AU7852687A - Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness or metastatic profusion - Google Patents

Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness or metastatic profusion

Info

Publication number
AU7852687A
AU7852687A AU78526/87A AU7852687A AU7852687A AU 7852687 A AU7852687 A AU 7852687A AU 78526/87 A AU78526/87 A AU 78526/87A AU 7852687 A AU7852687 A AU 7852687A AU 7852687 A AU7852687 A AU 7852687A
Authority
AU
Australia
Prior art keywords
profusion
metastatic
inhibitors
tumor invasiveness
glycosaminoglycan derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU78526/87A
Inventor
Tatsuro Irimura
Motowo Nakajima
Garth L. Nicolson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System filed Critical University of Texas System
Publication of AU7852687A publication Critical patent/AU7852687A/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AU78526/87A 1986-08-21 1987-08-18 Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness or metastatic profusion Abandoned AU7852687A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89951186A 1986-08-21 1986-08-21
US899511 1986-08-21

Publications (1)

Publication Number Publication Date
AU7852687A true AU7852687A (en) 1988-03-08

Family

ID=25411107

Family Applications (1)

Application Number Title Priority Date Filing Date
AU78526/87A Abandoned AU7852687A (en) 1986-08-21 1987-08-18 Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness or metastatic profusion

Country Status (2)

Country Link
AU (1) AU7852687A (en)
WO (1) WO1988001280A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU637143B2 (en) * 1989-10-04 1993-05-20 N.V. Organon Sulphated glycosaminoglycuronan with antithrombotic activity

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5262403A (en) * 1986-03-10 1993-11-16 Board Of Regents, The University Of Texas System Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness of metastatic profusion-II
AR245455A1 (en) * 1989-08-18 1994-01-31 Ajorca Sa Procedure for obtaining heparin, partially or totally n-acetylated in the glucosaminic remains, and products thus obtained, excluding pharmaceutical use.
AU6872691A (en) * 1989-10-27 1991-05-31 Case Western Reserve University Inhibition of cell growth by keratan sulfate, chondroitin sulfate, dermatan sulfate and other glycans
DE69331633T2 (en) * 1992-07-24 2002-10-31 Thomas P. Kennedy MEDICINAL PRODUCTS FOR INHIBITING NEUTROPHILIC ELASTASE AND CATHEPSIN G
IT1284143B1 (en) * 1996-09-06 1998-05-08 Istituto Scient Di Chimica E B SEMI-SYNTHETIC HEPARANSULPHATES WITH HIGH ANTIMETASTIC ACTIVITY AND REDUCED HEMORRAGIC RISK
US6177545B1 (en) * 1997-09-02 2001-01-23 Insight Strategy & Marketing Ltd. Heparanase specific molecular probes and their use in research and medical applications
AU2878600A (en) 1999-03-01 2000-09-21 Hadasit Medical Research Services & Development Company Ltd Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells
US7781416B2 (en) 2000-01-25 2010-08-24 Sigma-Tau Research Switzerland S.A. Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
IT1316986B1 (en) 2000-01-25 2003-05-26 Sigma Tau Ind Farmaceuti GLYCOSAMINOGLICAN DERIVATIVES PARTIALLY DESULPHATED NONANTICOAGULANTS WITH ANTIANGIOGENIC ACTIVITY.
US7879824B2 (en) 2001-07-31 2011-02-01 Dermal Research Laboratories, Inc. Methods of preventing or treating diseases and conditions using complex carbohydrates
CA2417867C (en) * 2000-07-31 2012-09-11 Dermal Research Laboratories, Inc. Methods of preventing or treating diseases and conditions using complex carbohydrates
KR100855331B1 (en) * 2001-09-12 2008-09-04 시그마타우 리서치 스위츠랜드 에스.에이 Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
US7538096B2 (en) 2004-03-16 2009-05-26 The General Hospital Corporation Treatment and prevention of abnormal cellular proliferation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2553287B1 (en) * 1983-10-18 1986-09-12 Choay Sa COMPOSITIONS BASED ON MUCOPOLYSACCHARIDES OR OLIGOSACCHARIDES, ESPECIALLY BASED ON HEPARIN FRACTIONS OR FRAGMENTS, SUITABLE FOR THE TREATMENT OF CELL PROLIFERATION DISORDERS
JPS6117A (en) * 1984-06-11 1986-01-06 Seikagaku Kogyo Co Ltd Mucopolysaccharide-type cancer-metastatis suppressing agent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU637143B2 (en) * 1989-10-04 1993-05-20 N.V. Organon Sulphated glycosaminoglycuronan with antithrombotic activity

Also Published As

Publication number Publication date
WO1988001280A1 (en) 1988-02-25

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