MX363923B - Composicion de farmaco de carbohidrato novedoso para el tratamiento de enfermedades humanas. - Google Patents

Composicion de farmaco de carbohidrato novedoso para el tratamiento de enfermedades humanas.

Info

Publication number
MX363923B
MX363923B MX2014007934A MX2014007934A MX363923B MX 363923 B MX363923 B MX 363923B MX 2014007934 A MX2014007934 A MX 2014007934A MX 2014007934 A MX2014007934 A MX 2014007934A MX 363923 B MX363923 B MX 363923B
Authority
MX
Mexico
Prior art keywords
linked
treatment
composition
human diseases
novel carbohydrate
Prior art date
Application number
MX2014007934A
Other languages
English (en)
Other versions
MX2014007934A (es
Inventor
G Traber Peter
Zomer Eliezer
A Klyosov Anatole
Chekhova Elena
Original Assignee
Galectin Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galectin Therapeutics Inc filed Critical Galectin Therapeutics Inc
Publication of MX2014007934A publication Critical patent/MX2014007934A/es
Publication of MX363923B publication Critical patent/MX363923B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/738—Cross-linked polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0045—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Galacturonans, e.g. methyl ester of (alpha-1,4)-linked D-galacturonic acid units, i.e. pectin, or hydrolysis product of methyl ester of alpha-1,4-linked D-galacturonic acid units, i.e. pectinic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere a composiciones para usarse en el tratamiento de enfermedades dependientes de la galectina. En particular, composiciones que comprenden un galactoarabino-ramnoga lacturonato ramificado, selectivamente despolimerizado cuyo esqueleto está comprendido predominantemente por porciones de ácido galacturónico (GalA) 1,4-enlazado, con una composición de esqueleto menor de GaiA 1,4-enlazado y ramnosa (Rha) 1,2-enlazada alternados, que a su vez está enlazado a cualquier cantidad de cadenas laterales que incluyen predominantemente residuos de 1,4-b-D-galactosa (Gal) y 1,5-a-L-arabinosa (Ara).
MX2014007934A 2011-12-28 2012-09-14 Composicion de farmaco de carbohidrato novedoso para el tratamiento de enfermedades humanas. MX363923B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161580830P 2011-12-28 2011-12-28
PCT/US2012/055311 WO2013101314A1 (en) 2011-12-28 2012-09-14 Composition of novel carbohydrate drug for treatment of human diseases

Publications (2)

Publication Number Publication Date
MX2014007934A MX2014007934A (es) 2015-03-09
MX363923B true MX363923B (es) 2019-04-08

Family

ID=48698494

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014007934A MX363923B (es) 2011-12-28 2012-09-14 Composicion de farmaco de carbohidrato novedoso para el tratamiento de enfermedades humanas.

Country Status (14)

Country Link
US (8) US8871925B2 (es)
EP (1) EP2797942B1 (es)
JP (3) JP6133894B2 (es)
KR (1) KR101968370B1 (es)
CN (1) CN104245717B (es)
AU (2) AU2012363033B2 (es)
BR (1) BR112014015940B1 (es)
CA (1) CA2861492C (es)
DK (1) DK2797942T3 (es)
ES (1) ES2699386T3 (es)
IL (1) IL233313A (es)
MX (1) MX363923B (es)
WO (1) WO2013101314A1 (es)
ZA (1) ZA201505849B (es)

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WO2008011216A2 (en) * 2006-05-16 2008-01-24 Pro-Pharmaceuticals, Inc. Galactose-pronged polysaccharides in a formulation for antifibrotic therapies
BR112014006220A2 (pt) * 2011-09-16 2017-04-11 Galectin Therapeutics Inc composições de galacto-ramnogalacturonato para o tratamento de esteatohepatite não alcoólica e de doença de gordura no fígado não alcoólica
DK2797942T3 (en) 2011-12-28 2018-12-10 Galectin Therapeutics Inc Composition of Hitherto-Unknown Carbohydrate Drugs for the Treatment of Human Diseases
BR112014030534A2 (pt) 2012-06-06 2017-06-27 Galectin Therapeutics Inc composições de galacto-ramnogalacturonato para o tratamento de doenças associadas com óxido nítrico sintase induzível elevada
ES2773921T3 (es) 2012-09-17 2020-07-15 Galectin Therapeutics Inc Método para mejorar las inmunoterapias específicas en el tratamiento del cáncer
CN104822382B9 (zh) 2012-10-10 2019-01-18 卡莱克汀医疗有限公司 用于治疗糖尿病性肾病和相关疾病的半乳糖分支的糖类化合物
US9339515B2 (en) 2013-02-20 2016-05-17 Galectin Therapeutics, Inc. Method for treatment of pulmonary fibrosis
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FR3036943A1 (fr) * 2015-06-02 2016-12-09 Echosens Dispositif non invasif de detection de lesion hepatique
AU2017228365B2 (en) * 2016-03-04 2021-05-27 Galectin Sciences, Llc Selenogalactoside compounds for the prevention and treatment of diseases associated with galectin and the use thereof
WO2018132745A1 (en) * 2017-01-13 2018-07-19 Sivanaray Inc. Compounds, compositions and methods for prevention or treatment of liver and lipid-related conditions
CA3062648A1 (en) 2017-05-12 2018-11-15 Galectin Sciences, Llc Compounds for the prevention and treatment of diseases and the use thereof
TWI814739B (zh) 2017-09-08 2023-09-11 美商艾弗洛生物科技股份有限公司 細菌胞外囊泡
CN112672765A (zh) 2018-06-29 2021-04-16 格莱科斯生物医药公司 结合物
DE102019003442A1 (de) 2019-05-15 2020-11-19 Ilma biochem GmbH Verwendung von niedermolekularen glykosidisch gebundenen endständigen Galactosiden und Fucosiden zur Bindung von als Galectin wirkenden Toxinen im Rahmen der Behandlung von Vergiftungen, insbesondere bei Vergiftungen mit Ricin
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US20230277573A1 (en) * 2020-07-17 2023-09-07 Dsm Nutritional Products, Llc Oligosaccharide compositions and methods of use
CN116211884B (zh) * 2023-02-16 2024-05-17 海孵(海南自贸区)医疗科技有限责任公司 一种鼻腔喷雾剂及其制备方法

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BR112014030534A2 (pt) 2012-06-06 2017-06-27 Galectin Therapeutics Inc composições de galacto-ramnogalacturonato para o tratamento de doenças associadas com óxido nítrico sintase induzível elevada
ES2773921T3 (es) 2012-09-17 2020-07-15 Galectin Therapeutics Inc Método para mejorar las inmunoterapias específicas en el tratamiento del cáncer
CN104822382B9 (zh) 2012-10-10 2019-01-18 卡莱克汀医疗有限公司 用于治疗糖尿病性肾病和相关疾病的半乳糖分支的糖类化合物
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Also Published As

Publication number Publication date
BR112014015940B1 (pt) 2022-08-09
US20140350238A1 (en) 2014-11-27
JP2015503658A (ja) 2015-02-02
KR20140143137A (ko) 2014-12-15
DK2797942T3 (en) 2018-12-10
BR112014015940A8 (pt) 2021-09-28
US8962824B2 (en) 2015-02-24
WO2013101314A1 (en) 2013-07-04
ES2699386T3 (es) 2019-02-11
CN104245717B (zh) 2017-10-24
US10799525B2 (en) 2020-10-13
US20210093656A1 (en) 2021-04-01
JP6133894B2 (ja) 2017-05-24
AU2016222423B2 (en) 2018-02-22
JP6262386B2 (ja) 2018-01-17
CA2861492C (en) 2019-09-24
US20180256626A1 (en) 2018-09-13
IL233313A (en) 2017-08-31
US20130261078A1 (en) 2013-10-03
AU2012363033A1 (en) 2014-07-17
EP2797942A4 (en) 2015-06-03
ZA201505849B (en) 2017-03-26
US9974802B2 (en) 2018-05-22
US10420793B2 (en) 2019-09-24
US20230000898A1 (en) 2023-01-05
JP2017149976A (ja) 2017-08-31
US9649327B2 (en) 2017-05-16
BR112014015940A2 (pt) 2017-06-13
US8871925B2 (en) 2014-10-28
EP2797942B1 (en) 2018-10-31
CA2861492A1 (en) 2013-07-04
US20170202870A1 (en) 2017-07-20
CN104245717A (zh) 2014-12-24
US20150174151A1 (en) 2015-06-25
KR101968370B1 (ko) 2019-04-11
AU2012363033B2 (en) 2016-06-02
EP2797942A1 (en) 2014-11-05
US20200078390A1 (en) 2020-03-12
IL233313A0 (en) 2014-08-31
US11413303B2 (en) 2022-08-16
MX2014007934A (es) 2015-03-09
JP6415677B2 (ja) 2018-10-31
AU2016222423A1 (en) 2016-09-22
JP2018076519A (ja) 2018-05-17

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