SK287566B6 - Derivát čiastočne desulfátovaných glykózaminoglykánov, spôsob jeho prípravy a použitie - Google Patents

Derivát čiastočne desulfátovaných glykózaminoglykánov, spôsob jeho prípravy a použitie Download PDF

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Publication number
SK287566B6
SK287566B6 SK1067-2002A SK10672002A SK287566B6 SK 287566 B6 SK287566 B6 SK 287566B6 SK 10672002 A SK10672002 A SK 10672002A SK 287566 B6 SK287566 B6 SK 287566B6
Authority
SK
Slovakia
Prior art keywords
heparin
uranium
modified
acids
partially
Prior art date
Application number
SK1067-2002A
Other languages
English (en)
Slovak (sk)
Other versions
SK10672002A3 (sk
Inventor
Benito Casu
Giangiacomo Torri
Anna Maria Naggi
Giuseppe Giannini
Claudio Pisano
Sergio Penco
Original Assignee
Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. filed Critical Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Publication of SK10672002A3 publication Critical patent/SK10672002A3/sk
Publication of SK287566B6 publication Critical patent/SK287566B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Polymers & Plastics (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SK1067-2002A 2000-01-25 2001-01-24 Derivát čiastočne desulfátovaných glykózaminoglykánov, spôsob jeho prípravy a použitie SK287566B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2000RM000041A IT1316986B1 (it) 2000-01-25 2000-01-25 Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica.
PCT/IT2001/000034 WO2001055221A1 (en) 2000-01-25 2001-01-24 Derivatives of partially desulphated glycosaminoglycans endowed with antiangiogenic activity and devoid of anticoagulating effect

Publications (2)

Publication Number Publication Date
SK10672002A3 SK10672002A3 (sk) 2002-12-03
SK287566B6 true SK287566B6 (sk) 2011-02-04

Family

ID=11454382

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1067-2002A SK287566B6 (sk) 2000-01-25 2001-01-24 Derivát čiastočne desulfátovaných glykózaminoglykánov, spôsob jeho prípravy a použitie

Country Status (21)

Country Link
US (4) US20030013682A1 (https=)
EP (1) EP1268558B1 (https=)
JP (1) JP5371167B2 (https=)
KR (1) KR100812406B1 (https=)
CN (1) CN100540570C (https=)
AT (1) ATE348115T1 (https=)
AU (1) AU782632B2 (https=)
BR (1) BR0107696A (https=)
CA (1) CA2397964C (https=)
CY (1) CY1108001T1 (https=)
CZ (1) CZ303030B6 (https=)
DE (1) DE60125154T2 (https=)
DK (1) DK1268558T3 (https=)
ES (1) ES2277911T3 (https=)
HU (1) HU229509B1 (https=)
IT (1) IT1316986B1 (https=)
MX (1) MXPA02007195A (https=)
PL (1) PL209479B1 (https=)
PT (1) PT1268558E (https=)
SK (1) SK287566B6 (https=)
WO (1) WO2001055221A1 (https=)

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US7781416B2 (en) 2000-01-25 2010-08-24 Sigma-Tau Research Switzerland S.A. Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
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AU2008202261B2 (en) * 2001-09-12 2011-07-28 Leadiant Biosciences S.A. Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
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PL3265075T3 (pl) 2015-03-06 2020-10-05 Leadiant Biosciences S.P.A. Terapia skojarzona szpiczaka mnogiego obejmująca roneparstat
JP2016014148A (ja) * 2015-09-10 2016-01-28 シグマ−タウ・リサーチ・スウィッツァーランド・ソシエテ・アノニム 抗血管新生活性を有し、抗凝血効果を有さない、ヘパラナーゼ阻害剤としての部分的に脱硫酸化されたグリコサミノグリカンの誘導体
CN107177015A (zh) * 2016-03-11 2017-09-19 梁颖 一种重乙酰化肝素修饰物及其制备方法和应用
US11787783B2 (en) 2016-12-13 2023-10-17 Beta Therapeutics Pty Ltd Heparanase inhibitors and use thereof
WO2018107200A1 (en) 2016-12-13 2018-06-21 Beta Therapeutics Pty Ltd Heparanase inhibitors and use thereof
CN108424474B (zh) * 2017-02-15 2023-07-25 清华大学 去抗凝肝素衍生物及其用于炎症性肠病的治疗
US11225531B2 (en) 2018-02-02 2022-01-18 Shenzhen Hepalink Pharmaceutical Group Co., Ltd. Glycosaminoglycan derivative and preparation method therefor and use thereof
EP3705126A1 (en) 2019-03-05 2020-09-09 Leadiant Biosciences S.p.A. Roneparstat for the treatment of amyloidosis
WO2021128253A1 (zh) * 2019-12-27 2021-07-01 深圳市海普瑞药业集团股份有限公司 一种糖胺聚糖衍生物及其应用

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Also Published As

Publication number Publication date
JP5371167B2 (ja) 2013-12-18
KR100812406B1 (ko) 2008-03-11
US20050222084A1 (en) 2005-10-06
HUP0204196A2 (hu) 2003-03-28
EP1268558B1 (en) 2006-12-13
WO2001055221A1 (en) 2001-08-02
HUP0204196A3 (en) 2003-05-28
AU782632B2 (en) 2005-08-18
CA2397964A1 (en) 2001-08-02
ES2277911T3 (es) 2007-08-01
US20050107331A1 (en) 2005-05-19
AU3406401A (en) 2001-08-07
JP2003523460A (ja) 2003-08-05
IT1316986B1 (it) 2003-05-26
CZ20022308A3 (cs) 2003-01-15
US8222231B2 (en) 2012-07-17
SK10672002A3 (sk) 2002-12-03
ITRM20000041A1 (it) 2001-07-25
CN100540570C (zh) 2009-09-16
HU229509B1 (en) 2014-01-28
PT1268558E (pt) 2007-02-28
DE60125154D1 (de) 2007-01-25
ITRM20000041A0 (it) 2000-01-25
DE60125154T2 (de) 2007-10-25
MXPA02007195A (es) 2003-01-28
US7790700B2 (en) 2010-09-07
CZ303030B6 (cs) 2012-03-07
EP1268558A1 (en) 2003-01-02
ATE348115T1 (de) 2007-01-15
DK1268558T3 (da) 2007-04-10
BR0107696A (pt) 2002-10-15
HK1051867A1 (zh) 2003-08-22
CN1396930A (zh) 2003-02-12
CY1108001T1 (el) 2013-09-04
PL209479B1 (pl) 2011-09-30
KR20020080381A (ko) 2002-10-23
US20100298263A1 (en) 2010-11-25
PL357209A1 (en) 2004-07-26
CA2397964C (en) 2010-10-12
US20030013682A1 (en) 2003-01-16

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MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20160124