MX2014007934A - Composicion de farmaco de carbohidrato novedoso para el tratamiento de enfermedades humanas. - Google Patents

Composicion de farmaco de carbohidrato novedoso para el tratamiento de enfermedades humanas.

Info

Publication number
MX2014007934A
MX2014007934A MX2014007934A MX2014007934A MX2014007934A MX 2014007934 A MX2014007934 A MX 2014007934A MX 2014007934 A MX2014007934 A MX 2014007934A MX 2014007934 A MX2014007934 A MX 2014007934A MX 2014007934 A MX2014007934 A MX 2014007934A
Authority
MX
Mexico
Prior art keywords
linked
treatment
composition
human diseases
novel carbohydrate
Prior art date
Application number
MX2014007934A
Other languages
English (en)
Other versions
MX363923B (es
Inventor
Peter G Traber
Eliezer Zomer
Anatole A Klyosov
Elena Chekhova
Original Assignee
Galectin Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galectin Therapeutics Inc filed Critical Galectin Therapeutics Inc
Publication of MX2014007934A publication Critical patent/MX2014007934A/es
Publication of MX363923B publication Critical patent/MX363923B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/738—Cross-linked polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0045—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Galacturonans, e.g. methyl ester of (alpha-1,4)-linked D-galacturonic acid units, i.e. pectin, or hydrolysis product of methyl ester of alpha-1,4-linked D-galacturonic acid units, i.e. pectinic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Aspectos de la invención proveen composiciones para usarse en el tratamiento de enfermedades dependientes de la galectina. En particular, composiciones que comprenden un galactoarabino-ramnoga lacturonato ramificado, selectivamente despolimerizado cuyo esqueleto está comprendido predominantemente por porciones de ácido galacturónico (GalA) 1,4-enlazado, con una composición de esqueleto menor de GaiA 1,4-enlazado y ramnosa (Rha) 1,2-enlazada alternados, que a su vez está enlazado a cualquier cantidad de cadenas laterales que incluyen predominantemente residuos de 1,4-b-D-galactosa (Gal) y 1,5-a-L-arabinosa (Ara).
MX2014007934A 2011-12-28 2012-09-14 Composicion de farmaco de carbohidrato novedoso para el tratamiento de enfermedades humanas. MX363923B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161580830P 2011-12-28 2011-12-28
PCT/US2012/055311 WO2013101314A1 (en) 2011-12-28 2012-09-14 Composition of novel carbohydrate drug for treatment of human diseases

Publications (2)

Publication Number Publication Date
MX2014007934A true MX2014007934A (es) 2015-03-09
MX363923B MX363923B (es) 2019-04-08

Family

ID=48698494

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014007934A MX363923B (es) 2011-12-28 2012-09-14 Composicion de farmaco de carbohidrato novedoso para el tratamiento de enfermedades humanas.

Country Status (14)

Country Link
US (8) US8871925B2 (es)
EP (1) EP2797942B1 (es)
JP (3) JP6133894B2 (es)
KR (1) KR101968370B1 (es)
CN (1) CN104245717B (es)
AU (2) AU2012363033B2 (es)
BR (1) BR112014015940B1 (es)
CA (1) CA2861492C (es)
DK (1) DK2797942T3 (es)
ES (1) ES2699386T3 (es)
IL (1) IL233313A (es)
MX (1) MX363923B (es)
WO (1) WO2013101314A1 (es)
ZA (1) ZA201505849B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008011216A2 (en) * 2006-05-16 2008-01-24 Pro-Pharmaceuticals, Inc. Galactose-pronged polysaccharides in a formulation for antifibrotic therapies
BR112014006220A2 (pt) * 2011-09-16 2017-04-11 Galectin Therapeutics Inc composições de galacto-ramnogalacturonato para o tratamento de esteatohepatite não alcoólica e de doença de gordura no fígado não alcoólica
WO2013101314A1 (en) 2011-12-28 2013-07-04 Galectin Therapeutics, Inc. Composition of novel carbohydrate drug for treatment of human diseases
CA2875979C (en) * 2012-06-06 2021-01-26 Galectin Therapeutics, Inc. Galacto-rhamnogalacturonate compositions for the treatment of diseases associated with elevated inducible nitric oxide synthase
DK2900061T3 (da) 2012-09-17 2020-03-02 Galectin Therapeutics Inc Fremgangsmåde til forstærkning af specifikke immunterapier ved cancerbehandling
KR102231732B1 (ko) 2012-10-10 2021-03-23 갈렉틴 테라퓨틱스, 인크. 당뇨병성 신장병증 및 관련 질환의 치료를 위한 갈락토스 갈래의 탄수화물 화합물
US9339515B2 (en) 2013-02-20 2016-05-17 Galectin Therapeutics, Inc. Method for treatment of pulmonary fibrosis
GB201502668D0 (en) * 2015-02-17 2015-04-01 Glycomar Ltd And Albert Bartlett & Sons Airdrie Ltd Method for isolation of polysaccharides
FR3036943A1 (fr) * 2015-06-02 2016-12-09 Echosens Dispositif non invasif de detection de lesion hepatique
WO2017152048A1 (en) * 2016-03-04 2017-09-08 Galectin Sciences, Llc Selenogalactoside compounds for the prevention and treatment of diseases associated with galectin and the use thereof
EP3568139A4 (en) * 2017-01-13 2020-10-28 Sivanaray, Inc. COMPOUNDS, COMPOSITIONS AND PROCEDURES FOR THE PREVENTION OR TREATMENT OF LIVER AND LIPID RELATED DISEASES
EP3621973A4 (en) 2017-05-12 2021-10-27 Galectin Sciences, LLC COMPOUNDS FOR THE PREVENTION AND TREATMENT OF DISEASES AND THEIR USE
JP7369690B2 (ja) 2017-09-08 2023-10-26 エヴェロ バイオサイエンシズ，インコーポレーテッド 細菌の細胞外小胞
US20210138080A1 (en) 2018-06-29 2021-05-13 Glykos Biomedical Oy Conjugates
DE102019003442A1 (de) 2019-05-15 2020-11-19 Ilma biochem GmbH Verwendung von niedermolekularen glykosidisch gebundenen endständigen Galactosiden und Fucosiden zur Bindung von als Galectin wirkenden Toxinen im Rahmen der Behandlung von Vergiftungen, insbesondere bei Vergiftungen mit Ricin
WO2021064729A1 (en) * 2019-10-02 2021-04-08 Patchor Ltd. Injectable composition for the treatment of musculoskeletal disorders and methods of use thereof
US20230038373A1 (en) 2019-12-18 2023-02-09 Glykos Biomedical Oy Stabile conjugate
BR112023000719A2 (pt) * 2020-07-17 2023-03-21 Dsm Nutritional Products Llc Composições de oligossacarídeo e métodos de uso
CN116211884B (zh) * 2023-02-16 2024-05-17 海孵(海南自贸区)医疗科技有限责任公司 一种鼻腔喷雾剂及其制备方法

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2132577A (en) 1934-08-28 1938-10-11 Gen Foods Corp Method of preparing pectin
US2444266A (en) 1944-03-31 1948-06-29 Us Agriculture Pectic materials and method of preparing same
US2503258A (en) 1948-01-23 1950-04-11 Us Agriculture Neutralization of pectinic acids with sodium bicarbonate
US4016351A (en) 1976-02-04 1977-04-05 Eschinasi Emile H Pectic substances with varying methoxyl content and process therefor
US4268533A (en) 1979-11-21 1981-05-19 General Foods Corporation Quick-set low methoxyl pectin composition
EP0181351A4 (en) * 1984-05-09 1989-06-21 Univ Australian METHOD FOR MODULATING IMMUNE REACTION.
US4686106A (en) 1986-06-16 1987-08-11 General Foods Corporation Pectin food product
US5071970A (en) 1988-11-23 1991-12-10 University Of Florida Process for producing pectin with a high-to-medium methoxyl content from beet pulp
US5605938A (en) 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
US7491708B1 (en) 1993-03-01 2009-02-17 David Platt Modified pectin
JP3360899B2 (ja) 1993-10-08 2003-01-07 日本医薬品工業株式会社 癌予防・治療剤
US5498702A (en) 1993-12-16 1996-03-12 California Natural Products Treated pectinic acid process and product
US5834442A (en) 1994-07-07 1998-11-10 Barbara Ann Karmanos Cancer Institute Method for inhibiting cancer metastasis by oral administration of soluble modified citrus pectin
US5681923A (en) 1995-10-06 1997-10-28 Platt; David Tumor derived carbohydrate binding protein
US6632797B2 (en) 1996-06-24 2003-10-14 Matti Siren Method of treating angiogenesis
KR100252194B1 (ko) 1997-10-10 2000-04-15 박호군 참당귀에서분리한신규한펙틴질다당류와그분리정제방법및그의면역증강제로서의용도
US7022683B1 (en) * 1998-05-13 2006-04-04 Carrington Laboratories, Inc. Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation
US5929051A (en) * 1998-05-13 1999-07-27 Carrington Laboratories, Inc. Aloe pectins
US6500807B1 (en) 1999-02-02 2002-12-31 Safescience, Inc. Modified pectin and nucleic acid composition
IT1316986B1 (it) 2000-01-25 2003-05-26 Sigma Tau Ind Farmaceuti Derivati glicosamminoglicani parzialmente desolfatati nonanticoagulanti ad attivita' antiangiogenica.
US6770622B2 (en) 2001-06-08 2004-08-03 Gary A. Jarvis N-terminally truncated galectin-3 for use in treating cancer
US6680306B2 (en) 2001-06-21 2004-01-20 Glycogenesys, Inc. Method for enhancing the effectiveness of cancer therapies
US20030004132A1 (en) 2001-06-22 2003-01-02 Yan Chang Method and material for treating immune diseases
US6890906B2 (en) 2001-11-21 2005-05-10 Glycogenesys, Inc. Method for controlling angiogenesis in animals
US20040121981A1 (en) 2001-11-21 2004-06-24 Glycogenesys, Inc. Method for controlling angiogenesis in animals
KR100594353B1 (ko) 2002-05-28 2006-07-03 주식회사 엠디바이오알파 신규한 인삼잎 및 줄기 다당체, 그 제조방법 및 그를활성성분으로 함유하는 항암제 및 항암보조제 조성물
JP2004107295A (ja) * 2002-09-20 2004-04-08 National Agriculture & Bio-Oriented Research Organization ヒスタミン遊離抑制剤
US20040223971A1 (en) 2003-04-07 2004-11-11 Glycogenesys, Inc. Composition and uses of galectin antagonists
DE602004014485D1 (de) * 2003-04-07 2008-07-31 Prospect Therapeutics Inc Zusammensetzung und anwendungen von galectin-antagonisten
WO2004096998A2 (en) 2003-04-29 2004-11-11 Vanderbilt University Nanoparticular tumor targeting and therapy
US20050053664A1 (en) 2003-09-08 2005-03-10 Eliezer Zomer Co-administration of a polysaccharide with a chemotherapeutic agent for the treatment of cancer
EP1765874A1 (en) 2004-03-26 2007-03-28 Glycogenesys, Inc. Modified pectins, compositions and methods related thereto
ITFI20040174A1 (it) * 2004-08-03 2004-11-03 Protera S R L Derivati arilsolfonammidici dell'acido idrossammico ad azione inibitoria di metalloproteinasi
EP1896582A4 (en) 2005-05-09 2009-04-08 Ono Pharmaceutical Co HUMAN MONOCLONAL ANTIBODIES FOR PROGRAMMED DEATH 1 (MP-1) AND METHODS FOR TREATING CANCER USING ANTI-MP-1 ANTIBODIES ALONE OR ASSOCIATED WITH OTHER IMMUNOTHERAPIES
WO2008011216A2 (en) * 2006-05-16 2008-01-24 Pro-Pharmaceuticals, Inc. Galactose-pronged polysaccharides in a formulation for antifibrotic therapies
KR101074158B1 (ko) * 2008-04-07 2011-10-17 재단법인 한국원자력의학원 간 보호 또는 간 질환의 예방 및 치료용 인삼다당체 조성물
US9646327B2 (en) 2011-08-09 2017-05-09 Yahoo! Inc. Disaggregation to isolate users for ad targeting
BR112014006220A2 (pt) 2011-09-16 2017-04-11 Galectin Therapeutics Inc composições de galacto-ramnogalacturonato para o tratamento de esteatohepatite não alcoólica e de doença de gordura no fígado não alcoólica
BR112014008731A2 (pt) * 2011-10-12 2017-04-25 Teva Pharma tratamento de esclerose múltipla com combinação de laquinimode e fingolimode
WO2013101314A1 (en) 2011-12-28 2013-07-04 Galectin Therapeutics, Inc. Composition of novel carbohydrate drug for treatment of human diseases
CA2875979C (en) * 2012-06-06 2021-01-26 Galectin Therapeutics, Inc. Galacto-rhamnogalacturonate compositions for the treatment of diseases associated with elevated inducible nitric oxide synthase
DK2900061T3 (da) 2012-09-17 2020-03-02 Galectin Therapeutics Inc Fremgangsmåde til forstærkning af specifikke immunterapier ved cancerbehandling
KR102231732B1 (ko) 2012-10-10 2021-03-23 갈렉틴 테라퓨틱스, 인크. 당뇨병성 신장병증 및 관련 질환의 치료를 위한 갈락토스 갈래의 탄수화물 화합물
US9339515B2 (en) 2013-02-20 2016-05-17 Galectin Therapeutics, Inc. Method for treatment of pulmonary fibrosis

Also Published As

Publication number Publication date
US11413303B2 (en) 2022-08-16
US10420793B2 (en) 2019-09-24
US9974802B2 (en) 2018-05-22
IL233313A0 (en) 2014-08-31
EP2797942B1 (en) 2018-10-31
US20140350238A1 (en) 2014-11-27
AU2016222423A1 (en) 2016-09-22
US9649327B2 (en) 2017-05-16
ES2699386T3 (es) 2019-02-11
US10799525B2 (en) 2020-10-13
US20130261078A1 (en) 2013-10-03
JP2015503658A (ja) 2015-02-02
AU2016222423B2 (en) 2018-02-22
JP2018076519A (ja) 2018-05-17
KR20140143137A (ko) 2014-12-15
BR112014015940A8 (pt) 2021-09-28
IL233313A (en) 2017-08-31
CN104245717B (zh) 2017-10-24
CA2861492A1 (en) 2013-07-04
AU2012363033B2 (en) 2016-06-02
US8871925B2 (en) 2014-10-28
BR112014015940A2 (pt) 2017-06-13
EP2797942A1 (en) 2014-11-05
US20210093656A1 (en) 2021-04-01
EP2797942A4 (en) 2015-06-03
BR112014015940B1 (pt) 2022-08-09
MX363923B (es) 2019-04-08
CA2861492C (en) 2019-09-24
US20170202870A1 (en) 2017-07-20
DK2797942T3 (en) 2018-12-10
JP6133894B2 (ja) 2017-05-24
AU2012363033A1 (en) 2014-07-17
KR101968370B1 (ko) 2019-04-11
WO2013101314A1 (en) 2013-07-04
JP6415677B2 (ja) 2018-10-31
US20230000898A1 (en) 2023-01-05
US8962824B2 (en) 2015-02-24
US20150174151A1 (en) 2015-06-25
CN104245717A (zh) 2014-12-24
JP2017149976A (ja) 2017-08-31
ZA201505849B (en) 2017-03-26
US20180256626A1 (en) 2018-09-13
JP6262386B2 (ja) 2018-01-17
US20200078390A1 (en) 2020-03-12

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