KR100294154B1 - 부프로피온함유서방형정제 - Google Patents
부프로피온함유서방형정제 Download PDFInfo
- Publication number
- KR100294154B1 KR100294154B1 KR1019950700497A KR19950700497A KR100294154B1 KR 100294154 B1 KR100294154 B1 KR 100294154B1 KR 1019950700497 A KR1019950700497 A KR 1019950700497A KR 19950700497 A KR19950700497 A KR 19950700497A KR 100294154 B1 KR100294154 B1 KR 100294154B1
- Authority
- KR
- South Korea
- Prior art keywords
- bupropion
- hydrochloride
- tablet
- sustained
- bupropion hydrochloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000007939 sustained release tablet Substances 0.000 title claims abstract description 17
- SNPPWIUOZRMYNY-UHFFFAOYSA-N bupropion Chemical compound CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-UHFFFAOYSA-N 0.000 title claims description 21
- 229960001058 bupropion Drugs 0.000 title claims description 21
- 239000003826 tablet Substances 0.000 claims abstract description 84
- IKBZAUYPBWFMDI-UHFFFAOYSA-N 5-bromo-4-methoxy-7-methyl-2,3-dihydro-1h-indene Chemical compound C1=C(Br)C(OC)=C2CCCC2=C1C IKBZAUYPBWFMDI-UHFFFAOYSA-N 0.000 claims abstract description 58
- 229960004367 bupropion hydrochloride Drugs 0.000 claims abstract description 58
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims abstract description 23
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims abstract description 23
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract description 23
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims abstract description 23
- QIJRTFXNRTXDIP-UHFFFAOYSA-N (1-carboxy-2-sulfanylethyl)azanium;chloride;hydrate Chemical compound O.Cl.SCC(N)C(O)=O QIJRTFXNRTXDIP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229960001305 cysteine hydrochloride Drugs 0.000 claims abstract description 11
- IVLXQGJVBGMLRR-UHFFFAOYSA-N 2-aminoacetic acid;hydron;chloride Chemical compound Cl.NCC(O)=O IVLXQGJVBGMLRR-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229960001269 glycine hydrochloride Drugs 0.000 claims abstract description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 230000036470 plasma concentration Effects 0.000 claims description 11
- 239000012458 free base Substances 0.000 claims description 7
- -1 hydroxypropyl Chemical group 0.000 claims description 3
- 238000013270 controlled release Methods 0.000 abstract description 3
- 238000000576 coating method Methods 0.000 description 19
- 239000011248 coating agent Substances 0.000 description 18
- 238000013268 sustained release Methods 0.000 description 15
- 239000012730 sustained-release form Substances 0.000 description 15
- 239000008187 granular material Substances 0.000 description 12
- 239000012528 membrane Substances 0.000 description 12
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 10
- 239000008213 purified water Substances 0.000 description 9
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 238000004519 manufacturing process Methods 0.000 description 7
- 238000005259 measurement Methods 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 6
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 239000008108 microcrystalline cellulose Substances 0.000 description 6
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 6
- 229940016286 microcrystalline cellulose Drugs 0.000 description 6
- 239000002245 particle Substances 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 239000007921 spray Substances 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 239000012729 immediate-release (IR) formulation Substances 0.000 description 4
- 235000019359 magnesium stearate Nutrition 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- HEYVINCGKDONRU-UHFFFAOYSA-N Bupropion hydrochloride Chemical compound Cl.CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 HEYVINCGKDONRU-UHFFFAOYSA-N 0.000 description 3
- 206010010904 Convulsion Diseases 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000004203 carnauba wax Substances 0.000 description 3
- 235000013869 carnauba wax Nutrition 0.000 description 3
- 238000005469 granulation Methods 0.000 description 3
- 230000003179 granulation Effects 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000004408 titanium dioxide Substances 0.000 description 3
- 230000004584 weight gain Effects 0.000 description 3
- 235000019786 weight gain Nutrition 0.000 description 3
- 229920003091 Methocel™ Polymers 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 239000012738 dissolution medium Substances 0.000 description 2
- 238000007922 dissolution test Methods 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 229940068968 polysorbate 80 Drugs 0.000 description 2
- 238000003127 radioimmunoassay Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- CTRXDTYTAAKVSM-UHFFFAOYSA-N 3-{[ethyl({4-[(4-{ethyl[(3-sulfophenyl)methyl]amino}phenyl)(2-sulfophenyl)methylidene]cyclohexa-2,5-dien-1-ylidene})azaniumyl]methyl}benzene-1-sulfonate Chemical compound C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S(O)(=O)=O)C=CC=1N(CC)CC1=CC=CC(S(O)(=O)=O)=C1 CTRXDTYTAAKVSM-UHFFFAOYSA-N 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 208000020401 Depressive disease Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229920003102 Methocel™ E4M Polymers 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000001430 anti-depressive effect Effects 0.000 description 1
- 239000000935 antidepressant agent Substances 0.000 description 1
- 229940005513 antidepressants Drugs 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 229940094170 bupropion hydrochloride 100 mg Drugs 0.000 description 1
- 229940094164 bupropion hydrochloride 150 mg Drugs 0.000 description 1
- 229940093754 bupropion hydrochloride 50 mg Drugs 0.000 description 1
- 239000007894 caplet Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- CEZCCHQBSQPRMU-UHFFFAOYSA-L chembl174821 Chemical compound [Na+].[Na+].COC1=CC(S([O-])(=O)=O)=C(C)C=C1N=NC1=C(O)C=CC2=CC(S([O-])(=O)=O)=CC=C12 CEZCCHQBSQPRMU-UHFFFAOYSA-L 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 description 1
- 229940111688 monobasic potassium phosphate Drugs 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000011003 system suitability test Methods 0.000 description 1
- 238000000825 ultraviolet detection Methods 0.000 description 1
- 229940009065 wellbutrin Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- General Preparation And Processing Of Foods (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9217295.6 | 1992-08-14 | ||
| GB929217295A GB9217295D0 (en) | 1992-08-14 | 1992-08-14 | Controlled released tablets |
| PCT/GB1993/001722 WO1994004138A1 (en) | 1992-08-14 | 1993-08-13 | Sustained release tablets containing bupropion |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR950702827A KR950702827A (ko) | 1995-08-23 |
| KR100294154B1 true KR100294154B1 (ko) | 2001-09-17 |
Family
ID=10720358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019950700497A Expired - Lifetime KR100294154B1 (ko) | 1992-08-14 | 1993-08-13 | 부프로피온함유서방형정제 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5427798A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0656775B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JPH08500110A (cg-RX-API-DMAC7.html) |
| KR (1) | KR100294154B1 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE161422T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU677595B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2142320C (cg-RX-API-DMAC7.html) |
| CY (1) | CY2143B1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE69316015T2 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2111168T3 (cg-RX-API-DMAC7.html) |
| GB (1) | GB9217295D0 (cg-RX-API-DMAC7.html) |
| GR (1) | GR3025794T3 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1004323A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL106693A (cg-RX-API-DMAC7.html) |
| LU (1) | LU90656I2 (cg-RX-API-DMAC7.html) |
| MX (1) | MX9304967A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ254947A (cg-RX-API-DMAC7.html) |
| SG (1) | SG43911A1 (cg-RX-API-DMAC7.html) |
| TW (1) | TW260607B (cg-RX-API-DMAC7.html) |
| WO (1) | WO1994004138A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA935942B (cg-RX-API-DMAC7.html) |
Families Citing this family (229)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5541231A (en) * | 1993-07-30 | 1996-07-30 | Glaxo Wellcome Inc. | Stabilized Pharmaceutical |
| GB9315856D0 (en) * | 1993-07-30 | 1993-09-15 | Wellcome Found | Stabilized pharmaceutical |
| US5616344A (en) * | 1994-06-14 | 1997-04-01 | Fuisz Technologies Ltd. | Apparatus and process for strengthening low density compression dosage units and product therefrom |
| DK1017392T3 (da) * | 1997-09-25 | 2002-10-21 | Bayer Ag | Lægemiddel |
| US6221917B1 (en) | 1997-12-30 | 2001-04-24 | American Home Products Corporation | Pharmaceutical composition containing bupropion hydrochloride and a stabilizer |
| US5968553A (en) * | 1997-12-30 | 1999-10-19 | American Home Products Corporation | Pharmaceutical composition containing bupropion hydrochloride and an inorganic acid stabilizer |
| US7098206B2 (en) * | 1998-01-21 | 2006-08-29 | Smithkline Beecham Corporation | Pharmaceutically active morpholinol |
| US6998400B2 (en) * | 1998-01-22 | 2006-02-14 | Smithkline Beecham Corporation | Pharmaceutically active morpholinol |
| AU2349999A (en) * | 1998-01-29 | 1999-08-16 | Sepracor, Inc. | Pharmacological uses of pure (+) -bupropion |
| CA2318738A1 (en) * | 1998-01-29 | 1999-08-05 | Sepracor Inc. | Methods and compositions for aiding in smoking cessation and for treating pain and other disorders using optically pure (-)-bupropion |
| EP1051167A1 (en) * | 1998-01-29 | 2000-11-15 | Sepracor, Inc. | Pharmaceutical uses of optically pure (-) -bupropion |
| AU2483499A (en) * | 1998-01-29 | 1999-08-16 | Sepracor, Inc. | Pharmaceutical uses of optically pure (+)-bupropion |
| US6150420A (en) * | 1998-06-01 | 2000-11-21 | Theramax, Inc. | Method for enhanced brain delivery of bupropion |
| US6153223A (en) * | 1998-06-05 | 2000-11-28 | Watson Pharmaceuticals, Inc. | Stabilized pharmaceutical compositions |
| US6033686A (en) * | 1998-10-30 | 2000-03-07 | Pharma Pass Llc | Controlled release tablet of bupropion hydrochloride |
| US6096341A (en) * | 1998-10-30 | 2000-08-01 | Pharma Pass Llc | Delayed release tablet of bupropion hydrochloride |
| US6238697B1 (en) * | 1998-12-21 | 2001-05-29 | Pharmalogix, Inc. | Methods and formulations for making bupropion hydrochloride tablets using direct compression |
| US6734213B2 (en) | 1999-01-20 | 2004-05-11 | Smithkline Beecham Corporation | Pharmaceutically active morpholinol |
| US6855820B2 (en) * | 1999-01-20 | 2005-02-15 | Smithkline Beecham Corporation | Pharmaceutically active morpholinol |
| US6210716B1 (en) * | 1999-02-26 | 2001-04-03 | Andrx Pharmaceuticals, Inc. | Controlled release bupropion formulation |
| US8545880B2 (en) * | 1999-02-26 | 2013-10-01 | Andrx Pharmaceuticals, Llc | Controlled release oral dosage form |
| US6589553B2 (en) * | 2001-02-08 | 2003-07-08 | Andrx Pharmaceuticals, Inc. | Controlled release oral dosage form |
| US6342496B1 (en) * | 1999-03-01 | 2002-01-29 | Sepracor Inc. | Bupropion metabolites and methods of use |
| US6337328B1 (en) * | 1999-03-01 | 2002-01-08 | Sepracor, Inc. | Bupropion metabolites and methods of use |
| USD430285S (en) * | 1999-04-16 | 2000-08-29 | Merck & Co., Inc. | Tablet |
| US6280763B1 (en) | 1999-05-10 | 2001-08-28 | Pierce Management, Llc | Apparatus and method for transdermal delivery of bupropion |
| MXPA02004413A (es) * | 1999-11-02 | 2002-09-02 | Depomed Inc | Induccion farmacologica del modo de alimentacion, para la administracion aumentada de drogas al estomago. |
| US6306436B1 (en) | 2000-04-28 | 2001-10-23 | Teva Pharmaceuticals Usa, Inc. | Stabilized, acid-free formulation for sustained release of bupropion hydrochloride |
| EP1357898A4 (en) * | 2001-02-08 | 2005-07-13 | Andrx Pharmaceuticals Inc | ORAL DOSAGE FORM WITH ENHANCED REGULATED RELEASE |
| ITMI20011457A1 (it) * | 2001-07-09 | 2003-01-09 | Valpharma Sa | Composizione farmaceutica a rilascio modificato contenente bupropionehc1 come sostanza attiva |
| US20030044462A1 (en) * | 2001-08-20 | 2003-03-06 | Kali Laboratories, Inc. | Sustained release tablets containing bupropion hydrochloride |
| IL163666A0 (en) | 2002-02-22 | 2005-12-18 | New River Pharmaceuticals Inc | Active agent delivery systems and methods for protecting and administering active agents |
| US20050215552A1 (en) * | 2002-05-17 | 2005-09-29 | Gadde Kishore M | Method for treating obesity |
| KR20110043664A (ko) * | 2002-05-17 | 2011-04-27 | 듀크 유니버시티 | 비만치료방법 |
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| AU2003284942A1 (en) * | 2002-10-30 | 2004-06-07 | Pharmacia Corporation | Oral extended release tablets and methods of making and using the same |
| US20040096497A1 (en) * | 2002-11-19 | 2004-05-20 | Ponder Garratt W. | Methods of providing controlled-release pharmaceutical compositions and controlled-release pharmaceutical compositions |
| US6893660B2 (en) * | 2002-11-21 | 2005-05-17 | Andrx Pharmaceuticals, Inc. | Stable pharmaceutical compositions without a stabilizer |
| ATE388698T1 (de) * | 2003-04-29 | 2008-03-15 | Orexigen Therapeutics Inc | Zusammensetzungen zur beeinflussung des gewichtsverlusts |
| DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| US20070048228A1 (en) * | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
| DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| US8075872B2 (en) * | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
| DE102004032051A1 (de) * | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
| DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| BRPI0318456B8 (pt) * | 2003-08-08 | 2021-05-25 | Biovail Laboratories Int Srl | tablete com liberação modificada |
| US7713959B2 (en) | 2004-01-13 | 2010-05-11 | Duke University | Compositions of an anticonvulsant and mirtazapine to prevent weight gain |
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1992
- 1992-08-14 GB GB929217295A patent/GB9217295D0/en active Pending
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1993
- 1993-08-12 US US08/105,447 patent/US5427798A/en not_active Expired - Lifetime
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- 1993-08-13 NZ NZ254947A patent/NZ254947A/en not_active IP Right Cessation
- 1993-08-13 CA CA002142320A patent/CA2142320C/en not_active Expired - Lifetime
- 1993-08-13 WO PCT/GB1993/001722 patent/WO1994004138A1/en not_active Ceased
- 1993-08-13 ES ES93918020T patent/ES2111168T3/es not_active Expired - Lifetime
- 1993-08-13 DE DE69316015T patent/DE69316015T2/de not_active Expired - Lifetime
- 1993-08-13 EP EP93918020A patent/EP0656775B1/en not_active Expired - Lifetime
- 1993-08-13 SG SG1996005086A patent/SG43911A1/en unknown
- 1993-08-13 AT AT93918020T patent/ATE161422T1/de active
- 1993-08-13 TW TW082106498A patent/TW260607B/zh not_active IP Right Cessation
- 1993-08-13 HK HK98103254A patent/HK1004323A1/en not_active IP Right Cessation
- 1993-08-13 IL IL106693A patent/IL106693A/xx not_active IP Right Cessation
- 1993-08-13 KR KR1019950700497A patent/KR100294154B1/ko not_active Expired - Lifetime
- 1993-08-13 JP JP6506019A patent/JPH08500110A/ja active Pending
- 1993-08-16 MX MX9304967A patent/MX9304967A/es unknown
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1997
- 1997-12-30 GR GR970403389T patent/GR3025794T3/el unknown
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1999
- 1999-11-29 CY CY9900040A patent/CY2143B1/xx unknown
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2000
- 2000-10-18 LU LU90656C patent/LU90656I2/fr unknown
Also Published As
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| CY2143B1 (en) | 2002-06-21 |
| IL106693A0 (en) | 1993-12-08 |
| KR950702827A (ko) | 1995-08-23 |
| NZ254947A (en) | 1996-04-26 |
| MX9304967A (es) | 1994-05-31 |
| AU677595B2 (en) | 1997-05-01 |
| US5427798A (en) | 1995-06-27 |
| WO1994004138A1 (en) | 1994-03-03 |
| CA2142320A1 (en) | 1994-03-03 |
| LU90656I2 (fr) | 2001-01-15 |
| CA2142320C (en) | 2001-10-09 |
| GR3025794T3 (en) | 1998-03-31 |
| GB9217295D0 (en) | 1992-09-30 |
| ES2111168T3 (es) | 1998-03-01 |
| TW260607B (cg-RX-API-DMAC7.html) | 1995-10-21 |
| JPH08500110A (ja) | 1996-01-09 |
| SG43911A1 (en) | 1997-11-14 |
| DE69316015T2 (de) | 1998-04-16 |
| DE69316015D1 (de) | 1998-02-05 |
| EP0656775A1 (en) | 1995-06-14 |
| ZA935942B (en) | 1995-02-13 |
| EP0656775B1 (en) | 1997-12-29 |
| AU4725893A (en) | 1994-03-15 |
| IL106693A (en) | 1997-06-10 |
| HK1004323A1 (en) | 1998-11-20 |
| ATE161422T1 (de) | 1998-01-15 |
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