KR0170458B1 - 신규한 아세틸 콜린에스테라제 저해제로서의 헤테로아릴 아민 - Google Patents

신규한 아세틸 콜린에스테라제 저해제로서의 헤테로아릴 아민 Download PDF

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Publication number
KR0170458B1
KR0170458B1 KR1019940701066A KR19940701066A KR0170458B1 KR 0170458 B1 KR0170458 B1 KR 0170458B1 KR 1019940701066 A KR1019940701066 A KR 1019940701066A KR 19940701066 A KR19940701066 A KR 19940701066A KR 0170458 B1 KR0170458 B1 KR 0170458B1
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KR
South Korea
Prior art keywords
compound
alkyl
phenyl
general formula
ring
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1019940701066A
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English (en)
Korean (ko)
Inventor
엘.첸 유핑
에이. 네이겔 아더
Original Assignee
알렌 제이. 스피겔
화이자 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hydrogenated Pyridines (AREA)
  • Control Of Indicators Other Than Cathode Ray Tubes (AREA)
  • Control Of El Displays (AREA)
KR1019940701066A 1991-10-03 1992-08-31 신규한 아세틸 콜린에스테라제 저해제로서의 헤테로아릴 아민 Expired - Fee Related KR0170458B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US771,283 1977-02-23
US77128391A 1991-10-03 1991-10-03
PCT/US1992/007230 WO1993007140A1 (en) 1991-10-03 1992-08-31 Heteroaryl amines as novel acetyl cholinesterase inhibitors

Publications (1)

Publication Number Publication Date
KR0170458B1 true KR0170458B1 (ko) 1999-02-18

Family

ID=25091318

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940701066A Expired - Fee Related KR0170458B1 (ko) 1991-10-03 1992-08-31 신규한 아세틸 콜린에스테라제 저해제로서의 헤테로아릴 아민

Country Status (36)

Country Link
US (4) US5574046A (en:Method)
EP (1) EP0606248B1 (en:Method)
JP (1) JP2546785B2 (en:Method)
KR (1) KR0170458B1 (en:Method)
CN (1) CN1035615C (en:Method)
AP (1) AP314A (en:Method)
AT (1) ATE235490T1 (en:Method)
AU (1) AU667053B2 (en:Method)
BG (1) BG61727B1 (en:Method)
BR (1) BR9206577A (en:Method)
CA (1) CA2119647C (en:Method)
CZ (1) CZ290807B6 (en:Method)
DE (2) DE9290112U1 (en:Method)
DK (1) DK0606248T3 (en:Method)
EG (1) EG21481A (en:Method)
ES (1) ES2193137T3 (en:Method)
FI (1) FI116939B (en:Method)
HU (1) HU225049B1 (en:Method)
IL (1) IL103274A (en:Method)
IS (1) IS1745B (en:Method)
MA (1) MA22672A1 (en:Method)
MX (1) MX9205678A (en:Method)
NO (1) NO308533B1 (en:Method)
NZ (1) NZ244601A (en:Method)
OA (1) OA09895A (en:Method)
PH (1) PH31290A (en:Method)
PL (3) PL171693B1 (en:Method)
PT (1) PT100917B (en:Method)
RO (1) RO112868B1 (en:Method)
RU (1) RU2100357C1 (en:Method)
SG (1) SG52618A1 (en:Method)
TW (1) TW263504B (en:Method)
UA (1) UA41290C2 (en:Method)
UY (1) UY23484A1 (en:Method)
WO (1) WO1993007140A1 (en:Method)
ZA (1) ZA927589B (en:Method)

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EP0976404A3 (en) * 1998-07-30 2001-06-27 Pfizer Products Inc. A pharmaceutical composition for the prevention and treatment of diseases of cognitive dysfunction in a mammal
US6218383B1 (en) 1998-08-07 2001-04-17 Targacept, Inc. Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
EP1604653A1 (en) 1998-09-30 2005-12-14 Takeda Pharmaceutical Company Limited Acetylcholinesterase inhibitors for improving excretory potency of urinary bladder
SE9902268D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
CN1317276C (zh) * 2000-09-29 2007-05-23 中国科学院上海药物研究所 一类吲哚基哌啶类化合物及其制备方法和用途
AU9619301A (en) * 2000-10-20 2002-04-29 Biovitrum Ab 2-, 3-, 4-, or 5-substituted-n1-(benzensulfonyl)indoles and their use in therapy
JP2006505571A (ja) * 2002-10-15 2006-02-16 リゲル ファーマシューテイカルズ、インコーポレイテッド 置換されたインドール及びｈｃｖ阻害剤としてのその使用
US20060014801A1 (en) * 2002-11-22 2006-01-19 The Johns Hopkins University Prevention and treatment of cognitive impairment using (R)-(-)-5-methyl-1-nicotynoyl-2-pyrazoline (MNP) and analogs
US20050267077A1 (en) * 2004-05-14 2005-12-01 Johns Hopkins University Method for improving cognitive function by co-administration of a GABAB receptor antagonist and an acetylcholinesterase inhibitor
EP1600447A1 (en) * 2004-05-28 2005-11-30 Neuropharma S.A.U. Butyrylcholinesterase selective inhibitors
JP2008501758A (ja) 2004-06-09 2008-01-24 グラクソ　グループ　リミテッド ピロロピリジン誘導体
WO2006071274A2 (en) * 2004-12-23 2006-07-06 Voyager Pharmaceutical Corporation Leuprolide acetate and acetylcholinesterase inhibitors or nmda receptor antagonists for the treatment of alzheimer’s disease
CN1808106B (zh) * 2005-01-21 2010-11-24 中国科学院上海药物研究所 一种用核磁共振筛选乙酰胆碱酯酶抑制剂的方法
PE20110565A1 (es) 2008-08-12 2011-09-02 Zinfandel Pharmaceuticals Inc Metodo de identificacion de factores de riesgo de la enfermedad
US8846315B2 (en) 2008-08-12 2014-09-30 Zinfandel Pharmaceuticals, Inc. Disease risk factors and methods of use
CN101503414B (zh) * 2009-03-04 2013-10-30 沈阳药科大学 噻唑并[3,2-b]-1,2,4-三嗪衍生物及其应用
JP6012468B2 (ja) * 2009-10-02 2016-10-25 アヴェクシン エーエス 抗炎症性２−オキソチアゾールおよび２−オキソオキサゾール
US20110212928A1 (en) 2010-02-09 2011-09-01 The Johns Hopkins University Methods and compositions for improving cognitive function
EA201391017A1 (ru) 2011-01-10 2014-04-30 Зинфандел Фармасьютикалз, Инк. Способы и готовые лекарственные формы для лечения болезни альцгеймера
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
CN105102438B (zh) 2013-01-29 2019-04-30 埃维克辛公司 抗炎症和抗肿瘤的2-氧代噻唑类和2-氧代噻吩类化合物
EP2968220B1 (en) 2013-03-15 2021-05-05 Agenebio, Inc. Methods and compositions for improving cognitive function
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
CN103333163A (zh) * 2013-07-09 2013-10-02 广州中医药大学 一种苯并呋喃类衍生物及其制备方法和应用
GB201413695D0 (en) 2014-08-01 2014-09-17 Avexxin As Compound
NZ738682A (en) 2015-05-22 2022-01-28 Agenebio Inc Extended release pharmaceutical compositions of levetiracetam
GB201604318D0 (en) 2016-03-14 2016-04-27 Avexxin As Combination therapy
CN107141266B (zh) * 2017-06-28 2019-04-09 佳木斯大学附属第一医院 一种用于治疗阿尔茨海默病的杂环化合物及其制备方法
CN115466211B (zh) * 2022-06-09 2024-02-23 中国人民解放军空军军医大学 一种n-苯基喹啉-4-胺类化合物及其应用

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BE889931A (fr) * 1980-08-12 1982-02-11 Glaxo Group Ltd Derives indoliques, leur preparation et leurs applications en tant que medicaments
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FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
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Also Published As

Publication number Publication date
OA09895A (en) 1995-09-15
HU9400952D0 (en) 1994-06-28
AU2519692A (en) 1993-05-03
US5574046A (en) 1996-11-12
US20020049210A1 (en) 2002-04-25
FI116939B (fi) 2006-04-13
IS3919A (is) 1993-04-04
CZ290807B6 (cs) 2002-10-16
AP314A (en) 1994-02-04
BG98689A (bg) 1995-03-31
RU2100357C1 (ru) 1997-12-27
IL103274A0 (en) 1993-02-21
HU225049B1 (en) 2006-05-29
ES2193137T3 (es) 2003-11-01
NZ244601A (en) 1995-03-28
MX9205678A (es) 1993-04-01
CN1071166A (zh) 1993-04-21
RO112868B1 (ro) 1998-01-30
PT100917A (pt) 1993-11-30
WO1993007140A1 (en) 1993-04-15
NO941179D0 (no) 1994-03-30
DE69232976T2 (de) 2003-10-02
PL171669B1 (en) 1997-06-30
JPH06510788A (ja) 1994-12-01
EG21481A (en) 2001-11-28
DE9290112U1 (de) 1994-06-01
AP9200421A0 (en) 1992-10-31
CA2119647A1 (en) 1993-04-15
AU667053B2 (en) 1996-03-07
CA2119647C (en) 1998-08-04
MA22672A1 (fr) 1993-07-01
PH31290A (en) 1998-07-06
UY23484A1 (es) 1993-03-11
SG52618A1 (en) 1998-09-28
DK0606248T3 (da) 2003-06-23
PL171693B1 (pl) 1997-06-30
NO941179L (no) 1994-03-30
EP0606248B1 (en) 2003-03-26
DE69232976D1 (de) 2003-04-30
ATE235490T1 (de) 2003-04-15
EP0606248A1 (en) 1994-07-20
TW263504B (en:Method) 1995-11-21
US6303633B1 (en) 2001-10-16
CZ78594A3 (en) 1995-07-12
HUT70544A (en) 1995-10-30
PT100917B (pt) 1999-07-30
BG61727B1 (bg) 1998-04-30
UA41290C2 (uk) 2001-09-17
FI941518L (fi) 1994-03-31
CN1035615C (zh) 1997-08-13
BR9206577A (pt) 1995-10-10
IS1745B (is) 2000-05-18
PL171984B1 (pl) 1997-07-31
US6124321A (en) 2000-09-26
ZA927589B (en) 1994-04-05
JP2546785B2 (ja) 1996-10-23
FI941518A0 (fi) 1994-03-31
IL103274A (en) 1996-11-14
NO308533B1 (no) 2000-09-25

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St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20081016

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

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St.27 status event code: N-4-6-H10-H13-oth-PC1903

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Not in force date: 20081016

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St.27 status event code: A-5-5-R10-R18-oth-X000