KR0184691B1 - 다양한 씨디44 표면단백질, 이 단백질을 코딩하는 디엔에이 서열, 이 단백질에 대한 항체와 진단과 치료의 용도 - Google Patents

다양한 씨디44 표면단백질, 이 단백질을 코딩하는 디엔에이 서열, 이 단백질에 대한 항체와 진단과 치료의 용도 Download PDF

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Publication number
KR0184691B1
KR0184691B1 KR1019920702741A KR920702741A KR0184691B1 KR 0184691 B1 KR0184691 B1 KR 0184691B1 KR 1019920702741 A KR1019920702741 A KR 1019920702741A KR 920702741 A KR920702741 A KR 920702741A KR 0184691 B1 KR0184691 B1 KR 0184691B1
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South Korea
Prior art keywords
proteins
rna
cells
protein
cdna
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Expired - Fee Related
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KR1019920702741A
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English (en)
Korean (ko)
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KR930700661A (ko
Inventor
피터 헤르리치
헬무트 폰타
우르슐라 군테르트
쉬그프레드 마투주쿠
아키임 웬젤
Original Assignee
페터 가트로브
케른포르쉐젠트룸 칼스루히 게엠베하
토마스 게링
유니버시타트 칼슈
하랄트 하우젠
도이취스 크레브스포르쉐젠트룸
레인하트 구른발트
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Application filed by 페터 가트로브, 케른포르쉐젠트룸 칼스루히 게엠베하, 토마스 게링, 유니버시타트 칼슈, 하랄트 하우젠, 도이취스 크레브스포르쉐젠트룸, 레인하트 구른발트 filed Critical 페터 가트로브
Publication of KR930700661A publication Critical patent/KR930700661A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2884—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD44
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/828—Cancer

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
KR1019920702741A 1990-05-07 1991-03-30 다양한 씨디44 표면단백질, 이 단백질을 코딩하는 디엔에이 서열, 이 단백질에 대한 항체와 진단과 치료의 용도 Expired - Fee Related KR0184691B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DEP4014510,7 1990-05-07
DEP4014510.7 1990-05-07
DE4014510A DE4014510A1 (de) 1990-05-07 1990-05-07 Variante cd44-oberflaechenproteine, diese kodierende c-dna-sequenzen, antikoerper gegen diese proteine sowie ihre verwendung in der diagnostik und therapie
PCT/EP1991/000614 WO1991017248A1 (de) 1990-05-07 1991-03-30 Variante cd44-oberflächenproteine, diese kodierende dna-sequenzen, antikörper gegen diese proteine sowie ihre verwendung in der diagnostik und therapie

Publications (2)

Publication Number Publication Date
KR930700661A KR930700661A (ko) 1993-03-15
KR0184691B1 true KR0184691B1 (ko) 1999-04-01

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ID=6405813

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920702741A Expired - Fee Related KR0184691B1 (ko) 1990-05-07 1991-03-30 다양한 씨디44 표면단백질, 이 단백질을 코딩하는 디엔에이 서열, 이 단백질에 대한 항체와 진단과 치료의 용도

Country Status (21)

Country Link
US (3) US5506119A (enExample)
EP (1) EP0531300B1 (enExample)
JP (1) JP3133062B2 (enExample)
KR (1) KR0184691B1 (enExample)
AT (1) ATE106943T1 (enExample)
AU (1) AU646858B2 (enExample)
BR (1) BR1100650A (enExample)
CA (1) CA2082382C (enExample)
DE (2) DE4014510A1 (enExample)
DK (1) DK0531300T3 (enExample)
FI (1) FI106128B (enExample)
HU (1) HU218905B (enExample)
IE (1) IE62096B1 (enExample)
IL (3) IL98024A (enExample)
NO (3) NO309770B1 (enExample)
NZ (1) NZ238056A (enExample)
PT (1) PT97574B (enExample)
TW (1) TW212202B (enExample)
WO (1) WO1991017248A1 (enExample)
YU (1) YU49126B (enExample)
ZA (1) ZA913389B (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5002873A (en) * 1989-03-17 1991-03-26 Fred Hutchinson Cancer Research Center DNA sequence encoding a lymphocyte adhesion receptor for high endothelium
US5443750A (en) * 1991-01-16 1995-08-22 The Procter & Gamble Company Detergent compositions with high activity cellulase and softening clays
DE4134982A1 (de) * 1991-10-23 1993-04-29 Kernforschungsz Karlsruhe Verwendung von antikoerper enthaltenden praeparationen zur immunsuppression
WO1994002633A1 (en) * 1992-07-21 1994-02-03 Isis Innovation Limited Diagnostic method
CA2165461A1 (en) * 1993-06-18 1995-01-05 Sirpa Jalkanen Compositions and diagnostic methods using monoclonal antibodies against cd44v6
CA2164728A1 (en) * 1993-06-22 1995-01-05 Helmut Ponta Processes for diagnosing and analysing tumours
DE4320624A1 (de) * 1993-06-22 1995-02-09 Boehringer Ingelheim Int Verfahren zur Diagnose und Analyse von Mammakarzinomen
DE4320623C2 (de) * 1993-06-22 1997-11-20 Boehringer Ingelheim Int Verfahren zur Diagnose und Analyse von Adenokarzinomen
DE4326573A1 (de) * 1993-08-07 1995-02-23 Boehringer Ingelheim Int Durch Exon v5 des CD44-Gens kodierte Polypeptide als Targets für Immuntherapie und Immunszintigraphie von Tumoren
DE4431297A1 (de) * 1994-09-02 1996-03-07 Boehringer Ingelheim Int Monoklonaler Antikörper gegen CD44v6
DE19540515C1 (de) * 1995-10-31 1997-02-06 Boehringer Ingelheim Int Tumortherapie durch adoptiven Transfer CD44v-spezifischer zytotoxischer T-Lymphozyten
DE19653607A1 (de) 1996-12-20 1998-06-25 Boehringer Ingelheim Int Verfahren zur Diagnose und Therapie von Hodgkin-Lymphomen
DE19708713C2 (de) * 1997-03-04 2002-11-28 Boehringer Ingelheim Int Verwendung von anti-CD44 Antikörpern enthaltenden Präparationen zur Behandlung bestimmter Tumore und zur Unterdrückung von Immunreaktionen
US8048416B2 (en) 1999-10-08 2011-11-01 Hoffmann-La Roche Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US20080124327A1 (en) * 1999-10-08 2008-05-29 Arius Research, Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US8071072B2 (en) 1999-10-08 2011-12-06 Hoffmann-La Roche Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US7947496B2 (en) 1999-10-08 2011-05-24 Hoffmann-La Roche Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US20050100542A1 (en) * 1999-10-08 2005-05-12 Young David S. Cytotoxicity mediation of cells evidencing surface expression of CD44
US7189397B2 (en) 1999-10-08 2007-03-13 Arius Research Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US20090004103A1 (en) * 1999-10-08 2009-01-01 Young David S F Cytotoxicity mediation of cells evidencing surface expression of CD44
DE10026833A1 (de) * 2000-05-30 2001-12-13 Karlsruhe Forschzent Verfahren zur Identifizierung von Verbindungen zur Modulierung der Aktivität eines Tumorsuppressorgens
US20040110933A1 (en) * 2002-09-13 2004-06-10 Dyax Corporation CD44-binding ligands
EP2886126B1 (en) 2013-12-23 2017-06-07 Exchange Imaging Technologies GmbH Nanoparticle conjugated to CD44 binding peptides
CN109608536B (zh) * 2018-12-12 2020-09-15 深圳市龙华区人民医院 基于前列腺癌干细胞标志物cd44的抗原表位多肽cd44-p3及其应用
CN109608537B (zh) * 2018-12-12 2020-09-15 深圳市龙华区人民医院 基于前列腺癌干细胞标志物cd44的抗原表位多肽cd44-p2及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4753894A (en) * 1984-02-08 1988-06-28 Cetus Corporation Monoclonal anti-human breast cancer antibodies
US5108904A (en) * 1990-03-26 1992-04-28 Alan Landay CD44 as a marker for HIV infection

Also Published As

Publication number Publication date
AU646858B2 (en) 1994-03-10
NO317154B1 (no) 2004-08-30
NO309770B1 (no) 2001-03-26
EP0531300B1 (de) 1994-06-08
YU79491A (sh) 1994-06-10
YU49126B (sh) 2004-03-12
ZA913389B (en) 1992-03-25
AU7565991A (en) 1991-11-27
HUT63652A (en) 1993-09-28
CA2082382A1 (en) 1991-11-08
FI106128B (fi) 2000-11-30
US5506119A (en) 1996-04-09
JPH05508309A (ja) 1993-11-25
IL134982A (en) 2004-05-12
PT97574B (pt) 1998-08-31
ATE106943T1 (de) 1994-06-15
PT97574A (pt) 1992-01-31
NO20001668L (no) 1993-05-06
HU218905B (hu) 2000-12-28
FI925043L (fi) 1992-11-06
FI925043A0 (fi) 1992-11-06
BR1100650A (pt) 2000-08-08
TW212202B (enExample) 1993-09-01
NZ238056A (en) 1993-01-27
NO310661B1 (no) 2001-08-06
EP0531300A1 (de) 1993-03-17
WO1991017248A1 (de) 1991-11-14
IL98024A0 (en) 1992-06-21
IL98024A (en) 2001-06-14
US5760178A (en) 1998-06-02
JP3133062B2 (ja) 2001-02-05
HU9203449D0 (en) 1993-01-28
IE62096B1 (en) 1995-01-11
NO980293D0 (no) 1998-01-23
NO924234D0 (no) 1992-11-04
DE59101889D1 (de) 1994-07-14
IL134982A0 (en) 2001-05-20
US5885575A (en) 1999-03-23
DK0531300T3 (da) 1994-10-10
CA2082382C (en) 2008-09-30
DE4014510A1 (de) 1991-11-14
NO20001668D0 (no) 2000-03-31
NO980293L (no) 1993-01-04
IE911526A1 (en) 1991-11-20
NO924234L (no) 1993-01-04

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