KR100300473B1 - 안지오텐신ii길항작용성이미다졸유도체,그의제조방법및그의치료적용도 - Google Patents

안지오텐신ii길항작용성이미다졸유도체,그의제조방법및그의치료적용도 Download PDF

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KR100300473B1
KR100300473B1 KR1019930009931A KR930009931A KR100300473B1 KR 100300473 B1 KR100300473 B1 KR 100300473B1 KR 1019930009931 A KR1019930009931 A KR 1019930009931A KR 930009931 A KR930009931 A KR 930009931A KR 100300473 B1 KR100300473 B1 KR 100300473B1
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South Korea
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group
phenyl
carbon atoms
methyl
reaction
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KR940000455A (ko
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야나기사와히로아끼
시모지야스오
아메미야요시야
가나자끼다꾸로
고이께히루유끼
사다도시오
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가와무라 요시부미
상꾜 가부시키가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1019930009931A 1992-06-02 1993-06-02 안지오텐신ii길항작용성이미다졸유도체,그의제조방법및그의치료적용도 Expired - Fee Related KR100300473B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP14116092 1992-06-02
JP92-141160 1992-06-02

Publications (2)

Publication Number Publication Date
KR940000455A KR940000455A (ko) 1994-01-03
KR100300473B1 true KR100300473B1 (ko) 2002-01-09

Family

ID=15285532

Family Applications (1)

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KR1019930009931A Expired - Fee Related KR100300473B1 (ko) 1992-06-02 1993-06-02 안지오텐신ii길항작용성이미다졸유도체,그의제조방법및그의치료적용도

Country Status (21)

Country Link
EP (1) EP0573218B1 (enExample)
JP (1) JP3461863B2 (enExample)
KR (1) KR100300473B1 (enExample)
CN (1) CN1051766C (enExample)
AT (1) ATE199548T1 (enExample)
AU (1) AU661153B2 (enExample)
CA (1) CA2097444C (enExample)
CZ (1) CZ287764B6 (enExample)
DE (1) DE69329982T2 (enExample)
DK (1) DK0573218T3 (enExample)
ES (1) ES2155827T3 (enExample)
FI (1) FI112476B (enExample)
GR (1) GR3035624T3 (enExample)
HU (1) HUT64329A (enExample)
IL (1) IL105825A (enExample)
NO (1) NO303872B1 (enExample)
NZ (1) NZ247750A (enExample)
PT (1) PT573218E (enExample)
RU (1) RU2086541C1 (enExample)
TW (1) TW228521B (enExample)
ZA (1) ZA933824B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT398202B (de) * 1991-10-04 1994-10-25 Chem Pharm Forsch Gmbh Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung
US5310929A (en) * 1992-08-06 1994-05-10 E. I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
HU219598B (hu) * 1992-12-17 2001-05-28 Sankyo Co. Ltd. Bifenilvegyületek imidazol- és piridinszármazékai, eljárás előállításukra és ezeket a vegyületeket tartalmazó gyógyszerkészítmények
NZ282485A (en) * 1994-03-16 1997-06-24 Sankyo Co Treatment of ocular hypertension using imidazole derivatives
KR100428725B1 (ko) * 1996-03-30 2004-07-07 주식회사 현대시스콤 디지탈이동통신교환기녹음안내장치의2단계자체루프백시험장치및방법
DE19731328A1 (de) * 1997-07-22 1999-01-28 Hoechst Ag Imidazol-Derivate mit Biphenylsulfonylcyanamid-Seitenkette, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
RU2380362C2 (ru) * 1999-10-11 2010-01-27 Сосьете Де Консей Де Решерш З Производные пятичленных гетероциклов, способ их получения и их применение в качестве лекарственных средств
GR20000100281A (el) * 2000-08-17 2002-05-24 Ιωαννης Ματσουκας Ανταγωνιστες του υποδοχεα της αγγεοτενσινης ιι και συνθετικες μεθοδοι για την θεραπεια της υπερτασης και καρδιοαγγειακων ασθενειων
CN1197866C (zh) * 2003-03-21 2005-04-20 上海医药工业研究院 4，6－二氢呋喃并[3,4－d]咪唑－6－酮衍生物及其盐和制备方法
KR101087519B1 (ko) * 2003-04-15 2011-11-28 상꾜 가부시키가이샤 안구 내 혈관 신생성 질환의 예방 또는 치료를 위한 의약
US7692023B2 (en) 2004-02-11 2010-04-06 Teva Pharmaceutical Industries Ltd. Candesartan cilexetil polymorphs
CN101024643A (zh) * 2006-02-20 2007-08-29 上海艾力斯医药科技有限公司 咪唑－5－羧酸类衍生物、制备方法及其应用
TWI448284B (zh) * 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
EP2176253B1 (en) * 2007-08-08 2011-10-12 LEK Pharmaceuticals d.d. A process for the preparation or purification of olmesartan medoxomil or olmesartan medoxomil hydrohalide salt
CN101481374B (zh) * 2008-01-09 2013-01-09 浙江华海药业股份有限公司 1-三苯甲基-5-(1，1｀-联苯基-2基)-1h-四唑类化合物脱去三苯甲基的方法
CN103319461A (zh) * 2013-07-02 2013-09-25 临海天宇药业有限公司 奥美沙坦酯中间体的制备方法以及奥美沙坦酯的合成方法
CN104262332A (zh) * 2014-09-16 2015-01-07 上海信谊百路达药业有限公司 一种奥美沙坦酯的制备方法
CN104356069B (zh) * 2014-11-18 2016-09-14 黄冈鲁班药业有限公司 奥美沙坦酯中间体4-(1-羟基-1-甲基乙基)-2-丙基咪唑-5-羧酸乙酯的制备方法及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
WO1991000277A1 (en) * 1989-06-30 1991-01-10 E.I. Du Pont De Nemours And Company Substituted imidazoles
IL98319A (en) * 1990-07-05 1997-04-15 Roussel Uclaf Sulphurous derivatives of imidazole, their preparation process, and pharmaceutical compositions containing them
IE920540A1 (en) * 1991-02-21 1992-08-26 Sankyo Co 1-biphenylmethylimidazole derivatives, their preparation and¹their therapetuic use
EP0505098A1 (en) * 1991-03-19 1992-09-23 Merck & Co. Inc. Imidazole derivatives bearing acidic functional groups as angiotensin II antagonists

Also Published As

Publication number Publication date
CA2097444A1 (en) 1993-12-03
FI932492L (fi) 1993-12-03
ES2155827T3 (es) 2001-06-01
HK1011983A1 (en) 1999-07-23
FI932492A0 (fi) 1993-06-01
NO931980D0 (no) 1993-06-01
NO931980L (no) 1993-12-03
RU2086541C1 (ru) 1997-08-10
JPH0649036A (ja) 1994-02-22
FI112476B (fi) 2003-12-15
IL105825A0 (en) 1993-09-22
IL105825A (en) 1998-01-04
EP0573218A2 (en) 1993-12-08
AU661153B2 (en) 1995-07-13
GR3035624T3 (en) 2001-06-29
ZA933824B (en) 1993-12-27
EP0573218A3 (en) 1994-06-01
PT573218E (pt) 2001-06-29
DE69329982T2 (de) 2001-09-27
HUT64329A (en) 1993-12-28
DE69329982D1 (de) 2001-04-12
ATE199548T1 (de) 2001-03-15
NZ247750A (en) 1995-05-26
TW228521B (enExample) 1994-08-21
AU3988093A (en) 1993-12-09
CZ287764B6 (en) 2001-01-17
CN1085896A (zh) 1994-04-27
NO303872B1 (no) 1998-09-14
JP3461863B2 (ja) 2003-10-27
DK0573218T3 (da) 2001-06-18
CA2097444C (en) 2005-03-29
CZ105093A3 (en) 1993-12-15
HU9301600D0 (en) 1993-09-28
KR940000455A (ko) 1994-01-03
CN1051766C (zh) 2000-04-26
EP0573218B1 (en) 2001-03-07

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