IT1306147B1 - Derivati di principi attivi ad attivita' terapeutica e/o nutrizionalee composizioni atte alla somministrazione orale contenenti tali - Google Patents

Derivati di principi attivi ad attivita' terapeutica e/o nutrizionalee composizioni atte alla somministrazione orale contenenti tali

Info

Publication number
IT1306147B1
IT1306147B1 IT1999RM000339A ITRM990339A IT1306147B1 IT 1306147 B1 IT1306147 B1 IT 1306147B1 IT 1999RM000339 A IT1999RM000339 A IT 1999RM000339A IT RM990339 A ITRM990339 A IT RM990339A IT 1306147 B1 IT1306147 B1 IT 1306147B1
Authority
IT
Italy
Prior art keywords
oral administration
therapeutic
derivatives
active ingredients
compositions suitable
Prior art date
Application number
IT1999RM000339A
Other languages
English (en)
Inventor
Antonietta Buononato
Original Assignee
Biosalts Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11406790&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IT1306147(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biosalts Srl filed Critical Biosalts Srl
Priority to IT1999RM000339A priority Critical patent/IT1306147B1/it
Publication of ITRM990339A0 publication Critical patent/ITRM990339A0/it
Priority to ES00935481T priority patent/ES2220468T3/es
Priority to US09/979,880 priority patent/US6703042B1/en
Priority to CA002374471A priority patent/CA2374471C/en
Priority to EP00935481A priority patent/EP1202956B1/en
Priority to PT00935481T priority patent/PT1202956E/pt
Priority to AU51018/00A priority patent/AU5101800A/en
Priority to DK00935481T priority patent/DK1202956T3/da
Priority to PCT/IT2000/000217 priority patent/WO2000073258A1/en
Priority to MXPA01012176A priority patent/MXPA01012176A/es
Priority to CNB008092923A priority patent/CN1162397C/zh
Priority to AT00935481T priority patent/ATE267162T1/de
Priority to DE60010896T priority patent/DE60010896T2/de
Publication of ITRM990339A1 publication Critical patent/ITRM990339A1/it
Publication of IT1306147B1 publication Critical patent/IT1306147B1/it
Application granted granted Critical
Priority to HK02108634.3A priority patent/HK1047084B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT1999RM000339A 1999-05-28 1999-05-28 Derivati di principi attivi ad attivita' terapeutica e/o nutrizionalee composizioni atte alla somministrazione orale contenenti tali IT1306147B1 (it)

Priority Applications (14)

Application Number Priority Date Filing Date Title
IT1999RM000339A IT1306147B1 (it) 1999-05-28 1999-05-28 Derivati di principi attivi ad attivita' terapeutica e/o nutrizionalee composizioni atte alla somministrazione orale contenenti tali
DE60010896T DE60010896T2 (de) 1999-05-28 2000-05-26 Therapeutisch und/oder ernährungsphysiologisch verbesserte derivate aktiver inhaltsstoffe und oral verabreichbare zusammensetzungen, die diese enthalten
DK00935481T DK1202956T3 (da) 1999-05-28 2000-05-26 Terapeutisk og/eller ernærngsmæssigt forstærkede derivater af aktive bestanddele og oralt indgivelsesbare præparater indeholdende de samme
PCT/IT2000/000217 WO2000073258A1 (en) 1999-05-28 2000-05-26 Therapeutically and/or nutritionally enhanced derivatives of active ingredients and orally administrable compositions containing same
CA002374471A CA2374471C (en) 1999-05-28 2000-05-26 Therapeutically and/or nutritionally enhanced derivatives of active ingredients and orally administrable compositions containing same
EP00935481A EP1202956B1 (en) 1999-05-28 2000-05-26 Therapeutically and/or nutritionally enhanced derivatives of active ingredients and orally administrable compositions containing same
PT00935481T PT1202956E (pt) 1999-05-28 2000-05-26 Derivados terapeuticos e/ou nuricionalmente melhorados de ingredientes activos e composicoes de administracao oral contendo o mesmo
AU51018/00A AU5101800A (en) 1999-05-28 2000-05-26 Therapeutically and/or nutritionally enhanced derivatives of active ingredients and orally administrable compositions containing same
ES00935481T ES2220468T3 (es) 1999-05-28 2000-05-26 Derivados de principios activos mejorados terapeutica y/o nutricionalmente y composiciones para administracion oral que los contienen.
US09/979,880 US6703042B1 (en) 1999-05-28 2000-05-26 Salts of L-carnitine and lower alkanoyl L-carnitine
MXPA01012176A MXPA01012176A (es) 1999-05-28 2000-05-26 Derivados mejorados terapeutica y/o nutricionalmente de ingredientes activos y composiciones oralmente administrables que los contienen,.
CNB008092923A CN1162397C (zh) 1999-05-28 2000-05-26 治疗和/或营养效果增强的活性成分衍生物和含有所述衍生物的口服组合物
AT00935481T ATE267162T1 (de) 1999-05-28 2000-05-26 Therapeutisch und/oder ernährungsphysiologisch verbesserte derivate aktiver inhaltsstoffe und oral verabreichbare zusammensetzungen, die diese enthalten
HK02108634.3A HK1047084B (zh) 1999-05-28 2002-11-29 治療和/或營養效果增强的活性成分衍生物和含有所述衍生物的口服組合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999RM000339A IT1306147B1 (it) 1999-05-28 1999-05-28 Derivati di principi attivi ad attivita' terapeutica e/o nutrizionalee composizioni atte alla somministrazione orale contenenti tali

Publications (3)

Publication Number Publication Date
ITRM990339A0 ITRM990339A0 (it) 1999-05-28
ITRM990339A1 ITRM990339A1 (it) 2000-11-28
IT1306147B1 true IT1306147B1 (it) 2001-05-30

Family

ID=11406790

Family Applications (1)

Application Number Title Priority Date Filing Date
IT1999RM000339A IT1306147B1 (it) 1999-05-28 1999-05-28 Derivati di principi attivi ad attivita' terapeutica e/o nutrizionalee composizioni atte alla somministrazione orale contenenti tali

Country Status (14)

Country Link
US (1) US6703042B1 (it)
EP (1) EP1202956B1 (it)
CN (1) CN1162397C (it)
AT (1) ATE267162T1 (it)
AU (1) AU5101800A (it)
CA (1) CA2374471C (it)
DE (1) DE60010896T2 (it)
DK (1) DK1202956T3 (it)
ES (1) ES2220468T3 (it)
HK (1) HK1047084B (it)
IT (1) IT1306147B1 (it)
MX (1) MXPA01012176A (it)
PT (1) PT1202956E (it)
WO (1) WO2000073258A1 (it)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1317924B1 (it) * 2000-10-31 2003-07-15 Sigma Tau Ind Farmaceuti Composizioni solide atte alla somministrazione orale comprendenti salinon igroscopici della l-carnitina e delle alcanoil l-carnitine con
CA2686905C (en) * 2007-05-11 2015-07-07 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Gel useful for the delivery of cosmetic active ingredients
US20090156648A1 (en) * 2007-12-12 2009-06-18 Iovate T. & P. Inc. Preparations containing pyridoxine and alpha-hydroxyisocaproic acid (HICA)
JP2011524415A (ja) * 2008-06-16 2011-09-01 サイアン ラボラトリーズ，エルエルシー Ｌ−カルニチンフィチン酸塩及びアルカノイル−ｌ−カルニチンフィチン酸塩と、その製造方法
US8067468B2 (en) * 2009-06-10 2011-11-29 Jian Chen L-carnitine and alkanoyl L-carnitine phytates and process for preparing the same
CA2903000C (en) 2013-01-28 2021-10-12 Hector L. Lopez Methods of improving tolerability, pharmacodynamics, and efficacy of .beta.-alanine and use therefor
CN105777534B (zh) * 2014-12-24 2018-07-06 辽宁科硕营养科技有限公司 柠檬酸钙盐及其制备方法与用途
CN110559265A (zh) * 2018-06-05 2019-12-13 辽宁科硕营养科技股份有限公司 一种乙酰左旋肉碱精氨酸二盐酸盐防潮颗粒的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3463261D1 (en) * 1983-12-28 1987-05-27 Sigma Tau Ind Farmaceuti Salts of l-carnitine and alkanoyl l-carnitines and process for preparing same
IT1209564B (it) * 1984-06-29 1989-08-30 Magis Farmaceutici Derivati della l-carnitina o di l-acil carnitina.
FR2635264B1 (fr) * 1988-08-12 1992-02-28 Bellon Labor Sa Roger Compositions pharmaceutiques et/ou dietetiques contenant de la l-carnitine et de la l-lysine
IT1291143B1 (it) * 1997-04-18 1998-12-29 Sigma Tau Ind Farmaceuti Composizioni solide atte alla somministrazione orale comprendenti l-carnitina colina tartrato o una alcanoil l-carnitina colina
IT1306130B1 (it) * 1999-04-16 2001-05-30 Sigma Tau Healthscience Spa Composizione comprendente una carnitina e glutatione, atta adaumentare l'assorbimento del glutatione sinergizzandone gli effetti.

Also Published As

Publication number Publication date
AU5101800A (en) 2000-12-18
ITRM990339A0 (it) 1999-05-28
MXPA01012176A (es) 2003-10-14
DK1202956T3 (da) 2004-09-27
CN1162397C (zh) 2004-08-18
PT1202956E (pt) 2004-09-30
CN1356976A (zh) 2002-07-03
CA2374471C (en) 2009-09-15
HK1047084A1 (en) 2003-02-07
EP1202956A1 (en) 2002-05-08
DE60010896D1 (de) 2004-06-24
US6703042B1 (en) 2004-03-09
EP1202956B1 (en) 2004-05-19
WO2000073258A1 (en) 2000-12-07
DE60010896T2 (de) 2005-07-07
ES2220468T3 (es) 2004-12-16
HK1047084B (zh) 2005-04-29
ITRM990339A1 (it) 2000-11-28
ATE267162T1 (de) 2004-06-15
CA2374471A1 (en) 2000-12-07

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