JP3645491B2 - プラバスタチンの微生物学的製法 - Google Patents

プラバスタチンの微生物学的製法 Download PDF

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Publication number
JP3645491B2
JP3645491B2 JP2000597248A JP2000597248A JP3645491B2 JP 3645491 B2 JP3645491 B2 JP 3645491B2 JP 2000597248 A JP2000597248 A JP 2000597248A JP 2000597248 A JP2000597248 A JP 2000597248A JP 3645491 B2 JP3645491 B2 JP 3645491B2
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Japan
Prior art keywords
formula
compound
pravastatin
culture
strain
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Expired - Fee Related
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JP2000597248A
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English (en)
Japanese (ja)
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JP2002535977A (ja
JP2002535977A5 (enExample
Inventor
イェッケル，アントニア
コンヤ，アッティラ
バルタ，イシュトゥバン
イルコイ，エバ
ソモジー，ジョルジュ
アムブルス，ガボール
ホルバツ，ジュラ
アルブレチュト，カロリュ
エム． サボ，イシュトゥバン
ネー シュト，ユリアンナ モゼス
シャラト，ヤノス
アンドール，アッティラ
ビリンチク，ラスロ
ボロス，サンドール
ラング，イルディコ
ネー イグロイ，マルギト ビドゥロ
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インスティテュート フォー ドラッグ リサーチ リミティド
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Publication of JP2002535977A publication Critical patent/JP2002535977A/ja
Application granted granted Critical
Publication of JP3645491B2 publication Critical patent/JP3645491B2/ja
Publication of JP2002535977A5 publication Critical patent/JP2002535977A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2000597248A 1999-02-03 2000-02-03 プラバスタチンの微生物学的製法 Expired - Fee Related JP3645491B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11845899P 1999-02-03 1999-02-03
US60/118,458 1999-02-03
US13475999P 1999-05-18 1999-05-18
US60/134,759 1999-05-18
PCT/US2000/002993 WO2000046175A1 (en) 1999-02-03 2000-02-03 Microbial process for preparing pravastatin

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2004254575A Division JP4197312B2 (ja) 1999-02-03 2004-09-01 プラバスタチンナトリウム

Publications (3)

Publication Number Publication Date
JP2002535977A JP2002535977A (ja) 2002-10-29
JP3645491B2 true JP3645491B2 (ja) 2005-05-11
JP2002535977A5 JP2002535977A5 (enExample) 2005-11-04

Family

ID=26816384

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2000597248A Expired - Fee Related JP3645491B2 (ja) 1999-02-03 2000-02-03 プラバスタチンの微生物学的製法
JP2004254575A Expired - Fee Related JP4197312B2 (ja) 1999-02-03 2004-09-01 プラバスタチンナトリウム

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2004254575A Expired - Fee Related JP4197312B2 (ja) 1999-02-03 2004-09-01 プラバスタチンナトリウム

Country Status (27)

Country Link
EP (1) EP1154979B1 (enExample)
JP (2) JP3645491B2 (enExample)
KR (2) KR20060061406A (enExample)
CN (3) CN1177793C (enExample)
AR (2) AR023368A1 (enExample)
AT (1) ATE294771T1 (enExample)
AU (2) AU774438B2 (enExample)
BG (1) BG105778A (enExample)
BR (1) BR0009180A (enExample)
CA (1) CA2361701C (enExample)
CZ (1) CZ20012761A3 (enExample)
DE (1) DE60019898T2 (enExample)
ES (1) ES2240072T3 (enExample)
HK (1) HK1042686B (enExample)
HR (1) HRP20010577B1 (enExample)
HU (1) HUP0200650A3 (enExample)
IL (1) IL144697A0 (enExample)
IS (1) IS6036A (enExample)
MX (1) MXPA01007807A (enExample)
NO (1) NO20013818L (enExample)
PL (1) PL350317A1 (enExample)
PT (1) PT1154979E (enExample)
RU (1) RU2004127981A (enExample)
SK (1) SK10932001A3 (enExample)
TR (2) TR200600009T2 (enExample)
WO (1) WO2000046175A1 (enExample)
YU (1) YU55701A (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI20305A (sl) † 1999-08-06 2001-02-28 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristali natrijeve soli pravastatina
EP1798214A3 (en) * 1999-11-30 2007-08-01 Teva Gyogyszergyár Zártköruen Muködo Részvenytarsaság Process for recovering statin compounds from a fermentation broth
AU1804601A (en) * 1999-11-30 2001-06-12 Biogal Gyogyszergyar Rt Process for recovering statin compounds from a fermentation broth
KR20020062340A (ko) 1999-12-14 2002-07-25 비오갈 기오기스제르갸르 알티. 신규 형태의 프라바스타틴 나트륨
HRP20030347A2 (en) * 2000-10-05 2005-04-30 Teva Gy�gyszergy�r R�szv�nyt�rsas�g Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
JP2003026634A (ja) * 2001-07-17 2003-01-29 Mercian Corp プラバスタチンナトリウム塩の製造方法
JP3463875B2 (ja) 2001-08-06 2003-11-05 三共株式会社 プラバスタチンを精製する方法
JP3422791B2 (ja) 2002-08-06 2003-06-30 三共株式会社 プラバスタチンの単離・精製方法
KR100540761B1 (ko) * 2002-08-09 2006-01-16 코바이오텍 (주) 프라바스타틴 나트륨의 제조방법
EP1452519A1 (en) * 2003-02-25 2004-09-01 Balkanpharma-Razgrad AD Method for the isolation and purification of pravastatin sodium
WO2004096785A1 (ja) * 2003-04-25 2004-11-11 Nippon Chemiphar Co., Ltd. （２s，３s）－３－［［（１s）－１－イソブトキシメチル－３－メチルブチル］カルバモイル］オキシラン－２－カルボン酸の塩
CN1244688C (zh) 2003-07-09 2006-03-08 上海天伟生物制药有限公司 生产普伐他汀钠的微生物和方法
TWI319707B (en) 2003-11-24 2010-01-21 Method of purifying pravastatin
TWI307360B (en) 2004-12-03 2009-03-11 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Process for constructing strain having compactin hydroxylation ability
US20110130450A1 (en) * 2008-04-02 2011-06-02 Aad Johannes Bouman Pravastatin extraction
EP3714959A1 (en) * 2019-03-29 2020-09-30 Basf Se Isolation of small molecules from the fermentation broth of a eukaryotic microorganism
CN117164541B (zh) * 2022-05-27 2025-09-30 黑龙江华瑞生物科技有限公司 一种从美伐他汀母液中分离纯化美伐他汀的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE249514T1 (de) * 1996-03-28 2003-09-15 Dsm Ip Assets Bv Verfahren zur herstellung von granulärer mikrobieller biomasse und gewinnung wertvoller komponenten aus mikrobieller biomasse

Also Published As

Publication number Publication date
EP1154979A4 (en) 2004-05-26
HK1042686A1 (en) 2002-08-23
CN1590363A (zh) 2005-03-09
CN1177793C (zh) 2004-12-01
SK10932001A3 (sk) 2002-06-04
KR20060061406A (ko) 2006-06-07
HRP20010577B1 (en) 2005-12-31
AU774438B2 (en) 2004-06-24
DE60019898T2 (de) 2006-08-10
HRP20010577A2 (en) 2002-12-31
AU3356700A (en) 2000-08-25
RU2004127981A (ru) 2006-03-10
CN1260344C (zh) 2006-06-21
ES2240072T3 (es) 2005-10-16
CN1347400A (zh) 2002-05-01
CA2361701C (en) 2007-04-10
JP4197312B2 (ja) 2008-12-17
IS6036A (is) 2001-08-02
PL350317A1 (en) 2002-12-02
KR100648541B1 (ko) 2006-11-24
CZ20012761A3 (cs) 2002-05-15
TR200600009T2 (tr) 2006-08-21
EP1154979A1 (en) 2001-11-21
NO20013818D0 (no) 2001-08-03
CA2361701A1 (en) 2000-08-10
PT1154979E (pt) 2005-08-31
JP2002535977A (ja) 2002-10-29
HUP0200650A2 (en) 2002-08-28
ATE294771T1 (de) 2005-05-15
AR023368A1 (es) 2002-09-04
EP1154979B1 (en) 2005-05-04
BG105778A (bg) 2002-05-31
AU2004214559A1 (en) 2004-10-21
CN1537935A (zh) 2004-10-20
IL144697A0 (en) 2002-06-30
NO20013818L (no) 2001-10-03
DE60019898D1 (de) 2005-06-09
WO2000046175A1 (en) 2000-08-10
JP2005047924A (ja) 2005-02-24
KR20010112257A (ko) 2001-12-20
HK1042686B (en) 2005-10-14
YU55701A (sh) 2004-07-15
MXPA01007807A (es) 2003-06-04
TR200103127T2 (tr) 2002-04-22
BR0009180A (pt) 2002-03-26
AR061765A2 (es) 2008-09-17
HUP0200650A3 (en) 2008-03-28

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