2 (enExample)
SA (1) SA00210487B1 (enExample)
SG (1) SG143019A1 (enExample)
SI (1) SI1210119T1 (enExample)
SK (2) SK2482002A3 (enExample)
TN (1) TNSN00173A1 (enExample)
UA (2) UA72539C2 (enExample)
UY (1) UY26303A1 (enExample)
WO (1) WO2001012229A1 (enExample)
ZA (2) ZA200308221B (enExample)

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GB2355656B (en) * 1999-08-17 2004-04-07 Galena As Pharmaceutical compositions for oral and topical administration
FR2826261B1 (fr) * 2001-06-26 2005-03-25 Lmd Composition a usage topique comprenant un produit cytotoxique et son utilisation dans le traitement de l'alopeche
DE10154464B4 (de) * 2001-11-08 2005-10-20 Max Delbrueck Centrum Oral verabreichbare pharmazeutische Zubereitung umfassend liposomal verkapseltes Taxol
KR20030065831A (ko) * 2002-02-01 2003-08-09 주식회사 태평양 사이클로스포린을 함유한 지속 방출형 약학적 조성물
US7101576B2 (en) * 2002-04-12 2006-09-05 Elan Pharma International Limited Nanoparticulate megestrol formulations
US9101540B2 (en) 2002-04-12 2015-08-11 Alkermes Pharma Ireland Limited Nanoparticulate megestrol formulations
EP1935407A1 (en) * 2002-12-03 2008-06-25 Elan Pharma International Limited Low viscosity liquid dosage forms
JP4518042B2 (ja) * 2002-12-04 2010-08-04 日油株式会社 コエンザイムｑ１０を含有する水溶性組成物の製造方法
EP1582206A4 (en) * 2002-12-04 2010-09-22 Nisshin Pharma Inc WATER-SOLUBLE COMPOSITION WITH COENZYM Q10
SI1585548T1 (sl) 2002-12-09 2018-11-30 Abraxis Bioscience, Llc Sestave in metode odmerjanja farmakoloških sredstev
US6979672B2 (en) * 2002-12-20 2005-12-27 Polichem, S.A. Cyclosporin-based pharmaceutical compositions
TW200616681A (en) * 2004-10-05 2006-06-01 Recordati Ireland Ltd Lercanidipine capsules
US8236286B2 (en) * 2004-10-20 2012-08-07 Kao Corporation Liquid compositions for the oral cavity
WO2006091780A2 (en) * 2005-02-24 2006-08-31 Elan Pharma International Limited Nanoparticulate formulations of docetaxel and analogues thereof
BRPI0921654A2 (pt) * 2008-11-28 2016-02-10 Advance Holdings Ltd formulação farmacêutica
ES2403380T3 (es) * 2009-03-12 2013-05-17 Lectio Pharmaentwicklungs- Und Verwertungs Gmbh Formulación farmacéutica que comprende cetoprofeno y un éster de polioxialquileno de un hidroxiácido graso
KR101100933B1 (ko) * 2009-04-23 2012-01-02 한국기술교육대학교 산학협력단 솔더 볼 제거 장치
EP3274054A1 (en) * 2015-03-27 2018-01-31 Arch Personal Care Products, L.P. Viscosity building composition for personal care products
CN112426403B (zh) * 2020-12-09 2021-09-17 南京天纵易康生物科技股份有限公司 一种口腔溃疡凝胶及其制备方法和应用
TW202406566A (zh) * 2022-05-02 2024-02-16 日商中外製藥股份有限公司 包含用於與界面活性劑結合使用之胜肽化合物的組合物
CN119770478B (zh) * 2024-12-31 2025-12-19 美济生物医药(广州)有限公司 紫杉醇口服药物组合物、制剂及其制备方法和应用

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국제특허공개공보 제98/10747호*

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MXPA02001631A (es) 2003-07-14
ES2237443T3 (es) 2005-08-01
HUP0203236A2 (hu) 2003-01-28
NO20020760L (no) 2002-04-16
DK1210119T3 (da) 2005-06-20
AR025324A1 (es) 2002-11-20
EE200300371A (et) 2003-10-15
IL148200A (en) 2007-12-03
CN101406453A (zh) 2009-04-15
EE04955B1 (et) 2008-02-15
EE04954B1 (et) 2008-02-15
HK1049629A1 (zh) 2003-05-23
HUP0203236A3 (en) 2004-06-28
HRP20020154B1 (en) 2006-07-31
KR20050095651A (ko) 2005-09-29
RU2003133451A (ru) 2005-04-20
SI1210119T1 (en) 2005-06-30
SG143019A1 (en) 2008-06-27
AU6461300A (en) 2001-03-13
KR20020059367A (ko) 2002-07-12
EG23994A (en) 2008-03-10
GB2355656B (en) 2004-04-07
JP2004238399A (ja) 2004-08-26
ZA200308221B (en) 2004-09-29
EP1210119B1 (en) 2005-02-09
AU777740B2 (en) 2004-10-28
UA75926C2 (en) 2006-06-15
CZ2002575A3 (cs) 2003-05-14
JP2003507343A (ja) 2003-02-25
GB2355656A (en) 2001-05-02
PT1334717E (pt) 2008-10-09
IL148200A0 (en) 2002-09-12
DE60018081T2 (de) 2006-01-05
ATE402691T1 (de) 2008-08-15
NO20020760D0 (no) 2002-02-15
US20070190132A1 (en) 2007-08-16
CY1105318T1 (el) 2010-03-03
ATE288766T1 (de) 2005-02-15
RU2279894C2 (ru) 2006-07-20
CZ296591B6 (cs) 2006-04-12
EE200200075A (et) 2003-04-15
SK2482002A3 (en) 2002-12-03
CA2380951A1 (en) 2001-02-22
PT1210119E (pt) 2005-05-31
SK286083B6 (sk) 2008-03-05
UA72539C2 (en) 2005-03-15
CA2380951C (en) 2010-03-23
PL353445A1 (en) 2003-11-17
DK1334717T3 (da) 2008-11-24
GB9919288D0 (en) 1999-10-20
EP1210119A1 (en) 2002-06-05
KR100828748B1 (ko) 2008-05-09
PE20010636A1 (es) 2001-06-02
EP1334717A3 (en) 2004-01-02
DE60322454D1 (de) 2008-09-11
NO20034778L (no) 2002-04-16
TNSN00173A1 (en) 2005-11-10
DE60018081D1 (de) 2005-03-17
CO5380014A1 (es) 2004-03-31
CZ296170B6 (cs) 2006-01-11
IL158108A (en) 2010-04-15
CA2452118A1 (en) 2001-02-22
EP1334717A2 (en) 2003-08-13
PL192769B1 (pl) 2006-12-29
AR043106A2 (es) 2005-07-20
WO2001012229A1 (en) 2001-02-22
JO2324B1 (en) 2005-09-12
BR0013385A (pt) 2002-05-07
NO20034778D0 (no) 2003-10-24
NZ517271A (en) 2004-02-27
RU2279895C2 (ru) 2006-07-20
CN1382061A (zh) 2002-11-27
EP1334717B1 (en) 2008-07-30
SA00210487B1 (ar) 2006-09-10
UY26303A1 (es) 2001-03-16
ZA200201315B (en) 2004-06-30
IL158108A0 (en) 2004-03-28
ES2311077T3 (es) 2009-02-01
HRP20020154A2 (en) 2003-12-31

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