KR100787293B1 - 중간물인 6.알파.,9.알파.-디플루오로-11.베타.,17.알파.-디히드록시-16.알파.-메틸-안드로스트-1,4-디엔-3-온 17.베타.-카르복실산을 제조하기 위한 산화 방법 - Google Patents

중간물인 6.알파.,9.알파.-디플루오로-11.베타.,17.알파.-디히드록시-16.알파.-메틸-안드로스트-1,4-디엔-3-온 17.베타.-카르복실산을 제조하기 위한 산화 방법 Download PDF

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KR100787293B1
KR100787293B1 KR1020027014367A KR20027014367A KR100787293B1 KR 100787293 B1 KR100787293 B1 KR 100787293B1 KR 1020027014367 A KR1020027014367 A KR 1020027014367A KR 20027014367 A KR20027014367 A KR 20027014367A KR 100787293 B1 KR100787293 B1 KR 100787293B1
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alpha
formula
compound
water
methyl
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Korean (ko)
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KR20030028736A (ko
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프레데릭 데이비드 알빈슨
스티븐 존 쿠테
존 말콤 로빈슨
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글락소 그룹 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020027014367A 2000-07-21 2001-07-20 중간물인 6.알파.,9.알파.-디플루오로-11.베타.,17.알파.-디히드록시-16.알파.-메틸-안드로스트-1,4-디엔-3-온 17.베타.-카르복실산을 제조하기 위한 산화 방법 Expired - Fee Related KR100787293B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0017988.7 2000-07-21
GBGB0017988.7A GB0017988D0 (en) 2000-07-21 2000-07-21 Novel process
PCT/GB2001/003289 WO2002008243A1 (en) 2000-07-21 2001-07-20 Oxidation process for preparing the intermediate 6.alpha.,9.alpha.-difluoro-11.beta.,17.alpha.-dihydroxy-16.alpha.-methyl-androst-1,4-dien-3-one 17.beta.-carboxylic acid

Publications (2)

Publication Number Publication Date
KR20030028736A KR20030028736A (ko) 2003-04-10
KR100787293B1 true KR100787293B1 (ko) 2007-12-20

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ID=9896132

Family Applications (1)

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KR1020027014367A Expired - Fee Related KR100787293B1 (ko) 2000-07-21 2001-07-20 중간물인 6.알파.,9.알파.-디플루오로-11.베타.,17.알파.-디히드록시-16.알파.-메틸-안드로스트-1,4-디엔-3-온 17.베타.-카르복실산을 제조하기 위한 산화 방법

Country Status (26)

Country Link
US (1) US20040043974A1 (enExample)
EP (1) EP1301526B1 (enExample)
JP (1) JP2004504403A (enExample)
KR (1) KR100787293B1 (enExample)
CN (1) CN1315864C (enExample)
AT (1) ATE398628T1 (enExample)
AU (2) AU2001270906B2 (enExample)
BR (1) BR0110430A (enExample)
CA (1) CA2406963A1 (enExample)
CY (1) CY1108553T1 (enExample)
CZ (1) CZ302592B6 (enExample)
DE (1) DE60134472D1 (enExample)
DK (1) DK1301526T3 (enExample)
ES (1) ES2307628T3 (enExample)
GB (1) GB0017988D0 (enExample)
HK (1) HK1056179B (enExample)
HU (1) HUP0301108A3 (enExample)
IL (2) IL152348A0 (enExample)
MX (1) MXPA02010967A (enExample)
NO (1) NO324836B1 (enExample)
NZ (1) NZ522083A (enExample)
PL (1) PL206652B1 (enExample)
PT (1) PT1301526E (enExample)
SI (1) SI1301526T1 (enExample)
WO (1) WO2002008243A1 (enExample)
ZA (1) ZA200208372B (enExample)

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US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
SI1305329T2 (sl) 2000-08-05 2015-07-31 Glaxo Group Limited S-fluorometil ester 6alfa,9alfa-difluoro-17alfa-(2-furanilkarboksil)oksi-11beta-hidroksi- 16alfa-metil-3-okso-androst-1,4-dien-17-karbotiojske kisline kot protivnetno sredstvo
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
CA2445839A1 (en) 2001-04-30 2002-11-07 Glaxo Group Limited Anti-inflammatory 17.beta.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.alpha
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
IL150654A (en) 2002-07-09 2006-12-10 Ori Lerman Method for acid isolation 6α, 9α - difluoro - ß, 17α11 - dihydroxy - 16α - methylfargana - 3 - oxo - 1, 4 - diene - 17ß - carboxylate
CA2530680A1 (en) * 2003-04-04 2004-10-14 Alpharma Aps Process for the preparation of steroidal carbothioic acid derivatives and intermediates
EP1466920A1 (en) * 2003-04-04 2004-10-13 Alpharma APS Process for the preparation of steroidal 17 beta-carbothioates
EP1526139A1 (en) * 2003-10-24 2005-04-27 S.N.I.F.F. Italia S.P.A. A process for preparing highly pure androstane 17-beta-carboxylic acids and androstane 17-beta-carbothioic acid fluoromethyl esters
GB0612027D0 (en) 2006-06-16 2006-07-26 Glaxo Group Ltd Novel process
NO331891B1 (no) 2007-03-20 2012-04-30 Clavis Pharma Asa Kjemiske forbindelser, et farmasoytisk preparat inneholdende slike forbindelser, samt anvendelse derav for behandling av kreft, inflammasjon og KOLS
PT105139B (pt) * 2010-06-01 2013-01-29 Hovione Farmaciencia S A Método para a monofluorometilação de substratos orgânicos para preparação de compostos orgânicos biologicamente activos
EP2611821A2 (en) 2010-09-01 2013-07-10 Cadila Healthcare Limited Process for preparing fluticasone propionate/furoate

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1964356A1 (de) * 1968-12-23 1970-07-02 Ciba Geigy Verfahren zur Herstellung von Estern von Steroid-17-carbonsaeuren
GB2018258A (en) * 1978-04-05 1979-10-17 Prochem Ets 3 acetoxy & 11 epoxy pregna 3,5 dienes and 1,3,5 trienes and their use in the synthesis of 6 halocorticoids
US4198336A (en) * 1978-04-05 1980-04-15 Syntex (U.S.A.) Inc. Chemical process for preparing androsta-4-ene 17α-carboxylic acids
WO1995018621A1 (en) * 1994-01-04 1995-07-13 Duke University Methods of inhibiting angiogenesis and tumor growth, and treating ophthalmologic conditions with angiostatic and therapeutic steroids
WO1997024365A1 (en) * 1995-12-29 1997-07-10 Glaxo Group Limited Lactone derivatives of 17.beta.-carboxy, carbothio and amide androstane derivatives
WO2001062722A2 (en) * 2000-02-25 2001-08-30 Abbott Laboratories Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4188385A (en) * 1978-04-05 1980-02-12 Syntex (U.S.A.) Inc. Thioetianic acid derivatives
US4263289A (en) * 1978-04-05 1981-04-21 Syntex (U.S.A.) Inc. Thio etianic acid derivatives
CY1291A (en) * 1980-02-15 1985-10-18 Glaxo Group Ltd Androstane 17 beta carbothioates
MXPA02009814A (es) * 2000-04-04 2003-03-27 Celanese Int Corp Composiciones de revestimiento receptivas de tinta que contienen alcohol polivinilico injertado con grupos funcionales amina.
US6777400B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1964356A1 (de) * 1968-12-23 1970-07-02 Ciba Geigy Verfahren zur Herstellung von Estern von Steroid-17-carbonsaeuren
GB2018258A (en) * 1978-04-05 1979-10-17 Prochem Ets 3 acetoxy & 11 epoxy pregna 3,5 dienes and 1,3,5 trienes and their use in the synthesis of 6 halocorticoids
US4198336A (en) * 1978-04-05 1980-04-15 Syntex (U.S.A.) Inc. Chemical process for preparing androsta-4-ene 17α-carboxylic acids
WO1995018621A1 (en) * 1994-01-04 1995-07-13 Duke University Methods of inhibiting angiogenesis and tumor growth, and treating ophthalmologic conditions with angiostatic and therapeutic steroids
WO1997024365A1 (en) * 1995-12-29 1997-07-10 Glaxo Group Limited Lactone derivatives of 17.beta.-carboxy, carbothio and amide androstane derivatives
WO2001062722A2 (en) * 2000-02-25 2001-08-30 Abbott Laboratories Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods

Also Published As

Publication number Publication date
PL359462A1 (en) 2004-08-23
IL152348A (en) 2008-08-07
ATE398628T1 (de) 2008-07-15
AU7090601A (en) 2002-02-05
NO324836B1 (no) 2007-12-17
PL206652B1 (pl) 2010-09-30
AU2001270906B2 (en) 2005-10-13
KR20030028736A (ko) 2003-04-10
CY1108553T1 (el) 2014-04-09
HK1056179B (en) 2009-07-17
HUP0301108A3 (en) 2008-04-28
JP2004504403A (ja) 2004-02-12
SI1301526T1 (sl) 2008-10-31
CZ20023472A3 (cs) 2003-04-16
IL152348A0 (en) 2003-05-29
DE60134472D1 (de) 2008-07-31
CZ302592B6 (cs) 2011-07-27
PT1301526E (pt) 2008-09-09
EP1301526A1 (en) 2003-04-16
BR0110430A (pt) 2003-07-08
MXPA02010967A (es) 2003-03-27
WO2002008243A1 (en) 2002-01-31
HUP0301108A2 (hu) 2003-08-28
US20040043974A1 (en) 2004-03-04
ZA200208372B (en) 2004-02-11
EP1301526B1 (en) 2008-06-18
CN1315864C (zh) 2007-05-16
HK1056179A1 (en) 2004-02-06
DK1301526T3 (da) 2008-10-06
NO20025054L (no) 2002-11-05
CA2406963A1 (en) 2002-01-31
ES2307628T3 (es) 2008-12-01
CN1437610A (zh) 2003-08-20
NO20025054D0 (no) 2002-10-21
NZ522083A (en) 2004-06-25
GB0017988D0 (en) 2000-09-13

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