DK1268558T3 - Derivater af delvist desulfaterede glycosaminoglycaner forsynet med antiangionisk aktivitet og uden antikoagulerende virkning - Google Patents

Derivater af delvist desulfaterede glycosaminoglycaner forsynet med antiangionisk aktivitet og uden antikoagulerende virkning

Info

Publication number
DK1268558T3
DK1268558T3 DK01906098T DK01906098T DK1268558T3 DK 1268558 T3 DK1268558 T3 DK 1268558T3 DK 01906098 T DK01906098 T DK 01906098T DK 01906098 T DK01906098 T DK 01906098T DK 1268558 T3 DK1268558 T3 DK 1268558T3
Authority
DK
Denmark
Prior art keywords
activity
derivatives
antiangionic
anticoagulant effect
partially desulfated
Prior art date
Application number
DK01906098T
Other languages
Danish (da)
English (en)
Inventor
Benito Casu
Giangiacomo Torri
Anna Maria Naggi
Giuseppe Sigma-Tau Giannini
Claudio Sigma-Tau Pisano
Sergio Penco
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Application granted granted Critical
Publication of DK1268558T3 publication Critical patent/DK1268558T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Diabetes (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DK01906098T 2000-01-25 2001-01-24 Derivater af delvist desulfaterede glycosaminoglycaner forsynet med antiangionisk aktivitet og uden antikoagulerende virkning DK1268558T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2000RM000041A IT1316986B1 (it) 2000-01-25 2000-01-25 Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica.
PCT/IT2001/000034 WO2001055221A1 (en) 2000-01-25 2001-01-24 Derivatives of partially desulphated glycosaminoglycans endowed with antiangiogenic activity and devoid of anticoagulating effect

Publications (1)

Publication Number Publication Date
DK1268558T3 true DK1268558T3 (da) 2007-04-10

Family

ID=11454382

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01906098T DK1268558T3 (da) 2000-01-25 2001-01-24 Derivater af delvist desulfaterede glycosaminoglycaner forsynet med antiangionisk aktivitet og uden antikoagulerende virkning

Country Status (22)

Country Link
US (4) US20030013682A1 (de)
EP (1) EP1268558B1 (de)
JP (1) JP5371167B2 (de)
KR (1) KR100812406B1 (de)
CN (1) CN100540570C (de)
AT (1) ATE348115T1 (de)
AU (1) AU782632B2 (de)
BR (1) BR0107696A (de)
CA (1) CA2397964C (de)
CY (1) CY1108001T1 (de)
CZ (1) CZ303030B6 (de)
DE (1) DE60125154T2 (de)
DK (1) DK1268558T3 (de)
ES (1) ES2277911T3 (de)
HK (1) HK1051867A1 (de)
HU (1) HU229509B1 (de)
IT (1) IT1316986B1 (de)
MX (1) MXPA02007195A (de)
PL (1) PL209479B1 (de)
PT (1) PT1268558E (de)
SK (1) SK287566B6 (de)
WO (1) WO2001055221A1 (de)

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IT1316986B1 (it) 2000-01-25 2003-05-26 Sigma Tau Ind Farmaceuti Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica.
AU2008202261B2 (en) * 2001-09-12 2011-07-28 Leadiant Biosciences S.A. Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
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JP6132302B2 (ja) * 2013-05-28 2017-05-24 リーディアント・バイオサイエンシーズ・ソシエタ・アノニマＬｅａｄｉａｎｔ Ｂｉｏｓｃｉｅｎｃｅｓ Ｓ．Ａ． 抗血管新生活性を有し、抗凝血効果を有さない、ヘパラナーゼ阻害剤としての部分的に脱硫酸化されたグリコサミノグリカンの誘導体
US10016449B2 (en) 2013-05-28 2018-07-10 Momenta Pharmaceuticals, Inc. Pharmaceutical compositions
ITLO20130005A1 (it) 2013-10-31 2015-05-01 He E Biochimiche G Ronzonr S R Derivati di glucosamminoglicani n-desolfatati e loro uso come farmaci
ITLO20130006A1 (it) 2013-11-06 2015-05-07 He E Biochimiche G Ronzoni S R Derivati carbossilati di glucosamminoglicani e loro uso come farmaci
CN103724458B (zh) * 2014-01-17 2016-03-30 福州大学 含n-非取代葡萄糖胺肝素六糖的制备及其纯化
US10576101B2 (en) 2015-03-06 2020-03-03 Leadiant Biosciences Sa Roneparstat combined therapy of multiple myeloma
JP2016014148A (ja) * 2015-09-10 2016-01-28 シグマ−タウ・リサーチ・スウィッツァーランド・ソシエテ・アノニム 抗血管新生活性を有し、抗凝血効果を有さない、ヘパラナーゼ阻害剤としての部分的に脱硫酸化されたグリコサミノグリカンの誘導体
CN107177015A (zh) * 2016-03-11 2017-09-19 梁颖 一种重乙酰化肝素修饰物及其制备方法和应用
US11787783B2 (en) 2016-12-13 2023-10-17 Beta Therapeutics Pty Ltd Heparanase inhibitors and use thereof
CA3046997A1 (en) 2016-12-13 2018-06-21 Beta Therapeutics Pty Ltd Heparanase inhibitors and use thereof
CN108424474B (zh) * 2017-02-15 2023-07-25 清华大学 去抗凝肝素衍生物及其用于炎症性肠病的治疗
US11225531B2 (en) 2018-02-02 2022-01-18 Shenzhen Hepalink Pharmaceutical Group Co., Ltd. Glycosaminoglycan derivative and preparation method therefor and use thereof
EP3705126A1 (de) 2019-03-05 2020-09-09 Leadiant Biosciences S.p.A. Roneparstat zur behandlung von amyloidose
CN114901702B (zh) * 2019-12-27 2024-01-09 深圳市海普瑞药业集团股份有限公司 一种糖胺聚糖衍生物及其应用

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IT1316986B1 (it) * 2000-01-25 2003-05-26 Sigma Tau Ind Farmaceuti Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica.

Also Published As

Publication number Publication date
DE60125154D1 (de) 2007-01-25
HU229509B1 (en) 2014-01-28
HUP0204196A3 (en) 2003-05-28
SK287566B6 (sk) 2011-02-04
CZ303030B6 (cs) 2012-03-07
MXPA02007195A (es) 2003-01-28
CZ20022308A3 (cs) 2003-01-15
DE60125154T2 (de) 2007-10-25
CN1396930A (zh) 2003-02-12
WO2001055221A1 (en) 2001-08-02
ITRM20000041A0 (it) 2000-01-25
US7790700B2 (en) 2010-09-07
PT1268558E (pt) 2007-02-28
AU3406401A (en) 2001-08-07
SK10672002A3 (sk) 2002-12-03
ES2277911T3 (es) 2007-08-01
CY1108001T1 (el) 2013-09-04
US20050107331A1 (en) 2005-05-19
US8222231B2 (en) 2012-07-17
IT1316986B1 (it) 2003-05-26
AU782632B2 (en) 2005-08-18
CA2397964A1 (en) 2001-08-02
US20100298263A1 (en) 2010-11-25
BR0107696A (pt) 2002-10-15
KR100812406B1 (ko) 2008-03-11
HUP0204196A2 (hu) 2003-03-28
EP1268558B1 (de) 2006-12-13
EP1268558A1 (de) 2003-01-02
JP2003523460A (ja) 2003-08-05
CN100540570C (zh) 2009-09-16
JP5371167B2 (ja) 2013-12-18
PL209479B1 (pl) 2011-09-30
US20050222084A1 (en) 2005-10-06
HK1051867A1 (en) 2003-08-22
CA2397964C (en) 2010-10-12
ITRM20000041A1 (it) 2001-07-25
KR20020080381A (ko) 2002-10-23
US20030013682A1 (en) 2003-01-16
ATE348115T1 (de) 2007-01-15
PL357209A1 (en) 2004-07-26

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