CN1315864C - 制备中间体6α,9α－二氟－11β,17α－二羟基－16α－甲基－雄甾－1,4－二烯－3－酮－17β－羧酸的氧化法 - Google Patents

制备中间体6α,9α－二氟－11β,17α－二羟基－16α－甲基－雄甾－1,4－二烯－3－酮－17β－羧酸的氧化法 Download PDF

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Publication number
CN1315864C
CN1315864C CNB018114407A CN01811440A CN1315864C CN 1315864 C CN1315864 C CN 1315864C CN B018114407 A CNB018114407 A CN B018114407A CN 01811440 A CN01811440 A CN 01811440A CN 1315864 C CN1315864 C CN 1315864C
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CN
China
Prior art keywords
formula
compound
water
difluoro
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB018114407A
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English (en)
Chinese (zh)
Other versions
CN1437610A (zh
Inventor
F·D·阿尔宾森
S·J·库特
J·M·罗宾逊
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Glaxo Group Ltd
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Glaxo Group Ltd
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Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of CN1437610A publication Critical patent/CN1437610A/zh
Application granted granted Critical
Publication of CN1315864C publication Critical patent/CN1315864C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CNB018114407A 2000-07-21 2001-07-20 制备中间体6α,9α－二氟－11β,17α－二羟基－16α－甲基－雄甾－1,4－二烯－3－酮－17β－羧酸的氧化法 Expired - Fee Related CN1315864C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0017988.7 2000-07-21
GBGB0017988.7A GB0017988D0 (en) 2000-07-21 2000-07-21 Novel process

Publications (2)

Publication Number Publication Date
CN1437610A CN1437610A (zh) 2003-08-20
CN1315864C true CN1315864C (zh) 2007-05-16

Family

ID=9896132

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB018114407A Expired - Fee Related CN1315864C (zh) 2000-07-21 2001-07-20 制备中间体6α,9α－二氟－11β,17α－二羟基－16α－甲基－雄甾－1,4－二烯－3－酮－17β－羧酸的氧化法

Country Status (26)

Country Link
US (1) US20040043974A1 (enExample)
EP (1) EP1301526B1 (enExample)
JP (1) JP2004504403A (enExample)
KR (1) KR100787293B1 (enExample)
CN (1) CN1315864C (enExample)
AT (1) ATE398628T1 (enExample)
AU (2) AU2001270906B2 (enExample)
BR (1) BR0110430A (enExample)
CA (1) CA2406963A1 (enExample)
CY (1) CY1108553T1 (enExample)
CZ (1) CZ302592B6 (enExample)
DE (1) DE60134472D1 (enExample)
DK (1) DK1301526T3 (enExample)
ES (1) ES2307628T3 (enExample)
GB (1) GB0017988D0 (enExample)
HK (1) HK1056179B (enExample)
HU (1) HUP0301108A3 (enExample)
IL (2) IL152348A0 (enExample)
MX (1) MXPA02010967A (enExample)
NO (1) NO324836B1 (enExample)
NZ (1) NZ522083A (enExample)
PL (1) PL206652B1 (enExample)
PT (1) PT1301526E (enExample)
SI (1) SI1301526T1 (enExample)
WO (1) WO2002008243A1 (enExample)
ZA (1) ZA200208372B (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
SI1305329T2 (sl) 2000-08-05 2015-07-31 Glaxo Group Limited S-fluorometil ester 6alfa,9alfa-difluoro-17alfa-(2-furanilkarboksil)oksi-11beta-hidroksi- 16alfa-metil-3-okso-androst-1,4-dien-17-karbotiojske kisline kot protivnetno sredstvo
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
CA2445839A1 (en) 2001-04-30 2002-11-07 Glaxo Group Limited Anti-inflammatory 17.beta.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.alpha
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
IL150654A (en) 2002-07-09 2006-12-10 Ori Lerman Method for acid isolation 6α, 9α - difluoro - ß, 17α11 - dihydroxy - 16α - methylfargana - 3 - oxo - 1, 4 - diene - 17ß - carboxylate
CA2530680A1 (en) * 2003-04-04 2004-10-14 Alpharma Aps Process for the preparation of steroidal carbothioic acid derivatives and intermediates
EP1466920A1 (en) * 2003-04-04 2004-10-13 Alpharma APS Process for the preparation of steroidal 17 beta-carbothioates
EP1526139A1 (en) * 2003-10-24 2005-04-27 S.N.I.F.F. Italia S.P.A. A process for preparing highly pure androstane 17-beta-carboxylic acids and androstane 17-beta-carbothioic acid fluoromethyl esters
GB0612027D0 (en) 2006-06-16 2006-07-26 Glaxo Group Ltd Novel process
NO331891B1 (no) 2007-03-20 2012-04-30 Clavis Pharma Asa Kjemiske forbindelser, et farmasoytisk preparat inneholdende slike forbindelser, samt anvendelse derav for behandling av kreft, inflammasjon og KOLS
PT105139B (pt) * 2010-06-01 2013-01-29 Hovione Farmaciencia S A Método para a monofluorometilação de substratos orgânicos para preparação de compostos orgânicos biologicamente activos
EP2611821A2 (en) 2010-09-01 2013-07-10 Cadila Healthcare Limited Process for preparing fluticasone propionate/furoate

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3636010A (en) * 1968-12-23 1972-01-18 Ciba Geigy Corp Esters of steroid-17-carboxylic acids
GB2018256A (en) * 1978-04-05 1979-10-17 Syntex Inc Thio atianic acid derivatives
US4198336A (en) * 1978-04-05 1980-04-15 Syntex (U.S.A.) Inc. Chemical process for preparing androsta-4-ene 17α-carboxylic acids
US5646136A (en) * 1994-01-04 1997-07-08 Duke University Methods of inhibiting angiogenesis and tumor growth, and treating ophthalmologic conditions with angiostatic and therapeutic steroids

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4263289A (en) * 1978-04-05 1981-04-21 Syntex (U.S.A.) Inc. Thio etianic acid derivatives
NL187577C (nl) * 1978-04-05 1991-11-18 Sibla Srl 3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.
CY1291A (en) * 1980-02-15 1985-10-18 Glaxo Group Ltd Androstane 17 beta carbothioates
NZ324373A (en) * 1995-12-29 1999-10-28 Glaxo Group Ltd Lactone derivatives of 17-beta-carboxy, carbonyl-thio and amide androstane derivatives
US20020133032A1 (en) * 2000-02-25 2002-09-19 Jufang Barkalow Method for the preparation of fluticasone and related 17beta-carbothioic esters using a novel carbothioic acid synthesis and novel purification methods
MXPA02009814A (es) * 2000-04-04 2003-03-27 Celanese Int Corp Composiciones de revestimiento receptivas de tinta que contienen alcohol polivinilico injertado con grupos funcionales amina.
US6777400B2 (en) * 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3636010A (en) * 1968-12-23 1972-01-18 Ciba Geigy Corp Esters of steroid-17-carboxylic acids
GB2018256A (en) * 1978-04-05 1979-10-17 Syntex Inc Thio atianic acid derivatives
US4198336A (en) * 1978-04-05 1980-04-15 Syntex (U.S.A.) Inc. Chemical process for preparing androsta-4-ene 17α-carboxylic acids
US5646136A (en) * 1994-01-04 1997-07-08 Duke University Methods of inhibiting angiogenesis and tumor growth, and treating ophthalmologic conditions with angiostatic and therapeutic steroids

Also Published As

Publication number Publication date
PL359462A1 (en) 2004-08-23
IL152348A (en) 2008-08-07
ATE398628T1 (de) 2008-07-15
AU7090601A (en) 2002-02-05
NO324836B1 (no) 2007-12-17
PL206652B1 (pl) 2010-09-30
AU2001270906B2 (en) 2005-10-13
KR20030028736A (ko) 2003-04-10
CY1108553T1 (el) 2014-04-09
HK1056179B (en) 2009-07-17
HUP0301108A3 (en) 2008-04-28
JP2004504403A (ja) 2004-02-12
SI1301526T1 (sl) 2008-10-31
CZ20023472A3 (cs) 2003-04-16
IL152348A0 (en) 2003-05-29
DE60134472D1 (de) 2008-07-31
CZ302592B6 (cs) 2011-07-27
KR100787293B1 (ko) 2007-12-20
PT1301526E (pt) 2008-09-09
EP1301526A1 (en) 2003-04-16
BR0110430A (pt) 2003-07-08
MXPA02010967A (es) 2003-03-27
WO2002008243A1 (en) 2002-01-31
HUP0301108A2 (hu) 2003-08-28
US20040043974A1 (en) 2004-03-04
ZA200208372B (en) 2004-02-11
EP1301526B1 (en) 2008-06-18
HK1056179A1 (en) 2004-02-06
DK1301526T3 (da) 2008-10-06
NO20025054L (no) 2002-11-05
CA2406963A1 (en) 2002-01-31
ES2307628T3 (es) 2008-12-01
CN1437610A (zh) 2003-08-20
NO20025054D0 (no) 2002-10-21
NZ522083A (en) 2004-06-25
GB0017988D0 (en) 2000-09-13

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Granted publication date: 20070516

Termination date: 20130720