DE69739532D1 - Prozess für die deacylierung von zyklischen lipopeptiden. - Google Patents

Prozess für die deacylierung von zyklischen lipopeptiden.

Info

Publication number
DE69739532D1
DE69739532D1 DE69739532T DE69739532T DE69739532D1 DE 69739532 D1 DE69739532 D1 DE 69739532D1 DE 69739532 T DE69739532 T DE 69739532T DE 69739532 T DE69739532 T DE 69739532T DE 69739532 D1 DE69739532 D1 DE 69739532D1
Authority
DE
Germany
Prior art keywords
hydrogen
hydroxy
deacylation
cyclic
cyclic lipopeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69739532T
Other languages
English (en)
Inventor
Satoshi Ueda
Miho Tanaka
Masami Ezaki
Kazutoshi Sakamoto
Seiji Hashimoto
Nobutaka Oohata
Masaru Tsuboi
Michio Yamashita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Application granted granted Critical
Publication of DE69739532D1 publication Critical patent/DE69739532D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69739532T 1996-03-08 1997-03-06 Prozess für die deacylierung von zyklischen lipopeptiden. Expired - Lifetime DE69739532D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP5138696 1996-03-08
JP19420796 1996-07-24
PCT/JP1997/000692 WO1997032975A1 (fr) 1996-03-08 1997-03-06 Processus de deacylation de lipopeptides cycliques

Publications (1)

Publication Number Publication Date
DE69739532D1 true DE69739532D1 (de) 2009-09-24

Family

ID=26391923

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69739532T Expired - Lifetime DE69739532D1 (de) 1996-03-08 1997-03-06 Prozess für die deacylierung von zyklischen lipopeptiden.

Country Status (10)

Country Link
US (3) US6207434B1 (de)
EP (3) EP1854877B1 (de)
JP (1) JP3123078B2 (de)
KR (1) KR100545506B1 (de)
CN (1) CN1161462C (de)
AT (2) ATE544851T1 (de)
CA (1) CA2248348C (de)
DE (1) DE69739532D1 (de)
ES (2) ES2327981T3 (de)
WO (1) WO1997032975A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100545506B1 (ko) * 1996-03-08 2006-10-04 아스테라스 세이야쿠 가부시키가이샤 환상 리포펩티드 물질의 탈아실화 방법
EP1666587A1 (de) * 1996-06-13 2006-06-07 Astellas Pharma Inc. Zyclische lipopeptid acylase
TWI233805B (en) * 1999-07-01 2005-06-11 Fujisawa Pharmaceutical Co Stabilized pharmaceutical composition in lyophilized form as antifungal agent
CA2377793A1 (en) * 1999-07-02 2001-01-11 Fujisawa Pharmaceutical Co., Ltd. Gene encoding cyclic lipopeptide acylase and expression of the same
JP2005095001A (ja) * 1999-10-22 2005-04-14 Fujisawa Pharmaceut Co Ltd ヘテロマーペプチドの遺伝子工学的固定化
BR0017028A (pt) 1999-12-15 2003-01-07 Cubist Pharm Inc Lipopepìdeos como agentes antibacterianos
WO2001044274A1 (en) 1999-12-15 2001-06-21 Cubist Pharmaceuticals, Inc. Lipopeptides as antibacterial agents
WO2001044272A2 (en) 1999-12-15 2001-06-21 Cubist Pharmaceuticals, Inc. Daptomycin analogs as antibacterial agents
IL160171A0 (en) 2001-08-06 2004-07-25 Cubist Pharm Inc Depsipeptide derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
US7045547B2 (en) * 2002-08-20 2006-05-16 University Of Delaware Acyl-CoA dehydrogenase allenic inhibitors
BRPI0923567A2 (pt) 2008-12-22 2016-09-27 Cubist Pharm Inc agentes antibactericidas novos para o tratamento de infecções gram positivas
US8877777B2 (en) 2010-09-30 2014-11-04 Shanghai Techwell Biopharmaceutical Co., Ltd. Process for purifying cyclolipopeptide compounds or the salts thereof
CN102533551B (zh) * 2010-12-15 2013-10-09 上海天伟生物制药有限公司 一种肽类抗生素的高产菌株及其制备方法和用途
CN102618606B (zh) * 2011-01-30 2014-09-10 浙江海正药业股份有限公司 一种棘白菌素生物转化方法
CN103074403B (zh) * 2011-10-26 2014-07-09 上海医药工业研究院 微生物酶转化棘白菌素b的方法
CN102627689B (zh) 2012-03-30 2014-08-06 上海天伟生物制药有限公司 一种环肽类化合物的水合物及其制备方法和用途
CN102659930B (zh) * 2012-03-30 2014-04-23 上海天伟生物制药有限公司 一种高纯度环肽类物质的晶体及其制备方法和用途
CN103387975A (zh) * 2012-05-11 2013-11-13 上海天伟生物制药有限公司 一种固定化环脂肽酰基转移酶及其制备方法和用途
EP2897971B1 (de) * 2012-09-24 2017-05-31 DSM Sinochem Pharmaceuticals Netherlands B.V. Verfahren zur herstellung eines zyklischen peptids
KR101425108B1 (ko) * 2012-09-25 2014-07-31 동국제약 주식회사 탈아실화된 환상 리포펩티드의 제조방법
CN106755221A (zh) * 2016-11-28 2017-05-31 无锡福祈制药有限公司 一种米卡芬净母核fr179642的制备方法
CN111909244A (zh) * 2020-08-14 2020-11-10 卓和药业集团有限公司 一种高纯度米卡芬净前体fr901379的制备方法
CN114874919B (zh) * 2022-05-09 2023-06-27 中国科学院青岛生物能源与过程研究所 一株米卡芬净前体fr901379高产菌株及其应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR901469A (fr) 1942-11-27 1945-07-27 Rohm & Haas Ges Mit Beschrankt Procédé pour produire des pellicules, revêtements et analogues ne gonflant pas àpartir de polymérisats simples ou mixtes de composés éthyléniques sous forme de dispersions aqueuses
JPS585189A (ja) * 1981-07-01 1983-01-12 Sanraku Inc 新規なアミドヒドロラ−ゼ
US4396543A (en) * 1982-05-21 1983-08-02 Eli Lilly And Company Derivatives of A-21978C cyclic peptides
GB8925593D0 (en) 1989-11-13 1990-01-04 Fujisawa Pharmaceutical Co Fr901379 substance and preparation thereof
EP0460882B1 (de) * 1990-06-07 1996-07-24 Eli Lilly And Company Lipopeptid Deacylase
IL101717A (en) 1991-05-09 1995-12-08 Fujisawa Pharmaceutical Co Material FW34211, process for preparation, and pharmaceutical preparations that kill fungi and protozoa containing it
GB9506372D0 (en) 1995-03-29 1995-05-17 Fujisawa Pharmaceutical Co New peptide compounds
KR100545506B1 (ko) * 1996-03-08 2006-10-04 아스테라스 세이야쿠 가부시키가이샤 환상 리포펩티드 물질의 탈아실화 방법
EP1666587A1 (de) * 1996-06-13 2006-06-07 Astellas Pharma Inc. Zyclische lipopeptid acylase
CA2377793A1 (en) * 1999-07-02 2001-01-11 Fujisawa Pharmaceutical Co., Ltd. Gene encoding cyclic lipopeptide acylase and expression of the same
JP2005095001A (ja) * 1999-10-22 2005-04-14 Fujisawa Pharmaceut Co Ltd ヘテロマーペプチドの遺伝子工学的固定化

Also Published As

Publication number Publication date
CN1161462C (zh) 2004-08-11
JP3123078B2 (ja) 2001-01-09
EP0885957B1 (de) 2009-08-12
EP1854877A2 (de) 2007-11-14
US6537789B1 (en) 2003-03-25
CA2248348C (en) 2008-06-10
CA2248348A1 (en) 1997-09-12
KR100545506B1 (ko) 2006-10-04
ATE439433T1 (de) 2009-08-15
EP2172546A1 (de) 2010-04-07
EP0885957A1 (de) 1998-12-23
WO1997032975A1 (fr) 1997-09-12
EP0885957A4 (de) 2004-06-09
US6207434B1 (en) 2001-03-27
ATE544851T1 (de) 2012-02-15
KR19990087515A (ko) 1999-12-27
ES2379107T3 (es) 2012-04-20
CN1218507A (zh) 1999-06-02
EP1854877B1 (de) 2012-02-08
ES2327981T3 (es) 2009-11-05
US6573084B1 (en) 2003-06-03
EP1854877A3 (de) 2009-05-20

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