TW260607B - - Google Patents

Info

Publication number
TW260607B
TW260607B TW082106498A TW82106498A TW260607B TW 260607 B TW260607 B TW 260607B TW 082106498 A TW082106498 A TW 082106498A TW 82106498 A TW82106498 A TW 82106498A TW 260607 B TW260607 B TW 260607B
Authority
TW
Taiwan
Prior art keywords
hydrochloride
tablet
release
bupropion
surface area
Prior art date
Application number
TW082106498A
Other languages
English (en)
Chinese (zh)
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10720358&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW260607(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wellcome Found filed Critical Wellcome Found
Application granted granted Critical
Publication of TW260607B publication Critical patent/TW260607B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW082106498A 1992-08-14 1993-08-13 TW260607B (cg-RX-API-DMAC7.html)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929217295A GB9217295D0 (en) 1992-08-14 1992-08-14 Controlled released tablets

Publications (1)

Publication Number Publication Date
TW260607B true TW260607B (cg-RX-API-DMAC7.html) 1995-10-21

Family

ID=10720358

Family Applications (1)

Application Number Title Priority Date Filing Date
TW082106498A TW260607B (cg-RX-API-DMAC7.html) 1992-08-14 1993-08-13

Country Status (21)

Country Link
US (1) US5427798A (cg-RX-API-DMAC7.html)
EP (1) EP0656775B1 (cg-RX-API-DMAC7.html)
JP (1) JPH08500110A (cg-RX-API-DMAC7.html)
KR (1) KR100294154B1 (cg-RX-API-DMAC7.html)
AT (1) ATE161422T1 (cg-RX-API-DMAC7.html)
AU (1) AU677595B2 (cg-RX-API-DMAC7.html)
CA (1) CA2142320C (cg-RX-API-DMAC7.html)
CY (1) CY2143B1 (cg-RX-API-DMAC7.html)
DE (1) DE69316015T2 (cg-RX-API-DMAC7.html)
ES (1) ES2111168T3 (cg-RX-API-DMAC7.html)
GB (1) GB9217295D0 (cg-RX-API-DMAC7.html)
GR (1) GR3025794T3 (cg-RX-API-DMAC7.html)
HK (1) HK1004323A1 (cg-RX-API-DMAC7.html)
IL (1) IL106693A (cg-RX-API-DMAC7.html)
LU (1) LU90656I2 (cg-RX-API-DMAC7.html)
MX (1) MX9304967A (cg-RX-API-DMAC7.html)
NZ (1) NZ254947A (cg-RX-API-DMAC7.html)
SG (1) SG43911A1 (cg-RX-API-DMAC7.html)
TW (1) TW260607B (cg-RX-API-DMAC7.html)
WO (1) WO1994004138A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA935942B (cg-RX-API-DMAC7.html)

Families Citing this family (229)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5541231A (en) * 1993-07-30 1996-07-30 Glaxo Wellcome Inc. Stabilized Pharmaceutical
GB9315856D0 (en) * 1993-07-30 1993-09-15 Wellcome Found Stabilized pharmaceutical
US5616344A (en) * 1994-06-14 1997-04-01 Fuisz Technologies Ltd. Apparatus and process for strengthening low density compression dosage units and product therefrom
DK1017392T3 (da) * 1997-09-25 2002-10-21 Bayer Ag Lægemiddel
US6221917B1 (en) 1997-12-30 2001-04-24 American Home Products Corporation Pharmaceutical composition containing bupropion hydrochloride and a stabilizer
US5968553A (en) * 1997-12-30 1999-10-19 American Home Products Corporation Pharmaceutical composition containing bupropion hydrochloride and an inorganic acid stabilizer
US7098206B2 (en) * 1998-01-21 2006-08-29 Smithkline Beecham Corporation Pharmaceutically active morpholinol
US6998400B2 (en) * 1998-01-22 2006-02-14 Smithkline Beecham Corporation Pharmaceutically active morpholinol
AU2349999A (en) * 1998-01-29 1999-08-16 Sepracor, Inc. Pharmacological uses of pure (+) -bupropion
CA2318738A1 (en) * 1998-01-29 1999-08-05 Sepracor Inc. Methods and compositions for aiding in smoking cessation and for treating pain and other disorders using optically pure (-)-bupropion
EP1051167A1 (en) * 1998-01-29 2000-11-15 Sepracor, Inc. Pharmaceutical uses of optically pure (-) -bupropion
AU2483499A (en) * 1998-01-29 1999-08-16 Sepracor, Inc. Pharmaceutical uses of optically pure (+)-bupropion
US6150420A (en) * 1998-06-01 2000-11-21 Theramax, Inc. Method for enhanced brain delivery of bupropion
US6153223A (en) * 1998-06-05 2000-11-28 Watson Pharmaceuticals, Inc. Stabilized pharmaceutical compositions
US6033686A (en) * 1998-10-30 2000-03-07 Pharma Pass Llc Controlled release tablet of bupropion hydrochloride
US6096341A (en) * 1998-10-30 2000-08-01 Pharma Pass Llc Delayed release tablet of bupropion hydrochloride
US6238697B1 (en) * 1998-12-21 2001-05-29 Pharmalogix, Inc. Methods and formulations for making bupropion hydrochloride tablets using direct compression
US6734213B2 (en) 1999-01-20 2004-05-11 Smithkline Beecham Corporation Pharmaceutically active morpholinol
US6855820B2 (en) * 1999-01-20 2005-02-15 Smithkline Beecham Corporation Pharmaceutically active morpholinol
US6210716B1 (en) * 1999-02-26 2001-04-03 Andrx Pharmaceuticals, Inc. Controlled release bupropion formulation
US8545880B2 (en) * 1999-02-26 2013-10-01 Andrx Pharmaceuticals, Llc Controlled release oral dosage form
US6589553B2 (en) * 2001-02-08 2003-07-08 Andrx Pharmaceuticals, Inc. Controlled release oral dosage form
US6342496B1 (en) * 1999-03-01 2002-01-29 Sepracor Inc. Bupropion metabolites and methods of use
US6337328B1 (en) * 1999-03-01 2002-01-08 Sepracor, Inc. Bupropion metabolites and methods of use
USD430285S (en) * 1999-04-16 2000-08-29 Merck & Co., Inc. Tablet
US6280763B1 (en) 1999-05-10 2001-08-28 Pierce Management, Llc Apparatus and method for transdermal delivery of bupropion
MXPA02004413A (es) * 1999-11-02 2002-09-02 Depomed Inc Induccion farmacologica del modo de alimentacion, para la administracion aumentada de drogas al estomago.
US6306436B1 (en) 2000-04-28 2001-10-23 Teva Pharmaceuticals Usa, Inc. Stabilized, acid-free formulation for sustained release of bupropion hydrochloride
EP1357898A4 (en) * 2001-02-08 2005-07-13 Andrx Pharmaceuticals Inc ORAL DOSAGE FORM WITH ENHANCED REGULATED RELEASE
ITMI20011457A1 (it) * 2001-07-09 2003-01-09 Valpharma Sa Composizione farmaceutica a rilascio modificato contenente bupropionehc1 come sostanza attiva
US20030044462A1 (en) * 2001-08-20 2003-03-06 Kali Laboratories, Inc. Sustained release tablets containing bupropion hydrochloride
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
US20050215552A1 (en) * 2002-05-17 2005-09-29 Gadde Kishore M Method for treating obesity
KR20110043664A (ko) * 2002-05-17 2011-04-27 듀크 유니버시티 비만치료방법
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
AU2003284942A1 (en) * 2002-10-30 2004-06-07 Pharmacia Corporation Oral extended release tablets and methods of making and using the same
US20040096497A1 (en) * 2002-11-19 2004-05-20 Ponder Garratt W. Methods of providing controlled-release pharmaceutical compositions and controlled-release pharmaceutical compositions
US6893660B2 (en) * 2002-11-21 2005-05-17 Andrx Pharmaceuticals, Inc. Stable pharmaceutical compositions without a stabilizer
ATE388698T1 (de) * 2003-04-29 2008-03-15 Orexigen Therapeutics Inc Zusammensetzungen zur beeinflussung des gewichtsverlusts
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
US20070048228A1 (en) * 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
US8075872B2 (en) * 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
DE102004032051A1 (de) * 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
BRPI0318456B8 (pt) * 2003-08-08 2021-05-25 Biovail Laboratories Int Srl tablete com liberação modificada
US7713959B2 (en) 2004-01-13 2010-05-11 Duke University Compositions of an anticonvulsant and mirtazapine to prevent weight gain
US20060160750A1 (en) * 2004-01-13 2006-07-20 Krishnan K R R Compositions of an anticonvulsant and an antipsychotic drug and methods of using the same for affecting weight loss
BRPI0506829A (pt) 2004-01-13 2007-05-29 Univ Duke composições de anticonvulsivo e droga antipsicótica e métodos para sua utilização para afetar perda de peso
US20060100205A1 (en) * 2004-04-21 2006-05-11 Eckard Weber Compositions for affecting weight loss
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
USD515202S1 (en) 2004-07-19 2006-02-14 Merck & Co., Inc Tablet
US8586085B2 (en) 2004-11-08 2013-11-19 Biokey, Inc. Methods and formulations for making pharmaceutical compositions containing bupropion
US20060099262A1 (en) * 2004-11-08 2006-05-11 Biokey, Inc. Methods and formulations for making controlled release oral dosage form
GB0425445D0 (en) * 2004-11-18 2004-12-22 Smithkline Beecham Corp Novel compositions
KR100670798B1 (ko) 2004-12-17 2007-01-17 한국전자통신연구원 데이터베이스 캐시 시스템
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
ZA200711123B (en) * 2005-06-27 2009-08-26 Biovail Lab Int Srl Modified-release formulations of a bupropion salt
WO2007048080A2 (en) * 2005-10-14 2007-04-26 Forest Laboratories, Inc. Stable pharmaceutical formulations containing escitalopram and bupropion
US7569605B2 (en) * 2005-10-14 2009-08-04 Forest Laboratories Holdings Limited Methods of treating central nervous system disorders with a low dose combination of escitalopram and bupropion
CN101370488B (zh) 2005-11-22 2012-07-18 奥雷西根治疗公司 增加胰岛素敏感性的组合物
ES2383330T3 (es) * 2005-11-28 2012-06-20 Orexigen Therapeutics, Inc. Formulación de liberación sostenida de zonisamida
WO2007101224A2 (en) * 2006-02-27 2007-09-07 The Board Of Trustees Of The Leland Stanford Junior University Inhibitors of the unfolded protein response and methods for their use
WO2007103366A2 (en) 2006-03-07 2007-09-13 Osteoscreen Ip, Llc Hmg co-a reductase inhibitor enhancement of bone and cartilage
US8916195B2 (en) 2006-06-05 2014-12-23 Orexigen Therapeutics, Inc. Sustained release formulation of naltrexone
CA2655139A1 (en) 2006-06-13 2008-04-10 The Board Of Trustees Of The Leland Stanford Junior University Epoxide inhibitors of cysteine proteases
US7674479B2 (en) * 2006-07-25 2010-03-09 Intelgenx Corp. Sustained-release bupropion and bupropion/mecamylamine tablets
US8703191B2 (en) * 2006-07-25 2014-04-22 Intelgenx Corp. Controlled-release pharmaceutical tablets
BRPI0715959A2 (pt) * 2006-08-21 2013-07-30 Jubilant Organosys Ltd composiÇço farmacÊutica de liberaÇço modificada de cloridrato de bupropion
US8088786B2 (en) 2006-11-09 2012-01-03 Orexigen Therapeutics, Inc. Layered pharmaceutical formulations
WO2008060964A2 (en) 2006-11-09 2008-05-22 Orexigen Therapeutics, Inc. Unit dosage package and methods for administering weight loss medications
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
JP2010523662A (ja) 2007-04-09 2010-07-15 セプラコール・インコーポレイテッド 睡眠関連呼吸障害を処置するための方法及び組成物
EP2167065A1 (en) * 2007-06-18 2010-03-31 The General Hospital Corporation Combination therapy for depression
US20090162434A1 (en) * 2007-12-21 2009-06-25 Disphar International Bv Mesalazine tablet
NZ586792A (en) 2008-01-25 2012-09-28 Gruenenthal Chemie Tamper resistant controlled release pharmaceutical tablets form having convex and concave surfaces
US9339500B2 (en) 2008-03-04 2016-05-17 Intra-Cellular Therapies, Inc. Methods of treating vasomotor symptoms
TWI524904B (zh) 2008-05-09 2016-03-11 歌林達股份有限公司 製備醫藥用固體劑型，尤指錠劑之方法，及製備固體劑型，尤指錠劑之前驅物之方法
MX2010012909A (es) 2008-05-30 2011-02-25 Orexigen Therapeutics Inc Metodos para tratamiento de condiciones de grasa visceral.
TW201039815A (en) 2009-04-13 2010-11-16 Resolvyx Pharmaceuticals Inc Compositions and methods for the treatment of inflammation
RU2555531C2 (ru) 2009-07-22 2015-07-10 Грюненталь Гмбх Защищенная от применения не по назначению лекарственная форма для чувствительных к окислению опиоидов
EP2456427B1 (en) * 2009-07-22 2015-03-04 Grünenthal GmbH Hot-melt extruded controlled release dosage form
US20110136815A1 (en) * 2009-12-08 2011-06-09 Horst Zerbe Solid oral film dosage forms and methods for making same
US10610528B2 (en) 2009-12-08 2020-04-07 Intelgenx Corp. Solid oral film dosage forms and methods for making same
JP6196041B2 (ja) 2010-01-11 2017-09-13 オレキシジェン・セラピューティクス・インコーポレーテッド 大うつ病を有する患者において減量療法を提供する方法
EP2531176B1 (en) 2010-02-03 2016-09-07 Grünenthal GmbH Preparation of a powdery pharmaceutical composition by means of an extruder
NZ608865A (en) 2010-09-02 2015-03-27 Gruenenthal Chemie Tamper resistant dosage form comprising an anionic polymer
PE20131102A1 (es) 2010-09-02 2013-10-12 Gruenenthal Chemie Forma de dosificacion resistente a manipulacion que comprende una sal inorganica
EP2627324A4 (en) 2010-10-11 2014-05-07 Univ Leland Stanford Junior SUBSTITUTED BENZAMIDES AND USES THEREOF
JP5909239B2 (ja) 2010-10-26 2016-04-26 マーズ インコーポレイテッド アルギナーゼ阻害剤としてのボロネート
NO2736495T3 (cg-RX-API-DMAC7.html) 2011-07-29 2018-01-20
CN103857386A (zh) 2011-07-29 2014-06-11 格吕伦塔尔有限公司 提供药物立即释放的抗破碎片剂
SG11201402305WA (en) 2011-11-21 2014-06-27 Calithera Biosciences Inc Heterocyclic inhibitors of glutaminase
BR112014019988A8 (pt) 2012-02-28 2017-07-11 Gruenenthal Gmbh Forma de dosagem resistente a socamento compreendendo um composto farmacologicamente ativo e um polímero aniônico
HK1207301A1 (en) 2012-04-12 2016-01-29 The Board Of Trustees Of The Leland Stanford Junior University Substituted benzamides and their uses
AR090695A1 (es) 2012-04-18 2014-12-03 Gruenenthal Gmbh Forma de dosificacion farmaceutica resistente a la adulteracion y resistente a la liberacion inmediata de la dosis
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
PE20150358A1 (es) 2012-06-06 2015-04-06 Orexigen Therapeutics Inc Metodos para el tratamiento del sobrepeso y de la obesidad
US10793535B2 (en) 2012-11-16 2020-10-06 Calithera Biosciences, Inc. Heterocyclic glutaminase inhibitors
CN105431546A (zh) 2013-03-15 2016-03-23 里兰斯坦福初级大学理事会 基于活性的探针化合物、组合物及其使用方法
AR096439A1 (es) 2013-05-29 2015-12-30 Gruenenthal Gmbh Forma de dosificación resistente al uso indebido que contiene una o más partículas
WO2014191397A1 (en) 2013-05-29 2014-12-04 Grünenthal GmbH Tamper-resistant dosage form containing one or more particles
CA2917136C (en) 2013-07-12 2022-05-31 Grunenthal Gmbh Tamper-resistant dosage form containing ethylene-vinyl acetate polymer
JP6480936B2 (ja) 2013-11-26 2019-03-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング クライオミリングによる粉末状医薬組成物の調製
JP2017518980A (ja) 2014-05-12 2017-07-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング タペンタドールを含む、改変防止即時放出カプセル製剤
US9872835B2 (en) 2014-05-26 2018-01-23 Grünenthal GmbH Multiparticles safeguarded against ethanolic dose-dumping
US9687485B2 (en) 2014-06-13 2017-06-27 Calithera Biosciences, Inc. Combination therapy with glutaminase inhibitors
EP3193876B1 (en) 2014-08-07 2022-01-12 Calithera Biosciences Inc. Crystal forms of glutaminase inhibitors
EP3180332B1 (en) 2014-08-13 2021-10-27 Eolas Therapeutics Inc. Difluoropyrrolidines as orexin receptor modulators
US20170333450A1 (en) 2014-10-31 2017-11-23 The Regents Of The University Of California Compositions and methods for treating hiv-associated cognitive dysfunction
EP4023645A1 (en) 2015-03-10 2022-07-06 Aurigene Discovery Technologies Limited 1,2,4-oxadiazole and thiadiazole compounds as immunomodulators
BR112017021475A2 (pt) 2015-04-24 2018-07-10 Gruenenthal Gmbh forma de dosagem resistente à adulteração (tamper) com liberação imediata e resistência contra extração de solvente
CN107921051A (zh) 2015-06-23 2018-04-17 卡里塞拉生物科学股份公司 抑制精氨酸酶活性的组合物和方法
US10016471B2 (en) 2015-06-29 2018-07-10 Phloronol, Inc. Solid pharmaceutical compositions of brown algae
US10842750B2 (en) 2015-09-10 2020-11-24 Grünenthal GmbH Protecting oral overdose with abuse deterrent immediate release formulations
GB2542881B (en) 2015-10-02 2020-01-01 Carr Andrew Crystal forms of ß-nicotinamide mononucleotide
AU2016335991A1 (en) 2015-10-05 2018-05-10 Calithera Biosciences, Inc. Combination therapy with glutaminase inhibitors and immuno-oncology agents
CA3003271A1 (en) 2015-10-30 2017-05-04 Calithera Biosciences, Inc. Compositions and methods for inhibiting arginase activity
EP3377512A4 (en) 2015-11-16 2019-09-18 Ichorion Therapeutics, Inc. NUCLEIC ACID PRODRUGS
EA036542B9 (ru) 2016-02-12 2020-12-22 Астразенека Аб Галоген-замещенные пиперидины в качестве модуляторов орексинового рецептора
JP7093955B2 (ja) 2016-04-14 2022-07-01 スピネカー バイオサイエンシーズ， インコーポレイテッド 治療剤の送達のためのケイ酸金属塩を含むポーラスシリコン物質
EP3445372A4 (en) 2016-04-22 2020-03-25 Viking Therapeutics, Inc. USE OF THYROID BETA AGONISTS
WO2017210565A1 (en) 2016-06-03 2017-12-07 Prisident And Fellows Of Harvard College Antifungal compounds
MA46062A (fr) 2016-08-25 2019-07-03 Boyce Thompson Institute For Plant Res Traitement par ascaroside de l'oesophagite à éosinophiles
WO2018039612A1 (en) 2016-08-26 2018-03-01 The Regents Of The University Of California Compositions and methods for promoting hair growth with mpc1 inhibitors
CN109906082A (zh) 2016-09-07 2019-06-18 塔夫茨大学信托人 使用免疫dash抑制剂和pge2拮抗剂的组合治疗
US10472364B2 (en) 2016-09-09 2019-11-12 Calithera Biosciences, Inc. Ectonucleotidase inhibitors and methods of use thereof
EP3939581B1 (en) 2016-09-09 2025-06-11 The Regents Of The University Of California Estrogen receptor ligands, compositions and methods related thereto
EP4275759B1 (en) 2016-09-26 2025-12-24 Dana-Farber Cancer Institute, Inc. Quinoline derivatives as chromobox (cbx) protein inhibitors for treating cancer
HRP20230634T1 (hr) 2016-09-28 2023-10-13 Medicon Pharmaceuticals, Inc. Pripravci za liječenje oftalmoloških stanja
AU2017336765B2 (en) 2016-09-28 2023-06-08 Medicon Pharmaceuticals, Inc. Compositions and methods for treating ophthalmic conditions
JP2020502259A (ja) 2016-11-08 2020-01-23 カリセラ バイオサイエンシズ，インコーポレイテッド アルギナーゼ阻害剤併用療法
JP7341061B2 (ja) 2016-11-22 2023-09-08 エレクトロファイ， インコーポレイテッド 治療用又は診断用薬剤を含む粒子並びにその懸濁液及び使用方法
RS61996B1 (sr) 2016-12-22 2021-07-30 Calithera Biosciences Inc Kompozicije i postupci za inhibiranje aktivnosti arginaze
ES2964985T3 (es) 2016-12-23 2024-04-10 Univ Leland Stanford Junior Compuestos sonda basados en actividad, composiciones y métodos de uso
BR112019014759A2 (pt) 2017-01-18 2020-03-03 Vanderbilt University Compostos heterocíclicos fundidos como inibidores seletivos de bmp
AU2018223982B2 (en) 2017-02-24 2022-02-03 Merck Patent Gmbh 1, 4, 6-trisubstituted-2-alkyl-1H-benzo[d]imidazole derivatives as dihydroorotate oxygenase inhibitors
PT3600270T (pt) 2017-03-31 2023-07-25 Aurigene Discovery Tech Ltd Compostos e composições para tratar distúrbios hematológicos
WO2018209288A1 (en) 2017-05-12 2018-11-15 Massachusetts Institute Of Technology Argonaute protein-double stranded rna complexes and uses related thereto
US11325943B2 (en) 2017-06-02 2022-05-10 Stealth Biotherapeutics Inc. Crystalline salt forms of SBT-20
WO2019006359A1 (en) 2017-06-30 2019-01-03 The Regents Of The University Of California COMPOSITIONS AND METHODS FOR MODULATION OF HAIR GROWTH
WO2019018539A1 (en) 2017-07-19 2019-01-24 California Institute Of Technology PROCESSES FOR PREPARING COMPOUNDS CONTAINING BIS-TETRAHYDROISOQUINOLINE
AU2018306303A1 (en) 2017-07-25 2020-02-20 Elektrofi, Inc. Formation of particles including agents
CN111868039A (zh) 2017-09-26 2020-10-30 加利福尼亚大学董事会 用于治疗癌症的组合物和方法
EP3692052A4 (en) 2017-10-04 2021-03-17 Dana Farber Cancer Institute, Inc. INHIBITION BY SMALL MOLECULES OF THE TRANSCRIPTION FACTOR SALL4 AND ITS USES
EA202090536A1 (ru) 2017-10-11 2020-07-22 Ориджен Дискавери Текнолоджис Лимитед Кристаллические формы 3-замещенного 1,2,4-оксадиазола
HRP20240700T1 (hr) 2017-10-31 2024-08-16 Curis, Inc. Inhibitor irak4 u kombinaciji sa inhibitorom bcl-2 za uporabu u liječenju raka
SG11202003625VA (en) 2017-11-03 2020-05-28 Aurigene Discovery Tech Ltd Dual inhibitors of tim-3 and pd-1 pathways
JP7378395B2 (ja) 2017-11-06 2023-11-13 オーリジーン オンコロジー リミテッド 免疫調節のためのコンジョイントセラピー
JP2021506916A (ja) 2017-12-22 2021-02-22 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ Ｋｅａｐ１のＢＴＢドメインの小分子モジュレータ
US11708329B2 (en) 2018-01-30 2023-07-25 The Regents Of The University Of California Inhibitors of the WNT/beta-catenin pathway
EA202091773A1 (ru) 2018-03-14 2021-06-22 Ориджен Дискавери Текнолоджис Лимитед Способ модуляции сигнальных путей tigit и pd-1 с применением 1,2,4-оксадиазольных соединений
EP3765460A1 (en) 2018-03-14 2021-01-20 Vanderbilt University Inhibition of bmp signaling, compounds, compositions and uses thereof
WO2019200274A1 (en) 2018-04-12 2019-10-17 MatRx Therapeutics Corporation Compositions and methods for treating elastic fiber breakdown
US11155638B2 (en) 2018-05-08 2021-10-26 Rhode Island Hospital Anti-CHI3L1 antibodies for the detection and/or treatment of nonalcoholic fattly liver disease/nonalcoholic steatonhepatitis and subsequent complications
JP7402225B2 (ja) 2018-05-11 2023-12-20 ロード アイランド ホスピタル ヌクレオシド系逆転写酵素阻害剤を用いて関節障害を処置するための組成物および方法
US12115262B2 (en) 2018-05-24 2024-10-15 Elektrofi, Inc. Particles comprising a therapeutic or diagnostic agent and suspensions and methods of use thereof
US20210122771A1 (en) 2018-06-29 2021-04-29 The Regents Of The University Of California New molecular tweezers against neurological disorders and viral infections
ES3030736T3 (en) 2018-07-27 2025-07-01 California Inst Of Techn Cdk inhibitors and uses thereof
JP2021535181A (ja) 2018-09-05 2021-12-16 ザ ジェネラル ホスピタル コーポレイション サイトカイン放出症候群を処置する方法
WO2020056109A1 (en) 2018-09-12 2020-03-19 The Board Of Regents Of The University Of Oklahoma Combination cancer therapies
EP3867223B1 (en) 2018-10-17 2025-12-10 The Regents of the University of California Prodrugs of alpha-ketoglutarate, alpha-ketobutyrate, alpha-ketoisovalerate, and alpha-ketoisohexanoate, and uses thereof
JP7504880B2 (ja) 2018-10-26 2024-06-24 ケロス セラピューティクス インコーポレイテッド Ａｌｋ２阻害剤の結晶形
IL282530B2 (en) 2018-10-31 2025-07-01 Intocell Inc History of compressed heterocyclic benzodiazepines and their uses
DK3911648T3 (da) 2019-01-18 2025-01-13 Astrazeneca Ab 6'-[[(1s,3s)-3-[[5-(difluormethoxy)-2-pyrimidinyl]amino]cyclopentyl]amino][1(2h),3'-bipyridin]-2-on som pcsk9-hæmmer og fremgangsmåder til anvendelse deraf
WO2020150474A1 (en) 2019-01-18 2020-07-23 Dogma Therapeutics, Inc. Pcsk9 inhibitors and methods of use thereof
SG11202107145SA (en) 2019-01-25 2021-08-30 Univ Brown Compositions and methods for treating, preventing or reversing age-associated inflammation and disorders
CN113365609A (zh) 2019-01-31 2021-09-07 伊勒卓菲公司 颗粒形成和形态
CN113573709A (zh) 2019-03-14 2021-10-29 阿斯利康(瑞典)有限公司 用于体重减轻的兰比斯特
JP6890865B1 (ja) 2019-06-03 2021-06-18 株式会社大分大学先端医学研究所 狂犬病治療のための環状アミド化合物およびその方法
AU2020344675A1 (en) 2019-09-13 2022-03-31 Elektrofi, Inc. Compositions and methods for the delivery of therapeutic biologics for treatment of disease
PH12022551138A1 (en) 2019-11-12 2023-07-17 Genzyme Corp 6-membered heteroarylaminosulfonamides for treating diseases and conditions mediated by deficient cftr activity
WO2021113806A1 (en) 2019-12-05 2021-06-10 Genzyme Corporation Arylamides and methods of use thereof
WO2021113809A1 (en) 2019-12-05 2021-06-10 Genzyme Corporation Arylamides and methods of use thereof
CA3164800A1 (en) 2019-12-16 2021-06-24 Unist(Ulsan National Institute Of Science And Technology) Compound for inhibiting neovascularization factors and use thereof
WO2021142221A1 (en) 2020-01-10 2021-07-15 The Regents Of The University Of California Compositions and methods for the treatment of neurodegenerative diseases
WO2021158959A2 (en) 2020-02-07 2021-08-12 Elektrofi, Inc. Peptide particles and methods of formation
US20230065628A1 (en) 2020-02-19 2023-03-02 Elektrofi, Inc. Droplet Formation and Particle Morphology
MX2022010986A (es) * 2020-03-05 2022-12-08 Abbvie Inc Metodos de administracion de elagolix.
EP4132914A4 (en) 2020-04-06 2024-04-03 The Regents of the University of California COMPOUNDS AND METHODS FOR INDUCING UCP1 EXPRESSION
CN115484934A (zh) 2020-04-17 2022-12-16 伊勒卓菲公司 通过连续液滴形成和脱水形成颗粒的方法
JP7519463B2 (ja) 2020-05-05 2024-07-19 ヌバレント， インク． ヘテロ芳香族大環状エーテル化学療法剤
PE20230309A1 (es) 2020-05-05 2023-02-14 Nuvalent Inc Agentes quimioterapeuticos de eteres macrociclicos heteroaromaticos
WO2021263072A1 (en) 2020-06-25 2021-12-30 Dana-Farber Cancer Institute, Inc. Methods of treating disease
CN111830151B (zh) * 2020-07-01 2021-05-04 迪沙药业集团有限公司 盐酸安非他酮组合物质量控制用系统适用性对照品
EP4192811A1 (en) 2020-08-10 2023-06-14 Dana-Farber Cancer Institute, Inc. Substituted 3-amino-4-methylbenzenesulfonamides as small molecule inhibitors of ubiquitin-specific protease 28
EP4192817A1 (en) 2020-08-10 2023-06-14 Dana-Farber Cancer Institute, Inc. Substituted 1,2,4-oxadiazoles as small molecule inhibitors of ubiquitin-specific protease 28
EP4192838A1 (en) 2020-08-10 2023-06-14 Dana-Farber Cancer Institute, Inc. Fused tricyclic pyrimidine-thieno-pyridine small molecule inhibitors of ubiquitin-specific protease 28
CN116323571A (zh) 2020-10-23 2023-06-23 丹娜法伯癌症研究院 肌酸激酶（ck）的共价抑制剂以及其用于治疗和预防癌症的用途
US20240058344A1 (en) 2020-12-18 2024-02-22 Cornell University Methods of treating neurodegenerative disorders and stat3-linked cancers using suppressors of electron leak
KR20230129455A (ko) 2020-12-21 2023-09-08 코넬 유니버시티 펩타이드-연결된 약물 전달 시스템
WO2022150574A1 (en) 2021-01-08 2022-07-14 Cornell University Inhibitors of mycobacterium tuberculosis lipoamide dehydrogenase
CA3213079A1 (en) 2021-04-13 2022-10-20 Kristin Lynne ANDREWS Amino-substituted heterocycles for treating cancers with egfr mutations
EP4396176A1 (en) 2021-09-03 2024-07-10 Genzyme Corporation Indole compounds and uses thereof in the treatement of cystic fibrosis
JP2024533216A (ja) 2021-09-03 2024-09-12 ジェンザイム・コーポレーション インドール化合物及び使用方法
CN118234725A (zh) 2021-10-01 2024-06-21 纽威伦特公司 杂芳族大环醚化合物的固体形式、药物组合物及制备
KR20240095536A (ko) 2021-10-01 2024-06-25 뉴베일런트, 아이엔씨. 헤테로방향족 매크로사이클릭 에테르 화합물을 사용한 고형 종양의 치료 방법
WO2023187422A1 (en) 2022-03-31 2023-10-05 Revolo Biotherapeutics Limited Compositions and their use in methods for treating intestinal inflammation
IL315589A (en) 2022-04-07 2024-11-01 Nuvalent Inc Solid tumor treatment methods using (19R)-5-chloro-3-ethyl-16-fluoro-10,19-dimethyl-20-oxa-3,4,10,11,23-pentazapentacyclo[19.3.1.02,6.08,12.013 18]pentacose-1(24),2(6),4,8,11,13,15,17,21(25),22-decayin-22-amine
EP4504736A1 (en) 2022-04-07 2025-02-12 Nuvalent, Inc. Solid forms, pharmaceutical compositions and preparation of heteroaromatic macrocyclic ether compounds
CN119403542A (zh) 2022-04-29 2025-02-07 伊勒卓菲公司 可注射悬浮液
CN119562822A (zh) 2022-05-16 2025-03-04 雷沃洛生物医疗有限公司 用于预防或治疗食物过敏的方法和组合物
WO2023250157A1 (en) 2022-06-24 2023-12-28 Cornell University Inhibitors of mycobacterium tuberculosis lipoamide dehydrogenase
CN118785900A (zh) * 2022-06-30 2024-10-15 艾克萨姆治疗公司 包含安非他酮和半胱氨酸的药物组合物
US12156914B2 (en) 2022-06-30 2024-12-03 Axsome Therapeutics, Inc. Pharmaceutical compositions comprising bupropion and cysteine
JP2025525415A (ja) 2022-07-13 2025-08-05 アストラゼネカ・アクチエボラーグ Ｐｃｓｋ９阻害剤およびその使用方法
TW202423948A (zh) 2022-08-04 2024-06-16 日商第一工業製藥股份有限公司 環狀胜肽衍生物與其製造方法以及組成物
WO2024036097A1 (en) 2022-08-12 2024-02-15 Nuvalent, Inc. Heteroaromatic macrocyclic ether compounds and isotopologues thereof
WO2024036098A1 (en) 2022-08-12 2024-02-15 Nuvalent, Inc. Heteroaromatic macrocyclic ether compounds
WO2024073334A1 (en) 2022-09-26 2024-04-04 Rose Research Center, Llc Combination for use in a method of preventing weight gain
WO2024071371A1 (ja) 2022-09-30 2024-04-04 ユビエンス株式会社 複素環式化合物
EP4595973A1 (en) 2022-09-30 2025-08-06 DKS Co. Ltd. Cyclic peptide derivative composition for treating or preventing eye disease
AU2023364043A1 (en) 2022-10-19 2025-04-10 Nuvalent, Inc. Heteroaromatic macrocyclic ether chemotherapeutic agents
JPWO2024096067A1 (cg-RX-API-DMAC7.html) 2022-11-04 2024-05-10
EP4613282A1 (en) 2022-11-04 2025-09-10 DKS Co. Ltd. Cyclic peptide derivative composition for treating or preventing central nervous system injury/disease
AU2024258768A1 (en) 2023-04-18 2025-12-04 Revolo Biotherapeutics Limited Methods and compositions for preventing or treating eosinophilic esophagitis
WO2024233456A1 (en) 2023-05-05 2024-11-14 The Board Of Regents Of The University Of Oklahoma Variants of adrenomedullin (am) and adrenomedullin 2/intermedin (am2/imd) and methods of use
WO2025037259A1 (en) 2023-08-15 2025-02-20 Revolo Biotherapeutics Limited Methods and compositions for preventing or treating severe asthma
WO2025042868A1 (en) 2023-08-23 2025-02-27 The Board Of Regents Of The University Of Oklahoma Combinations of heteroarotinoids and glycolytic inhibitors for use as cancer treatments
TW202525266A (zh) 2023-09-18 2025-07-01 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 可電離類脂質組成物及其治療用途
WO2025072117A1 (en) 2023-09-25 2025-04-03 Nuvalent, Inc. Heteroaromatic macrocyclic ether compounds and isotopologues thereof
WO2025072120A1 (en) 2023-09-25 2025-04-03 Nuvalent, Inc. Heteroaromatic macrocyclic ether compounds
WO2025085360A1 (en) 2023-10-16 2025-04-24 The Board Of Regents Of The University Of Oklahoma Heteroarotinoids and/or cdk4/6 inhibitors for treating human papillomavirus (hpv)-induced dysplasias, warts, and cancer in hpv-infected subjects
WO2025088586A1 (en) 2023-10-27 2025-05-01 Brown University Compositions, systems, and methods for treating cancer using tumor treating fields with inhibitors of mif, mica, and/or micb
WO2025106670A1 (en) 2023-11-14 2025-05-22 Flagship Pioneering Innovations Vii, Llc Ionizable lipidoid compositions and therapeutic uses thereof
WO2025212478A1 (en) 2024-04-01 2025-10-09 Nuvalent, Inc. Methods of treating solid tumor using heteroaromatic macrocyclic ether compounds
WO2025235872A1 (en) 2024-05-10 2025-11-13 Schrödinger, Inc. Heterocyclics as egfr inhibitors
WO2025235874A1 (en) 2024-05-10 2025-11-13 Schrödinger, Inc. Heterocyclics as egfr inhibitors
WO2025259911A1 (en) 2024-06-12 2025-12-18 Elektrofi, Inc. Determination of particulate contaminants in particles and compositions

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759838A (fr) * 1969-12-04 1971-06-03 Wellcome Found Cetones a activite biologique
US3885046A (en) * 1969-12-04 1975-05-20 Burroughs Wellcome Co Meta chloro or fluoro substituted alpha-T-butylaminopropionphenones in the treatment of depression
CA948388A (en) * 1970-02-27 1974-06-04 Paul B. Hansen Pattern bonded continuous filament web
US4347257A (en) * 1979-10-09 1982-08-31 Burroughs Wellcome Co. Prolactin suppression in mammals
IT1142259B (it) * 1980-01-21 1986-10-08 Wellcome Found Combinazioni di composti chetonici ed eterociclici utili come tranquillanti e relativo procedimento di produzione
US4347382A (en) * 1980-04-15 1982-08-31 Burroughs Wellcome Co. 3H Labeled compounds
US4347178A (en) * 1980-04-14 1982-08-31 Burroughs Wellcome Co. Compounds and methods of making
US4355179A (en) * 1980-04-14 1982-10-19 Burroughs Wellcome Co. Radioactive nuclide labeled propiophenone compounds
US4356165A (en) * 1980-04-14 1982-10-26 Burroughs Wellcome Co. Bupropion radioimmunoassay, and kit
US4347177A (en) * 1980-04-14 1982-08-31 Burroughs Wellcome Co. Compounds and methods of making them
US4347176A (en) * 1980-04-14 1982-08-31 Burroughs Wellcome Co. Compounds and methods of making same
US4425363A (en) * 1981-05-14 1984-01-10 Burroughs Wellcome Co. Treatment of tardive dyskinesia in mammals
US4435449A (en) * 1981-05-14 1984-03-06 Burroughs Wellcome Co. Treatment of minimal brain dysfunction (MBD)
US4393078A (en) * 1982-03-15 1983-07-12 Burroughs Wellcome Co. Bupropion and ethanol
US4438138A (en) * 1982-12-06 1984-03-20 Burroughs Wellcome Co. Reduction of cholesterol with meta-chloro α-t-butylaminopropiophenone
USRE33994E (en) * 1983-08-16 1992-07-14 Burroughs Wellcome Co. Pharmaceutical delivery system
GB8322007D0 (en) * 1983-08-16 1983-09-21 Wellcome Found Pharmaceutical delivery system
US4507323A (en) * 1984-07-25 1985-03-26 Burroughs Wellcome Co. Treatment of psychosexual dysfunctions
US4769027A (en) * 1984-08-15 1988-09-06 Burroughs Wellcome Co. Delivery system
EP0467488B1 (en) * 1984-08-17 1995-10-11 The Wellcome Foundation Limited Composition for the controlled discharge of an active ingredient
WO1992019241A1 (en) * 1991-05-07 1992-11-12 Dynagen, Inc. A controlled, sustained release delivery system for smoking cessation

Also Published As

Publication number Publication date
CY2143B1 (en) 2002-06-21
IL106693A0 (en) 1993-12-08
KR950702827A (ko) 1995-08-23
NZ254947A (en) 1996-04-26
MX9304967A (es) 1994-05-31
AU677595B2 (en) 1997-05-01
US5427798A (en) 1995-06-27
WO1994004138A1 (en) 1994-03-03
CA2142320A1 (en) 1994-03-03
LU90656I2 (fr) 2001-01-15
CA2142320C (en) 2001-10-09
GR3025794T3 (en) 1998-03-31
GB9217295D0 (en) 1992-09-30
ES2111168T3 (es) 1998-03-01
JPH08500110A (ja) 1996-01-09
SG43911A1 (en) 1997-11-14
DE69316015T2 (de) 1998-04-16
DE69316015D1 (de) 1998-02-05
KR100294154B1 (ko) 2001-09-17
EP0656775A1 (en) 1995-06-14
ZA935942B (en) 1995-02-13
EP0656775B1 (en) 1997-12-29
AU4725893A (en) 1994-03-15
IL106693A (en) 1997-06-10
HK1004323A1 (en) 1998-11-20
ATE161422T1 (de) 1998-01-15

Similar Documents

Publication Publication Date Title
TW260607B (cg-RX-API-DMAC7.html)
USD356306S (en) Touchscreen stylus
USD341134S (en) Keyboard
USD348572S (en) Chair
USD386493S (en) Telephone
USD361594S (en) Art supply package
USD325542S (en) Earring
USD423260S (en) Mesh back chair with cushions
USD272231S (en) Clip for holding a gas pump nozzle trigger in the open position
USD361675S (en) Chair
USD341038S (en) Chair
USD359554S (en) Tablet
USD336014S (en) Taco holder
USD356174S (en) Pocket torch
USD360995S (en) Settee
USD286402S (en) Combination handset telephone and stand set
USD345660S (en) Portable long barrel firearm stand
USD350651S (en) Portable one-leg seat
USD391291S (en) Ornamental pen
USD353077S (en) Party plate
USD360958S (en) Flashlight
USD405982S (en) Combined desk and hutch
USD318098S (en) Valve check member
USD364917S (en) Flood stopper
USD365463S (en) Computer desk

Legal Events

Date Code Title Description
MK4A Expiration of patent term of an invention patent