HUP0204196A2 - Antiangiogén aktivitással rendelkező és antikoaguláns hatástól mentes részlegesen deszulfatált glükózamininoglikán-származékok, eljárás előállításukra és ilyen vegyületeket tartalmazó gyógyászati készítmények - Google Patents
Antiangiogén aktivitással rendelkező és antikoaguláns hatástól mentes részlegesen deszulfatált glükózamininoglikán-származékok, eljárás előállításukra és ilyen vegyületeket tartalmazó gyógyászati készítményekInfo
- Publication number
- HUP0204196A2 HUP0204196A2 HU0204196A HUP0204196A HUP0204196A2 HU P0204196 A2 HUP0204196 A2 HU P0204196A2 HU 0204196 A HU0204196 A HU 0204196A HU P0204196 A HUP0204196 A HU P0204196A HU P0204196 A2 HUP0204196 A2 HU P0204196A2
- Authority
- HU
- Hungary
- Prior art keywords
- endowed
- devoid
- derivatives
- antiangiogenic activity
- preparation
- Prior art date
Links
- 229920002683 Glycosaminoglycan Polymers 0.000 title abstract 2
- 230000001772 anti-angiogenic effect Effects 0.000 title abstract 2
- 230000002429 anti-coagulating effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- AEMOLEFTQBMNLQ-PKKLWIBTSA-N D-Alluronic Acid Chemical group OC1O[C@H](C(O)=O)[C@@H](O)[C@@H](O)[C@H]1O AEMOLEFTQBMNLQ-PKKLWIBTSA-N 0.000 abstract 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003172 aldehyde group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 150000004676 glycans Polymers 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000002482 oligosaccharides Polymers 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000004804 polysaccharides Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/727—Heparin; Heparan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Toxicology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
A találmány tárgya 2-O-deszulfatált glükózaminoglikán-származék,közelebbről 2-O-deszulfatált heparin, melynek 2-O-deszulfatáltságifoka nem nagyobb az összes uronsavegység 60%-ánál. Közelebbről atalálmány tárgyát képezi az (I) általános képletű származék, ahol X ésX' jelentése aldehidcsoport vagy -CH2-D általános képletű csoport,ahol D jelentése hidroxilcsoport vagy aminosav, peptid vagy szénhidrátvagy oligoszacharid maradék; R és R1 jelentése SO3 képletű csoportvagy acilmaradék; n és m értéke egymástól függetlenül 1 és 40 közöttiszám; az n + m összege 6 és 40 közötti; az m:n aránya 10:2 és 1:1közötti, szimbólum azt jelzi, hogy az m és n jelzésű egységekstatisztikusan oszlanak el a poliszacharidlánc mentén és nemszükségszerűen egymás után. A találmány szerinti vegyületekantiangiogén aktivitással rendelkeznek és antikoaguláns hatástólmentesek. A találmány kiterjed továbbá a fenti vegyületek előállításieljárására és a vegyületeket tartalmazó gyógyászati készítményekre. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2000RM000041A IT1316986B1 (it) | 2000-01-25 | 2000-01-25 | Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica. |
| PCT/IT2001/000034 WO2001055221A1 (en) | 2000-01-25 | 2001-01-24 | Derivatives of partially desulphated glycosaminoglycans endowed with antiangiogenic activity and devoid of anticoagulating effect |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HUP0204196A2 true HUP0204196A2 (hu) | 2003-03-28 |
| HUP0204196A3 HUP0204196A3 (en) | 2003-05-28 |
| HU229509B1 HU229509B1 (en) | 2014-01-28 |
Family
ID=11454382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0204196A HU229509B1 (en) | 2000-01-25 | 2001-01-24 | Derivatives of partially desulphated glycosaminoglycans endowed with antiangiogenic activity and devoid of anticoagulating effect, process for their preparation and pharmaceutical compositions containing them |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US20030013682A1 (hu) |
| EP (1) | EP1268558B1 (hu) |
| JP (1) | JP5371167B2 (hu) |
| KR (1) | KR100812406B1 (hu) |
| CN (1) | CN100540570C (hu) |
| AT (1) | ATE348115T1 (hu) |
| AU (1) | AU782632B2 (hu) |
| BR (1) | BR0107696A (hu) |
| CA (1) | CA2397964C (hu) |
| CY (1) | CY1108001T1 (hu) |
| CZ (1) | CZ303030B6 (hu) |
| DE (1) | DE60125154T2 (hu) |
| DK (1) | DK1268558T3 (hu) |
| ES (1) | ES2277911T3 (hu) |
| HK (1) | HK1051867A1 (hu) |
| HU (1) | HU229509B1 (hu) |
| IT (1) | IT1316986B1 (hu) |
| MX (1) | MXPA02007195A (hu) |
| PL (1) | PL209479B1 (hu) |
| PT (1) | PT1268558E (hu) |
| SK (1) | SK287566B6 (hu) |
| WO (1) | WO2001055221A1 (hu) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7781416B2 (en) | 2000-01-25 | 2010-08-24 | Sigma-Tau Research Switzerland S.A. | Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect |
| IT1316986B1 (it) | 2000-01-25 | 2003-05-26 | Sigma Tau Ind Farmaceuti | Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica. |
| KR100855331B1 (ko) * | 2001-09-12 | 2008-09-04 | 시그마타우 리서치 스위츠랜드 에스.에이 | 혈관형성 억제 활성을 가지며 응고억제 효과는 없는,헤파라나제 억제제로서 부분적으로 탈황산화된글리코스아미노글리칸의 유도체 |
| AU2008202261B2 (en) * | 2001-09-12 | 2011-07-28 | Leadiant Biosciences S.A. | Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect |
| EP1765874A1 (en) | 2004-03-26 | 2007-03-28 | Glycogenesys, Inc. | Modified pectins, compositions and methods related thereto |
| WO2009007224A1 (en) * | 2007-07-10 | 2009-01-15 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Low molecular weight heparin derivatives having neuroprotective activity |
| US8569262B2 (en) | 2007-11-02 | 2013-10-29 | Momenta Pharmaceuticals, Inc. | Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization |
| US8592393B2 (en) | 2007-11-02 | 2013-11-26 | Momenta Pharmaceuticals, Inc. | Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization |
| JP5572095B2 (ja) * | 2007-11-02 | 2014-08-13 | モメンタ ファーマシューティカルズ インコーポレイテッド | 非抗凝固性多糖組成物 |
| EP2205642B1 (en) * | 2007-11-02 | 2016-01-27 | Momenta Pharmaceuticals, Inc. | Non-anticoagulant polysaccharide compositions |
| CN102985443B (zh) | 2010-04-16 | 2017-05-10 | 动量制药公司 | 组织靶向 |
| US8431826B2 (en) | 2010-05-14 | 2013-04-30 | James Robert Howard | Capacitive power and ground plane structure utilizing fractal elements for the reduction of radiated emissions |
| BR112012031906A2 (pt) | 2010-06-17 | 2016-08-23 | Momenta Pharmaceuticals Inc | métodos e composições para modular o crescimento de cabelo e pelos. |
| WO2013095215A1 (en) | 2011-12-19 | 2013-06-27 | Dilaforette Ab | Low anticoagulant heparins |
| RS56874B1 (sr) | 2011-12-19 | 2018-04-30 | Dilafor Ab | Glikozaminoglikani koji nisu antikoagulanti koji sadrže ponavljajuću jedinicu disaharida i njihova medicinska upotreba |
| BR112014015940B1 (pt) | 2011-12-28 | 2022-08-09 | Galectin Therapeutics, Inc | Polissacarídeo de grau farmacêutico, composição, e seus usos |
| KR102071739B1 (ko) | 2012-06-06 | 2020-01-30 | 갈렉틴 테라퓨틱스, 인크. | 상승된 유도성 산화 질소 합성효소와 연관된 질환의 치료를 위한 갈락토-람노갈락투로네이트 조성물 |
| US9507912B2 (en) | 2012-08-31 | 2016-11-29 | Nuvectra Corporation | Method and system of simulating a pulse generator on a clinician programmer |
| AU2013315019B2 (en) | 2012-09-17 | 2017-06-01 | Galectin Therapeutics, Inc. | Method for enhancing specific immunotherapies in cancer treatment |
| BR112015007985A8 (pt) | 2012-10-10 | 2019-08-27 | Galectin Therapeutics Inc | uso do carboidrato galactose denteada para preparação de composições para tratamento de nefropatia diabética e de distúrbios associados, e suas composições |
| WO2014130648A1 (en) | 2013-02-20 | 2014-08-28 | Galectin Therapeutics, Inc. | Method for treatment of pulmonary fibrosis |
| WO2014193818A1 (en) | 2013-05-28 | 2014-12-04 | Momenta Pharmaceuticals, Inc. | Pharmaceutical compositions |
| JP6132302B2 (ja) * | 2013-05-28 | 2017-05-24 | リーディアント・バイオサイエンシーズ・ソシエタ・アノニマＬｅａｄｉａｎｔ Ｂｉｏｓｃｉｅｎｃｅｓ Ｓ．Ａ． | 抗血管新生活性を有し、抗凝血効果を有さない、ヘパラナーゼ阻害剤としての部分的に脱硫酸化されたグリコサミノグリカンの誘導体 |
| ITLO20130005A1 (it) * | 2013-10-31 | 2015-05-01 | He E Biochimiche G Ronzonr S R | Derivati di glucosamminoglicani n-desolfatati e loro uso come farmaci |
| ITLO20130006A1 (it) * | 2013-11-06 | 2015-05-07 | He E Biochimiche G Ronzoni S R | Derivati carbossilati di glucosamminoglicani e loro uso come farmaci |
| CN103724458B (zh) * | 2014-01-17 | 2016-03-30 | 福州大学 | 含n-非取代葡萄糖胺肝素六糖的制备及其纯化 |
| US10576101B2 (en) | 2015-03-06 | 2020-03-03 | Leadiant Biosciences Sa | Roneparstat combined therapy of multiple myeloma |
| JP2016014148A (ja) * | 2015-09-10 | 2016-01-28 | シグマ−タウ・リサーチ・スウィッツァーランド・ソシエテ・アノニム | 抗血管新生活性を有し、抗凝血効果を有さない、ヘパラナーゼ阻害剤としての部分的に脱硫酸化されたグリコサミノグリカンの誘導体 |
| CN107177015A (zh) * | 2016-03-11 | 2017-09-19 | 梁颖 | 一种重乙酰化肝素修饰物及其制备方法和应用 |
| KR20190093214A (ko) | 2016-12-13 | 2019-08-08 | 베타 테라퓨틱스 피티와이 리미티드 | 헤파라나제 억제제 및 그의 용도 |
| US11787783B2 (en) | 2016-12-13 | 2023-10-17 | Beta Therapeutics Pty Ltd | Heparanase inhibitors and use thereof |
| CN108424474B (zh) * | 2017-02-15 | 2023-07-25 | 清华大学 | 去抗凝肝素衍生物及其用于炎症性肠病的治疗 |
| US11225531B2 (en) | 2018-02-02 | 2022-01-18 | Shenzhen Hepalink Pharmaceutical Group Co., Ltd. | Glycosaminoglycan derivative and preparation method therefor and use thereof |
| EP3705126A1 (en) | 2019-03-05 | 2020-09-09 | Leadiant Biosciences S.p.A. | Roneparstat for the treatment of amyloidosis |
| CN114901702B (zh) * | 2019-12-27 | 2024-01-09 | 深圳市海普瑞药业集团股份有限公司 | 一种糖胺聚糖衍生物及其应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4500519A (en) * | 1978-11-06 | 1985-02-19 | Choay S.A. | Mucopolysaccharides having biological properties, preparation and method of use |
| US5262403A (en) | 1986-03-10 | 1993-11-16 | Board Of Regents, The University Of Texas System | Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness of metastatic profusion-II |
| IL79255A0 (en) | 1986-06-26 | 1986-09-30 | Hadassah Med Org | Composition for metastasis prevention |
| AU7852687A (en) * | 1986-08-21 | 1988-03-08 | University Of Texas System, The | Glycosaminoglycan derivatives and their use as inhibitors of tumor invasiveness or metastatic profusion |
| FR2614026B1 (fr) * | 1987-04-16 | 1992-04-17 | Sanofi Sa | Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques |
| US5280016A (en) * | 1991-03-29 | 1994-01-18 | Glycomed Incorporated | Non-anticoagulant heparin derivatives |
| JPH05157344A (ja) * | 1991-12-09 | 1993-06-22 | Mitsubishi Heavy Ind Ltd | 空気調和機の吹出口 |
| JPH0512822A (ja) | 1991-12-16 | 1993-01-22 | Seiko Epson Corp | カートリツジ |
| JPH06157344A (ja) * | 1992-02-07 | 1994-06-03 | Childrens Medical Center Corp:The | 血管新生阻害のための医薬製剤及び血管新生阻害方法 |
| US5668118A (en) * | 1992-07-24 | 1997-09-16 | Cavalier Pharmaceuticals | Method of synthesis of 2-O-desulfated Heparin and use thereof for inhibition of elastase and Cathepspin G |
| US5296471A (en) | 1992-12-22 | 1994-03-22 | Glycomed Incorporated | Method for controlling o-desulfation of heparin and compositions produced thereby |
| US5696100A (en) * | 1992-12-22 | 1997-12-09 | Glycomed Incorporated | Method for controlling O-desulfation of heparin and compositions produced thereby |
| IT1264709B1 (it) | 1993-07-12 | 1996-10-04 | Italfarmaco Spa | Derivati eparinici ad attivita' antimetastatica |
| US5583121A (en) * | 1994-01-12 | 1996-12-10 | Michigan State University | Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes |
| AU2435795A (en) * | 1994-05-06 | 1995-11-29 | Glycomed Incorporated | O-desulfated heparin derivatives, methods of making and uses thereof |
| IL114951A (en) * | 1995-08-15 | 1999-08-17 | Hadasit Med Res Service | Quinazolinone-containing pharmaceutical compositions for prevention of neovascularization |
| US5854221A (en) * | 1996-12-12 | 1998-12-29 | The Children's Medical Center Corporation | Endothelial cell proliferation inhibitor and method of use |
| NZ326354A (en) * | 1996-01-15 | 1999-05-28 | Janssen Pharmaceutica Nv | 3-(substituted-1-piperazinyl)-6-(substituted-1,2,4-thiadiazol-5 -yl)-pyridazine derivatives and medicaments |
| JP4051099B2 (ja) * | 1997-01-31 | 2008-02-20 | 生化学工業株式会社 | 低分子化ヘパリン、その製造法及び医薬組成物 |
| IT1296581B1 (it) * | 1997-11-28 | 1999-07-14 | Istituto Scient Di Chimica E B | Materiali polimerici non trombogenici e ad esaltata compatibilita' con fluidi e tessuti organici |
| IT1296998B1 (it) * | 1997-12-19 | 1999-08-03 | Derivati Organici Lab | Composizione costituita da frazioni di eparina avente caratteristiche riproducibili con peso molecolare medio di 5200 d |
| US7781416B2 (en) * | 2000-01-25 | 2010-08-24 | Sigma-Tau Research Switzerland S.A. | Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect |
| IT1316986B1 (it) * | 2000-01-25 | 2003-05-26 | Sigma Tau Ind Farmaceuti | Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica. |
-
2000
- 2000-01-25 IT IT2000RM000041A patent/IT1316986B1/it active
-
2001
- 2001-01-24 WO PCT/IT2001/000034 patent/WO2001055221A1/en active IP Right Grant
- 2001-01-24 DE DE60125154T patent/DE60125154T2/de not_active Expired - Lifetime
- 2001-01-24 US US10/182,185 patent/US20030013682A1/en not_active Abandoned
- 2001-01-24 HU HU0204196A patent/HU229509B1/hu not_active IP Right Cessation
- 2001-01-24 SK SK1067-2002A patent/SK287566B6/sk not_active IP Right Cessation
- 2001-01-24 CN CNB018040942A patent/CN100540570C/zh not_active Expired - Fee Related
- 2001-01-24 PT PT01906098T patent/PT1268558E/pt unknown
- 2001-01-24 JP JP2001561068A patent/JP5371167B2/ja not_active Expired - Fee Related
- 2001-01-24 PL PL357209A patent/PL209479B1/pl unknown
- 2001-01-24 CZ CZ20022308A patent/CZ303030B6/cs not_active IP Right Cessation
- 2001-01-24 BR BR0107696-5A patent/BR0107696A/pt not_active IP Right Cessation
- 2001-01-24 CA CA2397964A patent/CA2397964C/en not_active Expired - Fee Related
- 2001-01-24 EP EP01906098A patent/EP1268558B1/en not_active Expired - Lifetime
- 2001-01-24 AU AU34064/01A patent/AU782632B2/en not_active Ceased
- 2001-01-24 ES ES01906098T patent/ES2277911T3/es not_active Expired - Lifetime
- 2001-01-24 DK DK01906098T patent/DK1268558T3/da active
- 2001-01-24 AT AT01906098T patent/ATE348115T1/de active
- 2001-01-24 MX MXPA02007195A patent/MXPA02007195A/es active IP Right Grant
- 2001-01-24 KR KR1020027009395A patent/KR100812406B1/ko not_active IP Right Cessation
-
2003
- 2003-06-11 HK HK03104131.9A patent/HK1051867A1/xx not_active IP Right Cessation
-
2004
- 2004-10-19 US US10/967,255 patent/US20050107331A1/en not_active Abandoned
-
2005
- 2005-01-04 US US11/028,512 patent/US7790700B2/en not_active Expired - Fee Related
-
2007
- 2007-02-01 CY CY20071100140T patent/CY1108001T1/el unknown
-
2010
- 2010-08-05 US US12/851,166 patent/US8222231B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HUP0204196A2 (hu) | Antiangiogén aktivitással rendelkező és antikoaguláns hatástól mentes részlegesen deszulfatált glükózamininoglikán-származékok, eljárás előállításukra és ilyen vegyületeket tartalmazó gyógyászati készítmények | |
| Shanmugam et al. | Heparinoid-active sulphated polysaccharides from marine algae as potential blood anticoagulant agents | |
| Wang et al. | Sulfation, anticoagulant and antioxidant activities of polysaccharide from green algae Enteromorpha linza | |
| HUP0401693A2 (hu) | Részlegesen deszulfatált glükóz-amino-glükánok származékai mint a herparanáz enzim inhibitorai, előállításuk és alkalmazásuk, valamint ilyen származékokat tartalmazó gyógyszerkészítmények | |
| US5763421A (en) | Heparin derivatives having antimetastatic activity | |
| HUP0303551A2 (hu) | Biotin vagy biotinszármazékok és antitrombotikus hatású poliszacharidok között legalább egy kovalens kötést tartalmazó vegyületek és ezeket tartalmazó gyógyszerkészítmények | |
| HUP9802394A2 (hu) | Szulfatált oligoszacharidok és ezeket hatóanyagként tartalmazó gyógyszerkészítmények | |
| SI2794667T1 (en) | Low anticoagulant heparins | |
| EP1300412A1 (en) | Hyaluronic acid oligosaccharide fractions and drugs containing the same | |
| CY1112808T1 (el) | Μειγματα ολιγοσακχαριτων προερχομενων απο την ηπαρινη, η παρασκευη τους και φαρμακευτικες συνθεσεις που τα περιεχουν | |
| SI2794665T1 (en) | Non-coagulating glycosaminoglycans containing a recurring disaccharide unit and their medical use | |
| GB1212055A (en) | Stable orally active heparinoid complexes | |
| HU206222B (en) | Process for producing selectively o-acylated glycosaminoglycans and pharmaceutical compositions comprising same | |
| RU2006106790A (ru) | Производные полисахаридов с высокой антитромботической активностью в плазме | |
| HUP0102042A1 (hu) | Új pentaszacharidok, előállítási eljárásuk, valamint az ezeket tartalmazó gyógyszerkészítmények | |
| JP5053512B2 (ja) | 非常に大きい硫酸化度を持つｋ５多糖体のエピマー化誘導体 | |
| JP2010518251A (ja) | ビオチンまたはビオチン誘導体との少なくとも１つの共有結合を含むヘパリン、これらの調製方法およびこれらの使用 | |
| HU211988A9 (en) | New sulfated polysaccharide, pharmaceutically acceptable salts thereof, process for preparation thereof, and drug containing the same | |
| US6900311B2 (en) | O-sulphated bacterial polysaccharides and their use | |
| US6329351B1 (en) | Semi-synthetic sulphaminoheparosansulphates having high anti-metastatic activity and reduced haemorrhagic risk | |
| Sampaio et al. | Insights on chemical-biological correlations learned from investigations on the sulfated galactan from the marine alga Bothryocladia occidentalis | |
| EP0256880B1 (en) | Alkanoyl esters of heparin of low molecular weight | |
| Franz et al. | Novel pharmaceutical applications of polysaccharides | |
| Yuvashri et al. | Chondroitin Sulfate from Marine Invertebrates: Isolation and Applications | |
| EP0956027B1 (en) | Semi-synthetic sulphaminoheparosansulphates having high anti-metastatic activity and reduced haemorrhagic risk |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of definitive patent protection due to non-payment of fees |