AU2001295893B2 - Solid compositions suitable for oral administration containing non-hygroscopic salts of L-carnitine and the alkanoyl L-carnitines with taurine chloride and glycine chloride - Google Patents

Solid compositions suitable for oral administration containing non-hygroscopic salts of L-carnitine and the alkanoyl L-carnitines with taurine chloride and glycine chloride Download PDF

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Publication number
AU2001295893B2
AU2001295893B2 AU2001295893A AU2001295893A AU2001295893B2 AU 2001295893 B2 AU2001295893 B2 AU 2001295893B2 AU 2001295893 A AU2001295893 A AU 2001295893A AU 2001295893 A AU2001295893 A AU 2001295893A AU 2001295893 B2 AU2001295893 B2 AU 2001295893B2
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Australia
Prior art keywords
carnitine
alkanoyl
salt
chloride
composition according
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Ceased
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AU2001295893A
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AU2001295893A1 (en
Inventor
Maria Ornella Tinti
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Alfasigma SpA
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Alfasigma SpA
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Assigned to Alfasigma S.p.A reassignment Alfasigma S.p.A Request for Assignment Assignors: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A23L33/22—Comminuted fibrous parts of plants, e.g. bagasse or pulp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/13—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/14—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton containing amino groups bound to the carbon skeleton
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Botany (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fodder In General (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
AU2001295893A 2000-10-31 2001-09-28 Solid compositions suitable for oral administration containing non-hygroscopic salts of L-carnitine and the alkanoyl L-carnitines with taurine chloride and glycine chloride Ceased AU2001295893B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT2000RM000567A IT1317924B1 (it) 2000-10-31 2000-10-31 Composizioni solide atte alla somministrazione orale comprendenti salinon igroscopici della l-carnitina e delle alcanoil l-carnitine con
ITRM2000A000567 2000-10-31
PCT/IT2001/000503 WO2002036543A1 (en) 2000-10-31 2001-09-28 Solid compositions suitable for oral administration containing non-hygroscopic salts of l-carnitine and the alkanoyl l-carnitines with taurine chloride and glycine chloride

Publications (2)

Publication Number Publication Date
AU2001295893A1 AU2001295893A1 (en) 2002-07-18
AU2001295893B2 true AU2001295893B2 (en) 2006-11-30

Family

ID=11454973

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2001295893A Ceased AU2001295893B2 (en) 2000-10-31 2001-09-28 Solid compositions suitable for oral administration containing non-hygroscopic salts of L-carnitine and the alkanoyl L-carnitines with taurine chloride and glycine chloride
AU9589301A Pending AU9589301A (en) 2000-10-31 2001-09-28 Solid compositions suitable for oral administration containing non-hygroscopic salts of l-carnitine and the alkanoyl l-carnitines with taurine chloride and glycine chloride

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU9589301A Pending AU9589301A (en) 2000-10-31 2001-09-28 Solid compositions suitable for oral administration containing non-hygroscopic salts of l-carnitine and the alkanoyl l-carnitines with taurine chloride and glycine chloride

Country Status (24)

Country Link
US (1) US7858820B2 (enExample)
EP (1) EP1330428B1 (enExample)
JP (1) JP4181406B2 (enExample)
KR (1) KR100764155B1 (enExample)
CN (1) CN1219748C (enExample)
AT (1) ATE312810T1 (enExample)
AU (2) AU2001295893B2 (enExample)
BR (1) BRPI0115019B1 (enExample)
CA (1) CA2427482C (enExample)
CY (1) CY1106062T1 (enExample)
CZ (1) CZ302802B6 (enExample)
DE (1) DE60115944T2 (enExample)
DK (1) DK1330428T3 (enExample)
ES (1) ES2253430T3 (enExample)
HU (1) HU229989B1 (enExample)
IT (1) IT1317924B1 (enExample)
MX (1) MXPA03003799A (enExample)
NZ (1) NZ525333A (enExample)
PL (1) PL205801B1 (enExample)
RU (1) RU2270191C2 (enExample)
SI (1) SI1330428T1 (enExample)
SK (1) SK287133B6 (enExample)
WO (1) WO2002036543A1 (enExample)
ZA (1) ZA200303328B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005031705A1 (de) * 2005-07-05 2007-01-18 Henkel Kgaa Mittel, enthaltend L-Carnitin oder L-Carnitinderivate und mindestens eine weitere Substanz ausgewählt aus Taurin und dessen Derivaten und mindestens einem Wirkstoff, erhältlich aus Pflanzen der Gattung Echinacea
KR101007927B1 (ko) 2008-12-24 2011-01-14 주식회사 셀트리온제약 시부트라민-ｌ-카르니틴 다이술폰산염, 이의 제조방법 및 이를 포함하는 약제학적 조성물
JP5451558B2 (ja) * 2010-08-27 2014-03-26 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ 美容活性成分の送達に有用なゲル
CN104276986B (zh) * 2013-07-12 2016-07-06 辽宁科硕营养科技有限公司 左旋肉碱牛磺酸盐的制备方法
JP6473352B2 (ja) * 2015-03-10 2019-02-20 利幸 糸井 虚血性疾患治療薬
CN107325013B (zh) * 2016-04-28 2019-04-12 辽宁科硕营养科技股份有限公司 一种合成甘氨酸丙酰左旋肉碱盐酸盐的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998043945A1 (en) * 1997-04-01 1998-10-08 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Solid compositions suitable for oral administration comprising non hygroscopic salts of l-carnitine and alkanoyl-l-carnitine with 2-aminoethanesulfonic acid
WO2000073258A1 (en) * 1999-05-28 2000-12-07 Biosalts S.R.L. Therapeutically and/or nutritionally enhanced derivatives of active ingredients and orally administrable compositions containing same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0150688B1 (en) * 1983-12-28 1987-04-22 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same
CA2030310A1 (en) * 1989-12-22 1991-06-23 Ronald E. Macleay Derivatives of n-hals-substituted amic acid hydrazides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998043945A1 (en) * 1997-04-01 1998-10-08 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Solid compositions suitable for oral administration comprising non hygroscopic salts of l-carnitine and alkanoyl-l-carnitine with 2-aminoethanesulfonic acid
WO2000073258A1 (en) * 1999-05-28 2000-12-07 Biosalts S.R.L. Therapeutically and/or nutritionally enhanced derivatives of active ingredients and orally administrable compositions containing same

Also Published As

Publication number Publication date
PL364823A1 (en) 2004-12-27
CZ302802B6 (cs) 2011-11-16
AU9589301A (en) 2002-05-15
ITRM20000567A0 (it) 2000-10-31
KR100764155B1 (ko) 2007-10-08
CN1219748C (zh) 2005-09-21
US20040024061A1 (en) 2004-02-05
CN1473144A (zh) 2004-02-04
DE60115944T2 (de) 2006-06-29
ITRM20000567A1 (it) 2002-05-01
MXPA03003799A (es) 2004-04-20
DK1330428T3 (da) 2006-04-18
NZ525333A (en) 2004-06-25
HUP0302294A3 (en) 2005-05-30
HU229989B1 (hu) 2015-04-28
JP4181406B2 (ja) 2008-11-12
JP2004513107A (ja) 2004-04-30
RU2270191C2 (ru) 2006-02-20
ZA200303328B (en) 2004-03-09
IT1317924B1 (it) 2003-07-15
CA2427482A1 (en) 2002-05-10
CZ20031041A3 (cs) 2003-08-13
HUP0302294A2 (hu) 2003-10-28
PL205801B1 (pl) 2010-05-31
CA2427482C (en) 2010-04-27
SK287133B6 (sk) 2010-01-07
US7858820B2 (en) 2010-12-28
ATE312810T1 (de) 2005-12-15
BRPI0115019B1 (pt) 2015-10-06
EP1330428A1 (en) 2003-07-30
HK1061230A1 (en) 2004-09-10
SK5012003A3 (en) 2003-11-04
SI1330428T1 (sl) 2006-04-30
DE60115944D1 (de) 2006-01-19
KR20030059211A (ko) 2003-07-07
BR0115019A (pt) 2003-12-23
EP1330428B1 (en) 2005-12-14
CY1106062T1 (el) 2011-06-08
WO2002036543A1 (en) 2002-05-10
ES2253430T3 (es) 2006-06-01

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FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: ALFASIGMA S.P.A

Free format text: FORMER OWNER(S): SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.

MK14 Patent ceased section 143(a) (annual fees not paid) or expired