HK1042686B - Microbial process for preparing pravastatin - Google Patents

Microbial process for preparing pravastatin Download PDF

Info

Publication number
HK1042686B
HK1042686B HK02103449.9A HK02103449A HK1042686B HK 1042686 B HK1042686 B HK 1042686B HK 02103449 A HK02103449 A HK 02103449A HK 1042686 B HK1042686 B HK 1042686B
Authority
HK
Hong Kong
Prior art keywords
compound
formula
pravastatin
broth
strain
Prior art date
Application number
HK02103449.9A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1042686A1 (en
Inventor
Jekkel Antonia
Konya Attila
Barta Istvan
Ilkoy Eva
Somogyi Gyorgy
Ambrus Gabor
Horvath Gyula
Albrecht Karoly
M. Szabo Istvan
Mozes Nee Suto Julianna
Salat Janos
Andor Attila
Birincsik Laszlo
Boros Sandor
Lang Ildiko
Bidlo Nee Igloy Margit
Original Assignee
Institute For Drug Research Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institute For Drug Research Ltd. filed Critical Institute For Drug Research Ltd.
Publication of HK1042686A1 publication Critical patent/HK1042686A1/en
Publication of HK1042686B publication Critical patent/HK1042686B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK02103449.9A 1999-02-03 2000-02-03 Microbial process for preparing pravastatin HK1042686B (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11845899P 1999-02-03 1999-02-03
US60/118,458 1999-02-03
US13475999P 1999-05-18 1999-05-18
US60/134,759 1999-05-18
PCT/US2000/002993 WO2000046175A1 (en) 1999-02-03 2000-02-03 Microbial process for preparing pravastatin

Publications (2)

Publication Number Publication Date
HK1042686A1 HK1042686A1 (en) 2002-08-23
HK1042686B true HK1042686B (en) 2005-10-14

Family

ID=26816384

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02103449.9A HK1042686B (en) 1999-02-03 2000-02-03 Microbial process for preparing pravastatin

Country Status (27)

Country Link
EP (1) EP1154979B1 (enExample)
JP (2) JP3645491B2 (enExample)
KR (2) KR20060061406A (enExample)
CN (3) CN1177793C (enExample)
AR (2) AR023368A1 (enExample)
AT (1) ATE294771T1 (enExample)
AU (2) AU774438B2 (enExample)
BG (1) BG105778A (enExample)
BR (1) BR0009180A (enExample)
CA (1) CA2361701C (enExample)
CZ (1) CZ20012761A3 (enExample)
DE (1) DE60019898T2 (enExample)
ES (1) ES2240072T3 (enExample)
HK (1) HK1042686B (enExample)
HR (1) HRP20010577B1 (enExample)
HU (1) HUP0200650A3 (enExample)
IL (1) IL144697A0 (enExample)
IS (1) IS6036A (enExample)
MX (1) MXPA01007807A (enExample)
NO (1) NO20013818L (enExample)
PL (1) PL350317A1 (enExample)
PT (1) PT1154979E (enExample)
RU (1) RU2004127981A (enExample)
SK (1) SK10932001A3 (enExample)
TR (2) TR200600009T2 (enExample)
WO (1) WO2000046175A1 (enExample)
YU (1) YU55701A (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI20305A (sl) † 1999-08-06 2001-02-28 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristali natrijeve soli pravastatina
EP1798214A3 (en) * 1999-11-30 2007-08-01 Teva Gyogyszergyár Zártköruen Muködo Részvenytarsaság Process for recovering statin compounds from a fermentation broth
AU1804601A (en) * 1999-11-30 2001-06-12 Biogal Gyogyszergyar Rt Process for recovering statin compounds from a fermentation broth
KR20020062340A (ko) 1999-12-14 2002-07-25 비오갈 기오기스제르갸르 알티. 신규 형태의 프라바스타틴 나트륨
HRP20030347A2 (en) * 2000-10-05 2005-04-30 Teva Gy�gyszergy�r R�szv�nyt�rsas�g Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
JP2003026634A (ja) * 2001-07-17 2003-01-29 Mercian Corp プラバスタチンナトリウム塩の製造方法
JP3463875B2 (ja) 2001-08-06 2003-11-05 三共株式会社 プラバスタチンを精製する方法
JP3422791B2 (ja) 2002-08-06 2003-06-30 三共株式会社 プラバスタチンの単離・精製方法
KR100540761B1 (ko) * 2002-08-09 2006-01-16 코바이오텍 (주) 프라바스타틴 나트륨의 제조방법
EP1452519A1 (en) * 2003-02-25 2004-09-01 Balkanpharma-Razgrad AD Method for the isolation and purification of pravastatin sodium
WO2004096785A1 (ja) * 2003-04-25 2004-11-11 Nippon Chemiphar Co., Ltd. （２s，３s）－３－［［（１s）－１－イソブトキシメチル－３－メチルブチル］カルバモイル］オキシラン－２－カルボン酸の塩
CN1244688C (zh) 2003-07-09 2006-03-08 上海天伟生物制药有限公司 生产普伐他汀钠的微生物和方法
TWI319707B (en) 2003-11-24 2010-01-21 Method of purifying pravastatin
TWI307360B (en) 2004-12-03 2009-03-11 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Process for constructing strain having compactin hydroxylation ability
US20110130450A1 (en) * 2008-04-02 2011-06-02 Aad Johannes Bouman Pravastatin extraction
EP3714959A1 (en) * 2019-03-29 2020-09-30 Basf Se Isolation of small molecules from the fermentation broth of a eukaryotic microorganism
CN117164541B (zh) * 2022-05-27 2025-09-30 黑龙江华瑞生物科技有限公司 一种从美伐他汀母液中分离纯化美伐他汀的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE249514T1 (de) * 1996-03-28 2003-09-15 Dsm Ip Assets Bv Verfahren zur herstellung von granulärer mikrobieller biomasse und gewinnung wertvoller komponenten aus mikrobieller biomasse

Also Published As

Publication number Publication date
EP1154979A4 (en) 2004-05-26
HK1042686A1 (en) 2002-08-23
CN1590363A (zh) 2005-03-09
CN1177793C (zh) 2004-12-01
SK10932001A3 (sk) 2002-06-04
KR20060061406A (ko) 2006-06-07
HRP20010577B1 (en) 2005-12-31
AU774438B2 (en) 2004-06-24
DE60019898T2 (de) 2006-08-10
HRP20010577A2 (en) 2002-12-31
AU3356700A (en) 2000-08-25
RU2004127981A (ru) 2006-03-10
CN1260344C (zh) 2006-06-21
ES2240072T3 (es) 2005-10-16
CN1347400A (zh) 2002-05-01
CA2361701C (en) 2007-04-10
JP4197312B2 (ja) 2008-12-17
JP3645491B2 (ja) 2005-05-11
IS6036A (is) 2001-08-02
PL350317A1 (en) 2002-12-02
KR100648541B1 (ko) 2006-11-24
CZ20012761A3 (cs) 2002-05-15
TR200600009T2 (tr) 2006-08-21
EP1154979A1 (en) 2001-11-21
NO20013818D0 (no) 2001-08-03
CA2361701A1 (en) 2000-08-10
PT1154979E (pt) 2005-08-31
JP2002535977A (ja) 2002-10-29
HUP0200650A2 (en) 2002-08-28
ATE294771T1 (de) 2005-05-15
AR023368A1 (es) 2002-09-04
EP1154979B1 (en) 2005-05-04
BG105778A (bg) 2002-05-31
AU2004214559A1 (en) 2004-10-21
CN1537935A (zh) 2004-10-20
IL144697A0 (en) 2002-06-30
NO20013818L (no) 2001-10-03
DE60019898D1 (de) 2005-06-09
WO2000046175A1 (en) 2000-08-10
JP2005047924A (ja) 2005-02-24
KR20010112257A (ko) 2001-12-20
YU55701A (sh) 2004-07-15
MXPA01007807A (es) 2003-06-04
TR200103127T2 (tr) 2002-04-22
BR0009180A (pt) 2002-03-26
AR061765A2 (es) 2008-09-17
HUP0200650A3 (en) 2008-03-28

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20090203