KR100648541B1 - 프라바스타틴을 제조하기 위한 미생물학적인 방법 - Google Patents

프라바스타틴을 제조하기 위한 미생물학적인 방법 Download PDF

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Publication number
KR100648541B1
KR100648541B1 KR1020017009821A KR20017009821A KR100648541B1 KR 100648541 B1 KR100648541 B1 KR 100648541B1 KR 1020017009821 A KR1020017009821 A KR 1020017009821A KR 20017009821 A KR20017009821 A KR 20017009821A KR 100648541 B1 KR100648541 B1 KR 100648541B1
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South Korea
Prior art keywords
pravastatin
delete delete
formula
ethyl acetate
solution
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Expired - Fee Related
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KR1020017009821A
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English (en)
Korean (ko)
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KR20010112257A (ko
Inventor
제켈안토니아
코냐아틸라
바르타이스트반
일코이에바
소모지지올지
암브루스가보
호르바스지울라
알브레트카롤리
자보이스트반엠
모제스니수토줄리안나
살랏자노스
안도르아틸라
비린식라스즈로
보로스산도르
랑일디코
비들로니이글로이마르짓
Original Assignee
인스티튜트 포 드럭 리서치 리미티드
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Publication of KR20010112257A publication Critical patent/KR20010112257A/ko
Application granted granted Critical
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020017009821A 1999-02-03 2000-02-03 프라바스타틴을 제조하기 위한 미생물학적인 방법 Expired - Fee Related KR100648541B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11845899P 1999-02-03 1999-02-03
US60/118,458 1999-02-03
US13475999P 1999-05-18 1999-05-18
US60/134,759 1999-05-18

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020067009407A Division KR20060061406A (ko) 1999-02-03 2000-02-03 프라바스타틴을 제조하기 위한 미생물학적인 방법

Publications (2)

Publication Number Publication Date
KR20010112257A KR20010112257A (ko) 2001-12-20
KR100648541B1 true KR100648541B1 (ko) 2006-11-24

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ID=26816384

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020067009407A Ceased KR20060061406A (ko) 1999-02-03 2000-02-03 프라바스타틴을 제조하기 위한 미생물학적인 방법
KR1020017009821A Expired - Fee Related KR100648541B1 (ko) 1999-02-03 2000-02-03 프라바스타틴을 제조하기 위한 미생물학적인 방법

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Application Number Title Priority Date Filing Date
KR1020067009407A Ceased KR20060061406A (ko) 1999-02-03 2000-02-03 프라바스타틴을 제조하기 위한 미생물학적인 방법

Country Status (27)

Country Link
EP (1) EP1154979B1 (enExample)
JP (2) JP3645491B2 (enExample)
KR (2) KR20060061406A (enExample)
CN (3) CN1177793C (enExample)
AR (2) AR023368A1 (enExample)
AT (1) ATE294771T1 (enExample)
AU (2) AU774438B2 (enExample)
BG (1) BG105778A (enExample)
BR (1) BR0009180A (enExample)
CA (1) CA2361701C (enExample)
CZ (1) CZ20012761A3 (enExample)
DE (1) DE60019898T2 (enExample)
ES (1) ES2240072T3 (enExample)
HK (1) HK1042686B (enExample)
HR (1) HRP20010577B1 (enExample)
HU (1) HUP0200650A3 (enExample)
IL (1) IL144697A0 (enExample)
IS (1) IS6036A (enExample)
MX (1) MXPA01007807A (enExample)
NO (1) NO20013818L (enExample)
PL (1) PL350317A1 (enExample)
PT (1) PT1154979E (enExample)
RU (1) RU2004127981A (enExample)
SK (1) SK10932001A3 (enExample)
TR (2) TR200600009T2 (enExample)
WO (1) WO2000046175A1 (enExample)
YU (1) YU55701A (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI20305A (sl) † 1999-08-06 2001-02-28 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristali natrijeve soli pravastatina
EP1798214A3 (en) * 1999-11-30 2007-08-01 Teva Gyogyszergyár Zártköruen Muködo Részvenytarsaság Process for recovering statin compounds from a fermentation broth
AU1804601A (en) * 1999-11-30 2001-06-12 Biogal Gyogyszergyar Rt Process for recovering statin compounds from a fermentation broth
KR20020062340A (ko) 1999-12-14 2002-07-25 비오갈 기오기스제르갸르 알티. 신규 형태의 프라바스타틴 나트륨
HRP20030347A2 (en) * 2000-10-05 2005-04-30 Teva Gy�gyszergy�r R�szv�nyt�rsas�g Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
JP2003026634A (ja) * 2001-07-17 2003-01-29 Mercian Corp プラバスタチンナトリウム塩の製造方法
JP3463875B2 (ja) 2001-08-06 2003-11-05 三共株式会社 プラバスタチンを精製する方法
JP3422791B2 (ja) 2002-08-06 2003-06-30 三共株式会社 プラバスタチンの単離・精製方法
KR100540761B1 (ko) * 2002-08-09 2006-01-16 코바이오텍 (주) 프라바스타틴 나트륨의 제조방법
EP1452519A1 (en) * 2003-02-25 2004-09-01 Balkanpharma-Razgrad AD Method for the isolation and purification of pravastatin sodium
WO2004096785A1 (ja) * 2003-04-25 2004-11-11 Nippon Chemiphar Co., Ltd. （２s，３s）－３－［［（１s）－１－イソブトキシメチル－３－メチルブチル］カルバモイル］オキシラン－２－カルボン酸の塩
CN1244688C (zh) 2003-07-09 2006-03-08 上海天伟生物制药有限公司 生产普伐他汀钠的微生物和方法
TWI319707B (en) 2003-11-24 2010-01-21 Method of purifying pravastatin
TWI307360B (en) 2004-12-03 2009-03-11 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Process for constructing strain having compactin hydroxylation ability
US20110130450A1 (en) * 2008-04-02 2011-06-02 Aad Johannes Bouman Pravastatin extraction
EP3714959A1 (en) * 2019-03-29 2020-09-30 Basf Se Isolation of small molecules from the fermentation broth of a eukaryotic microorganism
CN117164541B (zh) * 2022-05-27 2025-09-30 黑龙江华瑞生物科技有限公司 一种从美伐他汀母液中分离纯化美伐他汀的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE249514T1 (de) * 1996-03-28 2003-09-15 Dsm Ip Assets Bv Verfahren zur herstellung von granulärer mikrobieller biomasse und gewinnung wertvoller komponenten aus mikrobieller biomasse

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Publication number Publication date
EP1154979A4 (en) 2004-05-26
HK1042686A1 (en) 2002-08-23
CN1590363A (zh) 2005-03-09
CN1177793C (zh) 2004-12-01
SK10932001A3 (sk) 2002-06-04
KR20060061406A (ko) 2006-06-07
HRP20010577B1 (en) 2005-12-31
AU774438B2 (en) 2004-06-24
DE60019898T2 (de) 2006-08-10
HRP20010577A2 (en) 2002-12-31
AU3356700A (en) 2000-08-25
RU2004127981A (ru) 2006-03-10
CN1260344C (zh) 2006-06-21
ES2240072T3 (es) 2005-10-16
CN1347400A (zh) 2002-05-01
CA2361701C (en) 2007-04-10
JP4197312B2 (ja) 2008-12-17
JP3645491B2 (ja) 2005-05-11
IS6036A (is) 2001-08-02
PL350317A1 (en) 2002-12-02
CZ20012761A3 (cs) 2002-05-15
TR200600009T2 (tr) 2006-08-21
EP1154979A1 (en) 2001-11-21
NO20013818D0 (no) 2001-08-03
CA2361701A1 (en) 2000-08-10
PT1154979E (pt) 2005-08-31
JP2002535977A (ja) 2002-10-29
HUP0200650A2 (en) 2002-08-28
ATE294771T1 (de) 2005-05-15
AR023368A1 (es) 2002-09-04
EP1154979B1 (en) 2005-05-04
BG105778A (bg) 2002-05-31
AU2004214559A1 (en) 2004-10-21
CN1537935A (zh) 2004-10-20
IL144697A0 (en) 2002-06-30
NO20013818L (no) 2001-10-03
DE60019898D1 (de) 2005-06-09
WO2000046175A1 (en) 2000-08-10
JP2005047924A (ja) 2005-02-24
KR20010112257A (ko) 2001-12-20
HK1042686B (en) 2005-10-14
YU55701A (sh) 2004-07-15
MXPA01007807A (es) 2003-06-04
TR200103127T2 (tr) 2002-04-22
BR0009180A (pt) 2002-03-26
AR061765A2 (es) 2008-09-17
HUP0200650A3 (en) 2008-03-28

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