KR100764155B1 - 타우린 클로라이드와의 ｌ-카르니틴 및 알카노일 ｌ-카르니틴의 비 흡습성 염을 함유하는 경구 투여에 적합한 고형 조성물 - Google Patents

타우린 클로라이드와의 ｌ-카르니틴 및 알카노일 ｌ-카르니틴의 비 흡습성 염을 함유하는 경구 투여에 적합한 고형 조성물 Download PDF

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KR100764155B1
KR100764155B1 KR1020037005596A KR20037005596A KR100764155B1 KR 100764155 B1 KR100764155 B1 KR 100764155B1 KR 1020037005596 A KR1020037005596 A KR 1020037005596A KR 20037005596 A KR20037005596 A KR 20037005596A KR 100764155 B1 KR100764155 B1 KR 100764155B1
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carnitine
alkanoyl
salts
chloride
hygroscopic
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KR20030059211A (ko
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틴티마리아오넬라
Original Assignee
시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A23L33/22—Comminuted fibrous parts of plants, e.g. bagasse or pulp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/13—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/14—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Engineering & Computer Science (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Botany (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fodder In General (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
KR1020037005596A 2000-10-31 2001-09-28 타우린 클로라이드와의 ｌ-카르니틴 및 알카노일 ｌ-카르니틴의 비 흡습성 염을 함유하는 경구 투여에 적합한 고형 조성물 Expired - Fee Related KR100764155B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT2000RM000567A IT1317924B1 (it) 2000-10-31 2000-10-31 Composizioni solide atte alla somministrazione orale comprendenti salinon igroscopici della l-carnitina e delle alcanoil l-carnitine con
ITRM2000A000567 2000-10-31
PCT/IT2001/000503 WO2002036543A1 (en) 2000-10-31 2001-09-28 Solid compositions suitable for oral administration containing non-hygroscopic salts of l-carnitine and the alkanoyl l-carnitines with taurine chloride and glycine chloride

Publications (2)

Publication Number Publication Date
KR20030059211A KR20030059211A (ko) 2003-07-07
KR100764155B1 true KR100764155B1 (ko) 2007-10-08

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KR1020037005596A Expired - Fee Related KR100764155B1 (ko) 2000-10-31 2001-09-28 타우린 클로라이드와의 ｌ-카르니틴 및 알카노일 ｌ-카르니틴의 비 흡습성 염을 함유하는 경구 투여에 적합한 고형 조성물

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Country Link
US (1) US7858820B2 (enExample)
EP (1) EP1330428B1 (enExample)
JP (1) JP4181406B2 (enExample)
KR (1) KR100764155B1 (enExample)
CN (1) CN1219748C (enExample)
AT (1) ATE312810T1 (enExample)
AU (2) AU2001295893B2 (enExample)
BR (1) BRPI0115019B1 (enExample)
CA (1) CA2427482C (enExample)
CY (1) CY1106062T1 (enExample)
CZ (1) CZ302802B6 (enExample)
DE (1) DE60115944T2 (enExample)
DK (1) DK1330428T3 (enExample)
ES (1) ES2253430T3 (enExample)
HU (1) HU229989B1 (enExample)
IT (1) IT1317924B1 (enExample)
MX (1) MXPA03003799A (enExample)
NZ (1) NZ525333A (enExample)
PL (1) PL205801B1 (enExample)
RU (1) RU2270191C2 (enExample)
SI (1) SI1330428T1 (enExample)
SK (1) SK287133B6 (enExample)
WO (1) WO2002036543A1 (enExample)
ZA (1) ZA200303328B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101007927B1 (ko) 2008-12-24 2011-01-14 주식회사 셀트리온제약 시부트라민-ｌ-카르니틴 다이술폰산염, 이의 제조방법 및 이를 포함하는 약제학적 조성물

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005031705A1 (de) * 2005-07-05 2007-01-18 Henkel Kgaa Mittel, enthaltend L-Carnitin oder L-Carnitinderivate und mindestens eine weitere Substanz ausgewählt aus Taurin und dessen Derivaten und mindestens einem Wirkstoff, erhältlich aus Pflanzen der Gattung Echinacea
JP5451558B2 (ja) * 2010-08-27 2014-03-26 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ 美容活性成分の送達に有用なゲル
CN104276986B (zh) * 2013-07-12 2016-07-06 辽宁科硕营养科技有限公司 左旋肉碱牛磺酸盐的制备方法
JP6473352B2 (ja) * 2015-03-10 2019-02-20 利幸 糸井 虚血性疾患治療薬
CN107325013B (zh) * 2016-04-28 2019-04-12 辽宁科硕营养科技股份有限公司 一种合成甘氨酸丙酰左旋肉碱盐酸盐的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998043945A1 (en) 1997-04-01 1998-10-08 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Solid compositions suitable for oral administration comprising non hygroscopic salts of l-carnitine and alkanoyl-l-carnitine with 2-aminoethanesulfonic acid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0150688B1 (en) * 1983-12-28 1987-04-22 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same
CA2030310A1 (en) * 1989-12-22 1991-06-23 Ronald E. Macleay Derivatives of n-hals-substituted amic acid hydrazides
IT1306147B1 (it) * 1999-05-28 2001-05-30 Biosalts Srl Derivati di principi attivi ad attivita' terapeutica e/o nutrizionalee composizioni atte alla somministrazione orale contenenti tali

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998043945A1 (en) 1997-04-01 1998-10-08 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Solid compositions suitable for oral administration comprising non hygroscopic salts of l-carnitine and alkanoyl-l-carnitine with 2-aminoethanesulfonic acid

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101007927B1 (ko) 2008-12-24 2011-01-14 주식회사 셀트리온제약 시부트라민-ｌ-카르니틴 다이술폰산염, 이의 제조방법 및 이를 포함하는 약제학적 조성물

Also Published As

Publication number Publication date
PL364823A1 (en) 2004-12-27
CZ302802B6 (cs) 2011-11-16
AU9589301A (en) 2002-05-15
ITRM20000567A0 (it) 2000-10-31
CN1219748C (zh) 2005-09-21
US20040024061A1 (en) 2004-02-05
CN1473144A (zh) 2004-02-04
AU2001295893B2 (en) 2006-11-30
DE60115944T2 (de) 2006-06-29
ITRM20000567A1 (it) 2002-05-01
MXPA03003799A (es) 2004-04-20
DK1330428T3 (da) 2006-04-18
NZ525333A (en) 2004-06-25
HUP0302294A3 (en) 2005-05-30
HU229989B1 (hu) 2015-04-28
JP4181406B2 (ja) 2008-11-12
JP2004513107A (ja) 2004-04-30
RU2270191C2 (ru) 2006-02-20
ZA200303328B (en) 2004-03-09
IT1317924B1 (it) 2003-07-15
CA2427482A1 (en) 2002-05-10
CZ20031041A3 (cs) 2003-08-13
HUP0302294A2 (hu) 2003-10-28
PL205801B1 (pl) 2010-05-31
CA2427482C (en) 2010-04-27
SK287133B6 (sk) 2010-01-07
US7858820B2 (en) 2010-12-28
ATE312810T1 (de) 2005-12-15
BRPI0115019B1 (pt) 2015-10-06
EP1330428A1 (en) 2003-07-30
HK1061230A1 (en) 2004-09-10
SK5012003A3 (en) 2003-11-04
SI1330428T1 (sl) 2006-04-30
DE60115944D1 (de) 2006-01-19
KR20030059211A (ko) 2003-07-07
BR0115019A (pt) 2003-12-23
EP1330428B1 (en) 2005-12-14
CY1106062T1 (el) 2011-06-08
WO2002036543A1 (en) 2002-05-10
ES2253430T3 (es) 2006-06-01

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