KR100577493B1 - 재조합 알부민의 제조방법, 알부민 용액의 정제방법 및 재조합 알부민을 암호화하는 디엔에이 서열 - Google Patents

재조합 알부민의 제조방법, 알부민 용액의 정제방법 및 재조합 알부민을 암호화하는 디엔에이 서열 Download PDF

Info

Publication number
KR100577493B1
KR100577493B1 KR1020017009551A KR20017009551A KR100577493B1 KR 100577493 B1 KR100577493 B1 KR 100577493B1 KR 1020017009551 A KR1020017009551 A KR 1020017009551A KR 20017009551 A KR20017009551 A KR 20017009551A KR 100577493 B1 KR100577493 B1 KR 100577493B1
Authority
KR
South Korea
Prior art keywords
albumin
anion exchange
cation exchange
albumin solution
solution
Prior art date
Application number
KR1020017009551A
Other languages
English (en)
Korean (ko)
Other versions
KR20020008114A (ko
Inventor
헨드릭 반우르크
데이비드 존 미드
필립 하비 모턴
앤드류 존 카트라이트
재슨 카메론
데이비드 제임스 발란스
미쉘 가스통 조셉 그랜드조지
스티븐 베레젠코
존 로드니 우드로우
대럴 슬립
쟝-뤽 베르나르드 베롱
Original Assignee
델타 바이오테크놀로지 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 델타 바이오테크놀로지 리미티드 filed Critical 델타 바이오테크놀로지 리미티드
Publication of KR20020008114A publication Critical patent/KR20020008114A/ko
Application granted granted Critical
Publication of KR100577493B1 publication Critical patent/KR100577493B1/ko

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
KR1020017009551A 1999-01-30 2000-01-31 재조합 알부민의 제조방법, 알부민 용액의 정제방법 및 재조합 알부민을 암호화하는 디엔에이 서열 KR100577493B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9902000.0 1999-01-30
GB9902000A GB9902000D0 (en) 1999-01-30 1999-01-30 Process

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020057009776A Division KR100886554B1 (ko) 1999-01-30 2000-01-31 알부민 용액의 정제방법

Publications (2)

Publication Number Publication Date
KR20020008114A KR20020008114A (ko) 2002-01-29
KR100577493B1 true KR100577493B1 (ko) 2006-05-10

Family

ID=10846743

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020017009551A KR100577493B1 (ko) 1999-01-30 2000-01-31 재조합 알부민의 제조방법, 알부민 용액의 정제방법 및 재조합 알부민을 암호화하는 디엔에이 서열
KR1020057009776A KR100886554B1 (ko) 1999-01-30 2000-01-31 알부민 용액의 정제방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020057009776A KR100886554B1 (ko) 1999-01-30 2000-01-31 알부민 용액의 정제방법

Country Status (16)

Country Link
US (3) US7993877B2 (US07993877-20110809-P00003.png)
EP (3) EP2272961A1 (US07993877-20110809-P00003.png)
JP (3) JP4586150B2 (US07993877-20110809-P00003.png)
KR (2) KR100577493B1 (US07993877-20110809-P00003.png)
CN (4) CN1211485C (US07993877-20110809-P00003.png)
AT (1) ATE416254T1 (US07993877-20110809-P00003.png)
AU (2) AU763899B2 (US07993877-20110809-P00003.png)
CA (1) CA2359705C (US07993877-20110809-P00003.png)
DE (1) DE60040967D1 (US07993877-20110809-P00003.png)
DK (1) DK2048234T3 (US07993877-20110809-P00003.png)
ES (1) ES2317827T3 (US07993877-20110809-P00003.png)
GB (1) GB9902000D0 (US07993877-20110809-P00003.png)
HK (2) HK1042521B (US07993877-20110809-P00003.png)
MX (1) MXPA01007719A (US07993877-20110809-P00003.png)
SG (2) SG119194A1 (US07993877-20110809-P00003.png)
WO (1) WO2000044772A2 (US07993877-20110809-P00003.png)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9902000D0 (en) 1999-01-30 1999-03-17 Delta Biotechnology Ltd Process
AU2001266557A1 (en) 2000-04-12 2001-10-23 Human Genome Sciences, Inc. Albumin fusion proteins
ITBO20010426A1 (it) 2001-07-06 2003-01-06 Alfa Wassermann Spa Processo per la purificazione di proteine farmacologicamente attive mediante cromatografia in scambio cationico
US7176278B2 (en) 2001-08-30 2007-02-13 Biorexis Technology, Inc. Modified transferrin fusion proteins
EP2261250B1 (en) 2001-12-21 2015-07-01 Human Genome Sciences, Inc. GCSF-Albumin fusion proteins
GB0202633D0 (en) * 2002-02-05 2002-03-20 Delta Biotechnology Ltd Stabilization of protein preparations
WO2003066824A2 (en) 2002-02-07 2003-08-14 Aventis Behring Gmbh Albumin-fused kunitz domain peptides
SE526227C2 (sv) * 2002-05-15 2005-08-02 North China Pharmaceutical Group Metod för rening av rekombinant humant serumalbumin
GB0217033D0 (en) 2002-07-23 2002-08-28 Delta Biotechnology Ltd Gene and polypeptide sequences
GB0304576D0 (en) 2003-02-28 2003-04-02 Lonza Biologics Plc Protein a chromatography
WO2005054286A2 (en) 2003-12-03 2005-06-16 Delta Biotechnology Limited Interleukin-11 fusion proteins
GB0329681D0 (en) 2003-12-23 2004-01-28 Delta Biotechnology Ltd Gene expression technique
GB0329722D0 (en) * 2003-12-23 2004-01-28 Delta Biotechnology Ltd Modified plasmid and use thereof
US9057061B2 (en) 2003-12-23 2015-06-16 Novozymes Biopharma Dk A/S Gene expression technique
AU2005318697A1 (en) * 2004-12-22 2006-06-29 Novozymes A/S Recombinant production of serum albumin
WO2007063129A2 (en) * 2005-12-02 2007-06-07 Novozymes A/S Insolation of peptides , polypeptides and proteins
JP2007284425A (ja) * 2006-03-20 2007-11-01 Nokodai Tlo Kk タンパク質の精製方法
CA2657277C (en) 2006-07-13 2015-11-24 Upperton Limited Process for preparing particles of proteinaceous material
AU2007278994B2 (en) 2006-07-24 2013-08-15 Biorexis Pharmaceutical Corporation Exendin fusion proteins
EP2054437A2 (en) 2006-08-07 2009-05-06 Teva Biopharmaceuticals USA, Inc. Albumin-insulin fusion proteins
CA2676783C (en) 2007-02-02 2016-04-05 Globeimmune, Inc. Improved methods for producing yeast-based vaccines
CN101835801B (zh) 2007-08-08 2014-09-10 诺维信生物制药丹麦公司 转铁蛋白变体和偶联物
JP4452324B2 (ja) 2008-03-31 2010-04-21 積水メディカル株式会社 精製血清アルブミン及び免疫学的測定方法
CN101684459B (zh) * 2008-09-22 2012-01-25 上海普天欣生物技术有限公司 CehA突变体蛋白、基因、重组载体及其用途和制备方法
CN101747437B (zh) 2008-12-10 2012-09-26 浙江日升昌药业有限公司 凋亡素-ec-sod羧基末端蛋白转导域融合蛋白
SG2014012918A (en) 2009-02-11 2014-04-28 Novozymes Biopharma Dk As Albumin variants and conjugates
KR20120018827A (ko) 2009-02-20 2012-03-05 벤트리아 바이오사이언스 단백질의 조합을 함유하는 세포 배양 배지
HUE045635T2 (hu) 2009-04-09 2020-01-28 Sartorius Stedim Cellca Gmbh Eljárás továbbfejlesztett egysejtes klónozásra
US9403898B2 (en) 2009-05-07 2016-08-02 Novozymes Biopharma Dk A/S Method for purifying albumin
CN101691581B (zh) * 2009-06-25 2012-10-03 南京农业大学 染色体无标记随机整合载体pUTTns及其应用
US8129139B2 (en) * 2009-07-13 2012-03-06 Allergan, Inc. Process for obtaining botulinum neurotoxin
CN101690801B (zh) 2009-10-26 2012-08-01 上海交通大学 白细胞介素-1受体拮抗剂的用途及其药物组合物
RU2607374C2 (ru) 2009-10-30 2017-01-10 Новозаймс Байофарма Дк А/С Варианты альбумина
WO2011124718A1 (en) 2010-04-09 2011-10-13 Novozymes A/S Albumin derivatives and variants
BR112012027793B1 (pt) * 2010-04-29 2022-10-11 Takeda Pharmaceutical Company Limited Método para a purificação de uma proteína de ligação de cátion divalente
US20130225496A1 (en) 2010-11-01 2013-08-29 Novozymes Biopharma Dk A/S Albumin Variants
CN102127164B (zh) * 2010-12-20 2013-01-30 武汉禾元生物科技有限公司 一种从水稻种子中提取重组人血清白蛋白的方法
CN102532254B (zh) 2010-12-24 2015-06-24 武汉禾元生物科技股份有限公司 一种从水稻种子中分离纯化重组人血清白蛋白的方法
CN104011072B (zh) 2011-05-05 2018-10-12 阿尔布梅迪克斯医疗有限公司 白蛋白变体
CN103649111B (zh) * 2011-07-05 2018-03-13 阿尔布梅迪克斯医疗公司 白蛋白制剂和用途
US20140315817A1 (en) 2011-11-18 2014-10-23 Eleven Biotherapeutics, Inc. Variant serum albumin with improved half-life and other properties
KR20210134808A (ko) 2011-12-05 2021-11-10 팩터 바이오사이언스 인크. 세포를 형질감염시키는 방법들 및 생성물들
ES2923757T3 (es) 2011-12-16 2022-09-30 Modernatx Inc Composiciones de ARNm modificado
PL2825556T3 (pl) 2012-03-16 2018-10-31 Albumedix A/S Warianty albuminy
US9303079B2 (en) 2012-04-02 2016-04-05 Moderna Therapeutics, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
AU2013243953A1 (en) * 2012-04-02 2014-10-30 Modernatx, Inc. Modified polynucleotides for the production of nuclear proteins
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
US10501513B2 (en) * 2012-04-02 2019-12-10 Modernatx, Inc. Modified polynucleotides for the production of oncology-related proteins and peptides
CN102952836A (zh) * 2012-11-02 2013-03-06 浙江海正药业股份有限公司 重组人长效白介素1受体拮抗剂融合蛋白的纯化方法
CA2890766A1 (en) 2012-11-08 2014-05-15 Novozymes Biopharma Dk A/S Albumin variants
CN103880947B (zh) * 2012-12-21 2016-01-13 武汉禾元生物科技股份有限公司 一种分离纯化高纯度重组人血清白蛋白的层析方法
RU2663587C2 (ru) * 2013-03-06 2018-08-07 ГЛЭКСОСМИТКЛАЙН ЭлЭлСи Клетки-хозяева и способы использования
PL3016970T3 (pl) 2013-07-04 2019-09-30 Glykos Finland Oy Komórki grzybów nitkowatych z niedoborem O-mannozylotransferazy i sposoby ich zastosowania
EP3063171B1 (en) 2013-11-01 2019-07-24 University Of Oslo Albumin variants and uses thereof
TWI709570B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
CN106455621B (zh) * 2014-04-23 2021-07-20 阿雷克森制药公司 蛋清处理
SG11201700446XA (en) 2014-07-21 2017-02-27 Glykos Finland Oy Production of glycoproteins with mammalian-like n-glycans in filamentous fungi
ES2780367T3 (es) * 2015-01-01 2020-08-25 Shilpa Medicare Ltd Nuevo método de purificación eficiente de albumina sérica humana
US11241505B2 (en) 2015-02-13 2022-02-08 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
US10627415B2 (en) 2015-03-12 2020-04-21 Board Of Trustees Of Michigan State University Compositions and methods for diagnosing, monitoring, and treating an autoimmune disease
WO2016207730A1 (en) 2015-06-22 2016-12-29 The University Of Oslo Targeting of vaccine antigen to an intracellular compartment
CN105037487B (zh) * 2015-08-12 2017-03-22 山东泰邦生物制品有限公司 一种人血白蛋白的制备方法
CA2989966C (en) 2015-08-20 2024-04-30 Albumedix A/S Albumin variants and conjugates
WO2017112847A1 (en) 2015-12-22 2017-06-29 Albumedix A/S Improved protein expression strains
JP2019528284A (ja) 2016-08-17 2019-10-10 ファクター バイオサイエンス インコーポレイテッド 核酸産物およびその投与方法
KR102573478B1 (ko) 2016-10-04 2023-09-04 알부메딕스 리미티드 재조합 효모-유래 혈청 알부민의 용도
WO2018096396A1 (en) 2016-11-22 2018-05-31 University Of Oslo Albumin variants and uses thereof
US20200131225A1 (en) * 2017-04-20 2020-04-30 Novo Nordisk A/S Methods of purification of albumin fusion proteins
CA3064037A1 (en) 2017-06-20 2018-12-27 Albumedix Ltd Improved protein expression strains
EP3808837A4 (en) * 2018-06-15 2022-04-06 Fuso Pharmaceutical Industries, Ltd. CULTURE MEDIA FOR ASSISTED REPRODUCTIVE TECHNOLOGY
AU2019332764A1 (en) 2018-08-31 2021-05-06 Genzyme Corporation Sterile chromatography resin and use thereof in manufacturing processes
CN111229023B (zh) * 2018-11-29 2022-01-28 内蒙古东盛硅藻土科技创新产业园有限公司 一种化学降解添加剂
CN109879958A (zh) * 2019-03-08 2019-06-14 中国人民解放军军事科学院军事医学研究院 一种低糖基化血清白蛋白的制备方法
US10501404B1 (en) 2019-07-30 2019-12-10 Factor Bioscience Inc. Cationic lipids and transfection methods
JP2022550017A (ja) * 2019-10-01 2022-11-30 レプリゲン・コーポレーション 流体におけるタンパク質濃度の決定
CN112858682B (zh) * 2019-11-27 2023-06-02 广东唯实生物技术有限公司 用于尿微量白蛋白的检测试纸条及其制备方法、检测试剂盒和检测方法
WO2021111143A1 (en) 2019-12-04 2021-06-10 Albumedix Limited Methods and compositions produced thereby
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
CN112062833A (zh) * 2020-10-09 2020-12-11 国药集团武汉血液制品有限公司 一种从血浆组分ⅳ沉淀中提取人血白蛋白的方法
US20230331772A1 (en) 2020-12-08 2023-10-19 Tonghua Anrate Biopharmaceutical Co., Ltd Method for purification of recombinant proteins
CN112646045A (zh) * 2021-01-06 2021-04-13 海默斯（重庆）医学生物技术有限公司 一种重组角蛋白分离纯化方法
CN114907469A (zh) * 2021-02-08 2022-08-16 首都医科大学附属北京朝阳医院 一种人血清中白蛋白分离纯化方法
CN113735963A (zh) * 2021-09-10 2021-12-03 山东健通生物科技有限公司 一种重组人血清白蛋白纯化过程去除色素的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004687A1 (en) * 1992-08-14 1994-03-03 Rhone-Poulenc Rorer S.A. Modified fungal cells and method for producing recombinant products
WO1996037515A1 (en) * 1995-05-25 1996-11-28 Delta Biotechnology Limited Process of high purity albumin production

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9019919D0 (en) 1990-09-12 1990-10-24 Delta Biotechnology Ltd Purification of proteins
US5625041A (en) 1990-09-12 1997-04-29 Delta Biotechnology Limited Purification of proteins
US2433905A (en) 1943-11-01 1948-01-06 Jr Walter L Hughes Method for the crystallization of albumin and the preparation of protein products therefrom
AT317418B (de) 1972-06-16 1974-08-25 Brigitte Panhofer Verfahren zur Herstellung von intravenös beim Menschen anwendbarem Humanalbumin aus menschlichen Placenten
FR2190437B1 (US07993877-20110809-P00003.png) 1972-07-05 1975-08-08 Merieux Inst
CA1044537A (en) 1973-05-09 1978-12-19 Amf Incorporated Filter medium and process
DE2537123A1 (de) 1975-08-20 1977-03-03 New Zealand Inventions Dev Verfahren zur herstellung von albumin
SE405549B (sv) 1975-10-09 1978-12-18 Pharmacia Fine Chemicals Ab Forfarande for isolering av albumin ur plasmaprodukter genom kromatografisk fraktionering
US4043997A (en) 1976-05-28 1977-08-23 Cutter Laboratories, Inc. Method for isolating albumin using insoluble supports coupled to a dye
US4075197A (en) 1976-09-20 1978-02-21 Monsanto Company Serum albumin production
US4269605A (en) 1978-06-28 1981-05-26 Amicon Corporation Method and kit for separation of glycoproteins
IN150740B (US07993877-20110809-P00003.png) 1978-11-24 1982-12-04 Hoffmann La Roche
US4228154A (en) 1979-02-26 1980-10-14 Armour Pharmaceutical Company Purification of plasma albumin by ion exchange chromatography
CA1149298A (en) 1979-04-12 1983-07-05 Eugene H. Wegner Production of yeast cells at high cell densities
US4222934A (en) 1979-04-12 1980-09-16 American National Red Cross Preparation of albumin using ethanol
GB2053926B (en) 1979-07-20 1983-02-23 Atkinson A Albumin extraction by affinity chromatography
US4350156A (en) 1980-05-29 1982-09-21 Japan Foundation For Artificial Organs Method and apparatus for on-line filtration removal of macromolecules from a physiological fluid
NZ199722A (en) 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
US4491946A (en) 1981-03-09 1985-01-01 Gould Inc. Multi-station token pass communication system
US4562251A (en) 1981-03-26 1985-12-31 Amicon Corporation Agarose derivatives of amino phenyl boronic acid
IL66614A (en) 1981-08-28 1985-09-29 Genentech Inc Method of constructing a dna sequence encoding a polypeptide,microbial production of human serum albumin,and pharmaceutical compositions comprising it
US4391801A (en) 1981-10-29 1983-07-05 Cutter Laboratories, Inc. Plasma protein fraction substantially free of acetate ions
FR2543448A1 (fr) 1983-04-01 1984-10-05 Rhone Poulenc Spec Chim Procede de fractionnement du plasma
US4748120A (en) 1983-05-02 1988-05-31 Diamond Scientific Co. Photochemical decontamination treatment of whole blood or blood components
DE3344656A1 (de) 1983-12-09 1985-06-13 Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München Verfahren zur herstellung einer serumproteinloesung
CA1286622C (en) 1986-04-28 1991-07-23 Chokyun Rha Method for clarifying and stabilizing cell culture media
JPS62294621A (ja) 1986-06-13 1987-12-22 Green Cross Corp:The アルブミンの回収方法
JPS6383100A (ja) 1986-09-26 1988-04-13 Green Cross Corp:The ヒト尿中アルブミンの製造方法
IE63424B1 (en) 1987-04-09 1995-04-19 Delta Biotechnology Ltd Yeast vector
US4833233A (en) 1987-08-20 1989-05-23 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Human serum albumin crystals and method of preparation
CA1293217C (en) 1987-11-09 1991-12-17 Sooyoung Stanford Lee Controlled growth rate fermentation
IL88326A (en) 1987-11-18 1993-03-15 Gist Brocades Nv Purification of serum albumin
GB2214508A (en) 1988-01-27 1989-09-06 Bayer Ag Plasmid vector for the efficient expression of foreign genes fused with newly conceived transcriptional and translational signal sequences.
JPH01215289A (ja) 1988-02-22 1989-08-29 Toa Nenryo Kogyo Kk 遺伝子組換えによる正常ヒト血清アルブミンａの製造方法
US4990447A (en) 1988-06-24 1991-02-05 Gist-Brocades Nv Process for the purification of serum albumin
EP0387319B1 (en) 1988-07-23 1996-03-06 Delta Biotechnology Limited Secretory leader sequences
FR2649991B2 (fr) 1988-08-05 1994-03-04 Rhone Poulenc Sante Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces
US5277818A (en) 1988-10-31 1994-01-11 The Green Cross Corporation Albumin preparation and process for preparing the same
JP3554796B2 (ja) 1988-10-31 2004-08-18 三菱ウェルファーマ株式会社 アルブミン製剤及びその製造方法
US4891221A (en) 1988-11-23 1990-01-02 Edward Shanborm Whole blood antiviral process and composition
FR2648048B1 (fr) 1989-06-08 1994-06-03 Lille Transfusion Sanguine Procede de preparation de solutions d'albumine purifiee
GB8913586D0 (en) 1989-06-13 1989-08-02 Technicol Limited A method of determining the glycosylated protein level of a sample and an apparatus for use in the method
JPH0768137B2 (ja) 1989-06-15 1995-07-26 株式会社ミドリ十字 アルブミン製剤及びその製法
SE500110C2 (sv) * 1989-06-27 1994-04-18 Kabi Pharmacia Ab Sätt att rena ett protein från därtill bundna flervärda metalljoner
GB8927480D0 (en) 1989-12-05 1990-02-07 Delta Biotechnology Ltd Mutant fungal strain detection and new promoter
JPH0671434B2 (ja) 1989-09-18 1994-09-14 株式会社ミドリ十字 ヒト血清アルブミンの製造方法
US5250662A (en) 1989-10-05 1993-10-05 Alpha Therapeutic Corporation Albumin purification
CA2022165C (en) 1989-10-05 1999-11-23 Chong E. Chang Albumin purification
JP3127232B2 (ja) 1990-03-08 2001-01-22 ウェルファイド株式会社 蛋白質製剤の製造法
DE69133399T2 (de) 1990-04-19 2005-06-30 Bayer Corp. Methode zur Herstellung von im Wesentlichen monomeren normalen menschlichen Serum-Albumin
SE9002212D0 (sv) 1990-06-21 1990-06-21 Hightech Receptor Ab Igg binding protein
JP3230091B2 (ja) 1990-06-25 2001-11-19 ウェルファイド株式会社 ヒト血清アルブミンの着色抑制方法
JP2982296B2 (ja) 1990-11-19 1999-11-22 吉富製薬株式会社 アルブミン含有水溶液の精製法
JP2949846B2 (ja) 1990-11-30 1999-09-20 吉富製薬株式会社 アルブミン製剤の保存方法
FR2672604B1 (fr) 1991-02-07 1995-05-05 Pasteur Merieux Serums Vacc Procede pour isoler de l'albumine humaine a partir du surnageant iv, notamment iv-4, ou de la fraction v de cohn ou d'un surnageant ou fraction analogue.
US5284777A (en) * 1991-03-04 1994-02-08 Isolab, Inc. Combined glycated hemoglobin and immunoturbidometric glycated albumin assay from whole blood lysate
JPH0671432B2 (ja) 1991-03-20 1994-09-14 株式会社ミドリ十字 ヒト血清アルブミンの製造方法
US5330901A (en) * 1991-04-26 1994-07-19 Research Corporation Technologies, Inc. Expression of human serum albumin in Pichia pastoris
ES2141715T3 (es) 1991-07-12 2000-04-01 Dsm Nv Procedimiento para la purificacion de albumina de suero.
US5260308A (en) * 1991-11-06 1993-11-09 Mayo Foundation For Medical Education And Research Method to increase permeability of the blood-nerve/brain barriers to proteins
FR2686620B1 (fr) 1992-01-27 1995-06-23 Rhone Poulenc Rorer Sa Serum-albumine humaine, preparation et utilisation.
US5281582A (en) 1992-02-27 1994-01-25 Alliance Pharmaceuticals, Corp. Serum growth factor
US5440018A (en) 1992-05-20 1995-08-08 The Green Cross Corporation Recombinant human serum albumin, process for producing the same and pharmaceutical preparation containing the same
JPH07102148B2 (ja) * 1992-05-20 1995-11-08 株式会社ミドリ十字 遺伝子操作により得られるヒト血清アルブミンの製造方法、およびそれにより得られるヒト血清アルブミン含有組成物
CA2138985C (en) * 1992-06-24 2004-01-20 James Dyson Vacuum cleaner
JP3360315B2 (ja) 1992-07-31 2002-12-24 三菱ウェルファーマ株式会社 ヒト血清アルブミンの高度精製方法
WO1994003636A1 (en) 1992-08-03 1994-02-17 Abbott Laboratories Detecting and amplifying target nucleic acids using exonucleolytic activity
CA2116385A1 (en) 1993-02-25 1994-08-26 Akinori Sumi Human serum albumin and process for producing the same
DE4308532A1 (de) 1993-03-17 1994-09-22 Boehringer Mannheim Gmbh Monoklonale Antikörper gegen in vivo glykiertes Albumin
SE9301583D0 (sv) * 1993-05-07 1993-05-07 Kabi Pharmacia Ab Yeast strain and methods for expressing heterologous proteins in yeast
CA2136564C (en) 1993-11-26 2008-04-08 Kaoru Kobayashi Process for producing human serum albumin
GB9404270D0 (en) 1994-03-05 1994-04-20 Delta Biotechnology Ltd Yeast strains and modified albumins
JPH07308199A (ja) 1994-05-18 1995-11-28 Green Cross Corp:The ヒト血清アルブミンの製造方法
JP3702474B2 (ja) 1994-06-01 2005-10-05 三菱ウェルファーマ株式会社 血清アルブミン製剤の製造方法
GB9411356D0 (en) 1994-06-07 1994-07-27 Delta Biotechnology Ltd Yeast strains
GB2308006B (en) * 1994-07-21 1998-07-22 Gregory Lowell Millspaugh Method of and system for controlling energy including in fusion
US5561115A (en) 1994-08-10 1996-10-01 Bayer Corporation Low temperature albumin fractionation using sodium caprylate as a partitioning agent
CA2157219C (en) 1994-08-31 2010-10-05 Munehiro Noda Process for purifying recombinant human serum albumin
DE4432689A1 (de) 1994-09-14 1996-03-21 Basf Ag Mischung aus Alkylierungsprodukten von acetalisierten Monosacchariden mit Epoxiden
US6068995A (en) * 1994-10-25 2000-05-30 Yoshitomi Pharmaceutical Industries, Ltd. Method for producing protein
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
WO1997031947A1 (en) * 1996-02-29 1997-09-04 Delta Biotechnology Limited High purity albumin production process
GB9721892D0 (en) 1997-10-15 1997-12-17 British Tech Group Apparatus for and method of testing a sample
GB9902000D0 (en) * 1999-01-30 1999-03-17 Delta Biotechnology Ltd Process
JP4798832B2 (ja) 2000-10-24 2011-10-19 一般財団法人化学及血清療法研究所 ヒト血清アルブミン多量体の除去方法
US6693173B2 (en) 2000-12-26 2004-02-17 Alpha Therapeutic Corporation Method to remove citrate and aluminum from proteins
SE0201680L (sv) 2002-06-04 2003-09-02 Wexioedisk Ab Diskmaskin med uppsamlingsorgan för att ta emot diskvätska och sköljvätska

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994004687A1 (en) * 1992-08-14 1994-03-03 Rhone-Poulenc Rorer S.A. Modified fungal cells and method for producing recombinant products
WO1996037515A1 (en) * 1995-05-25 1996-11-28 Delta Biotechnology Limited Process of high purity albumin production

Also Published As

Publication number Publication date
US7993877B2 (en) 2011-08-09
AU2003248302B2 (en) 2006-09-07
AU2003248302A1 (en) 2003-10-30
MXPA01007719A (es) 2003-06-24
KR20020008114A (ko) 2002-01-29
EP2048234B1 (en) 2012-12-19
CN1526732A (zh) 2004-09-08
HK1042521A1 (en) 2002-08-16
CN1211485C (zh) 2005-07-20
CN1810834A (zh) 2006-08-02
JP5774612B2 (ja) 2015-09-09
CA2359705A1 (en) 2000-08-03
CN1526732B (zh) 2010-06-16
US20090171070A1 (en) 2009-07-02
GB9902000D0 (en) 1999-03-17
US20150056654A1 (en) 2015-02-26
ATE416254T1 (de) 2008-12-15
EP2048234A1 (en) 2009-04-15
ES2317827T3 (es) 2009-05-01
WO2000044772A2 (en) 2000-08-03
EP2272961A1 (en) 2011-01-12
JP4586150B2 (ja) 2010-11-24
KR100886554B1 (ko) 2009-03-02
AU763899B2 (en) 2003-07-31
DK2048234T3 (da) 2013-03-04
US9029102B2 (en) 2015-05-12
HK1042521B (zh) 2005-10-07
SG174629A1 (en) 2011-10-28
HK1096691A1 (en) 2007-06-08
SG119194A1 (en) 2006-02-28
WO2000044772A3 (en) 2000-11-30
CN1810834B (zh) 2013-04-17
US9555344B2 (en) 2017-01-31
CA2359705C (en) 2011-06-14
JP2010246551A (ja) 2010-11-04
JP2002542761A (ja) 2002-12-17
KR20050061612A (ko) 2005-06-22
EP1149163B1 (en) 2008-12-03
JP2013135675A (ja) 2013-07-11
CN1339065A (zh) 2002-03-06
CN1974599A (zh) 2007-06-06
DE60040967D1 (de) 2009-01-15
EP1149163A2 (en) 2001-10-31
AU2120700A (en) 2000-08-18
US20110301329A1 (en) 2011-12-08
JP5474661B2 (ja) 2014-04-16

Similar Documents

Publication Publication Date Title
KR100577493B1 (ko) 재조합 알부민의 제조방법, 알부민 용액의 정제방법 및 재조합 알부민을 암호화하는 디엔에이 서열
KR100543612B1 (ko) 고 순도 알부민 제조방법
JPH11509525A (ja) 高純度アルブミンの製造方法
WO1997031947A1 (en) High purity albumin production process
AU2007200939B2 (en) Process

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E902 Notification of reason for refusal
A107 Divisional application of patent
E902 Notification of reason for refusal
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment
FPAY Annual fee payment
FPAY Annual fee payment

Payment date: 20170330

Year of fee payment: 12

FPAY Annual fee payment

Payment date: 20180328

Year of fee payment: 13

FPAY Annual fee payment

Payment date: 20190418

Year of fee payment: 14