CY1112551T1 - Παραγωγα μερικως αποσουλφωμενων γλυκοζαμινογλυκανων ως αναστολεις ηπαρανασης, τα οποια διαθετουν αντιαγγειογονο δραστικοτητα και στερουνται αντιπηκτικης επιδρασης - Google Patents

Παραγωγα μερικως αποσουλφωμενων γλυκοζαμινογλυκανων ως αναστολεις ηπαρανασης, τα οποια διαθετουν αντιαγγειογονο δραστικοτητα και στερουνται αντιπηκτικης επιδρασης

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Publication number
CY1112551T1
CY1112551T1 CY20111100823T CY111100823T CY1112551T1 CY 1112551 T1 CY1112551 T1 CY 1112551T1 CY 20111100823 T CY20111100823 T CY 20111100823T CY 111100823 T CY111100823 T CY 111100823T CY 1112551 T1 CY1112551 T1 CY 1112551T1
Authority
CY
Cyprus
Prior art keywords
activity
derivatives
glycosaminoglycans
inhibitors
partially released
Prior art date
Application number
CY20111100823T
Other languages
English (en)
Inventor
B Casu
G Torri
A Naggi
Giuseppe Giannini
Claudio Pisano
Sergio Penco
Original Assignee
Sigma-Tau Research Switzerland S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma-Tau Research Switzerland S.A. filed Critical Sigma-Tau Research Switzerland S.A.
Publication of CY1112551T1 publication Critical patent/CY1112551T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)

Abstract

Περιγράφονται μερικώς αποσουλφωμένα παράγωγα γλυκοζαμινο-γλυκάνης, ιδίως η ηπαρίνη, και πιο συγκεκριμένα ενώσεις του τύπου (I) όπου οι ομάδες U, R και R1 έχουν τις σημασίες που υποδεικνύονται στην περιγραφή. Τα εν λόγω παράγωγα γλυκοζαμινογλυκάνης διαθέτουν αντι-αγγειογόνο και ανασταλτική της ηπαρανάσης δραστικότητα και στερούνται αντιπηκτικής δραστικότητας.
CY20111100823T 2001-09-12 2011-08-29 Παραγωγα μερικως αποσουλφωμενων γλυκοζαμινογλυκανων ως αναστολεις ηπαρανασης, τα οποια διαθετουν αντιαγγειογονο δραστικοτητα και στερουνται αντιπηκτικης επιδρασης CY1112551T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/IT2001/000472 WO2003022291A1 (en) 2001-09-12 2001-09-12 Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
EP01972468A EP1427427B1 (en) 2001-09-12 2001-09-12 Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect

Publications (1)

Publication Number Publication Date
CY1112551T1 true CY1112551T1 (el) 2016-02-10

Family

ID=11133723

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20111100823T CY1112551T1 (el) 2001-09-12 2011-08-29 Παραγωγα μερικως αποσουλφωμενων γλυκοζαμινογλυκανων ως αναστολεις ηπαρανασης, τα οποια διαθετουν αντιαγγειογονο δραστικοτητα και στερουνται αντιπηκτικης επιδρασης
CY20131100685T CY1114544T1 (el) 2001-09-12 2013-08-09 Παραγωγα πληρως ν-αποθειωμενων γλυκοζαμινογλυκανων ως αναστολεις ηπαρανασης, τα οποια διαθετουν αντιαγγειογονικη δραστικοτητα και δεν επιφερουν αντιθρομβωτικο αποτελεσμα

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20131100685T CY1114544T1 (el) 2001-09-12 2013-08-09 Παραγωγα πληρως ν-αποθειωμενων γλυκοζαμινογλυκανων ως αναστολεις ηπαρανασης, τα οποια διαθετουν αντιαγγειογονικη δραστικοτητα και δεν επιφερουν αντιθρομβωτικο αποτελεσμα

Country Status (20)

Country Link
US (1) US20050137167A1 (el)
EP (2) EP2343077B1 (el)
JP (1) JP2005506326A (el)
KR (1) KR100855331B1 (el)
CN (1) CN1547477B (el)
AT (1) ATE511846T1 (el)
AU (1) AU2001292231B2 (el)
BR (1) BR0117124A (el)
CA (1) CA2457719C (el)
CY (2) CY1112551T1 (el)
CZ (1) CZ307433B6 (el)
DK (1) DK1427427T3 (el)
ES (2) ES2367778T3 (el)
HK (1) HK1069537A1 (el)
HU (1) HU230385B1 (el)
MX (1) MXPA04002217A (el)
PT (2) PT2343077E (el)
SI (1) SI1427427T1 (el)
SK (1) SK288335B6 (el)
WO (1) WO2003022291A1 (el)

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Also Published As

Publication number Publication date
CN1547477B (zh) 2010-12-22
SI1427427T1 (sl) 2011-10-28
SK288335B6 (sk) 2016-02-02
US20050137167A1 (en) 2005-06-23
CY1114544T1 (el) 2016-10-05
ES2367778T3 (es) 2011-11-08
CA2457719A1 (en) 2003-03-20
EP1427427A1 (en) 2004-06-16
AU2001292231B2 (en) 2008-06-05
CZ307433B6 (cs) 2018-08-22
JP2005506326A (ja) 2005-03-03
PT2343077E (pt) 2013-08-29
HUP0401693A2 (hu) 2004-12-28
EP2343077A1 (en) 2011-07-13
BR0117124A (pt) 2004-09-28
CZ2004255A3 (cs) 2004-11-10
HU230385B1 (hu) 2016-03-29
KR20040048404A (ko) 2004-06-09
CA2457719C (en) 2012-01-03
DK1427427T3 (da) 2011-09-19
EP2343077B1 (en) 2013-07-17
SK1602004A3 (en) 2004-08-03
PT1427427E (pt) 2011-09-13
MXPA04002217A (es) 2004-07-08
KR100855331B1 (ko) 2008-09-04
ATE511846T1 (de) 2011-06-15
HK1069537A1 (en) 2005-05-27
WO2003022291A1 (en) 2003-03-20
CN1547477A (zh) 2004-11-17
EP1427427B1 (en) 2011-06-08
HUP0401693A3 (en) 2009-06-29
ES2431362T3 (es) 2013-11-26

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