EA009670B1 - МОДУЛИРОВАНИЕ ЭКСПРЕССИИ eIF4E - Google Patents

МОДУЛИРОВАНИЕ ЭКСПРЕССИИ eIF4E Download PDF

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Publication number
EA009670B1
EA009670B1 EA200600591A EA200600591A EA009670B1 EA 009670 B1 EA009670 B1 EA 009670B1 EA 200600591 A EA200600591 A EA 200600591A EA 200600591 A EA200600591 A EA 200600591A EA 009670 B1 EA009670 B1 EA 009670B1
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Eurasian Patent Office
Prior art keywords
compounds
nucleic acid
rna
antisense
oligonucleotides
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EA200600591A
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English (en)
Russian (ru)
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EA200600591A1 (ru
Inventor
Сьюзан М. Фрейер
Кеннет В. Доби
Эрик Г. Маркуссон
Эрик Э. Свайзе
Балкришен Бхат
Джереми Р. Графф
Брюс В. Коничек
Original Assignee
Ай Эс Ай Эс ФАРМАСЬЮТИКАЛЗ, ИНК.
Эли Лилли Энд Компани
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34381100&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA009670(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ай Эс Ай Эс ФАРМАСЬЮТИКАЛЗ, ИНК., Эли Лилли Энд Компани filed Critical Ай Эс Ай Эс ФАРМАСЬЮТИКАЛЗ, ИНК.
Publication of EA200600591A1 publication Critical patent/EA200600591A1/ru
Publication of EA009670B1 publication Critical patent/EA009670B1/ru

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    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/318Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C12N2310/3181Peptide nucleic acid, PNA
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    • C12N2310/32Chemical structure of the sugar
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/3212'-O-R Modification
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/32Chemical structure of the sugar
    • C12N2310/323Chemical structure of the sugar modified ring structure
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    • C12N2310/33415-Methylcytosine
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    • C12N2310/34Spatial arrangement of the modifications
    • C12N2310/341Gapmers, i.e. of the type ===---===
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/50Physical structure
    • C12N2310/53Physical structure partially self-complementary or closed

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EA200600591A 2003-09-18 2004-09-17 МОДУЛИРОВАНИЕ ЭКСПРЕССИИ eIF4E EA009670B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50411003P 2003-09-18 2003-09-18
US57653404P 2004-06-03 2004-06-03
PCT/US2004/030436 WO2005028628A2 (en) 2003-09-18 2004-09-17 Modulation of eif4e expression

Publications (2)

Publication Number Publication Date
EA200600591A1 EA200600591A1 (ru) 2006-10-27
EA009670B1 true EA009670B1 (ru) 2008-02-28

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ID=34381100

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EA200600591A EA009670B1 (ru) 2003-09-18 2004-09-17 МОДУЛИРОВАНИЕ ЭКСПРЕССИИ eIF4E

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US (5) US7425544B2 (enExample)
EP (4) EP2256201A3 (enExample)
JP (1) JP4672664B2 (enExample)
KR (1) KR100750788B1 (enExample)
CN (1) CN100558893C (enExample)
AR (1) AR045937A1 (enExample)
AU (1) AU2004274942B2 (enExample)
BR (1) BRPI0413930A (enExample)
CA (1) CA2539181A1 (enExample)
EA (1) EA009670B1 (enExample)
EC (1) ECSP066421A (enExample)
IL (2) IL173707A0 (enExample)
MA (1) MA28264A1 (enExample)
NO (1) NO20061673L (enExample)
NZ (2) NZ576775A (enExample)
PE (1) PE20050469A1 (enExample)
SG (1) SG146682A1 (enExample)
TW (1) TW200519202A (enExample)
WO (1) WO2005028628A2 (enExample)

Families Citing this family (113)

* Cited by examiner, † Cited by third party
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