KR100750788B1 - ｅＩＦ4Ｅ 발현의 조정 - Google Patents

ｅＩＦ4Ｅ 발현의 조정 Download PDF

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Publication number
KR100750788B1
KR100750788B1 KR1020067005449A KR20067005449A KR100750788B1 KR 100750788 B1 KR100750788 B1 KR 100750788B1 KR 1020067005449 A KR1020067005449 A KR 1020067005449A KR 20067005449 A KR20067005449 A KR 20067005449A KR 100750788 B1 KR100750788 B1 KR 100750788B1
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delete delete
eif4e
antisense
rna
compounds
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KR20060039031A (ko
Inventor
수잔 엠. 프레이어
케네쓰 더블유. 도비
에릭 지. 마르쿠손
에릭 이. 스웨이즈
발크리센 브하트
제레미 알. 그래프
브루스 더블유. 코니섹
Original Assignee
아이시스 파마수티컬즈 인코포레이티드
일라이 릴리 앤드 캄파니
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Application filed by 아이시스 파마수티컬즈 인코포레이티드, 일라이 릴리 앤드 캄파니 filed Critical 아이시스 파마수티컬즈 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C12N2310/3181—Peptide nucleic acid, PNA
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed

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  • General Engineering & Computer Science (AREA)
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  • Biophysics (AREA)
  • Plant Pathology (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020067005449A 2003-09-18 2004-09-17 ｅＩＦ4Ｅ 발현의 조정 Expired - Fee Related KR100750788B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US50411003P 2003-09-18 2003-09-18
US60/504,110 2003-09-18
US57653404P 2004-06-03 2004-06-03
US60/576,534 2004-06-03
PCT/US2004/030436 WO2005028628A2 (en) 2003-09-18 2004-09-17 Modulation of eif4e expression

Publications (2)

Publication Number Publication Date
KR20060039031A KR20060039031A (ko) 2006-05-04
KR100750788B1 true KR100750788B1 (ko) 2007-08-20

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US (5) US7425544B2 (enExample)
EP (4) EP2256201A3 (enExample)
JP (1) JP4672664B2 (enExample)
KR (1) KR100750788B1 (enExample)
CN (1) CN100558893C (enExample)
AR (1) AR045937A1 (enExample)
AU (1) AU2004274942B2 (enExample)
BR (1) BRPI0413930A (enExample)
CA (1) CA2539181A1 (enExample)
EA (1) EA009670B1 (enExample)
EC (1) ECSP066421A (enExample)
IL (2) IL173707A0 (enExample)
MA (1) MA28264A1 (enExample)
NO (1) NO20061673L (enExample)
NZ (2) NZ576775A (enExample)
PE (1) PE20050469A1 (enExample)
SG (1) SG146682A1 (enExample)
TW (1) TW200519202A (enExample)
WO (1) WO2005028628A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021045538A1 (ko) * 2019-09-03 2021-03-11 소바젠 주식회사 eIF4E 저해제를 포함하는 eIF4E 활성증가와 관련된 상태의 진단 또는 치료용 조성물

Families Citing this family (112)

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