HUP0102042A1 - Új pentaszacharidok, előállítási eljárásuk, valamint az ezeket tartalmazó gyógyszerkészítmények - Google Patents

Új pentaszacharidok, előállítási eljárásuk, valamint az ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP0102042A1
HUP0102042A1 HU0102042A HUP0102042A HUP0102042A1 HU P0102042 A1 HUP0102042 A1 HU P0102042A1 HU 0102042 A HU0102042 A HU 0102042A HU P0102042 A HUP0102042 A HU P0102042A HU P0102042 A1 HUP0102042 A1 HU P0102042A1
Authority
HU
Hungary
Prior art keywords
production
methods
same
pharmaceutical compositions
pentasaccharides
Prior art date
Application number
HU0102042A
Other languages
English (en)
Inventor
Maurice Petitou
Original Assignee
Akzo Nobel N.V.
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel N.V., Sanofi-Synthelabo filed Critical Akzo Nobel N.V.
Publication of HUP0102042A1 publication Critical patent/HUP0102042A1/hu
Publication of HUP0102042A3 publication Critical patent/HUP0102042A3/hu
Publication of HU228335B1 publication Critical patent/HU228335B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Jelen találmány sav formában lévő pentaszacharidra és gyógyászatilagelfogadott sóira vonatkozik, amelyekben az anion az alábbi képletnekfelel meg: ahol: - R1 jelentése (C1-C3)alkil; - R jelentése hidrogén,vagy -SO3-, (C1-C3)alkil vagy (C2-C3)acil csoport; - T jelentésehidrogén vagy etilcsoport; - n jelentése 1 vagy 2. A találmányszerinti vegyületek antitrombotikus és antikoaguláns hatássalrendelkeznek. Ó
HU0102042A 1998-01-19 1999-01-13 New pentasaccharides, their methods of production and pharmaceutical compositions comprising same HU228335B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9800514A FR2773801B1 (fr) 1998-01-19 1998-01-19 Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant
PCT/FR1999/000045 WO1999036428A1 (fr) 1998-01-19 1999-01-13 Nouveaux pentasaccharides, procedes pour leurs preparations et compositions pharmaceutiques les contenant

Publications (3)

Publication Number Publication Date
HUP0102042A1 true HUP0102042A1 (hu) 2001-10-28
HUP0102042A3 HUP0102042A3 (en) 2003-07-28
HU228335B1 HU228335B1 (en) 2013-03-28

Family

ID=9521913

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0102042A HU228335B1 (en) 1998-01-19 1999-01-13 New pentasaccharides, their methods of production and pharmaceutical compositions comprising same

Country Status (39)

Country Link
US (1) US6670338B1 (hu)
EP (1) EP1049706B1 (hu)
JP (1) JP4695756B2 (hu)
KR (1) KR100533565B1 (hu)
CN (1) CN1172948C (hu)
AR (1) AR012779A1 (hu)
AT (1) ATE241637T1 (hu)
AU (1) AU744137B2 (hu)
BR (1) BR9907100B1 (hu)
CA (1) CA2318326C (hu)
CO (1) CO4970823A1 (hu)
CZ (1) CZ299817B6 (hu)
DE (1) DE69908298T2 (hu)
DK (1) DK1049706T3 (hu)
DZ (1) DZ2706A1 (hu)
EE (1) EE04194B1 (hu)
EG (1) EG23760A (hu)
ES (1) ES2200494T3 (hu)
FR (1) FR2773801B1 (hu)
GT (1) GT199900006A (hu)
HK (1) HK1029999A1 (hu)
HR (1) HRP20000479B1 (hu)
HU (1) HU228335B1 (hu)
IL (2) IL137240A0 (hu)
MY (1) MY125636A (hu)
NO (1) NO316894B1 (hu)
NZ (1) NZ505614A (hu)
PL (1) PL191098B1 (hu)
PT (1) PT1049706E (hu)
RU (1) RU2193040C2 (hu)
SA (1) SA99191114B1 (hu)
SI (1) SI1049706T1 (hu)
SK (1) SK284176B6 (hu)
TR (1) TR200002077T2 (hu)
TW (1) TW550267B (hu)
UA (1) UA61124C2 (hu)
UY (1) UY25357A1 (hu)
WO (1) WO1999036428A1 (hu)
ZA (1) ZA99357B (hu)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2814463B1 (fr) * 2000-09-22 2002-11-15 Sanofi Synthelabo Nouveaux polysaccharides a activite antithrombotique comprenant au moins une liaison covalente avec la biotine ou un derive de la biotine
AU2003302238A1 (en) 2002-12-03 2004-06-23 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
CN100338084C (zh) * 2004-07-02 2007-09-19 北京大学 抑制异种器官移植免疫排斥反应的五糖抗原的合成方法
FR2874924B1 (fr) 2004-09-09 2006-12-01 Sanofi Aventis Sa Hexadecasaccharides biotinyles, leur preparation et leur utilisation therapeutique
TWI403334B (zh) 2004-12-23 2013-08-01 Merck Sharp & Dohme 包含生物素殘基之抗血栓雙重抑制劑
TWI376234B (en) 2005-02-01 2012-11-11 Msd Oss Bv Conjugates of a polypeptide and an oligosaccharide
US20070191306A1 (en) * 2005-08-17 2007-08-16 Bristol-Myers Squibb Company FACTOR Xa INHIBITOR FORMULATION AND METHOD
EP1908768A1 (en) * 2006-10-05 2008-04-09 Endotis Pharma Anticoagulant compounds
KR101529061B1 (ko) 2008-05-30 2015-06-16 모멘타 파머슈티컬스 인코포레이티드 당류 구조물, 그리고 이러한 구조물의 제조 및 사용 방법
EP2323605A4 (en) * 2008-09-10 2014-02-05 Syneron Medical Ltd TRANSDERMAL RELEASE OF OLIGOSACCHARIDES
US8288515B2 (en) 2009-07-31 2012-10-16 Reliable Biopharmaceutical Corporation Process for preparing Fondaparinux sodium and intermediates useful in the synthesis thereof
US8420790B2 (en) 2009-10-30 2013-04-16 Reliable Biopharmaceutical Corporation Efficient and scalable process for the manufacture of Fondaparinux sodium
WO2012172104A1 (en) 2011-06-17 2012-12-20 Endotis Pharma Synthetic pentasaccharides having short half-life and high activity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0300099A1 (en) * 1987-07-20 1989-01-25 Akzo N.V. New pentasaccharides
IL102758A (en) * 1991-08-23 1997-03-18 Akzo Nv Glycosaminoglycanoid derivatives, their preparation and pharmaceutical compositions comprising them
ES2147216T3 (es) * 1993-09-01 2000-09-01 Akzo Nobel Nv Bisconjugados que comprenden dos sacaridos y un grupo de union.
FR2751334B1 (fr) * 1996-07-19 1998-10-16 Sanofi Sa Polysaccharides synthetiques, procede pour leur preparation et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
AU1974699A (en) 1999-08-02
CO4970823A1 (es) 2000-11-07
SI1049706T1 (en) 2003-12-31
NZ505614A (en) 2003-02-28
GT199900006A (es) 2000-07-12
EP1049706B1 (fr) 2003-05-28
CA2318326A1 (en) 1999-07-22
SK10792000A3 (sk) 2001-01-18
EE200000421A1 (et) 2003-06-16
CA2318326C (en) 2010-07-06
IL137240A0 (en) 2001-07-24
SK284176B6 (sk) 2004-10-05
ES2200494T3 (es) 2004-03-01
AU744137B2 (en) 2002-02-14
PT1049706E (pt) 2003-09-30
US6670338B1 (en) 2003-12-30
PL341874A1 (en) 2001-05-07
DK1049706T3 (da) 2003-09-29
JP4695756B2 (ja) 2011-06-08
TW550267B (en) 2003-09-01
EE200000421A (et) 2001-12-17
AR012779A1 (es) 2000-11-08
ZA99357B (en) 2000-07-19
RU2193040C2 (ru) 2002-11-20
JP2002509154A (ja) 2002-03-26
KR100533565B1 (ko) 2005-12-06
BR9907100B1 (pt) 2013-09-03
CN1172948C (zh) 2004-10-27
KR20010034205A (ko) 2001-04-25
CN1293679A (zh) 2001-05-02
WO1999036428A1 (fr) 1999-07-22
TR200002077T2 (tr) 2000-12-21
HU228335B1 (en) 2013-03-28
EP1049706A1 (fr) 2000-11-08
DZ2706A1 (fr) 2003-09-01
DE69908298T2 (de) 2004-04-01
CZ299817B6 (cs) 2008-12-03
NO316894B1 (no) 2004-06-14
ATE241637T1 (de) 2003-06-15
NO20003661L (no) 2000-09-19
FR2773801B1 (fr) 2000-05-12
EE04194B1 (et) 2003-12-15
MY125636A (en) 2006-08-30
IL137240A (en) 2007-10-31
HUP0102042A3 (en) 2003-07-28
HK1029999A1 (en) 2001-04-20
HRP20000479A2 (en) 2001-02-28
PL191098B1 (pl) 2006-03-31
UA61124C2 (en) 2003-11-17
NO20003661D0 (no) 2000-07-17
FR2773801A1 (fr) 1999-07-23
DE69908298D1 (de) 2003-07-03
CZ20002636A3 (cs) 2000-11-15
SA99191114B1 (ar) 2006-10-11
BR9907100A (pt) 2000-10-24
UY25357A1 (es) 2000-12-29
HRP20000479B1 (en) 2006-04-30
EG23760A (en) 2007-08-08

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