KR100812406B1 - 혈관형성 억제 활성을 갖고 항응고 효과는 없는부분적으로 탈황산화된 글리코스아미노글리칸의 유도체 - Google Patents

혈관형성 억제 활성을 갖고 항응고 효과는 없는부분적으로 탈황산화된 글리코스아미노글리칸의 유도체 Download PDF

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KR100812406B1
KR100812406B1 KR1020027009395A KR20027009395A KR100812406B1 KR 100812406 B1 KR100812406 B1 KR 100812406B1 KR 1020027009395 A KR1020027009395 A KR 1020027009395A KR 20027009395 A KR20027009395 A KR 20027009395A KR 100812406 B1 KR100812406 B1 KR 100812406B1
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heparin
acid
modified
group
epoxide
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Expired - Fee Related
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Korean (ko)
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KR20020080381A (ko
Inventor
카주베니토
토리지안지아코모
나기안나마리아
지안니니기우세페
피사노클라우디오
펜코세르지오
Original Assignee
시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이.
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
KR1020027009395A 2000-01-25 2001-01-24 혈관형성 억제 활성을 갖고 항응고 효과는 없는부분적으로 탈황산화된 글리코스아미노글리칸의 유도체 Expired - Fee Related KR100812406B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2000RM000041A IT1316986B1 (it) 2000-01-25 2000-01-25 Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica.
ITRM2000A000041 2000-01-25

Publications (2)

Publication Number Publication Date
KR20020080381A KR20020080381A (ko) 2002-10-23
KR100812406B1 true KR100812406B1 (ko) 2008-03-11

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US (4) US20030013682A1 (https=)
EP (1) EP1268558B1 (https=)
JP (1) JP5371167B2 (https=)
KR (1) KR100812406B1 (https=)
CN (1) CN100540570C (https=)
AT (1) ATE348115T1 (https=)
AU (1) AU782632B2 (https=)
BR (1) BR0107696A (https=)
CA (1) CA2397964C (https=)
CY (1) CY1108001T1 (https=)
CZ (1) CZ303030B6 (https=)
DE (1) DE60125154T2 (https=)
DK (1) DK1268558T3 (https=)
ES (1) ES2277911T3 (https=)
HU (1) HU229509B1 (https=)
IT (1) IT1316986B1 (https=)
MX (1) MXPA02007195A (https=)
PL (1) PL209479B1 (https=)
PT (1) PT1268558E (https=)
SK (1) SK287566B6 (https=)
WO (1) WO2001055221A1 (https=)

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AU2008202261B2 (en) * 2001-09-12 2011-07-28 Leadiant Biosciences S.A. Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
SK288335B6 (sk) * 2001-09-12 2016-02-02 Sigma-Tau Research Switzerland S.A. Čiastočne alebo úplne N-desulfatovaný, N-reacetylovaný heparín, spôsob jeho prípravy, jeho použitie na prípravu liečiva s inhibičným účinkom na heparanázu, s antiangiogénnym a protizápalovým účinkom a farmaceutický prostriedok s jeho obsahom
WO2005095463A1 (en) 2004-03-26 2005-10-13 Glycogenesys, Inc. Modified pectins, compositions and methods related thereto
WO2009007224A1 (en) * 2007-07-10 2009-01-15 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Low molecular weight heparin derivatives having neuroprotective activity
US8592393B2 (en) 2007-11-02 2013-11-26 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
US8569262B2 (en) 2007-11-02 2013-10-29 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
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JP2016520613A (ja) 2013-05-28 2016-07-14 モメンタ ファーマシューティカルズ インコーポレイテッド 薬学的組成物
ITLO20130005A1 (it) 2013-10-31 2015-05-01 He E Biochimiche G Ronzonr S R Derivati di glucosamminoglicani n-desolfatati e loro uso come farmaci
ITLO20130006A1 (it) 2013-11-06 2015-05-07 He E Biochimiche G Ronzoni S R Derivati carbossilati di glucosamminoglicani e loro uso come farmaci
CN103724458B (zh) * 2014-01-17 2016-03-30 福州大学 含n-非取代葡萄糖胺肝素六糖的制备及其纯化
BR112017018869A2 (pt) 2015-03-06 2018-04-17 Leadiant Biosciences S.A roneparstat e roneparstat para o uso, kit de partes e kit de partes para o uso, composição farmacêutica, método para tratar um mamífero e método para inibição, tratamento, e/ou prevenção de mieloma múltiplo, mieloma de células plasmáticas, mieloma recorrente, refratário ou recidivante em um sujeito
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CN108424474B (zh) * 2017-02-15 2023-07-25 清华大学 去抗凝肝素衍生物及其用于炎症性肠病的治疗
WO2019149179A1 (zh) * 2018-02-02 2019-08-08 深圳市海普瑞药业集团股份有限公司 糖胺聚糖衍生物及其制备方法和用途
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WO1999027976A1 (en) 1997-11-28 1999-06-10 Baxter Biotech Technology S.A.R.L. Non thrombogenic polymers with compatibility with organic fluids and tissues

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CZ303030B6 (cs) 2012-03-07
ATE348115T1 (de) 2007-01-15
AU782632B2 (en) 2005-08-18
HU229509B1 (en) 2014-01-28
SK287566B6 (sk) 2011-02-04
JP5371167B2 (ja) 2013-12-18
EP1268558A1 (en) 2003-01-02
PL357209A1 (en) 2004-07-26
DE60125154D1 (de) 2007-01-25
US20100298263A1 (en) 2010-11-25
HUP0204196A2 (hu) 2003-03-28
CA2397964C (en) 2010-10-12
AU3406401A (en) 2001-08-07
CN100540570C (zh) 2009-09-16
CZ20022308A3 (cs) 2003-01-15
BR0107696A (pt) 2002-10-15
CY1108001T1 (el) 2013-09-04
US7790700B2 (en) 2010-09-07
US8222231B2 (en) 2012-07-17
US20050222084A1 (en) 2005-10-06
CN1396930A (zh) 2003-02-12
PT1268558E (pt) 2007-02-28
WO2001055221A1 (en) 2001-08-02
EP1268558B1 (en) 2006-12-13
SK10672002A3 (sk) 2002-12-03
DE60125154T2 (de) 2007-10-25
JP2003523460A (ja) 2003-08-05
IT1316986B1 (it) 2003-05-26
ITRM20000041A1 (it) 2001-07-25
HUP0204196A3 (en) 2003-05-28
HK1051867A1 (zh) 2003-08-22
PL209479B1 (pl) 2011-09-30
ITRM20000041A0 (it) 2000-01-25
KR20020080381A (ko) 2002-10-23
ES2277911T3 (es) 2007-08-01
CA2397964A1 (en) 2001-08-02
US20050107331A1 (en) 2005-05-19
US20030013682A1 (en) 2003-01-16
MXPA02007195A (es) 2003-01-28
DK1268558T3 (da) 2007-04-10

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