KR100613532B1 - Ｎ-아릴-2-옥사졸리딘온-5-카복스아미드 및 이의 유도체,및 항균제로서의 이의 용도 - Google Patents
Ｎ-아릴-2-옥사졸리딘온-5-카복스아미드 및 이의 유도체,및 항균제로서의 이의 용도 Download PDFInfo
- Publication number
- KR100613532B1 KR100613532B1 KR1020047013297A KR20047013297A KR100613532B1 KR 100613532 B1 KR100613532 B1 KR 100613532B1 KR 1020047013297 A KR1020047013297 A KR 1020047013297A KR 20047013297 A KR20047013297 A KR 20047013297A KR 100613532 B1 KR100613532 B1 KR 100613532B1
- Authority
- KR
- South Korea
- Prior art keywords
- oxo
- oxazolidinecarboxamide
- methyl
- dihydro
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CCCCC(CC)C(C)(C(CC)C(C)C(C)CCC)C(C1C(CCC(C)C(*C(C)CC)C(CC)CC)C(C(C)CC(C)C(C)(C)CCC(CC(C)C)C2CC2)C(C*)(CC=CC(CC)=C)C2=CC=CCC2)C1(C(C)C=C=C)C1C(CCCC[C@@]2(*)C3=CC(CC4=CCC4)C23)C1C Chemical compound CCCCC(CC)C(C)(C(CC)C(C)C(C)CCC)C(C1C(CCC(C)C(*C(C)CC)C(CC)CC)C(C(C)CC(C)C(C)(C)CCC(CC(C)C)C2CC2)C(C*)(CC=CC(CC)=C)C2=CC=CCC2)C1(C(C)C=C=C)C1C(CCCC[C@@]2(*)C3=CC(CC4=CCC4)C23)C1C 0.000 description 24
- KBZHXUAODILANB-UHFFFAOYSA-N CC(CC1)=CC[B]1=O Chemical compound CC(CC1)=CC[B]1=O KBZHXUAODILANB-UHFFFAOYSA-N 0.000 description 1
- DOBCCCCDMABCIV-UHFFFAOYSA-N CC(CN1C)OC1=O Chemical compound CC(CN1C)OC1=O DOBCCCCDMABCIV-UHFFFAOYSA-N 0.000 description 1
- VMBPHGICQXNCBX-PEPZGXQESA-N CC/C(/C)=C\C=C/N Chemical compound CC/C(/C)=C\C=C/N VMBPHGICQXNCBX-PEPZGXQESA-N 0.000 description 1
- QWBGRFLIHGVVJG-UHFFFAOYSA-N CC1=CN(C)OC1=O Chemical compound CC1=CN(C)OC1=O QWBGRFLIHGVVJG-UHFFFAOYSA-N 0.000 description 1
- LVGFBFMBIIAENK-UHFFFAOYSA-N CC1CC=[O]CC1 Chemical compound CC1CC=[O]CC1 LVGFBFMBIIAENK-UHFFFAOYSA-N 0.000 description 1
- GEYDQZALZLXUKY-UHFFFAOYSA-N CN(C1)CC2=C1CCC=N2 Chemical compound CN(C1)CC2=C1CCC=N2 GEYDQZALZLXUKY-UHFFFAOYSA-N 0.000 description 1
- VAKUBANIJMAQSY-UHFFFAOYSA-N CN(CC1)CCC1C(CO)=C Chemical compound CN(CC1)CCC1C(CO)=C VAKUBANIJMAQSY-UHFFFAOYSA-N 0.000 description 1
- AHVYPIQETPWLSZ-UHFFFAOYSA-N CN1CC=CC1 Chemical compound CN1CC=CC1 AHVYPIQETPWLSZ-UHFFFAOYSA-N 0.000 description 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Cc1ccccc1 Chemical compound Cc1ccccc1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 1
- AIWHKRDJYVGUKW-UHFFFAOYSA-N N[NH+](C(C1)OC=[O]N1c(cc1)cc(F)c1-c1ccncc1)[O-] Chemical compound N[NH+](C(C1)OC=[O]N1c(cc1)cc(F)c1-c1ccncc1)[O-] AIWHKRDJYVGUKW-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/12—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35949502P | 2002-02-25 | 2002-02-25 | |
| US60/359,495 | 2002-02-25 | ||
| PCT/US2003/003125 WO2003072553A1 (en) | 2002-02-25 | 2003-02-24 | N-aryl-2-oxazolidinone-5-carboxamides and their derivates and their use as antibacterials |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20040091668A KR20040091668A (ko) | 2004-10-28 |
| KR100613532B1 true KR100613532B1 (ko) | 2006-08-16 |
Family
ID=27766097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020047013297A Expired - Fee Related KR100613532B1 (ko) | 2002-02-25 | 2003-02-24 | Ｎ-아릴-2-옥사졸리딘온-5-카복스아미드 및 이의 유도체,및 항균제로서의 이의 용도 |
Country Status (36)
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7141588B2 (en) | 2002-02-25 | 2006-11-28 | Pfizer, Inc. | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
| WO2004033449A1 (en) * | 2002-10-10 | 2004-04-22 | Pharmacia & Upjohn Company Llc | Antimicrobial 1-aryl dihydropyridone compounds |
| BRPI0409217A (pt) * | 2003-04-09 | 2006-03-28 | Pharmacia & Upjohn Co Llc | derivados e análogos antimicrobianos da [3.1.0]bicicloexilfeniloxazolidinona |
| US8324398B2 (en) | 2003-06-03 | 2012-12-04 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
| JP5043428B2 (ja) | 2003-06-03 | 2012-10-10 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | ビアリール複素環式化合物ならびにその製造および使用方法 |
| DE602004027811D1 (de) | 2003-07-02 | 2010-08-05 | Kyorin Seiyaku Kk | Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon |
| WO2005005399A1 (en) * | 2003-07-02 | 2005-01-20 | Merck & Co., Inc. | Oxazolidinone antibiotics and derivatives thereof |
| TW200526626A (en) | 2003-09-13 | 2005-08-16 | Astrazeneca Ab | Chemical compounds |
| US7304050B2 (en) * | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
| AR046782A1 (es) | 2003-12-17 | 2005-12-21 | Rib X Pharmaceuticals Inc | Compuestos heterociclicos de biarilo halogenados, composiciones farmaceuticas que los contienen, metodos para su elaboracion y su uso como medicamentos. |
| KR100854211B1 (ko) | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
| WO2005082900A2 (en) * | 2004-01-28 | 2005-09-09 | Pharmacia & Upjohn Company Llc | Oxazolidinone amidoximes as antibacterial agents |
| MX2007001526A (es) * | 2004-08-06 | 2007-03-27 | Pharmacia & Upjohn Co Llc | Oxazolidinonas que contienen oxindoles como agentes antibacterianos. |
| EP1819699A2 (en) * | 2004-11-29 | 2007-08-22 | Pharmacia & Upjohn Company LLC | Diazepine oxazolidinones as antibacterial agents |
| EE05394B1 (et) * | 2004-12-24 | 2011-04-15 | Janssen Pharmaceutica N.V. | Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis |
| NZ561613A (en) | 2005-02-18 | 2010-12-24 | Astrazeneca Ab | Antibacterial piperidine derivatives |
| AU2006231919A1 (en) | 2005-04-06 | 2006-10-12 | Pharmacia & Upjohn Company Llc | 7-fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents |
| EP1874782A1 (en) | 2005-04-15 | 2008-01-09 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| DE602006019870D1 (de) | 2005-06-08 | 2011-03-10 | Rib X Pharmaceuticals Inc | Verfahren zur synthese von triazolen |
| WO2007000644A1 (en) | 2005-06-29 | 2007-01-04 | Pharmacia & Upjohn Company Llc | Homomorpholine oxazolidinones as antibacterial agents |
| WO2007004037A1 (en) * | 2005-07-06 | 2007-01-11 | Pharmacia & Upjohn Company Llc | Oxazolidinone carboxamides containing azetidine and cyclobutane as antibacterial agents |
| WO2007004032A1 (en) * | 2005-07-06 | 2007-01-11 | Pharmacia & Upjohn Company Llc | Oxazolidiones containing cyclobutane as antibacterial agents |
| JP2009520785A (ja) * | 2005-12-23 | 2009-05-28 | アストラゼネカ アクチボラグ | 抗菌性のピロロピリジン、ピロロピリミジン、及びピロロアゼピン |
| WO2007088478A1 (en) * | 2006-02-01 | 2007-08-09 | Pfizer Products Inc. | Indazole oxazolidinones as antibacterial agents |
| KR20080110877A (ko) | 2006-03-31 | 2008-12-19 | 재단법인 이쯔우 연구소 | 헤테로환을 갖는 신규 화합물 |
| WO2008026563A1 (en) * | 2006-08-30 | 2008-03-06 | Shionogi & Co., Ltd. | Hydrazine amide derivative |
| WO2008026564A1 (en) * | 2006-08-30 | 2008-03-06 | Shionogi & Co., Ltd. | Urea derivative |
| US8178683B2 (en) * | 2007-08-06 | 2012-05-15 | Micurx Pharmaceuticals, Inc. | Antimicrobial ortho-fluorophenyl oxazolidinones for treatment of bacterial infections |
| WO2009044777A1 (ja) | 2007-10-02 | 2009-04-09 | Research Foundation Itsuu Laboratory | ７員ヘテロ環を有するオキサゾリジノン誘導体 |
| US9643922B2 (en) | 2008-08-18 | 2017-05-09 | Yale University | MIF modulators |
| PE20110368A1 (es) * | 2008-08-18 | 2011-06-13 | Univ Yale | Moduladores de mif |
| US9540322B2 (en) | 2008-08-18 | 2017-01-10 | Yale University | MIF modulators |
| EP2367820B1 (en) * | 2008-11-20 | 2016-09-21 | Panacea Biotec Limited | Novel antimicrobial agents |
| KR101918678B1 (ko) | 2009-02-03 | 2018-11-14 | 머크 샤프 앤드 돔 코포레이션 | Ｒ)-3-(4-(2-(2-메틸테트라졸-5-일)피리딘-5-일)-3-플루오로페닐)-5-히드록시메틸 옥사졸리딘-2-온 디히드로겐 포스페이트의 결정형 |
| BR112012000657A2 (pt) | 2009-06-26 | 2016-11-16 | Panacea Biotec Ltd | novos azabicilohexanos |
| WO2012007500A2 (de) | 2010-07-15 | 2012-01-19 | Bayer Cropscience Ag | Neue heterocyclische verbindungen als schädlingsbekämpfungsmittel |
| UA112897C2 (uk) | 2012-05-09 | 2016-11-10 | Байєр Фарма Акцієнгезелльшафт | Біциклічно заміщені урацили та їх застосування для лікування і/або профілактики захворювань |
| CN105612166B (zh) | 2014-02-21 | 2019-02-19 | 上海盟科药业有限公司 | 治疗用水溶性(o-羰基)氨基磷酸酯前药 |
| JP7205529B2 (ja) * | 2018-02-26 | 2023-01-17 | 住友化学株式会社 | オキサゾリジノン化合物の製造方法 |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4705799A (en) * | 1983-06-07 | 1987-11-10 | E. I. Du Pont De Nemours And Company | Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents |
| US5043443A (en) * | 1988-07-29 | 1991-08-27 | Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazolidinyl arylbenzene derivatives |
| US5182403A (en) * | 1988-09-15 | 1993-01-26 | The Upjohn Company | Substituted 3(5'indazolyl) oxazolidin-2-ones |
| US5225565A (en) * | 1988-09-15 | 1993-07-06 | The Upjohn Company | Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones |
| US5164510A (en) * | 1988-09-15 | 1992-11-17 | The Upjohn Company | 5'Indolinyl-5β-amidomethyloxazolidin-2-ones |
| EP0417044A3 (en) | 1989-09-07 | 1991-06-12 | Ciba-Geigy Ag | Oxazolidinones and thiones as plantgrowth regulators |
| US5231188A (en) * | 1989-11-17 | 1993-07-27 | The Upjohn Company | Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents |
| ATE146783T1 (de) * | 1991-11-01 | 1997-01-15 | Upjohn Co | Substituierte aryl- und heteroaryl- phenyloxazolidinone |
| SK283420B6 (sk) * | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
| KR950702417A (ko) | 1992-07-08 | 1995-07-29 | 로렌스 티. 웰츠 | 마이코박테륨 투베르쿨로시스에 대해 유용한 5′-인돌리닐 옥사졸리디논(5′-indolinyl oxazolidinones useful against mycobacterium tuberculosis) |
| EP0673370B1 (en) * | 1992-12-08 | 1998-01-07 | PHARMACIA & UPJOHN COMPANY | Tropone-substituted phenyloxazolidinone antibacterial agents |
| US5688792A (en) * | 1994-08-16 | 1997-11-18 | Pharmacia & Upjohn Company | Substituted oxazine and thiazine oxazolidinone antimicrobials |
| MY115155A (en) | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
| EP0730591B1 (en) * | 1993-11-22 | 1999-07-14 | PHARMACIA & UPJOHN COMPANY | Esters of substituted-hydroxyacetyl piperazine phenyl oxazolidinones |
| JPH0873455A (ja) | 1994-03-15 | 1996-03-19 | Upjohn Co:The | オキサゾリジノン誘導体及びこれを有効成分とする医薬組成物 |
| DE4425612A1 (de) * | 1994-07-20 | 1996-04-04 | Bayer Ag | 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone |
| DE4425609A1 (de) * | 1994-07-20 | 1996-01-25 | Bayer Ag | Benzofuranyl- und Benzothienyloxazolidinone |
| DE4425613A1 (de) * | 1994-07-20 | 1996-01-25 | Bayer Ag | 5-gliedrige Heteroaryl-oxazolidinone |
| DE19514313A1 (de) * | 1994-08-03 | 1996-02-08 | Bayer Ag | Benzoxazolyl- und Benzothiazolyloxazolidinone |
| DE4429461A1 (de) * | 1994-08-19 | 1996-02-22 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten |
| JP3933198B2 (ja) | 1994-10-26 | 2007-06-20 | ファルマシア・アンド・アップジョン・カンパニー | フェニルオキサゾリジノン抗菌剤 |
| BR9509673A (pt) * | 1994-11-15 | 1997-09-30 | Upjohn Co | Compostos e uso dos mesmos |
| DK0807112T3 (da) | 1995-02-03 | 2001-12-17 | Upjohn Co | Antimikrobiel heteroaromatisk ringsubstitueret phenyloxazolidinon |
| HRP960159A2 (en) * | 1995-04-21 | 1997-08-31 | Bayer Ag | Benzocyclopentane oxazolidinones containing heteroatoms |
| NZ306310A (en) | 1995-05-11 | 2001-05-25 | Upjohn Co | Spirocyclic and bicyclic diazinyl and carbazinyl oxazolidinones |
| RU2175324C2 (ru) * | 1995-09-01 | 2001-10-27 | Фармация Энд Апджон Компани | Фенилоксазолидиноны, имеющие с-с-связь с 4-8-членными гетероциклическими кольцами |
| DE19601264A1 (de) * | 1996-01-16 | 1997-07-17 | Bayer Ag | Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone |
| DE19601265A1 (de) * | 1996-01-16 | 1997-07-17 | Bayer Ag | 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone |
| DE19601627A1 (de) * | 1996-01-18 | 1997-07-24 | Bayer Ag | Heteroatomhaltige Cyclopentanopyridyl-Oxazolidinone |
| GB9601666D0 (en) * | 1996-01-27 | 1996-03-27 | Zeneca Ltd | Chemical compounds |
| DE19604223A1 (de) * | 1996-02-06 | 1997-08-07 | Bayer Ag | Neue substituierte Oxazolidinone |
| GB9702213D0 (en) * | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
| GB9609919D0 (en) * | 1996-05-11 | 1996-07-17 | Zeneca Ltd | Chemical compounds |
| DE69716925T2 (de) * | 1996-08-21 | 2003-09-11 | Pharmacia & Upjohn Co., Kalamazoo | Isoxazoline derivate und ihre verwendung als antimikroben |
| CN1138765C (zh) | 1997-05-30 | 2004-02-18 | 法玛西雅厄普约翰美国公司 | 带有硫代羰基功能基的噁唑烷酮抗菌剂 |
| DE19730847A1 (de) | 1997-07-18 | 1999-01-28 | Bayer Ag | Tricyclisch substituierte Oxazolidinone |
| GB9717804D0 (en) * | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
| US6083967A (en) | 1997-12-05 | 2000-07-04 | Pharmacia & Upjohn Company | S-oxide and S,S-dioxide tetrahydrothiopyran phenyloxazolidinones |
| DE19802235A1 (de) | 1998-01-22 | 1999-07-29 | Bayer Ag | Mit tricyclischen Indolen substituierte Oxazolidinone |
| DE19802239A1 (de) | 1998-01-22 | 1999-07-29 | Bayer Ag | Neue mit Bicyclen substituierte Oxazolidinone |
| KR20010015910A (ko) * | 1998-01-23 | 2001-02-26 | 로렌스 티. 마이젠헬더 | 옥사졸리디논 조합 라이브러리, 조성물 및 제조 방법 |
| DE19805117A1 (de) | 1998-02-09 | 1999-08-12 | Bayer Ag | Neue Oxazolidinone mit azolhaltigen Tricyclen |
| TR200003595T2 (tr) | 1998-06-05 | 2001-07-23 | Astrazeneca Ab | Kimyasal bileşikler |
| GB9821938D0 (en) | 1998-10-09 | 1998-12-02 | Zeneca Ltd | Chemical compounds |
| EP1149089B1 (en) * | 1999-02-01 | 2003-03-26 | PHARMACIA & UPJOHN COMPANY | PROCESS TO PREPARE TETRAHYDROTHIOPYRAN-o-FLUORINATED CARBAMATES |
| ES2203473T3 (es) | 1999-05-27 | 2004-04-16 | PHARMACIA & UPJOHN COMPANY | Oxazolidinonas biciclicas como agentes antibacterianos. |
| GB9928499D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical processes and intermediates |
| HUP0203869A2 (hu) | 1999-12-21 | 2003-07-28 | Pharmacia & Upjohn Co. | Szulfoximin funkcionalitással rendelkező oxazolidinok és alkalmazásuk mikrobaellenes szerként, a vegyületeket tartalmazó gyógyszerkészítmények |
| GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| GB0100110D0 (en) | 2001-01-04 | 2001-02-14 | Univ Leeds | Modulation of calcium channel activity |
| GB0113297D0 (en) | 2001-06-01 | 2001-07-25 | Astrazeneca Ab | Chemical Process |
| CA2452513A1 (en) * | 2001-07-12 | 2003-01-23 | Pharmacia & Upjohn Company | Amide-containing compound having improved solubility and method of improving the solubility of an amide-containing compound |
-
2003
- 2003-02-20 AR ARP030100552A patent/AR038536A1/es unknown
- 2003-02-21 MY MYPI20030608A patent/MY135233A/en unknown
- 2003-02-24 CN CNA038044986A patent/CN1639135A/zh active Pending
- 2003-02-24 GE GEAP8378A patent/GEP20074198B/en unknown
- 2003-02-24 KR KR1020047013297A patent/KR100613532B1/ko not_active Expired - Fee Related
- 2003-02-24 EP EP03743112A patent/EP1478629B1/en not_active Expired - Lifetime
- 2003-02-24 YU YU72804A patent/YU72804A/sh unknown
- 2003-02-24 UA UA20040807036A patent/UA80112C2/uk unknown
- 2003-02-24 WO PCT/US2003/003125 patent/WO2003072553A1/en not_active Ceased
- 2003-02-24 US US10/373,286 patent/US6919329B2/en not_active Expired - Fee Related
- 2003-02-24 BR BR0307924-4A patent/BR0307924A/pt not_active IP Right Cessation
- 2003-02-24 AU AU2003210807A patent/AU2003210807A1/en not_active Abandoned
- 2003-02-24 OA OA1200400221A patent/OA12779A/en unknown
- 2003-02-24 EA EA200400893A patent/EA007490B1/ru not_active IP Right Cessation
- 2003-02-24 NZ NZ534521A patent/NZ534521A/en unknown
- 2003-02-24 HR HR20040717A patent/HRP20040717A2/hr not_active Application Discontinuation
- 2003-02-24 PL PL03372461A patent/PL372461A1/xx unknown
- 2003-02-24 JP JP2003571259A patent/JP2005524660A/ja active Pending
- 2003-02-24 AT AT03743112T patent/ATE342258T1/de not_active IP Right Cessation
- 2003-02-24 AP APAP/P/2004/003110A patent/AP1902A/en active
- 2003-02-24 DE DE60308998T patent/DE60308998T2/de not_active Expired - Lifetime
- 2003-02-24 DK DK03743112T patent/DK1478629T3/da active
- 2003-02-24 CA CA002476038A patent/CA2476038A1/en not_active Abandoned
- 2003-02-24 MX MXPA04008205A patent/MXPA04008205A/es active IP Right Grant
- 2003-02-24 ES ES03743112T patent/ES2271615T3/es not_active Expired - Lifetime
- 2003-02-24 PT PT03743112T patent/PT1478629E/pt unknown
- 2003-02-24 SI SI200330518T patent/SI1478629T1/sl unknown
- 2003-02-25 TW TW092103898A patent/TW200305568A/zh unknown
-
2004
- 2004-07-29 IS IS7376A patent/IS7376A/is unknown
- 2004-08-11 ZA ZA200406362A patent/ZA200406362B/xx unknown
- 2004-08-13 CO CO04079406A patent/CO5611128A2/es not_active Application Discontinuation
- 2004-08-24 MA MA27837A patent/MA27180A1/fr unknown
- 2004-08-24 TN TNP2004000163A patent/TNSN04163A1/fr unknown
- 2004-08-25 EC EC2004005245A patent/ECSP045245A/es unknown
- 2004-09-24 NO NO20044062A patent/NO20044062L/no not_active Application Discontinuation
-
2006
- 2006-11-17 CY CY20061101682T patent/CY1105797T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR100613532B1 (ko) | Ｎ-아릴-2-옥사졸리딘온-5-카복스아미드 및 이의 유도체,및 항균제로서의 이의 용도 | |
| US20080090884A1 (en) | Antimicrobial [3.1.0] bicyclohexylphenyl- oxazolidinone derivatives and analogues | |
| US7645781B2 (en) | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives | |
| WO2003006440A2 (en) | Amide-containing compound having improved solubility and method of improving the solubility of an amide-containing compound | |
| JP3887396B2 (ja) | 抗バクテリア・インドロン・オキサゾリジノン、その製造用中間体、及びそれを含有する医薬組成物 | |
| US6875784B2 (en) | Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives | |
| US7105547B2 (en) | Antimicrobial 1-aryl dihydropyridone compounds | |
| WO2005082897A1 (en) | Oxazolidinone antibacterial agents | |
| JP2008521790A (ja) | 抗菌剤としてのチアゼピンオキサゾリジノン | |
| US6828317B2 (en) | Antimicrobial thiadiazinone derivatives and their application for treatment of bacterial infections | |
| WO2005082900A2 (en) | Oxazolidinone amidoximes as antibacterial agents | |
| HK1075046A (en) | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives and their use as antibacterials |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
|
| A201 | Request for examination | ||
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PA0201 | Request for examination |
St.27 status event code: A-1-2-D10-D11-exm-PA0201 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
St.27 status event code: A-1-2-D10-D21-exm-PE0902 |
|
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| E701 | Decision to grant or registration of patent right | ||
| PE0701 | Decision of registration |
St.27 status event code: A-1-2-D10-D22-exm-PE0701 |
|
| PR1002 | Payment of registration fee |
St.27 status event code: A-2-2-U10-U12-oth-PR1002 Fee payment year number: 1 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
St.27 status event code: A-2-4-F10-F11-exm-PR0701 |
|
| PG1601 | Publication of registration |
St.27 status event code: A-4-4-Q10-Q13-nap-PG1601 |
|
| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-5-5-R10-R18-oth-X000 |
|
| LAPS | Lapse due to unpaid annual fee | ||
| PC1903 | Unpaid annual fee |
St.27 status event code: A-4-4-U10-U13-oth-PC1903 Not in force date: 20090810 Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE |
|
| PC1903 | Unpaid annual fee |
St.27 status event code: N-4-6-H10-H13-oth-PC1903 Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE Not in force date: 20090810 |