ZA933824B - Angiotensin II antagonist imidazole derivatives, their preparation and their therapeutic use - Google Patents

Angiotensin II antagonist imidazole derivatives, their preparation and their therapeutic use

Info

Publication number
ZA933824B
ZA933824B ZA933824A ZA933824A ZA933824B ZA 933824 B ZA933824 B ZA 933824B ZA 933824 A ZA933824 A ZA 933824A ZA 933824 A ZA933824 A ZA 933824A ZA 933824 B ZA933824 B ZA 933824B
Authority
ZA
South Africa
Prior art keywords
angiotensin
antagonist
preparation
therapeutic use
imidazole derivatives
Prior art date
Application number
ZA933824A
Other languages
English (en)
Inventor
Hiroaki Yanagisawa
Yasuo Shimoji
Yoshiya Amemiya
Takuso Kanazaki
Hiroyuki Koike
Toshio Sada
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of ZA933824B publication Critical patent/ZA933824B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA933824A 1992-06-02 1993-06-01 Angiotensin II antagonist imidazole derivatives, their preparation and their therapeutic use ZA933824B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14116092 1992-06-02

Publications (1)

Publication Number Publication Date
ZA933824B true ZA933824B (en) 1993-12-27

Family

ID=15285532

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA933824A ZA933824B (en) 1992-06-02 1993-06-01 Angiotensin II antagonist imidazole derivatives, their preparation and their therapeutic use

Country Status (22)

Country Link
EP (1) EP0573218B1 (xx)
JP (1) JP3461863B2 (xx)
KR (1) KR100300473B1 (xx)
CN (1) CN1051766C (xx)
AT (1) ATE199548T1 (xx)
AU (1) AU661153B2 (xx)
CA (1) CA2097444C (xx)
CZ (1) CZ287764B6 (xx)
DE (1) DE69329982T2 (xx)
DK (1) DK0573218T3 (xx)
ES (1) ES2155827T3 (xx)
FI (1) FI112476B (xx)
GR (1) GR3035624T3 (xx)
HK (1) HK1011983A1 (xx)
HU (1) HUT64329A (xx)
IL (1) IL105825A (xx)
NO (1) NO303872B1 (xx)
NZ (1) NZ247750A (xx)
PT (1) PT573218E (xx)
RU (1) RU2086541C1 (xx)
TW (1) TW228521B (xx)
ZA (1) ZA933824B (xx)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT398202B (de) * 1991-10-04 1994-10-25 Chem Pharm Forsch Gmbh Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung
US5310929A (en) * 1992-08-06 1994-05-10 E. I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
JP3501484B2 (ja) * 1992-12-17 2004-03-02 三共株式会社 ビフェニル誘導体
HUT74734A (en) * 1994-03-16 1997-02-28 Sankyo Co Use of biphenyl methyl imidazole derivatives for producing pharmaceutical compositions having ocular tension derpessant activity
KR100428725B1 (ko) * 1996-03-30 2004-07-07 주식회사 현대시스콤 디지탈이동통신교환기녹음안내장치의2단계자체루프백시험장치및방법
GR20000100281A (el) * 2000-08-17 2002-05-24 Ιωαννης Ματσουκας Ανταγωνιστες του υποδοχεα της αγγεοτενσινης ιι και συνθετικες μεθοδοι για την θεραπεια της υπερτασης και καρδιοαγγειακων ασθενειων
CN1197866C (zh) * 2003-03-21 2005-04-20 上海医药工业研究院 4，6－二氢呋喃并[3,4－d]咪唑－6－酮衍生物及其盐和制备方法
BRPI0409293A (pt) * 2003-04-15 2006-04-11 Sankyo Co medicamento para a prevenção ou tratamento de doenças angiogênicas intraoculares
WO2005077941A2 (en) 2004-02-11 2005-08-25 Teva Pharmaceutical Industries Ltd. Candesartan cilexetil polymorphs
CN101024643A (zh) * 2006-02-20 2007-08-29 上海艾力斯医药科技有限公司 咪唑－5－羧酸类衍生物、制备方法及其应用
TWI448284B (zh) * 2007-04-24 2014-08-11 Theravance Inc 雙效抗高血壓劑
CN101778842B (zh) * 2007-08-08 2014-10-29 力奇制药公司 制备或纯化奥美沙坦酯的方法
CN101481374B (zh) * 2008-01-09 2013-01-09 浙江华海药业股份有限公司 1-三苯甲基-5-(1，1｀-联苯基-2基)-1h-四唑类化合物脱去三苯甲基的方法
CN103319461A (zh) * 2013-07-02 2013-09-25 临海天宇药业有限公司 奥美沙坦酯中间体的制备方法以及奥美沙坦酯的合成方法
CN104262332A (zh) * 2014-09-16 2015-01-07 上海信谊百路达药业有限公司 一种奥美沙坦酯的制备方法
CN104356069B (zh) * 2014-11-18 2016-09-14 黄冈鲁班药业有限公司 奥美沙坦酯中间体4-(1-羟基-1-甲基乙基)-2-丙基咪唑-5-羧酸乙酯的制备方法及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
DE69025473T2 (de) * 1989-06-30 1996-10-17 Du Pont Substituierte imidazole und ihre verwendung als hemmmstoff fur angiotensin ii
IL98319A (en) * 1990-07-05 1997-04-15 Roussel Uclaf Sulphurous derivatives of imidazole, their preparation process, and pharmaceutical compositions containing them
FI112942B3 (fi) * 1991-02-21 2012-03-13 Daiichi Sankyo Co Ltd Menetelmä kohonneen verenpaineen hoitoon ja ennaltaehkäisyyn käyttökelpoisten 4'-(1H-imidatsol-1-yylimetyyli)-1,1' -bifenyylijohdannaisten valmistamiseksi
EP0505098A1 (en) * 1991-03-19 1992-09-23 Merck & Co. Inc. Imidazole derivatives bearing acidic functional groups as angiotensin II antagonists

Also Published As

Publication number Publication date
CZ105093A3 (en) 1993-12-15
DK0573218T3 (da) 2001-06-18
CN1085896A (zh) 1994-04-27
CA2097444A1 (en) 1993-12-03
DE69329982D1 (de) 2001-04-12
HK1011983A1 (en) 1999-07-23
DE69329982T2 (de) 2001-09-27
IL105825A0 (en) 1993-09-22
TW228521B (xx) 1994-08-21
NO303872B1 (no) 1998-09-14
GR3035624T3 (en) 2001-06-29
FI112476B (fi) 2003-12-15
AU3988093A (en) 1993-12-09
JPH0649036A (ja) 1994-02-22
ATE199548T1 (de) 2001-03-15
AU661153B2 (en) 1995-07-13
FI932492A (fi) 1993-12-03
FI932492A0 (fi) 1993-06-01
JP3461863B2 (ja) 2003-10-27
NZ247750A (en) 1995-05-26
HU9301600D0 (en) 1993-09-28
KR940000455A (ko) 1994-01-03
HUT64329A (en) 1993-12-28
CN1051766C (zh) 2000-04-26
CA2097444C (en) 2005-03-29
NO931980L (no) 1993-12-03
PT573218E (pt) 2001-06-29
ES2155827T3 (es) 2001-06-01
NO931980D0 (no) 1993-06-01
EP0573218A3 (en) 1994-06-01
IL105825A (en) 1998-01-04
KR100300473B1 (ko) 2002-01-09
EP0573218B1 (en) 2001-03-07
EP0573218A2 (en) 1993-12-08
RU2086541C1 (ru) 1997-08-10
CZ287764B6 (en) 2001-01-17

Similar Documents

Publication Publication Date Title
ZA933824B (en) Angiotensin II antagonist imidazole derivatives, their preparation and their therapeutic use
HK1073460A1 (en) Substituted 1, 3-oxathiolanes with antiviral properties
CA2061607A1 (en) 1-biphenylimidazole derivatives, their preparation and their therapeutic use
NO902632D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive imidazolyl-alkensyrer.
AU6601294A (en) Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses
FI935693A (fi) Bifenyylin johdannaiset, niiden valmistus ja käyttö korkean verenpaineen ja sydäntautien hoitoon
AU641952B2 (en) Substituted N-(imidazolyl)alkyl alanine derivatives
JPS6434979A (en) Pyrrolidine derivative and antiallergic composition
IT1255802B (it) Derivati imidazolici ad attivita' a ii antagonista
MX9800483A (es) Derivados de piperazina y su uso como antagonistas de 5-ht1a.
AU6948091A (en) Thiazolidine derivatives having anti-hypertensive activity and their therapeutic use
NZ216334A (en) Spiro imidazolone derivatives and pharmaceutical composition
ES8704940A1 (es) Procedimiento de preparacion de nuevos derivados alquilamino-furanonas y de sales y diastereoisomeros farmaceuticamente aceptables de los mismos.
IL113309A0 (en) Imidazopyridine derivatives, their preparation and use
ATE111462T1 (de) 1,4-dihydropyridin-derivate.
JO1660B1 (en) Benzimidazole compounds are a therapeutically effective substitute for chlorine and processes for preparing and using them
CA2049440A1 (en) Pyridinecarboxylic acid amide derivatives and pharmaceutical compositions comprising same
MX9800368A (es) Derivados de piperidina de difenilmetileno.