KR100186853B1 - 저콜레스테롤혈증제로서 유용한 하이드록시-치환된 아제티디논 화합물 - Google Patents

저콜레스테롤혈증제로서 유용한 하이드록시-치환된 아제티디논 화합물 Download PDF

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Publication number
KR100186853B1
KR100186853B1 KR1019960701555A KR19960701555A KR100186853B1 KR 100186853 B1 KR100186853 B1 KR 100186853B1 KR 1019960701555 A KR1019960701555 A KR 1019960701555A KR 19960701555 A KR19960701555 A KR 19960701555A KR 100186853 B1 KR100186853 B1 KR 100186853B1
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South Korea
Prior art keywords
hydroxy
azetidinone
phenyl
formula
methoxyphenyl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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KR1019960701555A
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English (en)
Korean (ko)
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KR960704842A (ko
Inventor
비. 로젠블룸 스튜어트
듀가 선딥
에이. 버네트 듀만
더블유. 클라더 죤
에이. 맥키트릭 브라이언
Original Assignee
에릭 에스.딕커
쉐링 코포레이션
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Application filed by 에릭 에스.딕커, 쉐링 코포레이션 filed Critical 에릭 에스.딕커
Publication of KR960704842A publication Critical patent/KR960704842A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Dental Preparations (AREA)
  • Pyrane Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1019960701555A 1993-09-21 1994-09-14 저콜레스테롤혈증제로서 유용한 하이드록시-치환된 아제티디논 화합물 Expired - Lifetime KR100186853B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US10244093A 1993-09-21 1993-09-21
US08/102,440 1993-09-21
US8/102440 1993-09-21
US8/257593 1994-06-09
US08/257,593 US5631365A (en) 1993-09-21 1994-06-09 Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US08/257,593 1994-06-09
PCT/US1994/010099 WO1995008532A1 (en) 1993-09-21 1994-09-14 Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents

Publications (2)

Publication Number Publication Date
KR960704842A KR960704842A (ko) 1996-10-09
KR100186853B1 true KR100186853B1 (ko) 1999-05-01

Family

ID=26799377

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960701555A Expired - Lifetime KR100186853B1 (ko) 1993-09-21 1994-09-14 저콜레스테롤혈증제로서 유용한 하이드록시-치환된 아제티디논 화합물

Country Status (35)

Country Link
US (5) US5631365A (enExample)
EP (1) EP0720599B1 (enExample)
JP (1) JP2803908B2 (enExample)
KR (1) KR100186853B1 (enExample)
CN (1) CN1050830C (enExample)
AT (1) ATE180249T1 (enExample)
AU (1) AU681445C (enExample)
BE (1) BE2014C056I2 (enExample)
BR (1) BR1100159A (enExample)
CA (1) CA2172149C (enExample)
CZ (2) CZ288861B6 (enExample)
DE (3) DE122004000026I2 (enExample)
DK (1) DK0720599T3 (enExample)
ES (1) ES2132432T3 (enExample)
FI (1) FI110321B (enExample)
FR (2) FR05C0040I2 (enExample)
GE (1) GEP20043149B (enExample)
GR (1) GR3030312T3 (enExample)
HU (1) HU221185B1 (enExample)
IL (1) IL110956A (enExample)
LU (4) LU91050I2 (enExample)
MA (1) MA23332A1 (enExample)
MY (1) MY111314A (enExample)
NL (2) NL300132I2 (enExample)
NO (6) NO305902B1 (enExample)
NZ (1) NZ274041A (enExample)
PL (1) PL182617B1 (enExample)
RU (1) RU2138480C1 (enExample)
SG (1) SG46208A1 (enExample)
SK (1) SK281067B6 (enExample)
TN (1) TNSN94094A1 (enExample)
TW (1) TW427974B (enExample)
UA (1) UA41948C2 (enExample)
WO (1) WO1995008532A1 (enExample)
ZA (1) ZA947086B (enExample)

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Free format text: TRIAL NUMBER: 2016100000321; TRIAL DECISION FOR CONFIRMATION OF THE SCOPE OF RIGHT_DEFENSIVE REQUESTED 20160204

Effective date: 20160422

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PJ1301 Trial decision

Appeal kind category: Confirmation of the scope of right_defensive

Request date: 20160219

Decision date: 20160422

Appeal identifier: 2016100000424

Appeal kind category: Confirmation of the scope of right_defensive

Request date: 20160204

Decision date: 20160422

Appeal identifier: 2016100000321

Patent event code: PJ13011S08D

Patent event date: 20160422

Comment text: Consolidated Trial Decision

Appeal kind category: Confirmation of the scope of right_defensive

Request date: 20160202

Decision date: 20160422

Appeal identifier: 2016100000301

EXPY Expiration of term
PC1801 Expiration of term