ATE348115T1 - Teildesulfatierte glykosaminoglykanderivate mit antiangiogenischer aktivität und ohne antikoagulierender wirkung - Google Patents

Teildesulfatierte glykosaminoglykanderivate mit antiangiogenischer aktivität und ohne antikoagulierender wirkung

Info

Publication number
ATE348115T1
ATE348115T1 AT01906098T AT01906098T ATE348115T1 AT E348115 T1 ATE348115 T1 AT E348115T1 AT 01906098 T AT01906098 T AT 01906098T AT 01906098 T AT01906098 T AT 01906098T AT E348115 T1 ATE348115 T1 AT E348115T1
Authority
AT
Austria
Prior art keywords
glycosaminoglycan derivatives
antiangiogenic activity
anticoagulant effect
partially desulphated
desulphated glycosaminoglycan
Prior art date
Application number
AT01906098T
Other languages
English (en)
Inventor
Benito Casu
Giangiacomo Torri
Anna Maria Naggi
Giuseppe Giannini
S P A Riunite
Claudio Pisano
Sergio Penco
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Application granted granted Critical
Publication of ATE348115T1 publication Critical patent/ATE348115T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
AT01906098T 2000-01-25 2001-01-24 Teildesulfatierte glykosaminoglykanderivate mit antiangiogenischer aktivität und ohne antikoagulierender wirkung ATE348115T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2000RM000041A IT1316986B1 (it) 2000-01-25 2000-01-25 Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica.

Publications (1)

Publication Number Publication Date
ATE348115T1 true ATE348115T1 (de) 2007-01-15

Family

ID=11454382

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01906098T ATE348115T1 (de) 2000-01-25 2001-01-24 Teildesulfatierte glykosaminoglykanderivate mit antiangiogenischer aktivität und ohne antikoagulierender wirkung

Country Status (21)

Country Link
US (4) US20030013682A1 (de)
EP (1) EP1268558B1 (de)
JP (1) JP5371167B2 (de)
KR (1) KR100812406B1 (de)
CN (1) CN100540570C (de)
AT (1) ATE348115T1 (de)
AU (1) AU782632B2 (de)
BR (1) BR0107696A (de)
CA (1) CA2397964C (de)
CY (1) CY1108001T1 (de)
CZ (1) CZ303030B6 (de)
DE (1) DE60125154T2 (de)
DK (1) DK1268558T3 (de)
ES (1) ES2277911T3 (de)
HU (1) HU229509B1 (de)
IT (1) IT1316986B1 (de)
MX (1) MXPA02007195A (de)
PL (1) PL209479B1 (de)
PT (1) PT1268558E (de)
SK (1) SK287566B6 (de)
WO (1) WO2001055221A1 (de)

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AU2008202261B2 (en) * 2001-09-12 2011-07-28 Leadiant Biosciences S.A. Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
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WO2009007224A1 (en) * 2007-07-10 2009-01-15 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Low molecular weight heparin derivatives having neuroprotective activity
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JP6132302B2 (ja) * 2013-05-28 2017-05-24 リーディアント・バイオサイエンシーズ・ソシエタ・アノニマＬｅａｄｉａｎｔ Ｂｉｏｓｃｉｅｎｃｅｓ Ｓ．Ａ． 抗血管新生活性を有し、抗凝血効果を有さない、ヘパラナーゼ阻害剤としての部分的に脱硫酸化されたグリコサミノグリカンの誘導体
ITLO20130005A1 (it) 2013-10-31 2015-05-01 He E Biochimiche G Ronzonr S R Derivati di glucosamminoglicani n-desolfatati e loro uso come farmaci
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CN108424474B (zh) * 2017-02-15 2023-07-25 清华大学 去抗凝肝素衍生物及其用于炎症性肠病的治疗
CN111670038B (zh) * 2018-02-02 2024-01-26 深圳市海普瑞药业集团股份有限公司 糖胺聚糖衍生物及其制备方法和用途
EP3705126A1 (de) 2019-03-05 2020-09-09 Leadiant Biosciences S.p.A. Roneparstat zur behandlung von amyloidose
WO2021128253A1 (zh) * 2019-12-27 2021-07-01 深圳市海普瑞药业集团股份有限公司 一种糖胺聚糖衍生物及其应用

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Also Published As

Publication number Publication date
AU3406401A (en) 2001-08-07
US20050107331A1 (en) 2005-05-19
JP2003523460A (ja) 2003-08-05
ITRM20000041A1 (it) 2001-07-25
JP5371167B2 (ja) 2013-12-18
HK1051867A1 (zh) 2003-08-22
BR0107696A (pt) 2002-10-15
EP1268558B1 (de) 2006-12-13
MXPA02007195A (es) 2003-01-28
ITRM20000041A0 (it) 2000-01-25
HUP0204196A3 (en) 2003-05-28
SK10672002A3 (sk) 2002-12-03
US20100298263A1 (en) 2010-11-25
AU782632B2 (en) 2005-08-18
KR20020080381A (ko) 2002-10-23
CZ20022308A3 (cs) 2003-01-15
US20050222084A1 (en) 2005-10-06
HU229509B1 (en) 2014-01-28
DE60125154D1 (de) 2007-01-25
DK1268558T3 (da) 2007-04-10
WO2001055221A1 (en) 2001-08-02
CN1396930A (zh) 2003-02-12
CA2397964A1 (en) 2001-08-02
US20030013682A1 (en) 2003-01-16
IT1316986B1 (it) 2003-05-26
CN100540570C (zh) 2009-09-16
PL209479B1 (pl) 2011-09-30
ES2277911T3 (es) 2007-08-01
SK287566B6 (sk) 2011-02-04
CY1108001T1 (el) 2013-09-04
HUP0204196A2 (hu) 2003-03-28
DE60125154T2 (de) 2007-10-25
EP1268558A1 (de) 2003-01-02
CZ303030B6 (cs) 2012-03-07
US8222231B2 (en) 2012-07-17
KR100812406B1 (ko) 2008-03-11
US7790700B2 (en) 2010-09-07
PL357209A1 (en) 2004-07-26
CA2397964C (en) 2010-10-12
PT1268558E (pt) 2007-02-28

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