KR100454784B1 - 안정화된 동결건조형 의약 조성물 - Google Patents
안정화된 동결건조형 의약 조성물 Download PDFInfo
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- KR100454784B1 KR100454784B1 KR10-2001-7002318A KR20017002318A KR100454784B1 KR 100454784 B1 KR100454784 B1 KR 100454784B1 KR 20017002318 A KR20017002318 A KR 20017002318A KR 100454784 B1 KR100454784 B1 KR 100454784B1
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Classifications
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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Landscapes
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- Chemical & Material Sciences (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
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| KR20010072903A KR20010072903A (ko) | 2001-07-31 |
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| TWI233805B (en) * | 1999-07-01 | 2005-06-11 | Fujisawa Pharmaceutical Co | Stabilized pharmaceutical composition in lyophilized form as antifungal agent |
| ITMI20021040A1 (it) * | 2002-05-16 | 2003-11-17 | Novuspharma Spa | Composizioni farmaceutiche iniettabili di un derivato antracenedionico ad attivita' antitumorale |
| EP1525884B1 (en) | 2002-07-31 | 2011-10-12 | Senju Pharmaceutical Co., Ltd. | Aqueous liquid preparations and light-stabilized aqueous liquid preparations |
| US8877168B1 (en) | 2002-07-31 | 2014-11-04 | Senju Pharmaceuticals Co., Ltd. | Aqueous liquid preparations and light-stabilized aqueous liquid preparations |
| US7119061B2 (en) * | 2002-11-18 | 2006-10-10 | Vicuron Pharmaceuticals, Inc. | Dalbavancin compositions for treatment of bacterial infections |
| AU2003298662A1 (en) * | 2002-11-18 | 2004-06-15 | Vicuron Pharmaceuticals Inc. | Dalbavancin compositions for treatment of bacterial infections |
| US20060074014A1 (en) * | 2002-11-18 | 2006-04-06 | Vicuron Pharmaceuticals Inc. | Dalbavancin compositions for treatment of bacterial infections |
| CA2558191C (en) * | 2004-03-04 | 2011-01-04 | Eisai R&D Management Co., Ltd. | Composition containing benzamidine derivative and method for stabilizing benzamidine derivative |
| US7514450B2 (en) * | 2004-05-19 | 2009-04-07 | Neurosearch A/S | Azabicyclic aryl derivatives |
| EP2417986A1 (en) * | 2004-11-22 | 2012-02-15 | Anadis Ltd. | Bioactive compositions |
| KR101307999B1 (ko) | 2004-12-01 | 2013-09-12 | 니폰 조키 세야쿠 가부시키가이샤 | 건조물 및 그 제조방법 |
| KR20080028942A (ko) * | 2005-07-20 | 2008-04-02 | 교와 메덱스 가부시키가이샤 | 생체 시료 중의 펩티드의 안정화 방법 |
| CN1962852B (zh) * | 2006-11-27 | 2011-11-09 | 西北农林科技大学 | 红景天多糖在制备抗冻剂中的新用途及其产品和制备方法 |
| CN102614491B (zh) * | 2011-01-31 | 2014-04-16 | 上海天伟生物制药有限公司 | 一种含有棘白菌素类抗真菌剂米卡芬净的药用组合物及其制备方法和用途 |
| CN102614492B (zh) * | 2011-01-31 | 2013-12-11 | 上海天伟生物制药有限公司 | 一种含有棘白菌素类抗真菌剂米卡芬净的液体药用组合物 |
| CN104968348B (zh) * | 2012-05-22 | 2018-04-17 | Paion英国有限公司 | 包含短效苯二氮杂*类化合物的组合物 |
| US20140274994A1 (en) | 2013-03-15 | 2014-09-18 | Cubist Pharmaceuticals, Inc. | Stabilizing ceftolozane |
| US20140274993A1 (en) | 2013-03-15 | 2014-09-18 | Cubist Pharmaceuticals, Inc. | Ceftolozane-tazobactam pharmaceutical compositions |
| US9872906B2 (en) | 2013-03-15 | 2018-01-23 | Merck Sharp & Dohme Corp. | Ceftolozane antibiotic compositions |
| CN103330933B (zh) * | 2013-04-26 | 2015-08-05 | 江苏豪森药业股份有限公司 | 含有米卡芬净或其盐的药物组合物 |
| CN103330932B (zh) * | 2013-04-26 | 2015-12-23 | 江苏豪森药业股份有限公司 | 一种米卡芬净或其盐的药物组合物 |
| ES2978920T3 (es) * | 2013-06-05 | 2024-09-23 | Univ British Columbia | Compuestos antifibrogénicos, métodos y usos de los mismos |
| US10376496B2 (en) | 2013-09-09 | 2019-08-13 | Merck, Sharp & Dohme Corp. | Treating infections with ceftolozane/tazobactam in subjects having impaired renal function |
| US8906898B1 (en) | 2013-09-27 | 2014-12-09 | Calixa Therapeutics, Inc. | Solid forms of ceftolozane |
| KR101611349B1 (ko) | 2014-04-14 | 2016-04-12 | 신우철 | 안정성이 개선된 밀크씨슬 엑스의 제형 |
| JP7109189B2 (ja) * | 2014-05-29 | 2022-07-29 | シャンハイ テックウェル バイオファーマシューティカル カンパニー リミテッド | シクロペプチド系化合物の組成物およびその製造方法と使用 |
| RU2732129C2 (ru) * | 2014-12-05 | 2020-09-11 | Мейдзи Сейка Фарма Ко., Лтд. | Способ производства кристаллов производного диазабициклооктана и стабильного лиофилизированного препарата |
| DK3240529T3 (da) * | 2014-12-31 | 2022-02-28 | Galenicum Health S L U | Stabile farmaceutiske sammensætninger omfattende micafungin |
| PL3058958T3 (pl) | 2015-02-23 | 2019-02-28 | Selectchemie Ag | Kompozycja anidulafunginy |
| AU2017376960B2 (en) | 2016-12-16 | 2023-12-14 | Baxter Healthcare Sa | Micafungin compositions |
| US11185527B2 (en) | 2017-06-26 | 2021-11-30 | Wayne State University | Methods and compositions relating to steroid hormone receptor-dependent cancers |
| RU2666148C1 (ru) * | 2017-10-05 | 2018-09-06 | Общество с ограниченной ответственностью "Новые Антибиотики" | Способ получения водорастворимой лиофилизированной формы соли бис(2-тио-4,6-диоксо-1,2,3,4,5,6-гексагидропиримидин-5-ил)-(4-нитрофенил)метана |
| EP3485873A1 (en) | 2017-11-17 | 2019-05-22 | Cadila Healthcare Limited | Stable pharmaceutical injectable compositions of micafungin |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997039763A1 (en) * | 1996-04-19 | 1997-10-30 | Merck & Co., Inc. | Compositions comprising antifungal agent and acetate buffer |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPH03193735A (ja) | 1989-12-22 | 1991-08-23 | Shionogi & Co Ltd | グリコペプチド系抗生物質の安定化組成物 |
| JPH03240727A (ja) | 1990-02-15 | 1991-10-28 | Toyo Jozo Co Ltd | ニューモシスチス・カリニ肺炎治療剤 |
| IE912046A1 (en) * | 1990-06-18 | 1991-12-18 | Fujisawa Pharmaceutical Co | New polypeptide compound and a process for preparation¹thereof |
| JP3193735B2 (ja) | 1991-07-24 | 2001-07-30 | 株式会社リコー | カラー画像形成装置の搬送装置 |
| RU2095081C1 (ru) * | 1991-12-13 | 1997-11-10 | Акционерное общество "Биофа" | Фармацевтическая композиция антивирусного действия |
| JPH0651641A (ja) | 1992-07-30 | 1994-02-25 | Olympus Optical Co Ltd | 湿式現像装置 |
| JPH06172204A (ja) * | 1992-12-09 | 1994-06-21 | Asahi Chem Ind Co Ltd | アクレアシン類含有リポソーム製剤およびその製造法 |
| JP3240727B2 (ja) | 1993-02-25 | 2001-12-25 | ソニー株式会社 | 偏平型陰極線管の画像歪補正装置 |
| US6268338B1 (en) * | 1993-04-30 | 2001-07-31 | Merck & Co., Inc. | Cyclohexapeptidyl amine compounds |
| AU681119B2 (en) * | 1993-05-17 | 1997-08-21 | Fujisawa Pharmaceutical Co., Ltd. | New polypeptide compound and a process for preparation thereof |
| WO1996011210A1 (en) * | 1994-10-07 | 1996-04-18 | Fujisawa Pharmaceutical Co., Ltd. | Cyclic hexapeptides having antibiotic activity |
| GB9512854D0 (en) * | 1995-06-23 | 1995-08-23 | Wellcome Found | Novel formulation |
| US6245349B1 (en) * | 1996-02-23 | 2001-06-12 | éLAN CORPORATION PLC | Drug delivery compositions suitable for intravenous injection |
| DE69739532D1 (de) * | 1996-03-08 | 2009-09-24 | Astellas Pharma Inc | Prozess für die deacylierung von zyklischen lipopeptiden. |
| JPH09301997A (ja) | 1996-05-17 | 1997-11-25 | Yamanouchi Pharmaceut Co Ltd | 新規環状ペプチド系化合物 |
| FR2755857B1 (fr) * | 1996-11-19 | 1998-12-24 | Rhone Poulenc Rorer Sa | Compositions pharmaceutiques stabilisees, a base de quinupristine et de dalfopristine et leur preparation |
| AUPO371596A0 (en) * | 1996-11-19 | 1996-12-12 | Fujisawa Pharmaceutical Co., Ltd. | New compound |
| AUPO381496A0 (en) * | 1996-11-25 | 1996-12-19 | Fujisawa Pharmaceutical Co., Ltd. | New compound |
| JPH10279498A (ja) * | 1997-04-07 | 1998-10-20 | Nippon Shinyaku Co Ltd | 慢性関節リウマチ治療剤 |
| JP3544847B2 (ja) * | 1998-01-16 | 2004-07-21 | 三菱電機株式会社 | 光学的情報再生方法および装置 |
| DK1582204T3 (da) * | 1999-03-03 | 2013-11-04 | Lilly Co Eli | Echinocandin-farmaceutiske formuleringer, der indeholder miceldannende overfladeaktive stoffer |
| IL145188A0 (en) * | 1999-03-03 | 2002-06-30 | Lilly Co Eli | Processes for making pharmaceutical oral ecb formulations and compositions |
| TWI233805B (en) * | 1999-07-01 | 2005-06-11 | Fujisawa Pharmaceutical Co | Stabilized pharmaceutical composition in lyophilized form as antifungal agent |
-
2000
- 2000-06-28 TW TW089112754A patent/TWI233805B/zh not_active IP Right Cessation
- 2000-06-29 PL PL346297A patent/PL200141B1/pl unknown
- 2000-06-29 WO PCT/JP2000/004381 patent/WO2001002002A1/en not_active Ceased
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- 2000-06-29 JP JP2001507492A patent/JP3381722B2/ja not_active Expired - Lifetime
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- 2000-06-29 NZ NZ510290A patent/NZ510290A/en not_active IP Right Cessation
- 2000-06-29 KR KR10-2001-7002318A patent/KR100454784B1/ko not_active Expired - Lifetime
- 2000-06-29 BR BR0006823-3A patent/BR0006823A/pt not_active IP Right Cessation
- 2000-06-29 PT PT00940916T patent/PT1107777E/pt unknown
- 2000-06-29 US US09/786,125 patent/US6774104B1/en not_active Expired - Lifetime
- 2000-06-29 ES ES00940916T patent/ES2225161T3/es not_active Expired - Lifetime
- 2000-06-29 HK HK02101689.2A patent/HK1040057B/zh not_active IP Right Cessation
- 2000-06-29 CN CNB008012164A patent/CN1179748C/zh not_active Expired - Lifetime
- 2000-06-29 AU AU55722/00A patent/AU752265B2/en not_active Expired
- 2000-06-30 AR ARP000103372A patent/AR024634A1/es not_active Application Discontinuation
-
2001
- 2001-02-15 IL IL141455A patent/IL141455A/en not_active IP Right Cessation
- 2001-02-22 NO NO20010893A patent/NO330353B1/no not_active IP Right Cessation
- 2001-02-26 ZA ZA200101589A patent/ZA200101589B/en unknown
- 2001-10-10 JP JP2001312701A patent/JP4691866B2/ja not_active Expired - Lifetime
-
2004
- 2004-02-06 US US10/772,281 patent/US7112565B2/en not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997039763A1 (en) * | 1996-04-19 | 1997-10-30 | Merck & Co., Inc. | Compositions comprising antifungal agent and acetate buffer |
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