CN101481374B - 1-三苯甲基-5-(1,1`-联苯基-2基)-1h-四唑类化合物脱去三苯甲基的方法 - Google Patents
1-三苯甲基-5-(1,1`-联苯基-2基)-1h-四唑类化合物脱去三苯甲基的方法 Download PDFInfo
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- CN101481374B CN101481374B CN 200810032436 CN200810032436A CN101481374B CN 101481374 B CN101481374 B CN 101481374B CN 200810032436 CN200810032436 CN 200810032436 CN 200810032436 A CN200810032436 A CN 200810032436A CN 101481374 B CN101481374 B CN 101481374B
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- alcohol
- trityl
- methyl
- reaction
- chloride
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- Plural Heterocyclic Compounds (AREA)
Abstract
Description
反应条件 | 反应温度 | 反应时间 |
乙酰氯 | 15~20℃ | 0.5h |
HCl甲醇溶液 | 5℃ | 3.5h |
蚁酸 | 30~35℃ | 5h |
甲醇 | 回流 | 24h |
硼酸 | 回流 | 8h |
甲醇、氯化锌、水 | 回流 | 2.5h |
Claims (11)
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CN 200810032436 CN101481374B (zh) | 2008-01-09 | 2008-01-09 | 1-三苯甲基-5-(1,1`-联苯基-2基)-1h-四唑类化合物脱去三苯甲基的方法 |
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CN 200810032436 CN101481374B (zh) | 2008-01-09 | 2008-01-09 | 1-三苯甲基-5-(1,1`-联苯基-2基)-1h-四唑类化合物脱去三苯甲基的方法 |
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CN101481374A CN101481374A (zh) | 2009-07-15 |
CN101481374B true CN101481374B (zh) | 2013-01-09 |
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Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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KR101251741B1 (ko) * | 2010-12-16 | 2013-04-05 | 동화약품주식회사 | 칸데사르탄실렉세틸의 개선된 제조방법 |
CN116375687A (zh) * | 2021-12-22 | 2023-07-04 | 浙江华海药业股份有限公司 | 一种高纯度的氯沙坦钾及其制备方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1085896A (zh) * | 1992-06-02 | 1994-04-27 | 三共株式会社 | 血管紧张素ii拮抗剂咪唑衍生物,它们的制备及其治疗用途 |
EP1661891A1 (en) * | 2004-11-30 | 2006-05-31 | KRKA, D.D., Novo Mesto | A process for the synthesis of valsartan |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1085896A (zh) * | 1992-06-02 | 1994-04-27 | 三共株式会社 | 血管紧张素ii拮抗剂咪唑衍生物,它们的制备及其治疗用途 |
EP1661891A1 (en) * | 2004-11-30 | 2006-05-31 | KRKA, D.D., Novo Mesto | A process for the synthesis of valsartan |
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Owner name: SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY Effective date: 20130311 |
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CB03 | Change of inventor or designer information |
Inventor after: Shi Huilin Inventor after: Zhao Guobiao Inventor after: Dong Peng Inventor after: Zhou Hu Inventor after: Tu Guoliang Inventor after: Wang Youhu Inventor after: Dan Xiaoyan Inventor before: Zhao Guobiao Inventor before: Dong Peng |
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COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: ZHAO GUOBIAO DONG PENG TO: SHI HUILIN ZHAO GUOBIAO DONG PENG ZHOU HU TU GUOLIANG WANG YOUHU DAN XIAOYAN |
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TR01 | Transfer of patent right |
Effective date of registration: 20130311 Address after: 317024, Taizhou City, Zhejiang Province, Hai Zhen, town of Patentee after: Zhejiang Huahai Pharmaceutical Co., Ltd. Patentee after: Shanghai Institute of pharmaceutical industry Address before: 317024, Zhejiang province Linhai City Xun Town Li Zhuang Patentee before: Zhejiang Huahai Pharmaceutical Co., Ltd. |
|
C41 | Transfer of patent application or patent right or utility model | ||
CB03 | Change of inventor or designer information |
Inventor after: Zhao Guobiao Inventor after: Dong Peng Inventor before: Shi Huilin Inventor before: Zhao Guobiao Inventor before: Dong Peng Inventor before: Zhou Hu Inventor before: Tu Guoliang Inventor before: Wang Youhu Inventor before: Dan Xiaoyan |
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COR | Change of bibliographic data | ||
TR01 | Transfer of patent right |
Effective date of registration: 20151106 Address after: 317024, Taizhou City, Zhejiang Province, Hai Zhen, town of Patentee after: Zhejiang Huahai Pharmaceutical Co., Ltd. Address before: 317024, Taizhou City, Zhejiang Province, Hai Zhen, town of Patentee before: Zhejiang Huahai Pharmaceutical Co., Ltd. Patentee before: Shanghai Institute of pharmaceutical industry |