KR100748386B1 - 단백질 키나제 ｃ 억제제로서의 인돌릴말레이미드 유도체 - Google Patents

단백질 키나제 ｃ 억제제로서의 인돌릴말레이미드 유도체 Download PDF

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KR100748386B1
KR100748386B1 KR1020037005805A KR20037005805A KR100748386B1 KR 100748386 B1 KR100748386 B1 KR 100748386B1 KR 1020037005805 A KR1020037005805 A KR 1020037005805A KR 20037005805 A KR20037005805 A KR 20037005805A KR 100748386 B1 KR100748386 B1 KR 100748386B1
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mmol
formula
compound
alkyl
solution
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KR20030042036A (ko
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라이너 알베르트
니겔 그라함 쿠크
실바인 코텐스
클라우스 에르하르트
장-삐에르 에베노우
리차드 세드라니
마트 페터 본
유르겐 바그너
게르하르트 젠크
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노파르티스 아게
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    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Obesity (AREA)
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  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • AIDS & HIV (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
KR1020037005805A 2000-11-07 2001-11-05 단백질 키나제 ｃ 억제제로서의 인돌릴말레이미드 유도체 Expired - Fee Related KR100748386B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US24640000P 2000-11-07 2000-11-07
US60/246,400 2000-11-07
US28370501P 2001-04-13 2001-04-13
US60/283,705 2001-04-13
PCT/EP2001/012785 WO2002038561A1 (en) 2000-11-07 2001-11-05 Indolylmaleimide derivatives as protein kinase c inhibitors

Related Child Applications (1)

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KR1020067017472A Division KR100916613B1 (ko) 2000-11-07 2001-11-05 단백질 키나제 ｃ 억제제로서의 인돌릴말레이미드 유도체

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Publication Number Publication Date
KR20030042036A KR20030042036A (ko) 2003-05-27
KR100748386B1 true KR100748386B1 (ko) 2007-08-10

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KR1020087002849A Ceased KR20080014934A (ko) 2000-11-07 2001-11-05 단백질 키나제 ｃ 억제제로서의 인돌릴말레이미드 유도체
KR1020037005805A Expired - Fee Related KR100748386B1 (ko) 2000-11-07 2001-11-05 단백질 키나제 ｃ 억제제로서의 인돌릴말레이미드 유도체
KR1020067017472A Expired - Fee Related KR100916613B1 (ko) 2000-11-07 2001-11-05 단백질 키나제 ｃ 억제제로서의 인돌릴말레이미드 유도체

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KR1020087002849A Ceased KR20080014934A (ko) 2000-11-07 2001-11-05 단백질 키나제 ｃ 억제제로서의 인돌릴말레이미드 유도체

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KR1020067017472A Expired - Fee Related KR100916613B1 (ko) 2000-11-07 2001-11-05 단백질 키나제 ｃ 억제제로서의 인돌릴말레이미드 유도체

Country Status (30)

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EP (2) EP2070921A1 (OSRAM)
JP (1) JP4234426B2 (OSRAM)
KR (3) KR20080014934A (OSRAM)
CN (1) CN1253449C (OSRAM)
AR (1) AR035211A1 (OSRAM)
AT (1) ATE445613T1 (OSRAM)
AU (3) AU2002221810B2 (OSRAM)
BR (1) BRPI0115193B1 (OSRAM)
CA (1) CA2428133C (OSRAM)
CY (1) CY1110564T1 (OSRAM)
CZ (1) CZ307144B6 (OSRAM)
DE (1) DE60140201D1 (OSRAM)
DK (1) DK1337527T3 (OSRAM)
EC (1) ECSP104578A (OSRAM)
ES (1) ES2332770T3 (OSRAM)
HU (1) HU228999B1 (OSRAM)
IL (3) IL155618A0 (OSRAM)
MX (1) MXPA03004037A (OSRAM)
MY (2) MY139979A (OSRAM)
NO (1) NO327427B1 (OSRAM)
NZ (2) NZ535616A (OSRAM)
PE (1) PE20020544A1 (OSRAM)
PL (1) PL208794B1 (OSRAM)
PT (1) PT1337527E (OSRAM)
RU (2) RU2329263C2 (OSRAM)
SG (1) SG159378A1 (OSRAM)
SI (1) SI1337527T1 (OSRAM)
SK (1) SK287919B6 (OSRAM)
TW (2) TW200738687A (OSRAM)
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PE20040079A1 (es) * 2002-04-03 2004-04-19 Novartis Ag Derivados de indolilmaleimida
US6987110B2 (en) 2002-06-05 2006-01-17 Janssen Pharmaceutica N.V. Substituted pyrrolines as kinase inhibitors
JP2005531607A (ja) 2002-06-05 2005-10-20 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ キナーゼ阻害剤として置換ピロリン
GB0303319D0 (en) 2003-02-13 2003-03-19 Novartis Ag Organic compounds
EP1670497A4 (en) 2003-09-16 2009-07-15 Garvan Inst Med Res METHOD FOR IDENTIFYING MODULATORS OF PROTEIN KINASE C EPSILON (PKC Ε) AND METHOD FOR TREATING THEREOF CONVERTING DERIVED GLUCOSE METABOLISM
EP1682103A1 (en) * 2003-10-27 2006-07-26 Novartis AG Indolyl-pyrroledione derivatives for the treatment of neurological and vascular disorders related to beta-amyloid generation and/or aggregation
TWI344364B (en) * 2003-11-10 2011-07-01 Synta Pharmaceuticals Corp Fused heterocyclic compounds
ES2303218T3 (es) 2004-01-19 2008-08-01 Novartis Ag Derivados de indolilmaleimida.
GB0401089D0 (en) * 2004-01-19 2004-02-18 Novartis Ag Organic compounds
CA2560311A1 (en) * 2004-04-08 2005-10-20 Novartis Ag Protein kinase c inhibitors for the treatment of autoimmune diseases and of transplant rejection
GB0410713D0 (en) * 2004-05-13 2004-06-16 Novartis Ag Organic compounds
EP1819697B1 (en) 2004-12-08 2012-08-01 Johannes Gutenberg-Universität Mainz 3-(indolyl)-4-arylmaleimide derivatives and their use as angiogenesis inhibitors
GB0504203D0 (en) * 2005-03-01 2005-04-06 Novartis Ag Organic compounds
GB0507918D0 (en) 2005-04-19 2005-05-25 Novartis Ag Organic compounds
US20080207594A1 (en) 2005-05-04 2008-08-28 Davelogen Aktiengesellschaft Use of Gsk-3 Inhibitors for Preventing and Treating Pancreatic Autoimmune Disorders
GB0511060D0 (en) 2005-05-31 2005-07-06 Novartis Ag Organic compounds
ES2396671T3 (es) * 2005-07-11 2013-02-25 Novartis Ag Derivados de la indolilmaleimida como inhibidores de la proteína quinasa
EP4218815A3 (en) 2005-10-26 2024-03-27 Novartis AG Use of anti il-1beta antibodies
EP2275103B1 (en) 2005-11-21 2014-04-23 Novartis AG mTOR inhibitors in the treatment of endocrine tumors
GB0601744D0 (en) 2006-01-27 2006-03-08 Novartis Ag Organic compounds
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