LU90656I2 - Hydrochlorure de bupropion - Google Patents

Hydrochlorure de bupropion

Info

Publication number
LU90656I2
LU90656I2 LU90656C LU90656C LU90656I2 LU 90656 I2 LU90656 I2 LU 90656I2 LU 90656 C LU90656 C LU 90656C LU 90656 C LU90656 C LU 90656C LU 90656 I2 LU90656 I2 LU 90656I2
Authority
LU
Luxembourg
Prior art keywords
hydrochloride
bupropion hydrochloride
tablet
bupropion
release
Prior art date
Application number
LU90656C
Other languages
English (en)
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10720358&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU90656(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of LU90656I2 publication Critical patent/LU90656I2/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
LU90656C 1992-08-14 2000-10-18 Hydrochlorure de bupropion LU90656I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929217295A GB9217295D0 (en) 1992-08-14 1992-08-14 Controlled released tablets
PCT/GB1993/001722 WO1994004138A1 (fr) 1992-08-14 1993-08-13 Comprimes a liberation prolongee contenant du bupropione

Publications (1)

Publication Number Publication Date
LU90656I2 true LU90656I2 (fr) 2001-01-15

Family

ID=10720358

Family Applications (1)

Application Number Title Priority Date Filing Date
LU90656C LU90656I2 (fr) 1992-08-14 2000-10-18 Hydrochlorure de bupropion

Country Status (21)

Country Link
US (1) US5427798A (fr)
EP (1) EP0656775B1 (fr)
JP (1) JPH08500110A (fr)
KR (1) KR100294154B1 (fr)
AT (1) ATE161422T1 (fr)
AU (1) AU677595B2 (fr)
CA (1) CA2142320C (fr)
CY (1) CY2143B1 (fr)
DE (1) DE69316015T2 (fr)
ES (1) ES2111168T3 (fr)
GB (1) GB9217295D0 (fr)
GR (1) GR3025794T3 (fr)
HK (1) HK1004323A1 (fr)
IL (1) IL106693A (fr)
LU (1) LU90656I2 (fr)
MX (1) MX9304967A (fr)
NZ (1) NZ254947A (fr)
SG (1) SG43911A1 (fr)
TW (1) TW260607B (fr)
WO (1) WO1994004138A1 (fr)
ZA (1) ZA935942B (fr)

Families Citing this family (190)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9315856D0 (en) * 1993-07-30 1993-09-15 Wellcome Found Stabilized pharmaceutical
US5541231A (en) * 1993-07-30 1996-07-30 Glaxo Wellcome Inc. Stabilized Pharmaceutical
US5616344A (en) * 1994-06-14 1997-04-01 Fuisz Technologies Ltd. Apparatus and process for strengthening low density compression dosage units and product therefrom
PL192273B1 (pl) * 1997-09-25 2006-09-29 Bayer Ag Preparat środka leczniczego w postaci pastylki o kontrolowanej dyfuzji lub w postaci układu matrycowego, o kontrolowanym uwalnianiu substancji czynnej
US5968553A (en) * 1997-12-30 1999-10-19 American Home Products Corporation Pharmaceutical composition containing bupropion hydrochloride and an inorganic acid stabilizer
US6221917B1 (en) 1997-12-30 2001-04-24 American Home Products Corporation Pharmaceutical composition containing bupropion hydrochloride and a stabilizer
US7098206B2 (en) * 1998-01-21 2006-08-29 Smithkline Beecham Corporation Pharmaceutically active morpholinol
US6998400B2 (en) * 1998-01-22 2006-02-14 Smithkline Beecham Corporation Pharmaceutically active morpholinol
CA2318960A1 (fr) * 1998-01-29 1999-08-05 Sepracor Inc. Utilisations pharmaceutiques de (+)-bupropion optiquement pur
CA2318921A1 (fr) 1998-01-29 1999-08-05 John R. Mccullough Usages pharmacologiques de (+)-bupropion optiquement pur
CA2318738A1 (fr) * 1998-01-29 1999-08-05 Sepracor Inc. Procedes et compositions de (-)-bupropion optiquement pur destines a faciliter la desaccoutumance au tabac et au traitement de douleurs et d'autres troubles
US6110973A (en) 1998-01-29 2000-08-29 Sepracor Methods for treating obesity and weight gain using optically pure (-)-bupropion
US6150420A (en) * 1998-06-01 2000-11-21 Theramax, Inc. Method for enhanced brain delivery of bupropion
US6153223A (en) * 1998-06-05 2000-11-28 Watson Pharmaceuticals, Inc. Stabilized pharmaceutical compositions
US6033686A (en) * 1998-10-30 2000-03-07 Pharma Pass Llc Controlled release tablet of bupropion hydrochloride
US6096341A (en) * 1998-10-30 2000-08-01 Pharma Pass Llc Delayed release tablet of bupropion hydrochloride
US6238697B1 (en) * 1998-12-21 2001-05-29 Pharmalogix, Inc. Methods and formulations for making bupropion hydrochloride tablets using direct compression
US6734213B2 (en) 1999-01-20 2004-05-11 Smithkline Beecham Corporation Pharmaceutically active morpholinol
US6855820B2 (en) 1999-01-20 2005-02-15 Smithkline Beecham Corporation Pharmaceutically active morpholinol
US8545880B2 (en) * 1999-02-26 2013-10-01 Andrx Pharmaceuticals, Llc Controlled release oral dosage form
US6210716B1 (en) * 1999-02-26 2001-04-03 Andrx Pharmaceuticals, Inc. Controlled release bupropion formulation
US6589553B2 (en) * 2001-02-08 2003-07-08 Andrx Pharmaceuticals, Inc. Controlled release oral dosage form
US6337328B1 (en) 1999-03-01 2002-01-08 Sepracor, Inc. Bupropion metabolites and methods of use
US6342496B1 (en) 1999-03-01 2002-01-29 Sepracor Inc. Bupropion metabolites and methods of use
USD430285S (en) * 1999-04-16 2000-08-29 Merck & Co., Inc. Tablet
US6280763B1 (en) 1999-05-10 2001-08-28 Pierce Management, Llc Apparatus and method for transdermal delivery of bupropion
EP1242057A2 (fr) * 1999-11-02 2002-09-25 DepoMed, Inc. Declenchement pharmacologique du mode par ingestion pour une administration amelioree de medicaments dans l'estomac
US6306436B1 (en) 2000-04-28 2001-10-23 Teva Pharmaceuticals Usa, Inc. Stabilized, acid-free formulation for sustained release of bupropion hydrochloride
CA2796884A1 (fr) * 2001-02-08 2002-08-15 Andrx Pharmaceuticals, Inc. Forme posologique orale a liberation regulee amelioree
ITMI20011457A1 (it) * 2001-07-09 2003-01-09 Valpharma Sa Composizione farmaceutica a rilascio modificato contenente bupropionehc1 come sostanza attiva
US20030044462A1 (en) * 2001-08-20 2003-03-06 Kali Laboratories, Inc. Sustained release tablets containing bupropion hydrochloride
CN1649614A (zh) 2002-02-22 2005-08-03 新河药品股份有限公司 活性剂传递系统和保护及施用活性剂的方法
EP1505967B1 (fr) * 2002-05-17 2016-07-13 Duke University Procede de traitement de l'obesite
US20050215552A1 (en) * 2002-05-17 2005-09-29 Gadde Kishore M Method for treating obesity
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
AU2003284942A1 (en) * 2002-10-30 2004-06-07 Pharmacia Corporation Oral extended release tablets and methods of making and using the same
US20040096497A1 (en) * 2002-11-19 2004-05-20 Ponder Garratt W. Methods of providing controlled-release pharmaceutical compositions and controlled-release pharmaceutical compositions
US6893660B2 (en) * 2002-11-21 2005-05-17 Andrx Pharmaceuticals, Inc. Stable pharmaceutical compositions without a stabilizer
PT2316456T (pt) 2003-04-29 2017-09-05 Orexigen Therapeutics Inc Composições para afetar a perda de peso compreendendo naltrexona e bupropion
US8075872B2 (en) 2003-08-06 2011-12-13 Gruenenthal Gmbh Abuse-proofed dosage form
DE102004032051A1 (de) * 2004-07-01 2006-01-19 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform
US20070048228A1 (en) * 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
EP1575565B1 (fr) * 2003-08-08 2010-01-06 Biovail Laboratories International Srl Comprime d'hydrochlorure de bupropion a liberation modifiee
US20060160750A1 (en) * 2004-01-13 2006-07-20 Krishnan K R R Compositions of an anticonvulsant and an antipsychotic drug and methods of using the same for affecting weight loss
US7713959B2 (en) * 2004-01-13 2010-05-11 Duke University Compositions of an anticonvulsant and mirtazapine to prevent weight gain
KR20060128995A (ko) 2004-01-13 2006-12-14 듀크 유니버시티 체중감량에 영향을 미치는 항경련제와 항정신병 약물의조성물
WO2005107806A1 (fr) * 2004-04-21 2005-11-17 Orexigen Therapeutics, Inc. Compositions agissant sur une perte de poids
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
US20060099262A1 (en) * 2004-11-08 2006-05-11 Biokey, Inc. Methods and formulations for making controlled release oral dosage form
US8586085B2 (en) 2004-11-08 2013-11-19 Biokey, Inc. Methods and formulations for making pharmaceutical compositions containing bupropion
GB0425445D0 (en) * 2004-11-18 2004-12-22 Smithkline Beecham Corp Novel compositions
KR100670798B1 (ko) 2004-12-17 2007-01-17 한국전자통신연구원 데이터베이스 캐시 시스템
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
NZ561375A (en) * 2005-06-27 2011-06-30 Biovail Lab Int Srl Bupropion hydrobromide, and crystalline forms, compositions, and uses of this compound
CA2626025A1 (fr) * 2005-10-14 2007-04-26 Forest Laboratories, Inc. Formulations pharmaceutiques stables contenant de l'escitalopram et du bupropion
EP1954257A4 (fr) * 2005-10-14 2009-05-20 Lundbeck & Co As H Procedes de traitement de troubles du systeme nerveux central avec une combinaison de faible dose d'escitaloprame et de bupropion
ES2761812T3 (es) 2005-11-22 2020-05-21 Nalpropion Pharmaceuticals Inc Composición y métodos de aumento de la sensibilidad a la insulina
PT1954241E (pt) * 2005-11-28 2012-06-01 Orexigen Therapeutics Inc Formulação de zonisamida de libertação sustentada
AU2007220039A1 (en) * 2006-02-27 2007-09-07 The Board Of Trustees Of The Leland Stanford Junior University Inhibitors of the unfolded protein response and methods for their use
EP1996118A4 (fr) 2006-03-07 2013-03-06 Osteoscreen Ip Llc RENFORCEMENT DE L'OS ET DU CARTILAGE PAR UN INHIBITEUR DE LA HMG Co-A RÉDUCTASE
US8916195B2 (en) 2006-06-05 2014-12-23 Orexigen Therapeutics, Inc. Sustained release formulation of naltrexone
CN101808634A (zh) 2006-06-13 2010-08-18 利兰·斯坦福青年大学托管委员会 半胱氨酸蛋白酶的环氧化物抑制剂
US8703191B2 (en) * 2006-07-25 2014-04-22 Intelgenx Corp. Controlled-release pharmaceutical tablets
US7674479B2 (en) * 2006-07-25 2010-03-09 Intelgenx Corp. Sustained-release bupropion and bupropion/mecamylamine tablets
US20100008987A1 (en) * 2006-08-21 2010-01-14 Pasula Basavaiah Chowdary Modified Release Pharmaceutical Composition of Bupropion Hydrochloride
ATE460925T1 (de) 2006-11-09 2010-04-15 Orexigen Therapeutics Inc Mehrschichtige pharmazeutische formulierungen mit einer schnell auflösenden zwischenschicht
CA2668885C (fr) 2006-11-09 2016-08-02 Orexigen Therapeutics, Inc. Procedes d'administration de medications pour la perte de poids
DE102007011485A1 (de) 2007-03-07 2008-09-11 Grünenthal GmbH Darreichungsform mit erschwertem Missbrauch
RU2009141168A (ru) 2007-04-09 2011-05-20 Сепракор Инк. (Us) Способы и композиции, содержащие дезвенлафаксин или дулоксетин, для лечения расстройств дыхания во время сна
US20090023744A1 (en) * 2007-06-18 2009-01-22 The General Hospital Corporation Combination therapy for depression
US20090162434A1 (en) * 2007-12-21 2009-06-25 Disphar International Bv Mesalazine tablet
TWI454288B (zh) 2008-01-25 2014-10-01 Gruenenthal Chemie 藥物劑型
US9339500B2 (en) 2008-03-04 2016-05-17 Intra-Cellular Therapies, Inc. Methods of treating vasomotor symptoms
PT2273983T (pt) 2008-05-09 2016-10-28 Gruenenthal Gmbh Processo para a preparação de uma formulação em pó intermediária e uma forma de dosagem sólida final sob utilização de uma etapa de congelamento por atomização
CA2725930A1 (fr) 2008-05-30 2009-12-30 Orexigen Therapeutics, Inc. Procedes pour traiter des pathologies des graisses viscerales
TW201039815A (en) 2009-04-13 2010-11-16 Resolvyx Pharmaceuticals Inc Compositions and methods for the treatment of inflammation
CN102573805A (zh) 2009-07-22 2012-07-11 格吕伦塔尔有限公司 热熔挤出的控制释放剂型
ES2560210T3 (es) 2009-07-22 2016-02-17 Grünenthal GmbH Forma de dosificación resistente a la manipulación para opiádes sensibles a la oxidación
US10610528B2 (en) 2009-12-08 2020-04-07 Intelgenx Corp. Solid oral film dosage forms and methods for making same
US20110136815A1 (en) * 2009-12-08 2011-06-09 Horst Zerbe Solid oral film dosage forms and methods for making same
KR101841442B1 (ko) 2010-01-11 2018-03-23 오렉시젠 세러퓨틱스 인크. 주우울증 환자들에 있어서 체중 감량 치료를 제공하는 방법
CN102821757B (zh) 2010-02-03 2016-01-20 格吕伦塔尔有限公司 通过挤出机制备粉末状药物组合物
RU2604676C2 (ru) 2010-09-02 2016-12-10 Грюненталь Гмбх Устойчивая к разрушению лекарственная форма, содержащая неорганическую соль
TWI516286B (zh) 2010-09-02 2016-01-11 歌林達股份有限公司 含陰離子聚合物之抗破碎劑型
WO2012051117A2 (fr) 2010-10-11 2012-04-19 The Board Of Trustees Of The Leland Stanford Junior University Benzamides substitués et leurs utilisations
PL2632927T3 (pl) 2010-10-26 2016-09-30 Boroniany jako inhibitory arginazy
LT2736495T (lt) 2011-07-29 2017-11-10 Grünenthal GmbH Sugadinimui atspari tabletė, pasižyminti greitu vaisto atpalaidavimu
CN103857386A (zh) 2011-07-29 2014-06-11 格吕伦塔尔有限公司 提供药物立即释放的抗破碎片剂
CA2856386C (fr) 2011-11-21 2022-05-31 Calithera Biosciences Inc. Inhibiteurs heterocycliques de glutaminase
JP6117249B2 (ja) 2012-02-28 2017-04-19 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 薬理学的に活性な化合物および陰イオン性ポリマーを含むタンパーレジスタント剤形
EP2838534A4 (fr) 2012-04-12 2015-11-11 Univ Leland Stanford Junior Benzamides substituées et leurs utilisations
CA2868142A1 (fr) 2012-04-18 2013-10-24 Grunenthal Gmbh Forme pharmaceutique inviolable et resistante a la liberation massive
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
EP2858640B1 (fr) 2012-06-06 2020-03-25 Nalpropion Pharmaceuticals LLC Composition à être utilisée dans une méthode de traitement de la surcharge pondérale et de l'obésité dans de patients présentant un risque cardiovasculaire élevé
EP3954686A1 (fr) 2012-11-16 2022-02-16 Calithera Biosciences, Inc. Inhibiteurs de glutaminase hétérocycliques
EP2971065B1 (fr) 2013-03-15 2022-12-14 The Board of Trustees of the Leland Stanford Junior University Composés de sonde basée sur l'activité, compositions et méthodes d'utilisation
JP6445537B2 (ja) 2013-05-29 2018-12-26 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング １個または複数の粒子を含有する改変防止（ｔａｍｐｅｒ−ｒｅｓｉｓｔａｎｔ）剤形
US9737490B2 (en) 2013-05-29 2017-08-22 Grünenthal GmbH Tamper resistant dosage form with bimodal release profile
CN105682643B (zh) 2013-07-12 2019-12-13 格吕伦塔尔有限公司 含有乙烯-醋酸乙烯酯聚合物的防篡改剂型
AU2014356581C1 (en) 2013-11-26 2020-05-28 Grunenthal Gmbh Preparation of a powdery pharmaceutical composition by means of cryo-milling
EP3142646A1 (fr) 2014-05-12 2017-03-22 Grünenthal GmbH Formulation pour capsule à libération immédiate résistant aux manipulations illicites comprenant du tapentadol
US9872835B2 (en) 2014-05-26 2018-01-23 Grünenthal GmbH Multiparticles safeguarded against ethanolic dose-dumping
JP6798890B2 (ja) 2014-06-13 2020-12-09 キャリセラ バイオサイエンシーズ， インコーポレイテッド グルタミナーゼ阻害剤との併用療法
CA2957225A1 (fr) 2014-08-07 2016-02-11 Calithera Biosciences, Inc. Formes cristallines d'inhibiteurs de glutaminase
ES2901418T3 (es) 2014-08-13 2022-03-22 Eolas Therapeutics Inc Difluoropirrolidinas como moduladores del receptor de orexina
US20170333450A1 (en) 2014-10-31 2017-11-23 The Regents Of The University Of California Compositions and methods for treating hiv-associated cognitive dysfunction
CN114213356A (zh) 2015-03-10 2022-03-22 奥瑞基尼探索技术有限公司 作为免疫调节剂的1,2,4-噁二唑和噻二唑化合物
CN107889459A (zh) 2015-04-24 2018-04-06 格吕伦塔尔有限公司 具有立即释放和对溶剂萃取的抗性的抗篡改剂型
WO2016210106A1 (fr) 2015-06-23 2016-12-29 Calithera Biosciences, Inc. Compositions et procédés d'inhibition de l'activité de l'arginase
WO2017003951A1 (fr) * 2015-06-29 2017-01-05 Phloronol, Inc. Compositions pharmaceutiques solides d'algues brunes
EP3346991A1 (fr) 2015-09-10 2018-07-18 Grünenthal GmbH Protection contre un surdosage par voie orale à l'aide de formulations à libération immédiate dissuasives d'abus
GB2542881B (en) 2015-10-02 2020-01-01 Carr Andrew Crystal forms of ß-nicotinamide mononucleotide
CA3000996A1 (fr) 2015-10-05 2017-04-13 Calithera Biosciences, Inc. Polytherapie a l'aide d'inhibiteurs de glutaminase et agents immuno-oncologiques
SI3368541T1 (sl) 2015-10-30 2020-10-30 Calithera Biosciences, Inc. Sestavki in postopki za zaviranje arginazne dejavnosti
MX2018005872A (es) 2015-11-16 2019-05-16 Ichorion Therapeutics Inc Profarmacos de acido nucleico.
WO2017139603A1 (fr) 2016-02-12 2017-08-17 Astrazeneca Ab Pipéridines halosubstituées en tant que modulateurs de récepteur des orexines
WO2017210565A1 (fr) 2016-06-03 2017-12-07 Prisident And Fellows Of Harvard College Composés antifongiques
WO2018039612A1 (fr) 2016-08-26 2018-03-01 The Regents Of The University Of California Compositions et méthodes favorisant la croissance des cheveux au moyen d'inhibiteurs de mpc1
CN110234656B (zh) 2016-09-09 2023-02-28 卡利泰拉生物科技公司 外核苷酸酶抑制剂及其使用方法
EP3509583B1 (fr) 2016-09-09 2021-06-30 The Regents of the University of California Ligands du récepteur des oestrogènes, compositions et méthodes associées
EP4275759A3 (fr) 2016-09-26 2024-01-17 Dana-Farber Cancer Institute, Inc. Dérivés de quinoline en tant qi'inhibiteurs de la protéine chromobox (cbx) pour le traitement du cancer
RS64399B1 (sr) 2016-09-28 2023-08-31 Medicon Pharmaceuticals Inc Kompozicije za lečenje oftalmoloških stanja
US11510931B2 (en) 2016-09-28 2022-11-29 Medicon Pharmaceuticals, Inc. Compositions and methods for treating ophthalmic conditions
WO2018089490A1 (fr) 2016-11-08 2018-05-17 Calithera Biosciences, Inc. Polythérapies faisant appel à un inhibiteur d'arginase
PT3559009T (pt) 2016-12-22 2021-05-04 Calithera Biosciences Inc Composições e métodos para inibir a atividade da arginase
CN116217656A (zh) 2016-12-23 2023-06-06 里兰斯坦福初级大学理事会 基于活性的探针化合物、组合物及其使用方法
US20200054643A1 (en) 2017-01-18 2020-02-20 Vanderbilt University Fused heterocyclic compounds as selective bmp inhibitors
MA47593A (fr) 2017-02-24 2020-01-01 Merck Patent Gmbh Dérivés de 1, 4, 6-trisubstitué-2-alkyl-1h-benzo[d]imidazole en tant qu'inhibiteurs de dihydroorotate oxygénase
HRP20230657T8 (hr) 2017-03-31 2023-11-10 Aurigene Oncology Limited Spojevi i pripravci za liječenje hematoloških poremećaja
US10994025B2 (en) 2017-05-12 2021-05-04 Massachusetts Institute Of Technology Argonaute protein-double stranded RNA complexes and uses related thereto
US11325943B2 (en) 2017-06-02 2022-05-10 Stealth Biotherapeutics Inc. Crystalline salt forms of SBT-20
KR20240033119A (ko) 2017-06-30 2024-03-12 더 리전트 오브 더 유니버시티 오브 캘리포니아 모발 성장을 조절하기 위한 조성물 및 방법
US10526334B2 (en) 2017-07-19 2020-01-07 California Institute Of Technology Methods for preparing bis-tetrahydroisoquinoline-containing compounds
SG11202003081WA (en) 2017-10-11 2020-05-28 Aurigene Discovery Tech Ltd Crystalline forms of 3-substituted 1,2,4-oxadiazole
IL315025A (en) 2017-10-31 2024-10-01 Curis Inc Compounds and preparations for the treatment of hematological disorders
WO2019087087A1 (fr) 2017-11-03 2019-05-09 Aurigene Discovery Technologies Limited Double inhibiteurs de voies tim-3 et pd-1
EP3706798A1 (fr) 2017-11-06 2020-09-16 Aurigene Discovery Technologies Limited Thérapies conjointes à des fins d'immunomodulation
WO2019122265A1 (fr) 2017-12-22 2019-06-27 Medimmune Limited Modulateurs à petites molécules du domaine btb de keap1
WO2019152536A1 (fr) 2018-01-30 2019-08-08 The Regents Of The University Of California Inhibiteurs de la voie wnt/bêta-caténine
WO2019178383A1 (fr) 2018-03-14 2019-09-19 Vanderbilt University Inhibition de la signalisation bmp, composés, compositions et leurs utilisations
EP3773614A1 (fr) 2018-04-12 2021-02-17 Matrx Therapeutics Corporation Compositions et procédés de traitement de rupture de fibre élastique
US11155638B2 (en) 2018-05-08 2021-10-26 Rhode Island Hospital Anti-CHI3L1 antibodies for the detection and/or treatment of nonalcoholic fattly liver disease/nonalcoholic steatonhepatitis and subsequent complications
EP3813841A4 (fr) 2018-06-29 2022-03-09 The Regents Of The University Of California Nouvelles pinces moléculaires contre des troubles neurologiques et des infections virales
WO2020023917A1 (fr) 2018-07-27 2020-01-30 California Institute Of Technology Inhibiteurs de cdk et leurs utilisations
WO2020051322A1 (fr) 2018-09-05 2020-03-12 The General Hospital Corporation Méthodes de traitement du syndrome de libération de cytokine
CN114269345A (zh) 2018-10-26 2022-04-01 科乐斯疗法公司 Alk2抑制剂的晶体形式
WO2020150473A2 (fr) 2019-01-18 2020-07-23 Dogma Therapeutics, Inc. Inhibiteurs de pcsk9 et leurs procédés d'utilisation
EP3914604A4 (fr) 2019-01-25 2022-10-19 Brown University Compositions et procédés pour traiter, prévenir ou inverser une inflammation et des troubles associés à l'âge
JP2022523510A (ja) 2019-01-31 2022-04-25 エレクトロフィ，インコーポレイテッド 粒子形成及び形態構造
CA3131753A1 (fr) 2019-03-14 2020-09-17 Astrazeneca Ab Lanabecestat pour perte de poids
WO2020246503A1 (fr) 2019-06-03 2020-12-10 株式会社大分大学先端医学研究所 Composés d'amide cyclique pour le traitement de la rage et méthode associée
EP4027978A1 (fr) 2019-09-13 2022-07-20 Elektrofi, Inc. Compositions et procédés pour l'administration de produits biologiques thérapeutiques pour le traitement d'une maladie
IL292965A (en) 2019-11-12 2022-07-01 Genzyme Corp Heteroarylaminosulfonamides with 6 positions and methods of using them
WO2021113806A1 (fr) 2019-12-05 2021-06-10 Genzyme Corporation Arylamides et leurs procédés d'utilisation
WO2021113809A1 (fr) 2019-12-05 2021-06-10 Genzyme Corporation Arylamides et leurs procédés d'utilisation
WO2021125800A1 (fr) 2019-12-16 2021-06-24 울산과학기술원 Composé destiné à inhiber le facteur d'angiogenèse et son utilisation
EP4087847A4 (fr) 2020-01-10 2024-02-28 The Regents of the University of California Compositions et méthodes de traitement de maladies neurodégénératives
WO2021158959A2 (fr) 2020-02-07 2021-08-12 Elektrofi, Inc. Particules peptidiques et procédés de formation
WO2021168271A1 (fr) 2020-02-19 2021-08-26 Elektrofi, Inc. Formation de gouttelettes et morphologie de particules
WO2021207135A1 (fr) 2020-04-06 2021-10-14 The Regents Of The University Of California Composés et procédés pour induire l'expression d'ucp1
AU2021257476A1 (en) 2020-04-17 2022-11-03 Elektrofi, Inc. Methods of forming particles by continuous droplet formation and dehydration
AU2021268664A1 (en) 2020-05-05 2022-10-20 Nuvalent, Inc. Heteroaromatic macrocyclic ether chemotherapeutic agents
WO2021263072A1 (fr) 2020-06-25 2021-12-30 Dana-Farber Cancer Institute, Inc. Méthodes de traitement d'une maladie
CN111830151B (zh) * 2020-07-01 2021-05-04 迪沙药业集团有限公司 盐酸安非他酮组合物质量控制用系统适用性对照品
WO2022035806A1 (fr) 2020-08-10 2022-02-17 Dana-Farber Cancer Institute, Inc. Inhibiteurs à petites molécules pyrimidine-thiéno-pyridine tricycliques fusionnées de la protéase 28 spécifique de l'ubiquitine
EP4192811A1 (fr) 2020-08-10 2023-06-14 Dana-Farber Cancer Institute, Inc. 3-amino-4-méthylbenzènesulfonamides substitués en tant qu'inhibiteurs à petites molécules de la protéase 28 spécifique à l'ubiquitine
WO2022035805A1 (fr) 2020-08-10 2022-02-17 Dana-Farber Cancer Institute, Inc. 1,2,4-oxadiazoles substitués utilisés en tant qu'inhibiteurs de petites molécules de la protéase 28 spécifique de l'ubiquitine
CN116323571A (zh) 2020-10-23 2023-06-23 丹娜法伯癌症研究院 肌酸激酶（ck）的共价抑制剂以及其用于治疗和预防癌症的用途
WO2022133237A2 (fr) 2020-12-18 2022-06-23 Cornell University Méthodes de traitement de troubles neurodégénératifs et de cancers liés à stat3 au moyen de suppresseurs de fuite d'électrons
AU2021409394A1 (en) 2020-12-21 2023-07-27 Cornell University Peptide-linked drug delivery system
WO2022150574A1 (fr) 2021-01-08 2022-07-14 Cornell University Inhibiteurs de la lipoamide déshydrogénase de mycobacterium tuberculosis
PE20240327A1 (es) 2021-04-13 2024-02-22 Nuvalent Inc Heterociclos con sustitucion amino para tratar canceres con mutaciones de egfr
EP4396176A1 (fr) 2021-09-03 2024-07-10 Genzyme Corporation Composés indoles et leurs utilisations dans le traitement de la fibrose kystique
WO2023034992A1 (fr) 2021-09-03 2023-03-09 Genzyme Corporation Composés indoles et procédés d'utilisation
WO2023056405A1 (fr) 2021-10-01 2023-04-06 Nuvalent, Inc. Formes solides, compositions pharmaceutiques et préparation de composés éther macrocycliques hétéroaromatiques
WO2023056431A1 (fr) 2021-10-01 2023-04-06 Nuvalent, Inc. Méthodes de traitement d'une tumeur solide à l'aide de composés éther macrocycliques hétéroaromatiques
AU2023247081A1 (en) 2022-03-31 2024-10-10 Revolo Biotherapeutics Limited Compositions and their use in methods for treating intestinal inflammation
WO2023196910A1 (fr) 2022-04-07 2023-10-12 Nuvalent, Inc Méthodes de traitement d'une tumeur solide à l'aide de (19r)-5-chloro-3-éthyl-16-fluoro-10,19-diméthyl-20-oxa-3,4,10,11,23-pentaazapentacyclo[19.3.1.02,6. 08,12.013,18]pentacosa-1(24), 2(6),4,8,11,13,15,17,21(25),22-décaén-22-amine
WO2023196900A1 (fr) 2022-04-07 2023-10-12 Nuvalent, Inc. Formes solides, compositions pharmaceutiques et préparation de composés éther macrocycliques hétéroaromatiques
WO2023212721A1 (fr) 2022-04-29 2023-11-02 Elektrofi, Inc. Suspensions injectables
WO2023223015A1 (fr) 2022-05-16 2023-11-23 Revolo Biotherapeutics Limited Méthodes et compositions de prévention ou de traitement d'allergies alimentaires
WO2023250157A1 (fr) 2022-06-24 2023-12-28 Cornell University Inhibiteurs de mycobacterium tuberculosis lipoamide déshydrogénase
WO2024013209A1 (fr) 2022-07-13 2024-01-18 Astrazeneca Ab Inhibiteurs de pcsk9 et leurs procédés d'utilisation
WO2024036097A1 (fr) 2022-08-12 2024-02-15 Nuvalent, Inc. Composés d'éther macrocycliques hétéroaromatiques et isotopologues de ceux-ci
WO2024036098A1 (fr) 2022-08-12 2024-02-15 Nuvalent, Inc. Composés d'éther macrocycliques hétéroaromatiques
WO2024073334A1 (fr) 2022-09-26 2024-04-04 Rose Research Center, Llc Combinaison destinée à être utilisée dans un procédé de prévention de gain de poids
WO2024086634A1 (fr) 2022-10-19 2024-04-25 Nuvalent, Inc. Agents chimiothérapeutiques à base d'éther macrocyclique hétéroaromatique

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759838A (fr) * 1969-12-04 1971-06-03 Wellcome Found Cetones a activite biologique
US3885046A (en) * 1969-12-04 1975-05-20 Burroughs Wellcome Co Meta chloro or fluoro substituted alpha-T-butylaminopropionphenones in the treatment of depression
CA948388A (en) * 1970-02-27 1974-06-04 Paul B. Hansen Pattern bonded continuous filament web
US4347257A (en) * 1979-10-09 1982-08-31 Burroughs Wellcome Co. Prolactin suppression in mammals
JPS56104819A (en) * 1980-01-21 1981-08-20 Wellcome Found Blending agent
US4347177A (en) * 1980-04-14 1982-08-31 Burroughs Wellcome Co. Compounds and methods of making them
US4356165A (en) * 1980-04-14 1982-10-26 Burroughs Wellcome Co. Bupropion radioimmunoassay, and kit
US4347178A (en) * 1980-04-14 1982-08-31 Burroughs Wellcome Co. Compounds and methods of making
US4347382A (en) * 1980-04-15 1982-08-31 Burroughs Wellcome Co. 3H Labeled compounds
US4355179A (en) * 1980-04-14 1982-10-19 Burroughs Wellcome Co. Radioactive nuclide labeled propiophenone compounds
US4347176A (en) * 1980-04-14 1982-08-31 Burroughs Wellcome Co. Compounds and methods of making same
US4435449A (en) * 1981-05-14 1984-03-06 Burroughs Wellcome Co. Treatment of minimal brain dysfunction (MBD)
US4425363A (en) * 1981-05-14 1984-01-10 Burroughs Wellcome Co. Treatment of tardive dyskinesia in mammals
US4393078A (en) * 1982-03-15 1983-07-12 Burroughs Wellcome Co. Bupropion and ethanol
US4438138A (en) * 1982-12-06 1984-03-20 Burroughs Wellcome Co. Reduction of cholesterol with meta-chloro α-t-butylaminopropiophenone
GB8322007D0 (en) * 1983-08-16 1983-09-21 Wellcome Found Pharmaceutical delivery system
USRE33994E (en) * 1983-08-16 1992-07-14 Burroughs Wellcome Co. Pharmaceutical delivery system
US4507323A (en) * 1984-07-25 1985-03-26 Burroughs Wellcome Co. Treatment of psychosexual dysfunctions
US4769027A (en) * 1984-08-15 1988-09-06 Burroughs Wellcome Co. Delivery system
DE3485618D1 (de) * 1984-08-17 1992-04-30 Wellcome Found Zusammensetzung zur kontrollierten abgabe eines wirkstoffes und ihre herstellung.
AU2154892A (en) * 1991-05-07 1992-12-21 Dynagen, Inc. A controlled, sustained release delivery system for treating drug dependency

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US5427798A (en) 1995-06-27
CY2143B1 (en) 2002-06-21
GB9217295D0 (en) 1992-09-30
CA2142320C (fr) 2001-10-09
MX9304967A (es) 1994-05-31
EP0656775B1 (fr) 1997-12-29
KR950702827A (ko) 1995-08-23
TW260607B (fr) 1995-10-21
IL106693A (en) 1997-06-10
SG43911A1 (en) 1997-11-14
WO1994004138A1 (fr) 1994-03-03
DE69316015D1 (de) 1998-02-05
IL106693A0 (en) 1993-12-08
HK1004323A1 (en) 1998-11-20
ATE161422T1 (de) 1998-01-15
ZA935942B (en) 1995-02-13
KR100294154B1 (ko) 2001-09-17
AU677595B2 (en) 1997-05-01
DE69316015T2 (de) 1998-04-16
CA2142320A1 (fr) 1994-03-03
GR3025794T3 (en) 1998-03-31
ES2111168T3 (es) 1998-03-01
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JPH08500110A (ja) 1996-01-09
AU4725893A (en) 1994-03-15

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